ES2579355T3 - Dispositivos para la administración extraocular mínimamente invasiva de radiación a la porción posterior del ojo - Google Patents
Dispositivos para la administración extraocular mínimamente invasiva de radiación a la porción posterior del ojo Download PDFInfo
- Publication number
- ES2579355T3 ES2579355T3 ES13173448.5T ES13173448T ES2579355T3 ES 2579355 T3 ES2579355 T3 ES 2579355T3 ES 13173448 T ES13173448 T ES 13173448T ES 2579355 T3 ES2579355 T3 ES 2579355T3
- Authority
- ES
- Spain
- Prior art keywords
- approximately
- cannula
- ellipsoid
- eye
- radiation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1014—Intracavitary radiation therapy
- A61N5/1017—Treatment of the eye, e.g. for "macular degeneration"
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0612—Eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0041—Catheters; Hollow probes characterised by the form of the tubing pre-formed, e.g. specially adapted to fit with the anatomy of body channels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0082—Catheter tip comprising a tool
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Radiology & Medical Imaging (AREA)
- Pathology (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Radiation-Therapy Devices (AREA)
- Prostheses (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Una cánula que comprende una porción distal curvada (110) para colocación alrededor de una porción de un globo de un ojo; una porción proximal curvada (120), una porción proximal recta y un punto de inflexión en el que la porción distal y las porciones proximales se conectan entre sí, en la que (a) la porción distal tiene un radio de curvatura (180) entre aproximadamente 9 y 15 mm y una longitud del arco (185) entre aproximadamente 25 y 35 mm; y (b) la porción proximal tiene un radio de curvatura (190) entre aproximadamente un radio de la sección transversal interna (173) de la cánula y aproximadamente 1 metro; y en la que en uso un ángulo θ1 (425), que está entre (i) una línea 3 (420) tangente a la porción distal y a la porción proximal curvada en el punto de inflexión entre la porción distal y la porción proximal y (ii) una línea paralela a la porción proximal recta de la cánula, está entre más de aproximadamente 0 grados y aproximadamente 180 grados.
Description
5
15
25
35
45
55
65
113 región central de la porción distal 120 porción proximal 130 punto de inflexión 140 mango 150 conector 160 localizador 171 diámetro interno de la cánula 172 diámetro externo de la cánula 173 radio interno de la porción proximal 180 radio de curvatura de la porción distal 181 círculo/óvalo definido por la curva de la porción distal 182 radio del círculo/óvalo definido por la curva de la porción distal 185 longitud del arco de porción distal 190 radio de curvatura de la porción proximal 191 círculo/óvalo definido por la curva de la porción proximal 192 radio de círculo/óvalo definido por la curva de la porción proximal 195 longitud del arco de la porción proximal 200 punta 210 cámara distal (en forma de disco) 220 eje visual del usuario 230 cápsula de Tenon 235 esclerótica 300 alambre de memoria 310 espiral plana 320 extremo distal del alambre 350 alambre guía 361 sustrato 362 isótopo (o “radionúclido”) 363 superficie inferior del sustrato 364 ventana del moldeador de la radiación 366 moldeador de la radiación 400 fuente en forma de semillas 405 disco 406 altura del disco 407 diámetro del disco 410 porción de alambre de la fuente radiactiva 420 línea ℓ3 425 ángulo θ1 431 plano P1 432 plano P2 450 elipsoide 500 orificio 510 ventana 520 borde distal del orificio/ventana 600 punta de indentación 610 fuente de luz 800 brazo de no alambre 810 anillo para el pulgar 820 sintonizador graduado 830 deslizador 900 cerdo de apantallamiento de la radiación 910 dispositivo usado para el enfoque de radiación intravítrea
Como se usa en el presente documento, el término “aproximadamente” significa más o menos el 10% del número referenciado. Por ejemplo, una realización en la que un ángulo es aproximadamente 50 grados incluye un ángulo entre 45 y 55 grados.
EL OJO
El ojo mamífero es una estructura generalmente esférica que realiza su función visual formando una imagen de un objeto exterior iluminado sobre un tejido fotosensible, la retina. La estructura portante básica para los elementos funcionales del ojo es la resistente vaina externa blanca generalmente esférica, la esclerótica 235, que comprende principalmente tejido conjuntivo colagenoso y se mantiene en su forma esférica por la presión interna del ojo. Externamente, la esclerótica 235 está rodeada por la cápsula de Tenon 230 (fascia bulbi), una delgada capa de tejido que va desde el limbo anteriormente al nervio óptico posteriormente. La cápsula 230 de Tenon está rodeada
8
5
15
25
35
45
55
65
través del cuadrante superonasal, el inferotemporal o el inferonasal.
La presente invención puede usarse en un procedimiento de introducción de radiación a un ojo humano que comprende las etapas de insertar una cánula 100 entre la cápsula 230 de Tenon y la esclerótica 235 del ojo humano en un punto posterior al limbo del ojo humano; en el que la cánula 100 comprende una porción 110 distal que tiene un radio de curvatura 180 entre aproximadamente 9 y 15 mm y una longitud 185 del arco entre aproximadamente 25 y 35 mm; una porción 120 proximal; y un medio para avanzar una FBR hacia la punta 200 de la cánula 100 (por ejemplo, punta 200 de la porción 110 distal); colocar la porción 110 distal sobre o próxima a la esclerótica 235 detrás de una lesión neovascular; avanzar la FBR a la punta 200 del extremo 110 distal; y exponer la lesión neovascular a la FBR.
En algunas realizaciones, el área de la esclerótica 235 expuesta a la radiación es aproximadamente 0,1 mm a aproximadamente 0,5 mm de diámetro. En algunas realizaciones, el área de la esclerótica 235 expuesta a la radiación es aproximadamente 0,5 mm a aproximadamente 2 mm de diámetro. En algunas realizaciones, el área de la esclerótica 235 expuesta a la radiación es aproximadamente 2 mm a 3 mm en diámetro. En algunas realizaciones, el área de la esclerótica 235 expuesta a la radiación es aproximadamente 3 mm a 5 mm de diámetro. En algunas realizaciones, el área de la esclerótica 235 expuesta a la radiación es aproximadamente 5 mm a 10 mm en diámetro. En algunas realizaciones, el área de la esclerótica 235 expuesta a la radiación es aproximadamente 10 mm a 25 mm de diámetro.
LA CÁNULA
La presente invención caracteriza una cánula 100 de forma fija para administrar una FBR a la parte posterior del ojo. La cánula 100 de forma fija tiene una forma fija definida y comprende una porción 110 distal conectada a una porción 120 proximal mediante un punto 130 de inflexión. La porción 110 distal de la cánula 100 de forma fija es para colocación alrededor de una parte del globo del ojo. En algunas realizaciones, la porción 110 distal de la cánula 100 de forma fija se inserta debajo de la cápsula 230 de Tenon y anteriormente la esclerótica 235. En algunas realizaciones, la cánula 100 de forma fija es hueca.
Como se usa en el presente documento, una cánula 100 de forma fija que tiene una forma “fija” se refiere a una cánula 100 de forma fija que tiene una única forma permanente y no puede manipularse en otra forma. Por ejemplo, la cánula 100 de forma fija de la presente invención tiene una forma “fija” debido a que generalmente tiene una forma, mientras que un endoscopio no tiene una forma “fija” debido a que es flexible y puede manipularse en otra forma. Una cánula 100 de forma fija que tiene una forma “fija” también puede construirse a partir de un material que tiene algo de flexibilidad. Por consiguiente, cuando se aplica una presión sobre la cánula 100 de forma fija de la presente invención, puede doblarse. Sin embargo, cuando se quita la presión, la cánula 100 de forma fija de la presente invención puede reanudar su forma fija original o retener una parte de la forma de deformación.
El punto 130 de inflexión se define como un punto sobre una curva en la que el signo o dirección de la curvatura cambia. En algunas realizaciones, puede ser una porción proximal recta de la cánula de forma fija entre la porción distal y la porción proximal curvada. Por consiguiente, en algunas realizaciones, las porciones proximales y distales se separan en un punto de inflexión en el que la curvatura cambia de signo. En algunas realizaciones, la porción proximal termina en un punto en el que la curvatura cambia de un valor finito a cero.
El punto 130 de inflexión ayuda a doblar la porción 120 proximal de la cánula 100 de forma fija lejos del eje 220 visual del sujeto (por ejemplo, paciente) y del usuario (por ejemplo, médico) que inserta la cánula 100 de forma fija en un sujeto. En algunas realizaciones, el usuario puede visualizar la porción posterior del ojo del sujeto empleando un dispositivo oftalmoscópico coaxial tal como un oftalmoscopio indirecto o un microscopio quirúrgico mientras que la cánula 100 de forma fija está en el sitio.
Dimensiones de la porción distal de la cánula de forma fija
Las dimensiones del globo del ojo son bastante constantes en adultos, normalmente variables no más de aproximadamente 1 mm en diversos estudios. Sin embargo, en hiperopía y miopía, el diámetro anteroposterior del globo puede variar significativamente de la medición normal.
