MX2012000763A - Derivados sustituidos de triazol e imidazol como moduladores de la gamma secretasa. - Google Patents
Derivados sustituidos de triazol e imidazol como moduladores de la gamma secretasa.Info
- Publication number
- MX2012000763A MX2012000763A MX2012000763A MX2012000763A MX2012000763A MX 2012000763 A MX2012000763 A MX 2012000763A MX 2012000763 A MX2012000763 A MX 2012000763A MX 2012000763 A MX2012000763 A MX 2012000763A MX 2012000763 A MX2012000763 A MX 2012000763A
- Authority
- MX
- Mexico
- Prior art keywords
- sup
- imidazole derivatives
- gamma secretase
- substituted triazole
- secretase modulators
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Abstract
La presente invención se refiere a novedosos derivados de triazol e imidazol de la Fórmula (I) (ver fórmula (I)) donde R1, R2, A1, A2, A3, A4, X y Het1 tienen el significado que se define en las reivindicaciones; los compuestos según la presente invención resultan de utilidad como moduladores de la gamma secretasa; la invención también se refiere a los procedimientos para elaborar tales compuestos novedosos, a composiciones farmacéuticas que comprenden dichos compuestos a modo de ingrediente activo, así como al uso de dichos compuestos como medicamento.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09165585 | 2009-07-15 | ||
EP10164625 | 2010-06-01 | ||
PCT/EP2010/060083 WO2011006903A1 (en) | 2009-07-15 | 2010-07-13 | Substituted triazole and imidazole derivatives as gamma secretase modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2012000763A true MX2012000763A (es) | 2012-02-08 |
Family
ID=42542935
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012000763A MX2012000763A (es) | 2009-07-15 | 2010-07-13 | Derivados sustituidos de triazol e imidazol como moduladores de la gamma secretasa. |
Country Status (18)
Country | Link |
---|---|
US (1) | US8946266B2 (es) |
EP (1) | EP2454239B1 (es) |
JP (2) | JP2012532912A (es) |
KR (1) | KR20120050450A (es) |
CN (1) | CN102482227A (es) |
AP (1) | AP2011006034A0 (es) |
AU (1) | AU2010272578B2 (es) |
BR (1) | BR112012000915A2 (es) |
CA (1) | CA2778517A1 (es) |
EA (1) | EA021047B1 (es) |
ES (1) | ES2519565T3 (es) |
IL (1) | IL217491A (es) |
MX (1) | MX2012000763A (es) |
NZ (1) | NZ597505A (es) |
SG (1) | SG177644A1 (es) |
TW (1) | TW201109316A (es) |
WO (1) | WO2011006903A1 (es) |
ZA (1) | ZA201200285B (es) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2010002098A (es) * | 2007-08-31 | 2010-03-30 | Eisai R&D Man Co Ltd | Compuesto policiclico. |
US7935815B2 (en) * | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
PA8854101A1 (es) | 2008-12-18 | 2010-07-27 | Ortho Mcneil Janssen Pharm | Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa |
AP2011005779A0 (en) | 2009-02-06 | 2011-08-31 | Ortho Mcneil Janssen Pharm | Novel susbstituted bicyclic heterocyclic compoundsas gamma secretase modulators. |
TWI461425B (zh) | 2009-02-19 | 2014-11-21 | Janssen Pharmaceuticals Inc | 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類 |
CN102333777B (zh) | 2009-02-26 | 2014-06-25 | 卫材R&D管理有限公司 | 含氮的稠合杂环化合物及其作为β淀粉样蛋白生成抑制剂的用途 |
US8703954B2 (en) | 2009-02-26 | 2014-04-22 | Eisai R&D Management Co., Ltd. | Salt of tetrahydrotriazolopyridine derivative and crystal thereof |
NZ596843A (en) | 2009-05-07 | 2012-12-21 | Janssen Pharmaceuticals Inc | Novel substituted indazole and aza-indazole derivatives as gamma secretase modulators |
