EA202092589A3 - Cxcr2-связывающие полипептиды - Google Patents
Cxcr2-связывающие полипептидыInfo
- Publication number
- EA202092589A3 EA202092589A3 EA202092589A EA202092589A EA202092589A3 EA 202092589 A3 EA202092589 A3 EA 202092589A3 EA 202092589 A EA202092589 A EA 202092589A EA 202092589 A EA202092589 A EA 202092589A EA 202092589 A3 EA202092589 A3 EA 202092589A3
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- polypeptides
- cxcr2
- binding polypeptides
- relates
- present
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
Настоящее изобретение относится к полипептидам, направленным против хемокинового рецептора CXCR2 или специфически связывающимся с этим рецептором, в частности к полипептидам, способным модулировать передачу сигнала от CXCR2. Настоящее изобретение также относится к нуклеиновым кислотам, к векторам и к клеткам-хозяевам, способным экспрессировать полипептиды по изобретению, к фармацевтическим композициям, содержащим указанные полипептиды, и к применению указанных полипептидов и композиций для лечения заболеваний, связанных с нарушением функции CXCR2.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41108310P | 2010-11-08 | 2010-11-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
EA202092589A2 EA202092589A2 (ru) | 2021-03-31 |
EA202092589A3 true EA202092589A3 (ru) | 2021-06-30 |
Family
ID=45001722
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201390666A EA037063B1 (ru) | 2010-11-08 | 2011-11-07 | Cxcr2-связывающие полипептиды |
EA202092589A EA202092589A3 (ru) | 2010-11-08 | 2011-11-07 | Cxcr2-связывающие полипептиды |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201390666A EA037063B1 (ru) | 2010-11-08 | 2011-11-07 | Cxcr2-связывающие полипептиды |
Country Status (25)
Country | Link |
---|---|
US (3) | US8591896B2 (ru) |
EP (3) | EP3578568A3 (ru) |
JP (2) | JP5933573B2 (ru) |
KR (2) | KR101832040B1 (ru) |
CN (1) | CN103328512B (ru) |
AR (1) | AR083784A1 (ru) |
AU (4) | AU2011328246B2 (ru) |
CA (1) | CA2817132A1 (ru) |
CL (1) | CL2013001168A1 (ru) |
CO (1) | CO6761351A2 (ru) |
CR (1) | CR20130202A (ru) |
CU (1) | CU24111B1 (ru) |
EA (2) | EA037063B1 (ru) |
ES (1) | ES2723775T3 (ru) |
GT (1) | GT201300113A (ru) |
IL (1) | IL225897B (ru) |
MA (1) | MA34711B1 (ru) |
MX (2) | MX343085B (ru) |
NZ (1) | NZ610075A (ru) |
PE (1) | PE20140772A1 (ru) |
SG (1) | SG189981A1 (ru) |
TW (2) | TWI619811B (ru) |
UA (1) | UA115027C2 (ru) |
UY (1) | UY33714A (ru) |
WO (1) | WO2012062713A1 (ru) |
Families Citing this family (21)
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JP2020508074A (ja) * | 2017-02-27 | 2020-03-19 | モナッシュ ユニバーシティ | Cxcr2抗体及びその使用 |
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AU2007306340A1 (en) | 2006-10-11 | 2008-04-17 | Ablynx N.V. | Amino acid sequences that bind to serum proteins in a manner that is essentially independent of the pH, compounds comprising the same, and use thereof |
WO2008074839A2 (en) | 2006-12-19 | 2008-06-26 | Ablynx N.V. | Amino acid sequences directed against gpcrs and polypeptides comprising the same for the treatment of gpcr-related diseases and disorders |
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JP6034023B2 (ja) * | 2008-05-16 | 2016-11-30 | アブリンクス エン.ヴェー. | Cxcr4及び他のgpcrに指向性を有するアミノ酸配列及びそれを含む化合物 |
WO2010043650A2 (en) * | 2008-10-14 | 2010-04-22 | Ablynx Nv | Amino acid sequences directed against cellular receptors for viruses and bacteria |
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KR101832040B1 (ko) | 2010-11-08 | 2018-04-04 | 노파르티스 아게 | Cxcr2 결합 폴리펩티드 |
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