El diámetro anteroposterior externo del globo oscila entre aproximadamente 21,7 mm y 28,75 mm con un promedio de aproximadamente 24,15 mm (el radio oscila de aproximadamente 10,8 mm a 14,4 mm con un promedio de aproximadamente 12,1 mm) en ojos emetrópicos, mientras que el diámetro anteroposterior interno promedia aproximadamente 22,12 mm (el radio promedia aproximadamente 11,1 mm). En alta hipermetropía y miopía, el diámetro anteroposterior es frecuentemente de tan solo aproximadamente 20 mm y de hasta aproximadamente 29 mm o más, respectivamente.
El diámetro transversal (por ejemplo, el diámetro del globo en el ecuador anatómico medido desde el lado nasal al temporal) promedia aproximadamente 23,48 mm (el radio promedia aproximadamente 11,75 mm) y el diámetro vertical (por ejemplo, el diámetro del globo en el ecuador anatómico medido superiormente a inferiormente)
11
En algunas realizaciones, el elipsoide 450 tiene dimensiones “a” y “b” que están ambas entre aproximadamente 9 y 15 mm, por ejemplo, aproximadamente 12,1 mm. Este elipsoide 450 puede ser apropiado para diseñar una cánula 100 de forma fija para un ojo emetrópico, en el que el ojo es generalmente esférico. En algunas realizaciones, el 5 elipsoide 450 tiene una dimensión “a” entre aproximadamente 11 mm y 17 mm, por ejemplo, aproximadamente 14 mm, y una dimensión “b” entre aproximadamente 9 mm y 15 mm, por ejemplo, aproximadamente 12,1 mm. Este elipsoide 450 puede ser apropiado para diseñar una cánula 100 de forma fija para un ojo miope, en el que la longitud axial es aproximadamente 28 mm. En algunas realizaciones, el elipsoide 450 tiene una dimensión “a” entre aproximadamente 7 y 13 mm, por ejemplo, 10 mm, y una dimensión “b” entre aproximadamente 9 y 15 mm, por
10 ejemplo, 12 mm. Este elipsoide 450 puede ser apropiado para un ojo hipérope, en el que la longitud axial es aproximadamente 20 mm.
En algunas realizaciones, la porción 120 proximal tiene la forma de un arco derivado del elipsoide 450 que tiene la dimensión del eje x “d”, la dimensión del eje y “e” y la dimensión del eje z “f”. En algunas realizaciones, “d” está entre
15 aproximadamente 0 y 1 metro, “e” está entre aproximadamente 0 y 1 metro y “f” está entre aproximadamente 0 y 1 metro. En algunas realizaciones, “d” está entre aproximadamente 0 y 50 mm, “e” está entre aproximadamente 0 y 50 mm y “f” está entre aproximadamente 0 y 50 mm.
En algunas realizaciones, el elipsoide 450 tiene una dimensión “d”, “e” y/o “f” entre aproximadamente 1 y 3 mm. En
20 algunas realizaciones, el elipsoide 450 tiene una dimensión “d”, “e” y/o “f” entre aproximadamente 3 y 5 mm. En algunas realizaciones, el elipsoide 450 tiene una dimensión “d”, “e” y/o “f” entre aproximadamente 5 y 8 mm. En algunas realizaciones, el elipsoide 450 tiene una dimensión “d”, “e” y/o “f” entre aproximadamente 8 y 10 mm. En algunas realizaciones, el elipsoide 450 tiene una dimensión “d”, “e” y/o “f” entre aproximadamente 10 y 12 mm. En algunas realizaciones, el elipsoide 450 tiene una dimensión “d”, “e” y/o “f” entre aproximadamente 12 y 15 mm. En
25 algunas realizaciones, el elipsoide 450 tiene una dimensión “d”, “e” y/o “f” entre aproximadamente 15 y 18 mm. En algunas realizaciones, el elipsoide 450 tiene una dimensión “d”, “e” y/o “f” entre aproximadamente 18 y 20 mm. En algunas realizaciones, el elipsoide 450 tiene una dimensión “d”, “e” y/o “f” entre aproximadamente 20 y 25 mm. En algunas realizaciones, el elipsoide 450 tiene una dimensión “d”, “e” y/o “f” entre aproximadamente 25 y 30 mm. En algunas realizaciones, el elipsoide 450 tiene una dimensión “d”, “e” y/o “f” entre aproximadamente 30 y 40 mm. En
30 algunas realizaciones, el elipsoide 450 tiene una dimensión “d”, “e” y/o “f” entre aproximadamente 40 y 50 mm. En algunas realizaciones, el elipsoide 450 tiene una dimensión “d”, “e” y/o “f” superior a aproximadamente 50 mm.
El elipsoide 450 puede ser una esfera, en la que “a” es igual a “b”, y “b” es igual a “c”. El elipsoide 450 puede ser un elipsoide escaleno (por ejemplo, elipsoide triaxial) en el que “a” no es igual a “b”, “b” no es igual a “c” y “a” no es igual
35 a “c”.
En algunas realizaciones, el elipsoide 450 es un elipsoide achatado en el que “a” es igual a “b”, y tanto “a” como “b” son mayores que “c”. En algunas realizaciones, el elipsoide 450 es un elipsoide prolato en el que “a” es igual a “b”, y tanto “a” como “b” son inferiores a “c”.
40 En algunas realizaciones, “a” es aproximadamente igual a “b” (por ejemplo, para un ojo emetrópico). En algunas realizaciones, “a” no es igual a “b” (por ejemplo, para un ojo emetrópico). En algunas realizaciones, “b” es aproximadamente igual a “c”. En algunas realizaciones, “b” no es igual a “c”. En algunas realizaciones, “a” es aproximadamente igual a “c”. En algunas realizaciones, “a” no es igual a “c”. En algunas realizaciones, “d” es
45 aproximadamente igual a “e”. En algunas realizaciones, “d” no es igual a “e”. En algunas realizaciones, “e” es aproximadamente igual a “f”. En algunas realizaciones, “e” no es igual a “f”. En algunas realizaciones, “d” es aproximadamente igual a “f”. En algunas realizaciones, “d” no es igual a “f”.
Las dimensiones de “a”, “b” y “c” pueden variar. La Tabla 1 enumera varias combinaciones de dimensiones. Las 50 dimensiones de “a”, “b” y “c” no se limitan a aquellas enumeradas en la Tabla 1.
TABLA 1 (dimensiones en mm +/-1 mm)
55
16
Claims (1)
-
imagen1
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1032208P | 2008-01-07 | 2008-01-07 | |
US10322P | 2008-01-07 | ||
US3323808P | 2008-03-03 | 2008-03-03 | |
US33238P | 2008-03-03 | ||
US3537108P | 2008-03-10 | 2008-03-10 | |
US35371P | 2008-03-10 | ||
US4769308P | 2008-04-24 | 2008-04-24 | |
US47693P | 2008-04-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2579355T3 true ES2579355T3 (es) | 2016-08-10 |
Family
ID=40853446
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09700518T Active ES2432665T3 (es) | 2008-01-07 | 2009-01-07 | Dispositivos para la administración extraocular mínimamente invasiva de radiación a la porción posterior del ojo |
ES13173448.5T Active ES2579355T3 (es) | 2008-01-07 | 2009-01-07 | Dispositivos para la administración extraocular mínimamente invasiva de radiación a la porción posterior del ojo |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09700518T Active ES2432665T3 (es) | 2008-01-07 | 2009-01-07 | Dispositivos para la administración extraocular mínimamente invasiva de radiación a la porción posterior del ojo |
Country Status (19)
Country | Link |
---|---|
US (4) | US8430804B2 (es) |
EP (3) | EP3108933B1 (es) |
JP (4) | JP5721169B2 (es) |
KR (3) | KR101634983B1 (es) |
CN (1) | CN101951965B (es) |
AU (1) | AU2009204223B2 (es) |
BR (1) | BRPI0906416B1 (es) |
CA (1) | CA2714985C (es) |
CL (1) | CL2010000710A1 (es) |
DK (3) | DK2676701T3 (es) |
EA (2) | EA034223B1 (es) |
ES (2) | ES2432665T3 (es) |
HK (1) | HK1147431A1 (es) |
HU (1) | HUE028406T2 (es) |
NZ (1) | NZ586144A (es) |
PL (2) | PL2676701T3 (es) |
TW (1) | TWI565457B (es) |
WO (1) | WO2009089288A1 (es) |
ZA (1) | ZA201003911B (es) |
Families Citing this family (106)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7867186B2 (en) | 2002-04-08 | 2011-01-11 | Glaukos Corporation | Devices and methods for treatment of ocular disorders |
US6638239B1 (en) | 2000-04-14 | 2003-10-28 | Glaukos Corporation | Apparatus and method for treating glaucoma |
US7431710B2 (en) | 2002-04-08 | 2008-10-07 | Glaukos Corporation | Ocular implants with anchors and methods thereof |
WO2002080811A2 (en) | 2001-04-07 | 2002-10-17 | Glaukos Corporation | Glaucoma stent and methods thereof for glaucoma treatment |
