EA201592182A1 - Ингибиторы фосфатидилинозитол-3-киназы - Google Patents

Ингибиторы фосфатидилинозитол-3-киназы

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Publication number
EA201592182A1
EA201592182A1 EA201592182A EA201592182A EA201592182A1 EA 201592182 A1 EA201592182 A1 EA 201592182A1 EA 201592182 A EA201592182 A EA 201592182A EA 201592182 A EA201592182 A EA 201592182A EA 201592182 A1 EA201592182 A1 EA 201592182A1
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EA
Eurasian Patent Office
Prior art keywords
phosphatidylinositol
kinase inhibitors
pi3kδ
isomers
compounds
Prior art date
Application number
EA201592182A
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English (en)
Other versions
EA028319B1 (ru
Inventor
Джерри Эвартс
Джошуа Каплан
Мусон Ким
Лина Пейтел
Стефан Перро
Гэри Филлипс
Дженнифер А. Трейберг
Джошуа Ван Вельдхьюзен
Original Assignee
Джилид Сайэнс, Инк.
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Application filed by Джилид Сайэнс, Инк. filed Critical Джилид Сайэнс, Инк.
Publication of EA201592182A1 publication Critical patent/EA201592182A1/ru
Publication of EA028319B1 publication Critical patent/EA028319B1/ru

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

В настоящем описании предложены ингибиторы фосфатидилинозитол-3-киназы (PI3K) формулы (I)или их фармацевтически приемлемые соли или изомеры, в которых n, m, R, R, Rи Rопределены в настоящем описании. Данные соединения являются подходящими для лечения состояний, опосредованных одной или более изоформами PI3K, такой как PI3Kδ. В настоящем описании также предложены фармацевтические композиции, которые содержат соединение формулы (I) или его фармацевтически приемлемые соли или изомеры, и способы применения указанных соединений и композиций для лечения состояний, опосредованных одной или более изоформами PI3K, такой как PI3Kδ.
EA201592182A 2013-06-14 2014-06-13 Ингибиторы фосфатидилинозитол-3-киназы EA028319B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361835333P 2013-06-14 2013-06-14
PCT/US2014/042392 WO2014201409A1 (en) 2013-06-14 2014-06-13 Phosphatidylinositol 3-kinase inhibitors

Publications (2)

Publication Number Publication Date
EA201592182A1 true EA201592182A1 (ru) 2016-06-30
EA028319B1 EA028319B1 (ru) 2017-11-30

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Family Applications (1)

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EA201592182A EA028319B1 (ru) 2013-06-14 2014-06-13 Ингибиторы фосфатидилинозитол-3-киназы

Country Status (24)

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US (2) US9221795B2 (ru)
EP (1) EP3008053B1 (ru)
JP (1) JP6030783B2 (ru)
KR (1) KR101709436B1 (ru)
CN (1) CN105308034B (ru)
AR (1) AR096621A1 (ru)
AU (2) AU2014277950B2 (ru)
BR (1) BR112015031475A2 (ru)
CA (1) CA2915129C (ru)
EA (1) EA028319B1 (ru)
ES (1) ES2667173T3 (ru)
HK (2) HK1220968A1 (ru)
IL (1) IL242677B (ru)
MX (1) MX347988B (ru)
NO (1) NO2994608T3 (ru)
NZ (1) NZ714710A (ru)
PL (1) PL3008053T3 (ru)
PT (1) PT3008053T (ru)
SG (1) SG11201509910YA (ru)
SI (1) SI3008053T1 (ru)
TR (1) TR201806822T4 (ru)
TW (1) TWI644909B (ru)
UY (1) UY35617A (ru)
WO (1) WO2014201409A1 (ru)

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AU2016201584A1 (en) 2016-03-31
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US9221795B2 (en) 2015-12-29
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