ES467637A1 - Un nuevo procedimiento para preparar un compuesto de cefa- losporina - Google Patents

Un nuevo procedimiento para preparar un compuesto de cefa- losporina

Info

Publication number
ES467637A1
ES467637A1 ES467637A ES467637A ES467637A1 ES 467637 A1 ES467637 A1 ES 467637A1 ES 467637 A ES467637 A ES 467637A ES 467637 A ES467637 A ES 467637A ES 467637 A1 ES467637 A1 ES 467637A1
Authority
ES
Spain
Prior art keywords
group
cephalosporins
compounds
cephalosporin synthesis
thiomethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES467637A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/862,871 external-priority patent/US4144391A/en
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES467637A1 publication Critical patent/ES467637A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedimiento para el desplazamiento del grupo acetoxi de un ácido cefalosporánico por medio de un nucleófilo de azufre en un solvente orgánico y bajo condiciones esencialmente anhidras. Las reacciones bajo estas condiciones no están complicadas por la formación de lactona; los rendimientos generalmente son mayores; y los productos se aíslan más fácilmente. Algunos de los productos se precipitan espontáneamente de la mezcla de reacción. Se cree que el presente procedimiento es de naturaleza general y aplicable a esencialmente cualquier nucleófilo de azufre y a cualquier ácido cefalosporánico.
ES467637A 1977-03-07 1978-03-07 Un nuevo procedimiento para preparar un compuesto de cefa- losporina Expired ES467637A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77501877A 1977-03-07 1977-03-07
US05/862,871 US4144391A (en) 1977-03-07 1977-12-27 Cephalosporin displacement reaction

Publications (1)

Publication Number Publication Date
ES467637A1 true ES467637A1 (es) 1980-04-01

Family

ID=27118982

Family Applications (1)

Application Number Title Priority Date Filing Date
ES467637A Expired ES467637A1 (es) 1977-03-07 1978-03-07 Un nuevo procedimiento para preparar un compuesto de cefa- losporina

Country Status (30)

Country Link
JP (1) JPS53130689A (es)
AT (1) AT366696B (es)
AU (1) AU515428B2 (es)
BG (1) BG31379A3 (es)
CA (1) CA1083141A (es)
CH (1) CH637964A5 (es)
CS (1) CS205115B2 (es)
CY (1) CY1196A (es)
DD (1) DD137356A5 (es)
DE (1) DE2809058A1 (es)
DK (1) DK97378A (es)
EG (1) EG13454A (es)
ES (1) ES467637A1 (es)
FI (1) FI69309C (es)
FR (1) FR2383189A1 (es)
GB (1) GB1597036A (es)
GR (1) GR68893B (es)
HK (1) HK49083A (es)
HU (1) HU179967B (es)
IE (1) IE46437B1 (es)
IL (1) IL54181A (es)
IT (1) IT1093504B (es)
MX (1) MX5142E (es)
NL (1) NL190703C (es)
NZ (1) NZ186610A (es)
PH (1) PH14596A (es)
PL (1) PL122152B1 (es)
PT (1) PT67732A (es)
SE (1) SE437991B (es)
YU (1) YU51478A (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5543043A (en) * 1978-09-22 1980-03-26 Sankyo Co Ltd Preparation of 3-substituted thiomethylcephalosporin derivative
US4576937A (en) * 1984-02-29 1986-03-18 Smithkline Beckman Corporation 7-D-Mandelamido-3(1-sulfomethyltetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid monosodium salt
GB8519606D0 (en) * 1985-08-05 1985-09-11 Fujisawa Pharmaceutical Co 3 7-d substituted-3-cephem compounds
JP2503500B2 (ja) * 1986-04-14 1996-06-05 萬有製薬株式会社 新規セフアロスポリン誘導体及びその製造法
JPS62281881A (ja) * 1986-09-08 1987-12-07 Sankyo Co Ltd ３−置換チオメチルセフアロスポリン誘導体の製法
US20120329770A1 (en) * 2010-02-26 2012-12-27 Gary Igor Dmitrienko Cephalosporin derivatives useful as beta-lactamase inhibitors and compositions and methods of use thereof
GB201818410D0 (en) * 2018-11-12 2018-12-26 Imperial Innovations Ltd Compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3641021A (en) * 1969-04-18 1972-02-08 Lilly Co Eli 3 7-(ring-substituted) cephalosporin compounds
JPS5116436B1 (es) * 1971-05-31 1976-05-24
JPS5143785A (en) * 1974-10-11 1976-04-14 Yamanouchi Pharma Co Ltd Shinsefuarosuhorinkanrenkagobutsuno goseiho
JPS612674B2 (es) * 1974-06-20 1986-01-27 Meiji Seika Co
CA1100129A (en) * 1974-08-02 1981-04-28 William H.W. Lunn Cephalosporin compounds
FI761035A (es) * 1975-04-21 1976-10-22 Erba Carlo Spa