US7331984B2 (en) | 2001-08-28 | 2008-02-19 | Glaukos Corporation | Glaucoma stent for treating glaucoma and methods of use |
US8308701B2 (en) | 2010-11-15 | 2012-11-13 | Aquesys, Inc. | Methods for deploying intraocular shunts |
US8721702B2 (en) | 2010-11-15 | 2014-05-13 | Aquesys, Inc. | Intraocular shunt deployment devices |
US10085884B2 (en) | 2006-06-30 | 2018-10-02 | Aquesys, Inc. | Intraocular devices |
US20120123316A1 (en) * | 2010-11-15 | 2012-05-17 | Aquesys, Inc. | Intraocular shunts for placement in the intra-tenon's space |
US8663303B2 (en) | 2010-11-15 | 2014-03-04 | Aquesys, Inc. | Methods for deploying an intraocular shunt from a deployment device and into an eye |
US8852256B2 (en) | 2010-11-15 | 2014-10-07 | Aquesys, Inc. | Methods for intraocular shunt placement |
US9095411B2 (en) | 2010-11-15 | 2015-08-04 | Aquesys, Inc. | Devices for deploying intraocular shunts |
US8506515B2 (en) | 2006-11-10 | 2013-08-13 | Glaukos Corporation | Uveoscleral shunt and methods for implanting same |
US20180296855A1 (en) * | 2008-01-07 | 2018-10-18 | Salutaris Medical Devices, Inc. | Brachytherapy applicator systems and methods |
DK2676701T3 (en) | 2008-01-07 | 2016-05-23 | Salutaris Medical Devices Inc | Devices for minimally-invasive extraocular delivery of radiation to the posterior portion of the eye |
US9056201B1 (en) | 2008-01-07 | 2015-06-16 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive delivery of radiation to the eye |
WO2017112891A1 (en) * | 2015-12-22 | 2017-06-29 | Salutaris Medical Devices, Inc. | Brachytherapy applicator systems and methods |
US8602959B1 (en) | 2010-05-21 | 2013-12-10 | Robert Park | Methods and devices for delivery of radiation to the posterior portion of the eye |
US8608632B1 (en) | 2009-07-03 | 2013-12-17 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive extraocular delivery of radiation and/or pharmaceutics to the posterior portion of the eye |
US9873001B2 (en) | 2008-01-07 | 2018-01-23 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive delivery of radiation to the eye |
US10022558B1 (en) | 2008-01-07 | 2018-07-17 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive delivery of radiation to the eye |
US8017915B2 (en) | 2008-03-14 | 2011-09-13 | Reflexion Medical, Inc. | Method and apparatus for emission guided radiation therapy |
USD691267S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to eye |
USD691269S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to an eye |
USD691268S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to eye |
USD691270S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to an eye |
US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
EP2496304A4 (en) * | 2009-11-02 | 2013-04-17 | Salutaris Medical Devices Inc | METHOD AND DEVICES FOR THE ADMINISTRATION OF MINIMALLY INVASIVE EXTRACOLAR RADIATION |
JP5487470B2 (ja) * | 2010-03-31 | 2014-05-07 | ソニー株式会社 | 後部強膜硬化装置 |
WO2011137162A1 (en) * | 2010-04-27 | 2011-11-03 | Neovista, Inc. | Radiotherapy delivery cannula with visual confirmation window |
US20160256320A1 (en) | 2010-11-15 | 2016-09-08 | Aquesys, Inc. | Intraocular shunt placement in the suprachoroidal space |
US10245178B1 (en) | 2011-06-07 | 2019-04-02 | Glaukos Corporation | Anterior chamber drug-eluting ocular implant |
US10080682B2 (en) | 2011-12-08 | 2018-09-25 | Aquesys, Inc. | Intrascleral shunt placement |
US9808373B2 (en) | 2013-06-28 | 2017-11-07 | Aquesys, Inc. | Intraocular shunt implantation |
US8852136B2 (en) | 2011-12-08 | 2014-10-07 | Aquesys, Inc. | Methods for placing a shunt into the intra-scleral space |
US9610195B2 (en) | 2013-02-27 | 2017-04-04 | Aquesys, Inc. | Intraocular shunt implantation methods and devices |
EP2825101A4 (en) | 2012-03-13 | 2015-12-16 | Suture Ease Llc | NEEDLE AND GUIDING APPARATUS FOR ANSE-SHAPED LOOP FOR SUTURE WIRE PASSAGE |
US9554940B2 (en) | 2012-03-26 | 2017-01-31 | Glaukos Corporation | System and method for delivering multiple ocular implants |
EP2874704A1 (en) * | 2012-07-19 | 2015-05-27 | Boston Scientific Scimed, Inc. | Radiation shielding catheter hub and related methods of use |
RU2508134C1 (ru) * | 2012-08-21 | 2014-02-27 | Федеральное государственное бюджетное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" | Способ лечения меланомы хориоидеи размером более 6,5 мм |
NL2009699C2 (en) * | 2012-10-25 | 2014-04-29 | Nucletron Operations Bv | A modular applicator for brachytherapy. |
WO2014074712A2 (en) * | 2012-11-07 | 2014-05-15 | Ip Liberty Vision Corporation | Light-guided ophthalmic radiation device |
US9707128B2 (en) | 2013-02-27 | 2017-07-18 | James M. Rynerson | Method and apparatus for reducing intraocular pressure of an eye |
US9592151B2 (en) | 2013-03-15 | 2017-03-14 | Glaukos Corporation | Systems and methods for delivering an ocular implant to the suprachoroidal space within an eye |
WO2015105539A2 (en) * | 2013-09-18 | 2015-07-16 | Salutaris Medical Devices, Inc. | Radiation system with emanating source surrounding an internal attenuation component |
CA2930027C (en) | 2013-11-14 | 2019-10-29 | Aquesys, Inc. | Intraocular shunt inserter |
US10117578B2 (en) | 2013-12-31 | 2018-11-06 | Ip Liberty Vision Corporation | Luminescent ophthalmic device |
US10166143B2 (en) | 2013-12-31 | 2019-01-01 | Ip Liberty Vision Corporation | Versatile light-guided ophthalmic treatment system |
US20170007216A1 (en) * | 2014-02-11 | 2017-01-12 | All Cape Gynecology Llc | Endocyte cannula |
CN110680606B (zh) | 2014-02-12 | 2023-07-21 | 陀螺仪治疗学有限公司 | 用于治疗剂的脉络膜上施用的方法和设备 |
CN103919642A (zh) * | 2014-03-14 | 2014-07-16 | 中国人民解放军第三军医大学第一附属医院 | 巩膜后注射*** |
ES2812098T3 (es) | 2014-05-16 | 2021-03-16 | Veosource Sa | Filtros de sangre autolimpiables implantables |
US20150342875A1 (en) | 2014-05-29 | 2015-12-03 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
EP3157408A4 (en) * | 2014-06-17 | 2018-03-07 | Ganiban, Gary | Devices and methods to provide hands free scleral depression during ophthalmic procedures |
USD760381S1 (en) | 2014-06-25 | 2016-06-28 | Donald Fox | Orbital injection cannula |
US10219936B2 (en) * | 2014-09-11 | 2019-03-05 | Orbit Biomedical Limited | Therapeutic agent delivery device with advanceable cannula and needle |
US10258502B2 (en) | 2014-09-18 | 2019-04-16 | Orbit Biomedical Limited | Therapeutic agent delivery device |
US11045665B2 (en) | 2015-05-06 | 2021-06-29 | Ip Liberty Vision Corporation | Light-guided ophthalmic radiation device |
US11318326B2 (en) | 2015-05-07 | 2022-05-03 | Qsa Global Inc. | Strontium sealed source |
WO2016178746A1 (en) | 2015-05-07 | 2016-11-10 | Illinois Tool Works Inc. | Strontium sealed source |
MA42406A (fr) | 2015-06-03 | 2018-05-16 | Aquesys Inc | Mise en place de shunt intraoculaire ab externo |
US11925578B2 (en) | 2015-09-02 | 2024-03-12 | Glaukos Corporation | Drug delivery implants with bi-directional delivery capacity |
WO2017053885A1 (en) | 2015-09-25 | 2017-03-30 | Glaukos Corporation | Punctal implants with controlled drug delivery features and methods of using same |
US10478553B2 (en) * | 2016-03-09 | 2019-11-19 | Orbit Biomedical Limited | Apparatus for subretinal administration of therapeutic agent via a curved needle |
EP3442479A1 (en) | 2016-04-20 | 2019-02-20 | Harold Alexander Heitzmann | Bioresorbable ocular drug delivery device |
USD815285S1 (en) | 2016-05-11 | 2018-04-10 | Salutaris Medical Devices, Inc. | Brachytherapy device |
USD814638S1 (en) | 2016-05-11 | 2018-04-03 | Salutaris Medical Devices, Inc. | Brachytherapy device |
USD814637S1 (en) | 2016-05-11 | 2018-04-03 | Salutaris Medical Devices, Inc. | Brachytherapy device |
