ES2723775T3 - Polipéptidos que se unen a CXCR2 - Google Patents

Polipéptidos que se unen a CXCR2 Download PDF

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Publication number
ES2723775T3
ES2723775T3 ES11785367T ES11785367T ES2723775T3 ES 2723775 T3 ES2723775 T3 ES 2723775T3 ES 11785367 T ES11785367 T ES 11785367T ES 11785367 T ES11785367 T ES 11785367T ES 2723775 T3 ES2723775 T3 ES 2723775T3
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ES
Spain
Prior art keywords
cxcr2
antigen binding
polypeptide
immunoglobulin
binding domain
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Active
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ES11785367T
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English (en)
Inventor
Michelle Bradley
Zarin Brown
Steven John Charlton
Karen Cromie
Bruno Dombrecht
Soren Steffensen
Heeke Gino Van
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Ablynx NV
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Ablynx NV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626—Diabody or triabody
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Un polipéptido que comprende al menos dos dominios de unión a antígeno de inmunoglobulina, donde el polipéptido se dirige contra el receptor de quimiocinas CXCR2 o se une a él, donde dicho polipéptido incluye un primer dominio de unión a antígeno comprendido dentro de un primer dominio variable único de inmunoglobulina, que reconoce un primer epítopo en CXCR2 y es capaz de unirse a un péptido lineal compuesto por la secuencia de aminoácidos expuesta en la SEQ ID N.º 7 y un segundo dominio de unión a antígeno comprendido dentro de un segundo dominio variable único de inmunoglobulina de un anticuerpo, y donde dicho segundo dominio de unión a antígeno se une a un epítopo dentro de los bucles externos de CXCR2 humano (residuos de aminoácidos 106-120, 184-208 y 274-294 de la SEQ ID N.º 1), y donde el polipéptido es un antagonista de la transducción de señales de CXCR2.
ES11785367T 2010-11-08 2011-11-07 Polipéptidos que se unen a CXCR2 Active ES2723775T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41108310P 2010-11-08 2010-11-08
PCT/EP2011/069571 WO2012062713A1 (en) 2010-11-08 2011-11-07 Cxcr2 binding polypeptides

Publications (1)

Publication Number Publication Date
ES2723775T3 true ES2723775T3 (es) 2019-09-02

Family

ID=45001722

Family Applications (2)

Application Number Title Priority Date Filing Date
ES18214738T Active ES2970234T3 (es) 2010-11-08 2011-11-07 Polipéptidos que se unen a CXCR2
ES11785367T Active ES2723775T3 (es) 2010-11-08 2011-11-07 Polipéptidos que se unen a CXCR2

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES18214738T Active ES2970234T3 (es) 2010-11-08 2011-11-07 Polipéptidos que se unen a CXCR2

Country Status (26)

Country Link
US (3) US8591896B2 (es)
EP (3) EP3575321B1 (es)
JP (2) JP5933573B2 (es)
KR (2) KR101832040B1 (es)
CN (1) CN103328512B (es)
AR (1) AR083784A1 (es)
AU (4) AU2011328246B2 (es)
BR (1) BR112013011003B1 (es)
CA (1) CA2817132A1 (es)
CL (1) CL2013001168A1 (es)
CO (1) CO6761351A2 (es)
CR (1) CR20130202A (es)
CU (1) CU24111B1 (es)
EA (2) EA202092589A3 (es)
ES (2) ES2970234T3 (es)
GT (1) GT201300113A (es)
IL (1) IL225897B (es)
MA (1) MA34711B1 (es)
MX (2) MX343085B (es)
NZ (1) NZ610075A (es)
PE (1) PE20140772A1 (es)
SG (1) SG189981A1 (es)
TW (2) TWI619811B (es)
UA (1) UA115027C2 (es)
UY (1) UY33714A (es)
WO (1) WO2012062713A1 (es)

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