Also Published As

Publication number Publication date
DK97378A (da) 1978-09-08
CS205115B2 (en) 1981-04-30
ATA150778A (de) 1981-09-15
FR2383189A1 (fr) 1978-10-06
HU179967B (en) 1983-01-28
FI69309B (fi) 1985-09-30
CH637964A5 (en) 1983-08-31
NL190703B (nl) 1994-02-01
IT7820912A0 (it) 1978-03-06
FI69309C (fi) 1986-01-10
FR2383189B1 (es) 1981-06-26
DD137356A5 (de) 1979-08-29
NL190703C (nl) 1994-07-01
SE437991B (sv) 1985-03-25
FI780716A (fi) 1978-09-08
IT1093504B (it) 1985-07-19
CA1083141A (en) 1980-08-05
DE2809058C2 (es) 1989-02-09
PH14596A (en) 1981-10-02
IE46437B1 (en) 1983-06-15
IL54181A (en) 1981-03-31
GB1597036A (en) 1981-09-03
AU515428B2 (en) 1981-04-02
PT67732A (en) 1978-04-01
AT366696B (de) 1982-04-26
IE780453L (en) 1978-09-07
SE7802530L (sv) 1978-09-08
PL205135A1 (pl) 1979-06-04
JPH025758B2 (es) 1990-02-05
DE2809058A1 (de) 1978-09-14
EG13454A (en) 1981-12-31
IL54181A0 (en) 1978-06-15
CY1196A (en) 1983-12-31
YU51478A (en) 1982-10-31
AU3382878A (en) 1979-09-06
GR68893B (es) 1982-03-15
BG31379A3 (en) 1981-12-15
NL7802376A (nl) 1978-09-11
HK49083A (en) 1983-11-04
JPS53130689A (en) 1978-11-14
PL122152B1 (en) 1982-06-30
NZ186610A (en) 1979-11-01
MX5142E (es) 1983-03-30

Similar Documents

Publication Publication Date Title
ES430104A1 (es) Procedimiento para la preparacion de derivados de la cefa- losporina.
ES469567A1 (es) Un procedimiento para la produccion de derivados de ciclos- porina
ES427859A1 (es) Un procedimiento para la preparacion de compuestos de cefa-losporina.
IE41918L (en) 3-thio-cephalosporins.
ES467637A1 (es) Un nuevo procedimiento para preparar un compuesto de cefa- losporina
JPS5517386A (en) Novel oxadiazolopyrimidine derivative
ES445348A1 (es) Un procedimiento para preparar compuestos de 3-aciloximetil-cefem.
ES477852A1 (es) Procedimiento de preparacion de nuevas amidas derivadas de acidos carboxilicos-5-pirimidinicos.
SE8105452L (sv) Forfarande for framstellning av cefalosporiner
CA1221358A (en) 2-THIACEPHEM AND (5R)-PENEM DERIVATIVES
GB2017087A (en) Process for the preparation of xanthone derivatives
ATE56963T1 (de) Verfahren zur herstellung von aminothiazolessigsaeurederivaten.
GB977071A (en) Hydroxylamine derivatives and process for making them
GB1505020A (en) Substituted 2-phenylimino-thiazolines a process for their preparation and their use as ectoparasiticides
ES457884A1 (es) Un procedimiento para preparar compuestos de sulfinil-azeti-dinona.
ATE12644T1 (de) Verfahren zur herstellung von 7-acylamino-3-(thio substituierte)methyl-3-cephem-4-carboxylsaeure-1 oxyd-verbindungen.
IE41394B1 (en) Substituted benimidazoles
ES485801A1 (es) Un procedimiento de preparacion de ciclo-1,3,2-oxazafosfo- ril-derivados
ES462366A1 (es) Procedimiento para la preparacion de fenilacetonitrilos sus-tituidos.
GB1539053A (en) Process for the preparation of alpha-(2-oxoimidazolidinyl carbonylamino)-acetamido cephalosporins
ES8400741A1 (es) Procedimiento para la preparacion de un derivado de dibenzoxepinona.
IL57273A (en) Method of preparation of substituted phenylpropyl halides and some new compounds prepared thereby
ATE16706T1 (de) Verfahren zur herstellung von cephalosporinverbindungen.
GB1498764A (en) Preparation of prostaglandin intermediates
JPS5430196A (en) Novel synthesis of 7alpha-methoxycephalosporanic acid derivative

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000301