JP2019518546A (ja) | 2016-05-31 | 2019-07-04 | キュラ, インク.Qura, Inc. | 埋込型眼圧センサ及び使用方法 |
KR20190019966A (ko) | 2016-06-02 | 2019-02-27 | 아큐시스, 인코포레이티드 | 안구내 약물 전달 |
USD808528S1 (en) | 2016-08-31 | 2018-01-23 | Salutaris Medical Devices, Inc. | Holder for a brachytherapy device |
USD808529S1 (en) | 2016-08-31 | 2018-01-23 | Salutaris Medical Devices, Inc. | Holder for a brachytherapy device |
US20190216645A1 (en) * | 2016-09-23 | 2019-07-18 | The Regents Of The University Of California | Surgical device for ab-externo sub-retinal fluid drainage |
KR101713055B1 (ko) | 2016-10-27 | 2017-03-07 | 이동호 | 안구의 미용을 위한 눈동자 확대부재 및 그 확대부재를 사용한 미용성형시술방법 및 그 시술기구 |
WO2018093937A1 (en) | 2016-11-15 | 2018-05-24 | Reflexion Medical, Inc. | Radiation therapy patient platform |
WO2018093933A1 (en) | 2016-11-15 | 2018-05-24 | Reflexion Medical, Inc. | System for emission-guided high-energy photon delivery |
US10960224B2 (en) | 2017-01-12 | 2021-03-30 | Janssen Pharmaceutica Nv | Trans-orbital infrared light therapy |
US11273072B2 (en) | 2017-01-13 | 2022-03-15 | Gyroscope Therapeutics Limited | Suprachoroidal injection device |
WO2018167787A1 (en) | 2017-03-13 | 2018-09-20 | Carmel Haifa University Economic Corporation Ltd. | Target-less calibration of turbid media |
WO2018183748A1 (en) | 2017-03-30 | 2018-10-04 | Reflexion Medical, Inc. | Radiation therapy systems and methods with tumor tracking |
EP3651851B1 (en) | 2017-07-11 | 2023-11-08 | RefleXion Medical, Inc. | Methods for pet detector afterglow management |
CN111148471B (zh) * | 2017-08-09 | 2023-08-22 | 反射医疗公司 | 用于发射引导放射治疗中的故障检测的***和方法 |
WO2021142255A1 (en) * | 2020-01-08 | 2021-07-15 | Radiance Therapeutics, Inc. | Methods, systems, and compositions for maintaining functioning drainage blebs associated with foreign bodies |
WO2021142298A1 (en) * | 2020-01-08 | 2021-07-15 | Radiance Therapeutics, Inc. | Methods, systems, and compositions for maintaining functioning drainage blebs |
GB201714392D0 (en) * | 2017-09-07 | 2017-10-25 | Marsteller Laurence | Methods and devices for treating glaucoma |
US11376040B2 (en) | 2017-10-06 | 2022-07-05 | Glaukos Corporation | Systems and methods for delivering multiple ocular implants |
USD846738S1 (en) | 2017-10-27 | 2019-04-23 | Glaukos Corporation | Implant delivery apparatus |
US11246753B2 (en) | 2017-11-08 | 2022-02-15 | Aquesys, Inc. | Manually adjustable intraocular flow regulation |
US20190344096A1 (en) * | 2017-12-05 | 2019-11-14 | Ip Liberty Vision Corporation | Methods and systems for shaping the radiation distribution profile of a protected radiation source used for treating medical conditions |
US11135089B2 (en) | 2018-03-09 | 2021-10-05 | Aquesys, Inc. | Intraocular shunt inserter |
US10952898B2 (en) | 2018-03-09 | 2021-03-23 | Aquesys, Inc. | Intraocular shunt inserter |
EP3856100A4 (en) | 2018-09-28 | 2022-06-22 | Radiance Therapeutics, Inc. | METHODS, SYSTEMS, AND COMPOSITIONS FOR MAINTAINING FUNCTIONAL DRAINAGE FILTER BUBBLES ASSOCIATED WITH MINIMALLY INVASIVE MICRO-SCLEROSTOMY |
USD933226S1 (en) | 2018-11-29 | 2021-10-12 | Radiance Therapeutics, Inc. | Ophthalmic brachytherapy set |
CN113556994A (zh) * | 2018-11-29 | 2021-10-26 | 光辉疗法公司 | 应用β辐射的眼科近距离放射治疗***和装置 |
USD933225S1 (en) | 2018-11-29 | 2021-10-12 | Radiance Therapeutics, Inc. | Ophthalmic brachytherapy device |
US20200205839A1 (en) * | 2018-12-31 | 2020-07-02 | J.D. Franco & Co., Llc | Intravascular devices, systems, and methods to address eye disorders |
US10926102B2 (en) | 2019-04-15 | 2021-02-23 | Janssen Pharmaceutica Nv | Transorbital NIR LIGHT THERAPY DEVICES |
US10874874B2 (en) * | 2019-04-15 | 2020-12-29 | Janssen Pharmaceutica Nv | Transorbital NIR light therapy device |
CA3146812A1 (en) | 2019-07-16 | 2021-01-21 | Qsa Global, Inc. | Strontium sealed source |
CN110963372B (zh) * | 2019-10-31 | 2021-07-06 | 苏州雷泰医疗科技有限公司 | 一种用于加速器的盘线器 |
CN115052565A (zh) * | 2019-12-06 | 2022-09-13 | 光辉疗法公司 | 在青光眼滤过手术和白内障摘除术联合手术之后实现健康眼内压的方法、***和组合物 |
JP2023518975A (ja) * | 2020-03-23 | 2023-05-09 | オプティゴン エルエルシー | 黄斑圧子およびその使用および製造方法 |
RU2750968C1 (ru) * | 2020-10-28 | 2021-07-07 | федеральное государственное автономное учреждение "Национальный медицинский исследовательский центр "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации | Устройство для определения проекции новообразования глазного дна на склеру |
RU205697U1 (ru) * | 2021-04-02 | 2021-07-29 | федеральное государственное автономное учреждение "Национальный медицинский исследовательский центр "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации | Офтальмоаппликатор для брахитерапии внутриглазных образований периферической локализации |
TW202320887A (zh) * | 2021-10-29 | 2023-06-01 | 美商莎魯塔理斯醫療設備股份有限公司 | 用於慢性漿液性脈絡視網膜病變(chorioretinopathy)之眼部放射治療的放射核種近接治療射源系統 |
WO2024091586A1 (en) * | 2022-10-28 | 2024-05-02 | Salutaris Medical Devices, Inc. | Radionuclide brachytherapy source systems for ocular radiotherapy |
Family Cites Families (236)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2309302A (en) | 1941-09-08 | 1943-01-26 | Cutter Lab | Transfusion equipment |
US2559793A (en) | 1949-01-27 | 1951-07-10 | Canadian Radium And Uranium Co | Beta irradiation method and means |
US3169527A (en) | 1963-05-13 | 1965-02-16 | Sheridan Corp | Lubricated catheter |
US3662882A (en) * | 1969-06-25 | 1972-05-16 | Molecular Research Corp | Method and apparatus for quality control of explosive primers by characteristic x-ray emission |
US4248354A (en) * | 1979-08-03 | 1981-02-03 | Midland-Ross Corporation | Rotary locksetting mechanism for a rigid jaw coupler |
US4300557A (en) | 1980-01-07 | 1981-11-17 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method for treating intraocular malignancies |
USD272089S (en) | 1981-02-17 | 1984-01-03 | Glassman Jacob A | Surgical instrument |
US5399298A (en) * | 1985-11-01 | 1995-03-21 | Barr & Stroud, Ltd. | Optical filters with coatings transmissive in narrow waveband regions |
US4976266A (en) | 1986-08-29 | 1990-12-11 | United States Department Of Energy | Methods of in vivo radiation measurement |
US4925450A (en) | 1987-03-20 | 1990-05-15 | The Cooper Companies, Inc. | Surgical aspirator cannula |
GB8821116D0 (en) * | 1988-09-08 | 1989-11-08 | Barr & Stroud Ltd | Infra-red transmitting optical components and optical coatings therefor |
NL8902307A (nl) | 1989-09-14 | 1991-04-02 | Cordis Europ | Catheter. |
US5199939B1 (en) | 1990-02-23 | 1998-08-18 | Michael D Dake | Radioactive catheter |
AU113882S (en) | 1990-03-07 | 1992-05-08 | Terumo Corp | Catheter |
US5109844A (en) * | 1990-10-11 | 1992-05-05 | Duke University | Retinal microstimulation |
US5127831A (en) | 1991-06-03 | 1992-07-07 | Bab Itai | Flexible-end irrigation probe |
US5302168A (en) * | 1991-09-05 | 1994-04-12 | Hess Robert L | Method and apparatus for restenosis treatment |
USD345417S (en) | 1991-12-06 | 1994-03-22 | AmRus Corp. | Thoracic drainage tube |
USD347473S (en) | 1992-04-10 | 1994-05-31 | Electro-Catheter Corporation | Steerable catheter handle |
WO1993020784A1 (en) | 1992-04-10 | 1993-10-28 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University | A microneedle for injection of ocular blood vessels |
US5261865A (en) * | 1992-06-02 | 1993-11-16 | Backsmart Inc. | Back strengthening device and method |
US5407441A (en) | 1992-06-04 | 1995-04-18 | Greenbaum; Scott | Ophthalmologic cannula |
US5295945A (en) * | 1992-08-03 | 1994-03-22 | Beth Israel Hospital Assoc. Inc. | Garment and method for positioning and securing a radioactive implant internally within the female genital organs |