EP2454239B1 (en) | 2009-07-15 | 2014-08-13 | Janssen Pharmaceuticals Inc. | Substituted triazole and imidazole derivatives as gamma secretase modulators |
TWI468402B (zh) | 2009-07-31 | 2015-01-11 | 必治妥美雅史谷比公司 | 降低β-類澱粉生成之化合物 |
US8637525B2 (en) | 2009-07-31 | 2014-01-28 | Bristol-Myers Squibb Company | Compounds for the reduction of beta-amyloid production |
BR112012017310A2 (pt) | 2010-01-15 | 2016-04-19 | Janssen Pharmaceuticals Inc | derivados de triazol substituídos como moduladores de gama secretase |
EP2611805A1 (en) | 2010-09-02 | 2013-07-10 | Takeda Pharmaceutical Company Limited | Fused triazoles for the treatment or prophylaxis of mild cognitive impairment |
CN102617457A (zh) * | 2011-01-28 | 2012-08-01 | 天津药物研究院 | 一种制备罗氟司特的新方法 |
CN102690194B (zh) * | 2011-03-24 | 2014-06-25 | 上海通远生物科技有限公司 | 3-环丙基甲氧基-4-二氟甲氧基苯甲酸的制备方法 |
KR20140047032A (ko) * | 2011-03-24 | 2014-04-21 | 얀센 파마슈티칼즈, 인코포레이티드 | 감마 세크레타제 조정제로서의 신규 치환 트리아졸릴 피페라진 및 트리아졸릴 피페리딘 유도체 |
WO2013005354A1 (ja) * | 2011-07-01 | 2013-01-10 | 武田薬品工業株式会社 | 複素環化合物 |
WO2013010812A1 (en) | 2011-07-15 | 2013-01-24 | Janssen Pharmaceutica Nv | Monoclonal antibodies specific for beta-amyloid x-37 and uses thereof |
IN2014MN00258A (es) | 2011-07-15 | 2015-09-25 | Janssen Pharmaceuticals Inc | |
ES2674451T3 (es) * | 2012-02-21 | 2018-06-29 | Merck Patent Gmbh | 2-amino-[1,2,4]triazolo[1,5-a] pirazinas 8-sustituidos como inhibidores de la SYK tirosina quinasa e inhibidores de la serina quinasa GCN2 |
AU2013261023B2 (en) | 2012-05-16 | 2016-11-24 | Cellzome Limited | Substituted 3, 4 - dihydro - 2H - pyrido [1, 2 -a] pyrazine - 1, 6 - dione derivatives useful for the treatment of (inter alia) Alzheimer's disease |
NZ704799A (en) * | 2012-08-24 | 2018-06-29 | Univ Texas | Heterocyclic modulators of hif activity for treatment of disease |
CA2889249C (en) * | 2012-12-20 | 2021-02-16 | Francois Paul Bischoff | Tricyclic 3,4-dihydro-2h-pyrido[1,2-a]pyrazine-1,6-dione derivatives as gamma secretase modulators |
EP2945944B1 (en) | 2013-01-17 | 2016-11-09 | Janssen Pharmaceutica, N.V. | Novel substituted pyrido-piperazinone derivatives as gamma secretase modulators |
NO3004079T3 (es) | 2013-06-04 | 2018-06-16 | ||
WO2014195321A1 (en) | 2013-06-04 | 2014-12-11 | Acturum Life Science AB | Triazole compounds and their use as gamma secretase modulators |
CN105263922B (zh) | 2013-06-04 | 2018-08-17 | 阿克图拉姆生命科学股份公司 | ***化合物及其作为γ分泌酶调节剂的用途 |
US10562897B2 (en) | 2014-01-16 | 2020-02-18 | Janssen Pharmaceutica Nv | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators |
DK3110420T3 (da) | 2014-02-25 | 2019-05-13 | Board Of Regents Univ Of Texas System | Salte af heterocykliske modulatorer af hif-aktivitet til behandling af sygdomme |
MX2017005715A (es) | 2014-10-31 | 2018-02-23 | Massachusetts Gen Hospital | Potentes moduladores de gamma-secretasa. |
EP3053920B1 (en) * | 2015-02-05 | 2020-04-08 | AB Science | Compounds with anti-tumoral activity |
EP3484884B1 (en) * | 2016-07-14 | 2021-01-27 | Hoffmann-La Roche AG | Fused pyrimidine derivatives |
WO2018087018A1 (en) | 2016-11-08 | 2018-05-17 | F. Hoffmann-La Roche Ag | Phenoxytriazoles |
AU2018348930A1 (en) | 2017-10-11 | 2020-03-26 | F. Hoffmann-La Roche Ag | Bicyclic compounds for use as RIP 1 kinase inhibitors |
EP4003966A1 (de) | 2019-07-22 | 2022-06-01 | Bayer Aktiengesellschaft | 5-amino substituierte pyrazole und triazole als schädlingsbekämpfungsmittel |
