ES467637A1 - Cephalosporin synthesis - Google Patents
Cephalosporin synthesisInfo
- Publication number
- ES467637A1 ES467637A1 ES467637A ES467637A ES467637A1 ES 467637 A1 ES467637 A1 ES 467637A1 ES 467637 A ES467637 A ES 467637A ES 467637 A ES467637 A ES 467637A ES 467637 A1 ES467637 A1 ES 467637A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- cephalosporins
- compounds
- cephalosporin synthesis
- thiomethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
3-(Thiomethyl)cephalosporins of the formula < IMAGE > in which the substituents are defined in Claim 1 are prepared by a novel process. These compounds are obtained by replacing, in a corresponding cephalosporanic acid which has an acyloxy group in the 3-position, this group by the group -SR<13> by reaction with a sulphur nucleophile in an organic solvent under virtually anhydrous conditions. The compounds obtained can be used for the control of infections in warm-blooded animals (mammals) or as an intermediate for the preparation of other cephalosporins.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77501877A | 1977-03-07 | 1977-03-07 | |
| US05/862,871 US4144391A (en) | 1977-03-07 | 1977-12-27 | Cephalosporin displacement reaction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES467637A1 true ES467637A1 (en) | 1980-04-01 |
Family
ID=27118982
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES467637A Expired ES467637A1 (en) | 1977-03-07 | 1978-03-07 | Cephalosporin synthesis |
Country Status (30)
| Country | Link |
|---|---|
| JP (1) | JPS53130689A (en) |
| AT (1) | AT366696B (en) |
| AU (1) | AU515428B2 (en) |
| BG (1) | BG31379A3 (en) |
| CA (1) | CA1083141A (en) |
| CH (1) | CH637964A5 (en) |
| CS (1) | CS205115B2 (en) |
| CY (1) | CY1196A (en) |
| DD (1) | DD137356A5 (en) |
| DE (1) | DE2809058A1 (en) |
| DK (1) | DK97378A (en) |
| EG (1) | EG13454A (en) |
| ES (1) | ES467637A1 (en) |
| FI (1) | FI69309C (en) |
| FR (1) | FR2383189A1 (en) |
| GB (1) | GB1597036A (en) |
| GR (1) | GR68893B (en) |
| HK (1) | HK49083A (en) |
| HU (1) | HU179967B (en) |
| IE (1) | IE46437B1 (en) |
| IL (1) | IL54181A (en) |
| IT (1) | IT1093504B (en) |
| MX (1) | MX5142E (en) |
| NL (1) | NL190703C (en) |
| NZ (1) | NZ186610A (en) |
| PH (1) | PH14596A (en) |
| PL (1) | PL122152B1 (en) |
| PT (1) | PT67732A (en) |
| SE (1) | SE437991B (en) |
| YU (1) | YU51478A (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5543043A (en) * | 1978-09-22 | 1980-03-26 | Sankyo Co Ltd | Preparation of 3-substituted thiomethylcephalosporin derivative |
| US4576937A (en) * | 1984-02-29 | 1986-03-18 | Smithkline Beckman Corporation | 7-D-Mandelamido-3(1-sulfomethyltetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid monosodium salt |
| GB8519606D0 (en) * | 1985-08-05 | 1985-09-11 | Fujisawa Pharmaceutical Co | 3 7-d substituted-3-cephem compounds |
| JP2503500B2 (en) * | 1986-04-14 | 1996-06-05 | 萬有製薬株式会社 | Novel cefalosporin derivative and method for producing the same |
| JPS62281881A (en) * | 1986-09-08 | 1987-12-07 | Sankyo Co Ltd | Production of 3-substituted thiomethylcephalosporin derivative |
| EP2539348A4 (en) * | 2010-02-26 | 2013-07-24 | Gary Igor Dmitrienko | Cephalosporin derivatives useful as -lactamase inhibitors and compositions and methods of use thereof |
| GB201818410D0 (en) * | 2018-11-12 | 2018-12-26 | Imperial Innovations Ltd | Compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3641021A (en) * | 1969-04-18 | 1972-02-08 | Lilly Co Eli | 3 7-(ring-substituted) cephalosporin compounds |
| JPS5116436B1 (en) * | 1971-05-31 | 1976-05-24 | ||
| JPS5143785A (en) * | 1974-10-11 | 1976-04-14 | Yamanouchi Pharma Co Ltd | Shinsefuarosuhorinkanrenkagobutsuno goseiho |
| JPS612674B2 (en) * | 1974-06-20 | 1986-01-27 | Meiji Seika Co | |
| CA1100129A (en) * | 1974-08-02 | 1981-04-28 | William H.W. Lunn | Cephalosporin compounds |
| FI761035A (en) * | 1975-04-21 | 1976-10-22 | Erba Carlo Spa |
-
1978
- 1978-03-02 CY CY1196A patent/CY1196A/en unknown
- 1978-03-02 GB GB8224/78A patent/GB1597036A/en not_active Expired
- 1978-03-02 CA CA298,070A patent/CA1083141A/en not_active Expired
- 1978-03-02 IL IL54181A patent/IL54181A/en unknown
- 1978-03-02 DE DE19782809058 patent/DE2809058A1/en active Granted
- 1978-03-02 PT PT67732A patent/PT67732A/en unknown
- 1978-03-02 AT AT0150778A patent/AT366696B/en not_active IP Right Cessation
- 1978-03-02 NZ NZ186610A patent/NZ186610A/en unknown
- 1978-03-03 PH PH20847A patent/PH14596A/en unknown
- 1978-03-03 GR GR55608A patent/GR68893B/el unknown
- 1978-03-03 FI FI780716A patent/FI69309C/en not_active IP Right Cessation
- 1978-03-03 CH CH236178A patent/CH637964A5/en not_active IP Right Cessation
- 1978-03-03 AU AU33828/78A patent/AU515428B2/en not_active Expired
- 1978-03-03 DK DK97378A patent/DK97378A/en not_active Application Discontinuation
- 1978-03-03 NL NL7802376A patent/NL190703C/en not_active IP Right Cessation
- 1978-03-03 HU HU78EI784A patent/HU179967B/en unknown
- 1978-03-03 FR FR7806158A patent/FR2383189A1/en active Granted
- 1978-03-06 YU YU00514/78A patent/YU51478A/en unknown
- 1978-03-06 SE SE7802530A patent/SE437991B/en not_active IP Right Cessation
- 1978-03-06 MX MX786901U patent/MX5142E/en unknown
- 1978-03-06 IE IE453/78A patent/IE46437B1/en not_active IP Right Cessation
- 1978-03-06 IT IT20912/78A patent/IT1093504B/en active
- 1978-03-07 BG BG7838941A patent/BG31379A3/en unknown
- 1978-03-07 PL PL1978205135A patent/PL122152B1/en unknown
- 1978-03-07 ES ES467637A patent/ES467637A1/en not_active Expired
- 1978-03-07 JP JP2646878A patent/JPS53130689A/en active Granted
- 1978-03-07 CS CS781436A patent/CS205115B2/en unknown
- 1978-03-07 DD DD78204007A patent/DD137356A5/en not_active IP Right Cessation
- 1978-03-07 EG EG149/78A patent/EG13454A/en active
-
1983
- 1983-10-27 HK HK490/83A patent/HK49083A/en not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20000301 |