US7661676B2 (en) * | 2001-09-28 | 2010-02-16 | Shuffle Master, Incorporated | Card shuffler with reading capability integrated into multiplayer automated gaming table |
US5643171A (en) | 1993-05-04 | 1997-07-01 | Neocardia, Llc | Method and apparatus for uniform radiation treatment of vascular lumens |
JPH09501326A (ja) | 1993-05-04 | 1997-02-10 | オムニトロン インターナショナル インコーポレイテッド | 放射線源ワイヤと、それを用いた装置および治療方法 |
US5540659A (en) | 1993-07-15 | 1996-07-30 | Teirstein; Paul S. | Irradiation catheter and method of use |
US5498227A (en) * | 1993-09-15 | 1996-03-12 | Mawad; Michel E. | Retrievable, shielded radiotherapy implant |
US5392914A (en) * | 1993-09-21 | 1995-02-28 | Rainin Instrument Co., Inc. | Refill pack for pipette tip racks |
US5683345A (en) | 1994-10-27 | 1997-11-04 | Novoste Corporation | Method and apparatus for treating a desired area in the vascular system of a patient |
US5637073A (en) * | 1995-08-28 | 1997-06-10 | Freire; Jorge E. | Radiation therapy for treating macular degeneration and applicator |
WO1997015234A1 (en) * | 1995-10-23 | 1997-05-01 | Johns Hopkins University | Surgical instrument |
US5970457A (en) | 1995-10-25 | 1999-10-19 | Johns Hopkins University | Voice command and control medical care system |
US5840008A (en) * | 1995-11-13 | 1998-11-24 | Localmed, Inc. | Radiation emitting sleeve catheter and methods |
US5713828A (en) | 1995-11-27 | 1998-02-03 | International Brachytherapy S.A | Hollow-tube brachytherapy device |
US6589502B1 (en) | 1995-11-27 | 2003-07-08 | International Brachytherapy S.A. | Radioisotope dispersed in a matrix for brachytherapy |
US6053900A (en) | 1996-02-16 | 2000-04-25 | Brown; Joe E. | Apparatus and method for delivering diagnostic and therapeutic agents intravascularly |
US6234951B1 (en) * | 1996-02-29 | 2001-05-22 | Scimed Life Systems, Inc. | Intravascular radiation delivery system |
US6099454A (en) | 1996-02-29 | 2000-08-08 | Scimed Life Systems, Inc. | Perfusion balloon and radioactive wire delivery system |
USD390656S (en) | 1996-08-01 | 1998-02-10 | Linder Gerald S | Transnasal conduit |
KR20000036228A (ko) * | 1996-09-23 | 2000-06-26 | 노보스트 코포레이션 | 내강내 방사선 치료 시스템 |
US5782742A (en) * | 1997-01-31 | 1998-07-21 | Cardiovascular Dynamics, Inc. | Radiation delivery balloon |
US6162428A (en) | 1997-02-12 | 2000-12-19 | Layton Bioscience, Inc. | hNT-neuron human neuronal cells to replace ganglion cells |
US6110097A (en) | 1997-03-06 | 2000-08-29 | Scimed Life Systems, Inc. | Perfusion balloon catheter with radioactive source |
US6676590B1 (en) | 1997-03-06 | 2004-01-13 | Scimed Life Systems, Inc. | Catheter system having tubular radiation source |
US6059713A (en) * | 1997-03-06 | 2000-05-09 | Scimed Life Systems, Inc. | Catheter system having tubular radiation source with movable guide wire |
US5871481A (en) * | 1997-04-11 | 1999-02-16 | Vidamed, Inc. | Tissue ablation apparatus and method |
US5947891A (en) | 1997-04-25 | 1999-09-07 | Morrison; Richard A. | Method and apparatus for homogeneously irradiating the vaginal mucosa with a linear source uterovaginal applicator |
US6482142B1 (en) | 1997-07-24 | 2002-11-19 | Proxima Therapeutics, Inc. | Asymmetric radiation dosing apparatus and method |
US6030333A (en) * | 1997-10-24 | 2000-02-29 | Radiomed Corporation | Implantable radiotherapy device |
US6471630B1 (en) | 1998-03-24 | 2002-10-29 | Radiomed Corporation | Transmutable radiotherapy device |
US6419621B1 (en) | 1997-10-24 | 2002-07-16 | Radiomed Corporation | Coiled brachytherapy device |
US6264596B1 (en) | 1997-11-03 | 2001-07-24 | Meadox Medicals, Inc. | In-situ radioactive medical device |
AU2320299A (en) | 1998-01-14 | 1999-08-02 | United States Surgical Corporation | Device and method for radiation therapy |
EP1056515A1 (en) | 1998-02-19 | 2000-12-06 | Radiance Medical Systems Inc. | Radioactive stent |
US5935155A (en) | 1998-03-13 | 1999-08-10 | John Hopkins University, School Of Medicine | Visual prosthesis and method of using same |
US5944747A (en) | 1998-03-13 | 1999-08-31 | Johns Hopkins University | Method for preferential outer retinal stimulation |
US6293899B1 (en) | 1998-03-24 | 2001-09-25 | Radiomed Corporation | Transmutable radiotherapy device |
US6296831B1 (en) | 1998-04-10 | 2001-10-02 | Battelle Memorial Institute | Stimulus sensitive gel with radioisotope and methods of making |
US20020131935A1 (en) | 1998-04-10 | 2002-09-19 | Fisher Darrell R. | Fibrin carrier compound for treatment of disease |
US6050930A (en) * | 1998-06-02 | 2000-04-18 | Teirstein; Paul S. | Irradiation catheter with expandable source |
US6402734B1 (en) | 1998-07-02 | 2002-06-11 | Jeffrey N. Weiss | Apparatus and method for cannulating retinal blood vessels |
WO2000006243A2 (en) * | 1998-07-28 | 2000-02-10 | Innerdyne, Inc. | Absorbable brachytherapy and chemotherapy delivery devices and methods |
US6958055B2 (en) | 1998-09-04 | 2005-10-25 | Nmt Group Plc | Retractable needle syringe including a sheath and an intravenous adapter |
US6149643A (en) | 1998-09-04 | 2000-11-21 | Sunrise Technologies International, Inc. | Method and apparatus for exposing a human eye to a controlled pattern of radiation |
US20030083231A1 (en) * | 1998-11-24 | 2003-05-01 | Ahlem Clarence N. | Blood cell deficiency treatment method |
US6135984A (en) | 1999-01-06 | 2000-10-24 | Dishler; Jon G. | Cannula for use in corrective laser eye surgery |
US6183435B1 (en) | 1999-03-22 | 2001-02-06 | Cordis Webster, Inc. | Multi-directional steerable catheters and control handles |
US6183410B1 (en) * | 1999-05-06 | 2001-02-06 | Precision Vascular Systems, Inc. | Radiation exposure device for blood vessels, body cavities and the like |
USD428140S (en) | 1999-05-10 | 2000-07-11 | Crystalmark Dental Systems, Inc. | Elephant evacuator |
US6315768B1 (en) * | 1999-06-08 | 2001-11-13 | Richard K. Wallace | Perfusion procedure and apparatus for preventing necrosis following failed balloon angioplasty |
US6368315B1 (en) | 1999-06-23 | 2002-04-09 | Durect Corporation | Composite drug delivery catheter |
US6464625B2 (en) | 1999-06-23 | 2002-10-15 | Robert A. Ganz | Therapeutic method and apparatus for debilitating or killing microorganisms within the body |
US6213976B1 (en) * | 1999-07-22 | 2001-04-10 | Advanced Research And Technology Institute, Inc. | Brachytherapy guide catheter |
US6267718B1 (en) | 1999-07-26 | 2001-07-31 | Ethicon, Endo-Surgery, Inc. | Brachytherapy seed cartridge |
AU775149B2 (en) * | 1999-10-21 | 2004-07-22 | Alcon Inc. | Sub-tenon drug delivery |
US6436026B1 (en) | 1999-10-22 | 2002-08-20 | Radiomed Corporation | Flexible, continuous, axially elastic interstitial brachytherapy source |
WO2001036047A1 (en) | 1999-11-18 | 2001-05-25 | Schrayer Howard L | Device for the inhibition of cellular proliferation |
US6527692B1 (en) | 1999-11-19 | 2003-03-04 | The Trustees Of Columbia University In The City Of New York | Radiation catheters optimized for stepped delivery technique |
US6613026B1 (en) | 1999-12-08 | 2003-09-02 | Scimed Life Systems, Inc. | Lateral needle-less injection apparatus and method |
AU2626601A (en) * | 2000-01-03 | 2001-07-16 | Johns Hopkins University, The | Device and method for manual retinal vein catheterization |
US6450938B1 (en) | 2000-03-21 | 2002-09-17 | Promex, Llc | Brachytherapy device |
US20010046491A1 (en) | 2000-03-23 | 2001-11-29 | Valerie Kristoffer C. | Tumor radiosensitization with mutant thymidine kinase in combination with a prodrug |
CA2404403C (en) | 2000-04-24 | 2010-06-08 | The University Of Miami | Multicomponent vaginal cylinder system for low dose rate brachytherapy of gynecological cancers |
