BR112012026801B8 - conjugados de pirrolobenzodiazepina direcionados, composição farmacêutica, uso dos mesmos para tratamento de uma doença proliferativa ou autoimune e ligante de medicamento - Google Patents

conjugados de pirrolobenzodiazepina direcionados, composição farmacêutica, uso dos mesmos para tratamento de uma doença proliferativa ou autoimune e ligante de medicamento

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Publication number
BR112012026801B8
BR112012026801B8 BR112012026801A BR112012026801A BR112012026801B8 BR 112012026801 B8 BR112012026801 B8 BR 112012026801B8 BR 112012026801 A BR112012026801 A BR 112012026801A BR 112012026801 A BR112012026801 A BR 112012026801A BR 112012026801 B8 BR112012026801 B8 BR 112012026801B8
Authority
BR
Brazil
Prior art keywords
targeted
proliferative
treatment
pharmaceutical composition
autoimmune disease
Prior art date
Application number
BR112012026801A
Other languages
English (en)
Other versions
BR112012026801A2 (pt
BR112012026801B1 (pt
Inventor
Burke Patrick
Senter Peter
Wilson Howard Phillip
Jeffrey Scott
Original Assignee
Medimmune Ltd
Seattle Genetics Inc
Spirogen Dev Sarl
Spirogen Sarl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Ltd, Seattle Genetics Inc, Spirogen Dev Sarl, Spirogen Sarl filed Critical Medimmune Ltd
Publication of BR112012026801A2 publication Critical patent/BR112012026801A2/pt
Publication of BR112012026801B1 publication Critical patent/BR112012026801B1/pt
Publication of BR112012026801B8 publication Critical patent/BR112012026801B8/pt

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
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    • C07D519/06—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00 containing at least one condensed beta-lactam ring system, provided for by groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00, e.g. a penem or a cepham system
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    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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Abstract

conjugados de pirroçobenzodiazepina direcionados são fornecidos conjugados que compreendem pdbs conjugados a um agente de direcionamento e métodos de uso de tais pbds.
BR112012026801A 2010-04-15 2011-04-15 conjugados de pirrolobenzodiazepina direcionados, composição farmacêutica, uso dos mesmos para tratamento de uma doença proliferativa ou autoimune e ligante de medicamento BR112012026801B8 (pt)

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