FR2383189A1 - Reaction de deplacement du groupement acetoxy, et de ses derives, des cephalosporines par un agent nucleophile soufre - Google Patents

Reaction de deplacement du groupement acetoxy, et de ses derives, des cephalosporines par un agent nucleophile soufre

Info

Publication number
FR2383189A1
FR2383189A1 FR7806158A FR7806158A FR2383189A1 FR 2383189 A1 FR2383189 A1 FR 2383189A1 FR 7806158 A FR7806158 A FR 7806158A FR 7806158 A FR7806158 A FR 7806158A FR 2383189 A1 FR2383189 A1 FR 2383189A1
Authority
FR
France
Prior art keywords
cephalosporins
displacement
derivatives
reaction
acetoxy group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7806158A
Other languages
English (en)
Other versions
FR2383189B1 (fr
Inventor
Lowell Deloss Hatfield
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/862,871 external-priority patent/US4144391A/en
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of FR2383189A1 publication Critical patent/FR2383189A1/fr
Application granted granted Critical
Publication of FR2383189B1 publication Critical patent/FR2383189B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un procédé de préparation de céphalosporines par déplacement du groupement acétoxy. On prépare un dérivé de céphalosporine de formule :
FR7806158A 1977-03-07 1978-03-03 Reaction de deplacement du groupement acetoxy, et de ses derives, des cephalosporines par un agent nucleophile soufre Granted FR2383189A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77501877A 1977-03-07 1977-03-07
US05/862,871 US4144391A (en) 1977-03-07 1977-12-27 Cephalosporin displacement reaction

Publications (2)

Publication Number Publication Date
FR2383189A1 true FR2383189A1 (fr) 1978-10-06
FR2383189B1 FR2383189B1 (fr) 1981-06-26

Family

ID=27118982

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7806158A Granted FR2383189A1 (fr) 1977-03-07 1978-03-03 Reaction de deplacement du groupement acetoxy, et de ses derives, des cephalosporines par un agent nucleophile soufre

Country Status (30)

Country Link
JP (1) JPS53130689A (fr)
AT (1) AT366696B (fr)
AU (1) AU515428B2 (fr)
BG (1) BG31379A3 (fr)
CA (1) CA1083141A (fr)
CH (1) CH637964A5 (fr)
CS (1) CS205115B2 (fr)
CY (1) CY1196A (fr)
DD (1) DD137356A5 (fr)
DE (1) DE2809058A1 (fr)
DK (1) DK97378A (fr)
EG (1) EG13454A (fr)
ES (1) ES467637A1 (fr)
FI (1) FI69309C (fr)
FR (1) FR2383189A1 (fr)
GB (1) GB1597036A (fr)
GR (1) GR68893B (fr)
HK (1) HK49083A (fr)
HU (1) HU179967B (fr)
IE (1) IE46437B1 (fr)
IL (1) IL54181A (fr)
IT (1) IT1093504B (fr)
MX (1) MX5142E (fr)
NL (1) NL190703C (fr)
NZ (1) NZ186610A (fr)
PH (1) PH14596A (fr)
PL (1) PL122152B1 (fr)
PT (1) PT67732A (fr)
SE (1) SE437991B (fr)
YU (1) YU51478A (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5543043A (en) * 1978-09-22 1980-03-26 Sankyo Co Ltd Preparation of 3-substituted thiomethylcephalosporin derivative
US4576937A (en) * 1984-02-29 1986-03-18 Smithkline Beckman Corporation 7-D-Mandelamido-3(1-sulfomethyltetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid monosodium salt
GB8519606D0 (en) * 1985-08-05 1985-09-11 Fujisawa Pharmaceutical Co 3 7-d substituted-3-cephem compounds
JP2503500B2 (ja) * 1986-04-14 1996-06-05 萬有製薬株式会社 新規セフアロスポリン誘導体及びその製造法
JPS62281881A (ja) * 1986-09-08 1987-12-07 Sankyo Co Ltd ３−置換チオメチルセフアロスポリン誘導体の製法
EP2539348A4 (fr) * 2010-02-26 2013-07-24 Gary Igor Dmitrienko Dérivés de la céphalosporine utiles comme inhibiteurs de la -lactamase et leurs compositions et procédés d'utilisation
GB201818410D0 (en) * 2018-11-12 2018-12-26 Imperial Innovations Ltd Compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3641021A (en) * 1969-04-18 1972-02-08 Lilly Co Eli 3 7-(ring-substituted) cephalosporin compounds
JPS5116436B1 (fr) * 1971-05-31 1976-05-24
JPS5143785A (en) * 1974-10-11 1976-04-14 Yamanouchi Pharma Co Ltd Shinsefuarosuhorinkanrenkagobutsuno goseiho
JPS612674B2 (fr) * 1974-06-20 1986-01-27 Meiji Seika Co
CA1100129A (fr) * 1974-08-02 1981-04-28 William H.W. Lunn Traduction non-disponible
FI761035A (fr) * 1975-04-21 1976-10-22 Erba Carlo Spa

Also Published As

Publication number Publication date
MX5142E (es) 1983-03-30
GR68893B (fr) 1982-03-15
HU179967B (en) 1983-01-28
NL7802376A (nl) 1978-09-11
GB1597036A (en) 1981-09-03
NZ186610A (en) 1979-11-01
SE7802530L (sv) 1978-09-08
NL190703B (nl) 1994-02-01
PL205135A1 (pl) 1979-06-04
CA1083141A (fr) 1980-08-05
FI69309B (fi) 1985-09-30
IE46437B1 (en) 1983-06-15
JPH025758B2 (fr) 1990-02-05
HK49083A (en) 1983-11-04
AT366696B (de) 1982-04-26
DE2809058A1 (de) 1978-09-14
CY1196A (en) 1983-12-31
DD137356A5 (de) 1979-08-29
DK97378A (da) 1978-09-08
NL190703C (nl) 1994-07-01
SE437991B (sv) 1985-03-25
JPS53130689A (en) 1978-11-14
IT1093504B (it) 1985-07-19
IL54181A (en) 1981-03-31
CS205115B2 (en) 1981-04-30
IT7820912A0 (it) 1978-03-06
DE2809058C2 (fr) 1989-02-09
PH14596A (en) 1981-10-02
FR2383189B1 (fr) 1981-06-26
IL54181A0 (en) 1978-06-15
YU51478A (en) 1982-10-31
PT67732A (en) 1978-04-01
ATA150778A (de) 1981-09-15
FI69309C (fi) 1986-01-10
BG31379A3 (en) 1981-12-15
ES467637A1 (es) 1980-04-01
EG13454A (en) 1981-12-31
IE780453L (en) 1978-09-07
AU3382878A (en) 1979-09-06
AU515428B2 (en) 1981-04-02
CH637964A5 (en) 1983-08-31
PL122152B1 (en) 1982-06-30
FI780716A (fi) 1978-09-08

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Legal Events

Date Code Title Description
ST Notification of lapse