GB0011581D0 (en) | 2000-05-15 | 2000-07-05 | Nycomed Amersham Plc | Grooved brachytherapy |
US6749553B2 (en) | 2000-05-18 | 2004-06-15 | Theragenics Corporation | Radiation delivery devices and methods for their manufacture |
US6443881B1 (en) * | 2000-06-06 | 2002-09-03 | Paul T. Finger | Ophthalmic brachytherapy device |
ATE404140T1 (de) * | 2000-08-30 | 2008-08-15 | Univ Johns Hopkins | Vorrichtung zur intraokularen wirkstoffverabreichung |
WO2002017799A1 (en) | 2000-08-30 | 2002-03-07 | Cerebral Vascular Applications Inc. | Medical instrument |
AU2001288432A1 (en) | 2000-09-01 | 2002-03-22 | Icos Corporation | Materials and methods to potentiate cancer treatment |
US6800076B2 (en) * | 2000-10-18 | 2004-10-05 | Retinalabs, Inc. | Soft tip cannula and methods for use thereof |
US6530875B1 (en) * | 2000-10-20 | 2003-03-11 | Imagyn Medical Technologies, Inc. | Brachytherapy seed deployment system |
US20040018228A1 (en) * | 2000-11-06 | 2004-01-29 | Afmedica, Inc. | Compositions and methods for reducing scar tissue formation |
US6540655B1 (en) | 2000-11-10 | 2003-04-01 | Scimed Life Systems, Inc. | Miniature x-ray unit |
US6514193B2 (en) * | 2000-11-16 | 2003-02-04 | Microspherix Llc | Method of administering a therapeutically active substance |
US7308487B1 (en) | 2000-12-12 | 2007-12-11 | Igate Corp. | System and method for providing fault-tolerant remote controlled computing devices |
US20020077687A1 (en) | 2000-12-14 | 2002-06-20 | Ahn Samuel S. | Catheter assembly for treating ischemic tissue |
EP1405072A2 (en) * | 2000-12-29 | 2004-04-07 | Oxford GlycoSciences (UK) Limited | Proteins, genes and their use for diagnosis and treatment of kidney response |
US20030171722A1 (en) | 2001-01-04 | 2003-09-11 | Michel Paques | Microsurgical injection and/or distending instruments and surgical method and apparatus utilizing same |
US7103416B2 (en) | 2001-01-16 | 2006-09-05 | Second Sight Medical Products, Inc. | Visual prosthesis including enhanced receiving and stimulating portion |
US20020099363A1 (en) | 2001-01-23 | 2002-07-25 | Woodward Benjamin W. | Radiation treatment system and method of using same |
US7070556B2 (en) | 2002-03-07 | 2006-07-04 | Ams Research Corporation | Transobturator surgical articles and methods |
US20030103945A1 (en) * | 2001-02-09 | 2003-06-05 | Chen Dong Feng | Methods and compositions for stimulating axon regeneration and preventing neuronal cell degeneration |
US6875165B2 (en) * | 2001-02-22 | 2005-04-05 | Retinalabs, Inc. | Method of radiation delivery to the eye |
CN2473631Y (zh) | 2001-04-11 | 2002-01-23 | 北方光电科技股份有限公司 | 一种天文望远镜用附加双目装置 |
US20030157161A1 (en) | 2001-05-01 | 2003-08-21 | Angiotech Pharmaceuticals, Inc. | Compositions and methods for treating inflammatory conditions utilizing protein or polysaccharide containing anti-microtubule agents |
EP1387676A2 (en) | 2001-05-01 | 2004-02-11 | Angiotech Pharmaceuticals, Inc. | Compositions comprising an anti-microtubule agent and a polypeptide or a polysaccharide and the use thereof for the preparation of a medicament for the treatment of inflammatory conditions |
US20020164061A1 (en) | 2001-05-04 | 2002-11-07 | Paik David S. | Method for detecting shapes in medical images |
CA2450771C (en) * | 2001-06-12 | 2010-09-07 | Johns Hopkins University School Of Medicine | Reservoir device for intraocular drug delivery |
US7485113B2 (en) * | 2001-06-22 | 2009-02-03 | Johns Hopkins University | Method for drug delivery through the vitreous humor |
WO2003001249A2 (en) | 2001-06-22 | 2003-01-03 | Ut-Battelle, Llc | Modulating photoreactivity in a cell |
US20030181531A1 (en) * | 2003-02-11 | 2003-09-25 | David Sherris | Compositions and methods of administering tubulin binding agents for the treatment of ocular diseases |
US20030014306A1 (en) * | 2001-07-13 | 2003-01-16 | Marko Kurt R. | Method and system for providing coupons |
US6977264B2 (en) * | 2001-07-25 | 2005-12-20 | Amgen Inc. | Substituted piperidines and methods of use |
US7115607B2 (en) | 2001-07-25 | 2006-10-03 | Amgen Inc. | Substituted piperazinyl amides and methods of use |
US6755338B2 (en) | 2001-08-29 | 2004-06-29 | Cerebral Vascular Applications, Inc. | Medical instrument |
US20030134810A1 (en) | 2001-10-09 | 2003-07-17 | Chris Springate | Methods and compositions comprising biocompatible materials useful for the administration of therapeutic agents |
US7153316B1 (en) | 2001-11-09 | 2006-12-26 | Mcdonald Marguerite B | Surgical instruments and method for corneal reformation |
US7146221B2 (en) | 2001-11-16 | 2006-12-05 | The Regents Of The University Of California | Flexible electrode array for artifical vision |
CA2468544A1 (en) | 2001-12-10 | 2003-06-19 | Amgen Inc. | Vanilloid receptor ligands |
US7481799B2 (en) | 2002-01-03 | 2009-01-27 | Oxira Medical Inc. | Delivery source of oxygen |
US6964653B2 (en) | 2002-02-06 | 2005-11-15 | Felipe Negron | Multi-use hygienic cleansing device |
JP2005517038A (ja) * | 2002-02-14 | 2005-06-09 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 眼疾患を治療するための方法および組成物 |
WO2003070105A1 (en) * | 2002-02-20 | 2003-08-28 | Liposonix, Inc. | Ultrasonic treatment and imaging of adipose tissue |
US20030232013A1 (en) | 2002-02-22 | 2003-12-18 | Gary Sieckman | Therapeutic and diagnostic targeting of cancers cells with tumor homing peptides |
US6918894B2 (en) | 2002-02-28 | 2005-07-19 | Medical Product Specialists | Huber needle with anti-rebound safety mechanism |
USD534650S1 (en) | 2002-05-16 | 2007-01-02 | Ams Research Corporation | Handle for a surgical instrument |
US20040006305A1 (en) * | 2002-07-03 | 2004-01-08 | Stephen Hebert | Balloon catheter having an expandable distal end |
ATE412446T1 (de) | 2002-09-10 | 2008-11-15 | Cianna Medical Inc | Brachytherapievorrichtung |
US7041048B2 (en) * | 2002-10-16 | 2006-05-09 | Sourcetech Medical, Llc | Apparatus and method for dose administration in brachytherapy |
USD543626S1 (en) | 2002-11-27 | 2007-05-29 | Ams Research Corporation | Handle for a surgical instrument |
USD492778S1 (en) | 2002-12-13 | 2004-07-06 | Philip Narini | Suture needle |
US7070554B2 (en) * | 2003-01-15 | 2006-07-04 | Theragenics Corporation | Brachytherapy devices and methods of using them |
US7794437B2 (en) | 2003-01-24 | 2010-09-14 | Doheny Retina Institute | Reservoirs with subretinal cannula for subretinal drug delivery |
US7070544B1 (en) | 2003-01-30 | 2006-07-04 | Randy Rindfleisch | Isolation exercise machine with leverage arm |
WO2004098523A2 (en) * | 2003-04-30 | 2004-11-18 | The Board Of Trustees At The University Of Illinois At Chicago | Intraocular brachytherapy device and method |
US7321796B2 (en) * | 2003-05-01 | 2008-01-22 | California Institute Of Technology | Method and system for training a visual prosthesis |
US20080214887A1 (en) | 2003-06-18 | 2008-09-04 | Heanue Joseph A | Brachytherapy apparatus and method using off-center radiation source |
US20060009493A1 (en) * | 2003-07-02 | 2006-01-12 | Sugen, Inc. | Indolinone hydrazides as c-Met inhibitors |
US20050049508A1 (en) * | 2003-08-06 | 2005-03-03 | Michael Forman | Treatment of age-related macular degeneration |
US7354391B2 (en) * | 2003-11-07 | 2008-04-08 | Cytyc Corporation | Implantable radiotherapy/brachytherapy radiation detecting apparatus and methods |
US7729739B2 (en) * | 2003-12-03 | 2010-06-01 | The Board Of Trustees Of The Leland Stanford Junior University | Heat diffusion based detection of structures of interest in medical images |
US20050148948A1 (en) | 2003-12-19 | 2005-07-07 | Caputa Steven G. | Sutureless ophthalmic drug delivery system and method |
CN1909859B (zh) | 2004-01-23 | 2010-05-12 | 伊萨恩斯外科手术股份有限公司 | 眼部复合微型插管 |
