EA201690195A1 - Конъюгатные соединения антитело-лекарство на основе димера 1-(хлорметил)-2,3-дигидро-1h-бензо[e]индола и способы применения и лечения - Google Patents
Конъюгатные соединения антитело-лекарство на основе димера 1-(хлорметил)-2,3-дигидро-1h-бензо[e]индола и способы применения и леченияInfo
- Publication number
- EA201690195A1 EA201690195A1 EA201690195A EA201690195A EA201690195A1 EA 201690195 A1 EA201690195 A1 EA 201690195A1 EA 201690195 A EA201690195 A EA 201690195A EA 201690195 A EA201690195 A EA 201690195A EA 201690195 A1 EA201690195 A1 EA 201690195A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- benzo
- methods
- dimer
- hlormethyl
- digydro
- Prior art date
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 229940127121 immunoconjugate Drugs 0.000 title 1
- RHKRZQHJRZVTBP-UHFFFAOYSA-N 1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole Chemical compound C1=CC=CC2=C3C(CCl)CNC3=CC=C21 RHKRZQHJRZVTBP-UHFFFAOYSA-N 0.000 abstract 2
- 239000000611 antibody drug conjugate Substances 0.000 abstract 2
- 229940049595 antibody-drug conjugate Drugs 0.000 abstract 2
- 239000000539 dimer Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06052—Val-amino acid
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
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- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
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Abstract
Изобретение относится к конъюгатам антитело-лекарство, включающим антитело, конъюгированное с фрагментом димер 1-(хлорметил)-2,3-дигидро-1H-бензо[е]индола (CBI)-лекарство через линкер, и способам применения данных конъюгатов антитело-лекарство.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361864889P | 2013-08-12 | 2013-08-12 | |
US201361916388P | 2013-12-16 | 2013-12-16 | |
US201461969499P | 2014-03-24 | 2014-03-24 | |
PCT/US2014/042560 WO2015023355A1 (en) | 2013-08-12 | 2014-06-16 | 1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment |
Publications (1)
Publication Number | Publication Date |
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EA201690195A1 true EA201690195A1 (ru) | 2016-05-31 |
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Family Applications (1)
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EA201690195A EA201690195A1 (ru) | 2013-08-12 | 2014-06-16 | Конъюгатные соединения антитело-лекарство на основе димера 1-(хлорметил)-2,3-дигидро-1h-бензо[e]индола и способы применения и лечения |
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US (1) | US10442836B2 (ru) |
EP (1) | EP3033111B1 (ru) |
JP (2) | JP6993084B2 (ru) |
KR (1) | KR20160042080A (ru) |
CN (1) | CN105636612B (ru) |
AU (1) | AU2014307080B2 (ru) |
BR (1) | BR112016002829A2 (ru) |
CA (1) | CA2918139A1 (ru) |
CL (1) | CL2016000318A1 (ru) |
CR (1) | CR20160125A (ru) |
EA (1) | EA201690195A1 (ru) |
HK (2) | HK1222544A1 (ru) |
IL (1) | IL243586A0 (ru) |
MX (1) | MX2016001862A (ru) |
PH (1) | PH12016500246A1 (ru) |
SG (1) | SG11201601005XA (ru) |
TW (1) | TWI636792B (ru) |
WO (1) | WO2015023355A1 (ru) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
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MX336540B (es) | 2010-06-08 | 2016-01-22 | Genentech Inc | Conjugados y anticuerpos manipulados geneticamente con cisteina. |
WO2013093809A1 (en) | 2011-12-23 | 2013-06-27 | Pfizer Inc. | Engineered antibody constant regions for site-specific conjugation and methods and uses therefor |
KR20160098328A (ko) * | 2013-12-13 | 2016-08-18 | 제넨테크, 인크. | 항-cd33 항체 및 면역접합체 |
CN105828840B (zh) | 2013-12-16 | 2020-08-04 | 基因泰克公司 | 1-(氯甲基)-2,3-二氢-1H-苯并[e]吲哚二聚体抗体-药物缀合物化合物及使用和治疗方法 |
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- 2014-06-16 US US14/305,643 patent/US10442836B2/en active Active
- 2014-06-16 CN CN201480055557.3A patent/CN105636612B/zh active Active
- 2014-06-16 SG SG11201601005XA patent/SG11201601005XA/en unknown
- 2014-06-16 MX MX2016001862A patent/MX2016001862A/es unknown
- 2014-06-16 JP JP2016533294A patent/JP6993084B2/ja active Active
- 2014-06-16 KR KR1020167006280A patent/KR20160042080A/ko not_active Application Discontinuation
- 2014-06-16 TW TW103120758A patent/TWI636792B/zh not_active IP Right Cessation
- 2014-06-16 EP EP14736243.8A patent/EP3033111B1/en active Active
- 2014-06-16 WO PCT/US2014/042560 patent/WO2015023355A1/en active Application Filing
- 2014-06-16 AU AU2014307080A patent/AU2014307080B2/en not_active Ceased
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2016
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2019
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EP3033111A1 (en) | 2016-06-22 |
WO2015023355A1 (en) | 2015-02-19 |
KR20160042080A (ko) | 2016-04-18 |
SG11201601005XA (en) | 2016-03-30 |
TWI636792B (zh) | 2018-10-01 |
HK1222544A1 (zh) | 2017-07-07 |
JP2016530254A (ja) | 2016-09-29 |
CA2918139A1 (en) | 2015-02-19 |
MX2016001862A (es) | 2016-08-03 |
CN105636612B (zh) | 2020-01-14 |
BR112016002829A2 (pt) | 2017-09-19 |
PH12016500246A1 (en) | 2016-05-16 |
AU2014307080A1 (en) | 2016-02-11 |
US10442836B2 (en) | 2019-10-15 |
CL2016000318A1 (es) | 2016-08-19 |
JP6993084B2 (ja) | 2022-02-03 |
TW201534327A (zh) | 2015-09-16 |
AU2014307080B2 (en) | 2018-06-07 |
EP3033111B1 (en) | 2019-03-13 |
HK1222566A1 (zh) | 2017-07-07 |
IL243586A0 (en) | 2016-02-29 |
JP2020040954A (ja) | 2020-03-19 |
US20150165063A1 (en) | 2015-06-18 |
CR20160125A (es) | 2016-05-04 |
CN105636612A (zh) | 2016-06-01 |
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