ES471688A1 - Procedimiento para la obtencion de derivados benz-aciloben- zimidazol-2-carboxilicos. - Google Patents

Procedimiento para la obtencion de derivados benz-aciloben- zimidazol-2-carboxilicos.

Info

Publication number
ES471688A1
ES471688A1 ES471688A ES471688A ES471688A1 ES 471688 A1 ES471688 A1 ES 471688A1 ES 471688 A ES471688 A ES 471688A ES 471688 A ES471688 A ES 471688A ES 471688 A1 ES471688 A1 ES 471688A1
Authority
ES
Spain
Prior art keywords
acid derivatives
carboxylic acid
benz
acylbenzimidazole
heterocyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES471688A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES471688A1 publication Critical patent/ES471688A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/807—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen all halogen atoms bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic

Abstract

Procedimiento para la obtención de derivados benz-acilobenzimidazol-2-carboxílicos de fórmula: **(Fórmula)** donde R significa un grupo carboxi en caso dado esterificado o amidado o un grupo hidroximetilo, en caso dado eterizado o esterifaco, R1 significa un resto alifático, cicloalifático, aromático, aralifático, heterocíclico, o heterocíclico-alifático, R2 significa un resto alifático, y Ph representa un grupo 1,2-fenileno conteniendo el resto R1-C(=O)-, bajo la condición de que R1 presente como mínimo 2 átomos de carbono, cuando Ph se encuentre por lo demás sin sustituir, R2 significa etilo y R represente acetoximetilo, de sales de estos compuestos con propiedades formadoras de sales.
ES471688A 1976-08-27 1978-07-13 Procedimiento para la obtencion de derivados benz-aciloben- zimidazol-2-carboxilicos. Expired ES471688A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU75684A LU75684A1 (es) 1976-08-27 1976-08-27

Publications (1)

Publication Number Publication Date
ES471688A1 true ES471688A1 (es) 1979-10-16

Family

ID=19728336

Family Applications (7)

Application Number Title Priority Date Filing Date
ES461906A Expired ES461906A1 (es) 1976-08-27 1977-08-26 Procedimiento para la obtencion de derivados benz-acilo-ben-zimidacol-2-carboxilicos.
ES471690A Expired ES471690A1 (es) 1976-08-27 1978-07-13 Procedimiento para la obtencion de derivados benz-aciloben- zimidazol-2-carboxilicos.
ES471687A Expired ES471687A1 (es) 1976-08-27 1978-07-13 Procedimiento para la obtencion de derivados benz-aciloben- zimidazol-2-carboxilicos.
ES471688A Expired ES471688A1 (es) 1976-08-27 1978-07-13 Procedimiento para la obtencion de derivados benz-aciloben- zimidazol-2-carboxilicos.
ES471686A Expired ES471686A1 (es) 1976-08-27 1978-07-13 Procedimiento para la obtencion de derivados benz-aciloben- zimidazol-carboxilicos.
ES471689A Expired ES471689A1 (es) 1976-08-27 1978-07-13 Procedimiento para la obtencion de derivados benz-aciloben- zimidazol-2-carboxilicos.
ES79479189A Expired ES8106706A1 (es) 1976-08-27 1979-04-02 Procedimiento para la obtencion de derivados benz-aciloben- zimidazol-2-carboxilicos.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES461906A Expired ES461906A1 (es) 1976-08-27 1977-08-26 Procedimiento para la obtencion de derivados benz-acilo-ben-zimidacol-2-carboxilicos.
ES471690A Expired ES471690A1 (es) 1976-08-27 1978-07-13 Procedimiento para la obtencion de derivados benz-aciloben- zimidazol-2-carboxilicos.
ES471687A Expired ES471687A1 (es) 1976-08-27 1978-07-13 Procedimiento para la obtencion de derivados benz-aciloben- zimidazol-2-carboxilicos.

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES471686A Expired ES471686A1 (es) 1976-08-27 1978-07-13 Procedimiento para la obtencion de derivados benz-aciloben- zimidazol-carboxilicos.
ES471689A Expired ES471689A1 (es) 1976-08-27 1978-07-13 Procedimiento para la obtencion de derivados benz-aciloben- zimidazol-2-carboxilicos.
ES79479189A Expired ES8106706A1 (es) 1976-08-27 1979-04-02 Procedimiento para la obtencion de derivados benz-aciloben- zimidazol-2-carboxilicos.

Country Status (32)