US7563222B2 (en) * | 2004-02-12 | 2009-07-21 | Neovista, Inc. | Methods and apparatus for intraocular brachytherapy |
DE602005024771D1 (de) * | 2004-02-12 | 2010-12-30 | Neovista Inc | Gerät für die intraokulare brachytherapie |
US20050203331A1 (en) | 2004-03-09 | 2005-09-15 | Szapucki Matthew P. | Neurosurgical instrument with gamma ray detector |
USD553738S1 (en) | 2004-03-29 | 2007-10-23 | Simonson Robert E | Handle for medical instruments |
US7228181B2 (en) * | 2004-04-06 | 2007-06-05 | Second Sight Medical Products, Inc. | Retinal prosthesis with side mounted inductive coil |
US20080058704A1 (en) * | 2004-04-29 | 2008-03-06 | Michael Hee | Apparatus and Method for Ocular Treatment |
EP1761293A4 (en) | 2004-06-04 | 2009-08-26 | Resmed Ltd | MASK FIT SYSTEM AND METHOD |
US7252006B2 (en) | 2004-06-07 | 2007-08-07 | California Institute Of Technology | Implantable mechanical pressure sensor and method of manufacturing the same |
US8180454B2 (en) | 2005-12-01 | 2012-05-15 | Second Sight Medical Products, Inc. | Fitting a neural prosthesis using impedance and electrode height |
EP1761776A1 (en) * | 2004-07-01 | 2007-03-14 | Paradigm Therapeutics Limited | Use of the receptor gpr86 |
US20060110428A1 (en) * | 2004-07-02 | 2006-05-25 | Eugene Dejuan | Methods and devices for the treatment of ocular conditions |
DE102005038611B4 (de) * | 2004-08-16 | 2023-01-12 | Iridex Corp. | Richtsondenbehandlungsvorrichtung zur Behandlung eines Auges |
US7402156B2 (en) * | 2004-09-01 | 2008-07-22 | Alcon, Inc. | Counter pressure device for ophthalmic drug delivery |
US20060052796A1 (en) * | 2004-09-08 | 2006-03-09 | Edward Perez | Combined epithelial delaminator and inserter |
US7684868B2 (en) * | 2004-11-10 | 2010-03-23 | California Institute Of Technology | Microfabricated devices for wireless data and power transfer |
EP1833800A1 (en) * | 2004-12-27 | 2007-09-19 | AstraZeneca AB | Pyrazolone compounds as metabotropic glutamate receptor agonists for the treatment of neurological and psychiatric disorders |
US7571004B2 (en) | 2005-01-26 | 2009-08-04 | Second Sight Medical Products, Inc. | Neural stimulation for increased persistence |
JP2006271651A (ja) | 2005-03-29 | 2006-10-12 | Matsumoto Shika Univ | 液体注入用針部品、及びその製造方法 |
CA2601864A1 (en) | 2005-04-08 | 2006-10-19 | Surmodics, Inc. | Sustained release implants and methods for subretinal delivery of bioactive agents to treat or prevent retinal disease |
US7774931B2 (en) | 2005-04-28 | 2010-08-17 | California Institute Of Technology | Method of fabricating an integrated intraocular retinal prosthesis device |
JP2008540038A (ja) | 2005-05-16 | 2008-11-20 | マリンクロッド・インコーポレイテッド | 放射性薬剤ピッグ及び携帯自動注入器 |
US20060287662A1 (en) | 2005-05-26 | 2006-12-21 | Ntk Enterprises, Inc. | Device, system, and method for epithelium protection during cornea reshaping |
US7482601B2 (en) | 2005-07-22 | 2009-01-27 | Isp Investments Inc. | Radiation sensitive film including a measuring scale |
US8512119B2 (en) * | 2005-09-07 | 2013-08-20 | Bally Gaming, Inc. | Tournament gaming systems and methods |
US8506394B2 (en) * | 2005-09-07 | 2013-08-13 | Bally Gaming, Inc. | Tournament gaming systems, gaming devices and methods |
US8317620B2 (en) * | 2005-09-07 | 2012-11-27 | Bally Gaming, Inc. | Tournament gaming systems |
WO2007059233A2 (en) * | 2005-11-15 | 2007-05-24 | Johns Hopkins University | An active cannula for bio-sensing and surgical intervention |
CN101505830A (zh) * | 2005-11-15 | 2009-08-12 | 内奥维斯塔公司 | 用于眼内近距离治疗的方法和器具 |
US8079946B2 (en) | 2005-11-18 | 2011-12-20 | Senorx, Inc. | Asymmetrical irradiation of a body cavity |
JP5388582B2 (ja) | 2006-01-17 | 2014-01-15 | トランセンド・メディカル・インコーポレイテッド | 薬剤投与処置装置 |
EP3838236A1 (en) * | 2006-01-17 | 2021-06-23 | Alcon Inc. | Glaucoma treatment device |
CA2646363C (en) * | 2006-03-14 | 2015-07-21 | The Johns Hopkins University | Apparatus for insertion of a medical device within a body during a medical imaging process and devices and methods related thereto |
ATE497797T1 (de) | 2006-03-14 | 2011-02-15 | Univ Southern California | Mems-vorrichtung zur wirkstofffreisetzung |
US7736360B2 (en) | 2006-03-17 | 2010-06-15 | Microcube, Llc | Devices and methods for creating continuous lesions |
CA2675974C (en) | 2006-04-04 | 2012-10-02 | Bae Systems Information And Electronic Systems Integration Inc. | Method and apparatus for protecting troops |
US8968077B2 (en) * | 2006-04-13 | 2015-03-03 | Idt | Methods and systems for interfacing with a third-party application |
USD575396S1 (en) | 2006-06-06 | 2008-08-19 | Jung Wu | Endoscopic facelift elevator |
EP2043572B1 (en) * | 2006-06-30 | 2014-12-31 | Aquesys Inc. | Apparatus for relieving pressure in an organ |
AU2007275577A1 (en) | 2006-07-21 | 2008-01-24 | Vertex Pharmaceuticals Incorporated | CGRP receptor antagonists |
MX2009001504A (es) | 2006-08-10 | 2009-08-31 | California Inst Of Techn | Valvula microfluidica con un miembro de libre flotacion y su metodo de fabricacion. |
US7547323B2 (en) | 2006-08-29 | 2009-06-16 | Sinexus, Inc. | Stent for irrigation and delivery of medication |
US7900518B2 (en) | 2006-08-29 | 2011-03-08 | California Inst Of Techn | Microfabricated implantable wireless pressure sensor for use in biomedical applications and pressure measurement and sensor implantation methods |
US8244363B2 (en) | 2006-10-20 | 2012-08-14 | Second Sight Medical Products, Inc. | Visual prosthesis |
US7357770B1 (en) | 2006-11-03 | 2008-04-15 | North American Scientific, Inc. | Expandable brachytherapy device with constant radiation source spacing |
US7654716B1 (en) * | 2006-11-10 | 2010-02-02 | Doheny Eye Institute | Enhanced visualization illumination system |
US7831309B1 (en) | 2006-12-06 | 2010-11-09 | University Of Southern California | Implants based on bipolar metal oxide semiconductor (MOS) electronics |
US8182466B2 (en) | 2006-12-29 | 2012-05-22 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Dual braided catheter shaft |
US8209024B2 (en) | 2007-01-22 | 2012-06-26 | Ut-Battelle, Llc | Method and apparatus for treating ischemic diseases |
EP2114514B1 (en) | 2007-02-16 | 2016-10-12 | Second Sight Medical Products, Inc. | Flexible circuit electrode array with film support |
EP2129964A4 (en) * | 2007-02-28 | 2013-11-06 | Doheny Eye Inst | HAND HELD PORTABLE LIGHTING SYSTEM |
WO2008143733A2 (en) | 2007-03-02 | 2008-11-27 | Dohney Eye Institute | Biocompatible implants and methods of making and attaching the same |
WO2008109077A2 (en) | 2007-03-02 | 2008-09-12 | Doheny Eye Institute | Nanoscale surface activation of silicone via laser processing |
EP2134415B1 (en) | 2007-03-08 | 2017-05-03 | Second Sight Medical Products, Inc. | Flexible circuit electrode array |
US9061150B2 (en) * | 2007-03-08 | 2015-06-23 | Second Sight Medical Products, Inc. | Saliency-based apparatus and methods for visual prostheses |
US20080249412A1 (en) | 2007-04-02 | 2008-10-09 | Doheny Eye Institute | Preoperative and Intra-Operative Lens Hardness Measurement by Ultrasound |
US8684935B2 (en) | 2007-04-12 | 2014-04-01 | Doheny Eye Institute | Intraocular ultrasound doppler techniques |
EP2136746B1 (en) | 2007-04-20 | 2012-12-19 | Doheny Eye Institute | Independent surgical center |
US8177064B2 (en) | 2007-04-20 | 2012-05-15 | Doheny Eye Institute | Surgical pack and tray |
US20100174415A1 (en) | 2007-04-20 | 2010-07-08 | Mark Humayun | Sterile surgical tray |
US8323271B2 (en) * | 2007-04-20 | 2012-12-04 | Doheny Eye Institute | Sterile surgical tray |
US8399751B2 (en) * | 2007-06-12 | 2013-03-19 | University Of Southern California | Functional abiotic nanosystems |
