BR112012025568A2 - proteínas de ligação ao tnf-<244>. - Google Patents
proteínas de ligação ao tnf-<244>.Info
- Publication number
- BR112012025568A2 BR112012025568A2 BR112012025568A BR112012025568A BR112012025568A2 BR 112012025568 A2 BR112012025568 A2 BR 112012025568A2 BR 112012025568 A BR112012025568 A BR 112012025568A BR 112012025568 A BR112012025568 A BR 112012025568A BR 112012025568 A2 BR112012025568 A2 BR 112012025568A2
- Authority
- BR
- Brazil
- Prior art keywords
- tnf
- binding proteins
- antibodies
- disclosed
- compositions
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6845—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon
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- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1021—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against cytokines, e.g. growth factors, VEGF, TNF, lymphokines or interferons
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Abstract
proteínas de ligação ao tnf-<244>. proteínas de ligação isoladas, por exemplo, anticorpos ou porções de ligação ao antígeno dos mesmos, que se ligam ao fator de necrose tumoral-alfa (tnf-<244>), por exemplo, tnf-<244> humano, e composições e moléculas com base em anticorpo relacionadas são divulgadas. também são divulgadas composições farmacêuticas compreendendo os anticorpos, assim como métodos terapêuticos e de diagnóstico para usar os anticorpos.
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US32163310P | 2010-04-07 | 2010-04-07 | |
PCT/US2011/031381 WO2011127141A1 (en) | 2010-04-07 | 2011-04-06 | TNF-α BINDING PROTEINS |
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BR112012025568A BR112012025568A2 (pt) | 2010-04-07 | 2011-04-06 | proteínas de ligação ao tnf-<244>. |
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CA2807014A1 (en) | 2010-08-03 | 2012-02-09 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
AR084210A1 (es) | 2010-12-08 | 2013-05-02 | Abbott Lab | PROTEINAS DE UNION AL TNF-a |
RU2014120981A (ru) | 2011-10-24 | 2015-12-10 | Эббви Инк. | Иммунные связывающие агенты против склеростина |
-
2011
- 2011-04-06 KR KR1020157005483A patent/KR20150038556A/ko not_active Application Discontinuation
- 2011-04-06 RU RU2012147249/10A patent/RU2012147249A/ru not_active Application Discontinuation
- 2011-04-06 JP JP2013503879A patent/JP2013523153A/ja active Pending
- 2011-04-06 AU AU2011237679A patent/AU2011237679B2/en not_active Ceased
- 2011-04-06 WO PCT/US2011/031381 patent/WO2011127141A1/en active Application Filing
- 2011-04-06 UA UAA201212680A patent/UA107490C2/uk unknown
- 2011-04-06 BR BR112012025568A patent/BR112012025568A2/pt not_active IP Right Cessation
- 2011-04-06 EP EP11766636.2A patent/EP2555797A4/en not_active Withdrawn
- 2011-04-06 NZ NZ603045A patent/NZ603045A/en not_active IP Right Cessation
- 2011-04-06 PE PE2012002003A patent/PE20130528A1/es not_active Application Discontinuation
- 2011-04-06 CA CA2795734A patent/CA2795734A1/en not_active Abandoned
- 2011-04-06 SG SG2012074308A patent/SG184473A1/en unknown
- 2011-04-06 US US13/081,212 patent/US9226983B2/en active Active
- 2011-04-06 CN CN201180027969.2A patent/CN102958537B/zh not_active Expired - Fee Related
- 2011-04-06 MX MX2012011629A patent/MX2012011629A/es not_active Application Discontinuation
- 2011-04-06 KR KR1020127029161A patent/KR20130010123A/ko not_active Application Discontinuation
- 2011-04-07 AR ARP110101162A patent/AR080840A1/es unknown
- 2011-04-07 TW TW100112086A patent/TWI508745B/zh not_active IP Right Cessation
- 2011-04-07 UY UY0001033319A patent/UY33319A/es not_active Application Discontinuation
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2012
- 2012-10-04 CL CL2012002783A patent/CL2012002783A1/es unknown
- 2012-10-05 GT GT201200271A patent/GT201200271A/es unknown
- 2012-10-05 CR CR20120506A patent/CR20120506A/es unknown
- 2012-10-09 IL IL222323A patent/IL222323A0/en unknown
- 2012-10-17 EC ECSP12012272 patent/ECSP12012272A/es unknown
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2015
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Also Published As
Publication number | Publication date |
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US9226983B2 (en) | 2016-01-05 |
KR20130010123A (ko) | 2013-01-25 |
ECSP12012272A (es) | 2012-11-30 |
AR080840A1 (es) | 2012-05-09 |
UY33319A (es) | 2011-12-01 |
SG184473A1 (en) | 2012-11-29 |
CA2795734A1 (en) | 2011-10-13 |
CN102958537B (zh) | 2015-09-16 |
AU2011237679B2 (en) | 2014-11-06 |
EP2555797A1 (en) | 2013-02-13 |
CL2012002783A1 (es) | 2013-07-12 |
US20160176958A1 (en) | 2016-06-23 |
UA107490C2 (uk) | 2015-01-12 |
PE20130528A1 (es) | 2013-05-26 |
IL222323A0 (en) | 2012-12-31 |
CN102958537A (zh) | 2013-03-06 |
CO6630164A2 (es) | 2013-03-01 |
TWI508745B (zh) | 2015-11-21 |
US20110250130A1 (en) | 2011-10-13 |
TW201138825A (en) | 2011-11-16 |
GT201200271A (es) | 2014-02-21 |
AU2011237679A1 (en) | 2012-11-01 |
JP2013523153A (ja) | 2013-06-17 |
CR20120506A (es) | 2013-02-15 |
KR20150038556A (ko) | 2015-04-08 |
RU2012147249A (ru) | 2014-05-20 |
EP2555797A4 (en) | 2014-02-12 |
MX2012011629A (es) | 2013-03-05 |
NZ603045A (en) | 2014-11-28 |
WO2011127141A1 (en) | 2011-10-13 |
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