Country Link
US (3) US4141982A (es)
JP (1) JPS5328172A (es)
AR (6) AR224610A1 (es)
AT (1) AT359060B (es)
AU (1) AU517209B2 (es)
BE (1) BE858157A (es)
CA (1) CA1098526A (es)
CH (8) CH631973A5 (es)
DD (1) DD132735A5 (es)
DE (1) DE2737462A1 (es)
DK (1) DK381277A (es)
ES (7) ES461906A1 (es)
FI (1) FI68230C (es)
FR (1) FR2362841A1 (es)
GB (2) GB1595914A (es)
GR (1) GR72908B (es)
HK (1) HK93784A (es)
HU (2) HU180700B (es)
IE (1) IE45665B1 (es)
IL (1) IL52820A (es)
LU (1) LU75684A1 (es)
MY (1) MY8500936A (es)
NL (1) NL7709471A (es)
NO (1) NO148488C (es)
NZ (1) NZ185035A (es)
OA (1) OA05753A (es)
PL (4) PL112665B1 (es)
PT (1) PT66947B (es)
SE (1) SE434397B (es)
SG (1) SG70784G (es)
SU (7) SU882410A3 (es)
ZA (1) ZA775182B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4312873A (en) * 1978-09-29 1982-01-26 Syntex (U.S.A.) Inc. 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity
US4322431A (en) * 1979-02-09 1982-03-30 Ciba-Geigy Corporation Pharmaceutical preparations containing benzimidazole 2-derivatives
US4492708A (en) * 1982-09-27 1985-01-08 Eli Lilly And Company Antiviral benzimidazoles
ATE67067T1 (de) * 1987-02-03 1991-09-15 Grace W R & Co Biozide.
JPH04197628A (ja) * 1990-11-28 1992-07-17 Sekisui Chem Co Ltd 壁パネルの製造方法
US5216003A (en) * 1992-01-02 1993-06-01 G. D. Searle & Co. Diacid-containing benzimidazole compounds for treatment of neurotoxic injury
FR2751649B1 (fr) * 1996-07-26 1998-08-28 Adir Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US9663703B2 (en) 2014-04-25 2017-05-30 James George Clements Method and compositions for enhanced oil recovery
CN109467512B (zh) * 2018-12-18 2021-06-08 苏州开元民生科技股份有限公司 一种3,4-二氨基-二苯甲酮的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB766749A (en) 1954-01-11 1957-01-23 Aschaffenburger Zellstoffwerke Benzimidazole cobalamines and process for their preparation and separation
US3318889A (en) * 1963-10-14 1967-05-09 S B Penick & Company 2-benzimidazole carbamates
DE1923481A1 (de) * 1969-05-08 1970-11-12 Hoechst Ag Verfahren zur Herstellung von Amiden und Estern der 1-Hydroxy-benzimidazol-2-carbonsaeure
NL7013343A (es) * 1969-09-26 1971-03-30
BE759237A (fr) * 1969-11-21 1971-05-01 Montedison Spa Procede de preparation d'amides a partir de composes heterocycliques azotes
BE792402A (fr) * 1971-12-07 1973-06-07 Ciba Geigy Composes heterocycliques azotes et medicaments anthelminthiqueset antimicrobiens qui en contiennent
US4026936A (en) * 1975-08-07 1977-05-31 Hoffmann-La Roche Inc. Anthelmintic pyridine and thiazole substituted benzimidazole carbamates

Also Published As

Publication number Publication date
HU180700B (en) 1983-04-29
SU745365A3 (ru) 1980-06-30
NO148488B (no) 1983-07-11
NZ185035A (en) 1981-05-29
OA05753A (fr) 1981-05-31
ATA620677A (de) 1980-03-15
IE45665B1 (en) 1982-10-20
CH634305A5 (de) 1983-01-31
CH631973A5 (de) 1982-09-15
US4344957A (en) 1982-08-17
PL110215B1 (en) 1980-07-31
ES471686A1 (es) 1979-10-16
FR2362841A1 (fr) 1978-03-24
HU186765B (en) 1985-09-30
AR222318A1 (es) 1981-05-15
PT66947B (en) 1979-02-07
HK93784A (en) 1984-12-07
AT359060B (de) 1980-10-27
ES471689A1 (es) 1979-10-16
IL52820A0 (en) 1977-10-31
PT66947A (en) 1977-09-01
GR72908B (es) 1984-01-04
AR224610A1 (es) 1981-12-30
CH637120A5 (de) 1983-07-15
BE858157A (fr) 1978-02-27
AR227621A1 (es) 1982-11-30
SU882410A3 (ru) 1981-11-15
SU888819A3 (ru) 1981-12-07
CH631974A5 (de) 1982-09-15
CH632749A5 (de) 1982-10-29
CH632253A5 (de) 1982-09-30
AU2825577A (en) 1979-03-01
AR225889A1 (es) 1982-05-14
DE2737462A1 (de) 1978-03-02
AR230990A1 (es) 1984-08-31
MY8500936A (en) 1985-12-31
ES471690A1 (es) 1979-10-16
GB1595914A (en) 1981-08-19
CH637121A5 (de) 1983-07-15
GB1595913A (en) 1981-08-19
US4141982A (en) 1979-02-27
PL200449A1 (pl) 1978-05-22
JPS6231706B2 (es) 1987-07-09
PL108853B1 (en) 1980-05-31
FR2362841B1 (es) 1981-11-20
CA1098526A (en) 1981-03-31
IE45665L (en) 1978-02-27
ZA775182B (en) 1978-07-26
AR231536A1 (es) 1984-12-28
US4213993A (en) 1980-07-22
NO148488C (no) 1983-10-19
SU923368A3 (ru) 1982-04-23
NL7709471A (nl) 1978-03-01
ES479189A0 (es) 1981-09-01
SU843744A3 (ru) 1981-06-30
ES461906A1 (es) 1978-12-01
SU831074A3 (ru) 1981-05-15
IL52820A (en) 1981-02-27
DK381277A (da) 1978-02-28
JPS5328172A (en) 1978-03-16
LU75684A1 (es) 1978-04-13
AU517209B2 (en) 1981-07-16
SG70784G (en) 1985-03-15
PL105527B1 (pl) 1979-10-31
FI68230C (fi) 1985-08-12
NO772962L (no) 1978-02-28
DD132735A5 (de) 1978-10-25
SE434397B (sv) 1984-07-23
PL112665B1 (en) 1980-10-31
ES8106706A1 (es) 1981-09-01
CH631975A5 (de) 1982-09-15
SE7709615L (sv) 1978-02-28
ES471687A1 (es) 1979-10-16
FI68230B (fi) 1985-04-30
FI772521A (fi) 1978-02-28
SU784766A3 (ru) 1980-11-30

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001009