US20090016075A1 (en) * | 2007-07-12 | 2009-01-15 | Doheny Eye Institute | Semiconductor lighting in console system for illuminating biological tissues |
US20090036827A1 (en) | 2007-07-31 | 2009-02-05 | Karl Cazzini | Juxtascleral Drug Delivery and Ocular Implant System |
WO2009020994A2 (en) * | 2007-08-06 | 2009-02-12 | Doheny Eye Institute | Ultrasound and microbubbles in ocular diagnostics and therapies |
EP2197368B1 (en) * | 2007-09-27 | 2017-08-23 | Doheny Eye Institute | Selectable stroke cutter |
US8684898B2 (en) | 2007-10-18 | 2014-04-01 | The Invention Science Fund I Llc | Ionizing-radiation-responsive compositions, methods, and systems |
ATE516849T1 (de) * | 2007-10-24 | 2011-08-15 | Second Sight Medical Prod Inc | Elektrodenanordnung für gleichmässigen neuralen druck mit mehreren befestigungspunkten |
US8734214B2 (en) * | 2007-11-29 | 2014-05-27 | International Business Machines Corporation | Simulation of sporting events in a virtual environment |
US8348824B2 (en) | 2007-11-30 | 2013-01-08 | Cytyc Corporation | Transparent catheters for endoscopic localization |
WO2009086112A2 (en) | 2007-12-20 | 2009-07-09 | University Of Southern California | Apparatus and methods for delivering therapeutic agents |
US20090227856A1 (en) | 2007-12-21 | 2009-09-10 | Brian Keith Russell | Electrocardiogram sensor |
DK2240220T3 (en) | 2008-01-03 | 2016-08-01 | Univ Southern California | Implantable devices for drug AND APPARATUS FOR refilling DEVICES |
US8583242B2 (en) | 2008-01-04 | 2013-11-12 | Doheny Eye Institute | Subchoroidal retinal prosthesis |
DK2676701T3 (en) | 2008-01-07 | 2016-05-23 | Salutaris Medical Devices Inc | Devices for minimally-invasive extraocular delivery of radiation to the posterior portion of the eye |
US7912556B2 (en) | 2008-03-04 | 2011-03-22 | Second Sight Medical Products, Inc. | Electrode array for even neural pressure |
WO2009140043A2 (en) * | 2008-04-26 | 2009-11-19 | University Of Southern California | Ocular imaging system |
WO2009137785A2 (en) | 2008-05-08 | 2009-11-12 | Replenish Pumps, Llc | Drug-delivery pumps and methods of manufacture |
CN103394142B (zh) | 2008-05-08 | 2015-08-19 | 迷你泵有限责任公司 | 可植入药物传送装置与用于填充该装置的设备和方法 |
CN102202719B (zh) | 2008-05-08 | 2014-11-26 | 迷你泵有限责任公司 | 可植入泵和用于可植入泵的插管 |
US9254385B2 (en) | 2008-05-14 | 2016-02-09 | Second Sight Medical Products, Inc. | Visual prosthesis for phosphene shape control |
USD595408S1 (en) | 2008-05-15 | 2009-06-30 | Generic Medical Devices, Inc. | Handle for use with medical instruments |
WO2009149175A1 (en) * | 2008-06-04 | 2009-12-10 | Neovista, Inc. | Handheld radiation delivery system for advancing a radiation source wire |
JP2011526919A (ja) | 2008-07-01 | 2011-10-20 | バーテックス ファーマシューティカルズ インコーポレイテッド | イオンチャネルの阻害剤としての複素環式誘導体 |
KR100893918B1 (ko) * | 2008-07-09 | 2009-04-21 | 박기훈 | 척추 고정용 커넥팅로드 연결장치 |
JP6124041B2 (ja) * | 2008-11-04 | 2017-05-10 | リージェンメド(ケイマン)エルティーディー. | 細胞足場構造体 |
USD642266S1 (en) | 2010-08-24 | 2011-07-26 | Marsteller Laurence J | Brachytherapy device |
US20100197826A1 (en) | 2009-01-30 | 2010-08-05 | Rajat Agrawal | Wound Closing Compounds With Additives |
USD616087S1 (en) | 2009-02-06 | 2010-05-18 | Luca Brigatti | Fixed-shape cannula for posterior delivery of radiation to eye |
USD616088S1 (en) | 2009-02-06 | 2010-05-18 | Luca Brigatti | Fixed-shaped cannula for posterior delivery of radiation to eye |
USD615645S1 (en) | 2009-02-06 | 2010-05-11 | Luca Brigatti | Fixed-shape cannula for posterior delivery of radiation to eye |
USD616540S1 (en) | 2009-02-06 | 2010-05-25 | Luca Brigatti | Fixed-shape cannula for posterior delivery of radiation to eye |
WO2010104752A2 (en) | 2009-03-08 | 2010-09-16 | Oprobe, Llc | Multi-function optical probe system for medical and veterinary applications |
-
2009
- 2009-01-07 DK DK13173448.5T patent/DK2676701T3/en active
- 2009-01-07 DK DK09700518.5T patent/DK2227257T3/da active
- 2009-01-07 EP EP16160953.2A patent/EP3108933B1/en active Active
- 2009-01-07 CN CN2009801017399A patent/CN101951965B/zh active Active
- 2009-01-07 PL PL13173448T patent/PL2676701T3/pl unknown
- 2009-01-07 KR KR1020107014923A patent/KR101634983B1/ko active IP Right Grant
- 2009-01-07 WO PCT/US2009/030343 patent/WO2009089288A1/en active Application Filing
- 2009-01-07 NZ NZ586144A patent/NZ586144A/xx unknown
- 2009-01-07 PL PL09700518T patent/PL2227257T3/pl unknown
- 2009-01-07 EP EP13173448.5A patent/EP2676701B1/en active Active
- 2009-01-07 BR BRPI0906416-8A patent/BRPI0906416B1/pt active IP Right Grant
- 2009-01-07 KR KR1020167024665A patent/KR101691368B1/ko active IP Right Grant
- 2009-01-07 EA EA201791532A patent/EA034223B1/ru not_active IP Right Cessation
- 2009-01-07 DK DK16160953T patent/DK3108933T3/da active
- 2009-01-07 JP JP2010541598A patent/JP5721169B2/ja active Active
- 2009-01-07 ES ES09700518T patent/ES2432665T3/es active Active
- 2009-01-07 HU HUE13173448A patent/HUE028406T2/en unknown
- 2009-01-07 US US12/350,079 patent/US8430804B2/en active Active
- 2009-01-07 AU AU2009204223A patent/AU2009204223B2/en active Active
- 2009-01-07 EA EA201070668A patent/EA028562B1/ru not_active IP Right Cessation
- 2009-01-07 EP EP09700518.5A patent/EP2227257B1/en active Active
- 2009-01-07 KR KR1020167005471A patent/KR101725117B1/ko active IP Right Grant
- 2009-01-07 ES ES13173448.5T patent/ES2579355T3/es active Active
- 2009-01-07 CA CA2714985A patent/CA2714985C/en active Active
- 2009-04-23 TW TW098113457A patent/TWI565457B/zh active
- 2009-07-03 US US12/497,644 patent/US20100004499A1/en not_active Abandoned
-
2010
- 2010-06-01 ZA ZA2010/03911A patent/ZA201003911B/en unknown
- 2010-07-01 CL CL2010000710A patent/CL2010000710A1/es unknown
-
2011
- 2011-02-16 HK HK11101537.5A patent/HK1147431A1/xx unknown
-
2013
- 2013-01-16 US US13/742,823 patent/US8597169B2/en active Active
- 2013-04-29 US US13/872,941 patent/US20130267758A1/en not_active Abandoned
-
2014
- 2014-10-15 JP JP2014211094A patent/JP6293637B2/ja active Active
-
2016
- 2016-08-26 JP JP2016166185A patent/JP6785599B2/ja active Active
-
2018
- 2018-10-12 JP JP2018193681A patent/JP2019048080A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2579355T3 (es) | Dispositivos para la administración extraocular mínimamente invasiva de radiación a la porción posterior del ojo | |
ES2573489T3 (es) | Endoiluminadores oftálmicos con luz dirigida | |
ES2919130T3 (es) | Cánula oftálmica iluminada | |
ES2689555T3 (es) | Sistema de lente gonioscópica con mecanismo de estabilización | |
US20060095127A1 (en) | Intraocular and intracorneal refractive lenses | |
ES2645491T3 (es) | Dispositivo de tratamiento de párpados | |
RU2419379C2 (ru) | Инструменты для хирургического доступа к деликатным тканям | |
PT2002803E (pt) | Lúmen para ponta injectora de lente para colocação assistida em lesão | |
PT2042124E (pt) | Lente intra-ocular | |
JPS6075054A (ja) | 眼内水晶体 | |
JP2000229103A (ja) | 眼球の後房レンズ経毛様体強膜縫着における毛様溝パッド | |
US10856969B2 (en) | Toric intraocular lens and intraocular lens insertion apparatus | |
CN209252792U (zh) | 内镜保护套 | |
JP2017517326A5 (es) | ||
JP2019524278A (ja) | 網膜下液排出器具、システム、及び方法 | |
US10251634B2 (en) | Scleral depressor | |
CN110267601A (zh) | 具有扩张器的导引头 | |
Singh et al. | Lacrimal stents and intubation systems: an insight | |
CN111195157B (zh) | 一种脑部手术定位用导向装置 | |
US20230157702A1 (en) | Guide for mandibular resection surgery | |
AU2009231656B2 (en) | System and method for identifying a position to insert a scleral prosthesis into an eye | |
ES2539523A1 (es) | Dispositivo para vitreoctomía | |
CN212015668U (zh) | 一种手术用一次性透明脑牵开导管 | |
JP6885623B2 (ja) | 鏡体 | |
CN212015795U (zh) | 一种脑部手术定位用绕耳廓3d打印导向装置 |