CN110759902B (zh) * | 2019-11-01 | 2022-04-22 | 海南一龄医疗产业发展有限公司 | Set8赖氨酸甲基转移酶抑制剂及其制备方法和用途 |
WO2022033991A1 (de) | 2020-08-13 | 2022-02-17 | Bayer Aktiengesellschaft | 5-amino substituierte triazole als schädlingsbekämpfungsmittel |
CN112480073B (zh) * | 2020-12-02 | 2022-03-22 | 武汉药明康德新药开发有限公司 | 1-烷基-3,5-芳基取代的1,2,4三氮唑化合物的合成方法 |
WO2023238065A1 (en) | 2022-06-09 | 2023-12-14 | Glaxosmithkline Intellectual Property Development Limited | Nitrogen containing condensed 2,3-dihydroquinazolinone compounds as nav1.8 inhibitors |
Family Cites Families (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5767144A (en) | 1994-08-19 | 1998-06-16 | Abbott Laboratories | Endothelin antagonists |
DE69615376T2 (de) | 1995-07-13 | 2002-09-05 | Knoll Gmbh | Piperazin-derivate als heilmittel |
KR20010100977A (ko) * | 1998-11-03 | 2001-11-14 | 스타르크, 카르크 | 치환된 2-페닐벤즈이미다졸, 그의 제조 및 그의 용도 |
MXPA01011112A (es) | 1999-06-10 | 2002-06-04 | Warner Lambert Co | Metodo para la inhibicion de la agregacion de las proteinas amiloides y formacion de imagenes de los depositos amiloides utilizando derivados de la isoindolina. |
AU5702201A (en) | 2000-04-13 | 2001-10-30 | Mayo Foundation | Abeta<sub>42</sub> lowering agents |
US20030176454A1 (en) | 2000-05-15 | 2003-09-18 | Akira Yamada | N-coating heterocyclic compounds |
DE10109867A1 (de) | 2001-03-01 | 2002-09-05 | Abbott Gmbh & Co Kg | Verwendung von Triazolverbindungen zur Prophylaxe und Therapie neurodegenerativer Erkrankungen, Hirntrauma und zerebraler Ischämie |
DE10238002A1 (de) | 2002-08-20 | 2004-03-04 | Merck Patent Gmbh | Benzimidazolderivate |
PL378753A1 (pl) | 2003-02-27 | 2006-05-15 | F.Hoffmann-La Roche Ag | Antagoniści receptora CCR-3 |
AU2004247013B2 (en) | 2003-05-14 | 2010-07-08 | Neurogenetic Pharmaceuticals, Inc. | Compounds and uses thereof in modulating amyloid beta |
RU2376292C2 (ru) | 2003-08-14 | 2009-12-20 | Ф.Хоффманн-Ля Рош Аг | Гамк-ергические модуляторы |
DE602005023965D1 (de) | 2004-03-08 | 2010-11-18 | Prosidion Ltd | Pyrrolopyridin-2-carbonsäurehydrazide als inhibitoren von glykogenphosphorylase |
KR101128065B1 (ko) | 2004-05-26 | 2012-04-12 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 신나미드 화합물 |
AU2005297966B2 (en) | 2004-10-26 | 2010-12-23 | Eisai R & D Management Co., Ltd. | Amorphous object of cinnamide compound |
US7572807B2 (en) | 2005-06-09 | 2009-08-11 | Bristol-Myers Squibb Company | Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors |
JP2009508929A (ja) | 2005-09-22 | 2009-03-05 | サノフイ−アベンテイス | Ccr3受容体リガンドとしてのアミノ−アルキル−アミド誘導体 |
US20070078136A1 (en) | 2005-09-22 | 2007-04-05 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
WO2007043786A1 (en) | 2005-10-10 | 2007-04-19 | Seiyang Yang | Dynamic-based verification apparatus for verification from electronic system level to gate level, and verification method using the same |
EP1937767B1 (en) | 2005-10-11 | 2013-05-22 | Chemtura Corporation | Diaromatic amines |
US20090163482A1 (en) | 2006-03-13 | 2009-06-25 | Mchardy Stanton Furst | Tetralines antagonists of the h-3 receptor |
GB0606774D0 (en) | 2006-04-03 | 2006-05-10 | Novartis Ag | Organic compounds |
US7893058B2 (en) | 2006-05-15 | 2011-02-22 | Janssen Pharmaceutica Nv | Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases |
US20080090834A1 (en) * | 2006-07-06 | 2008-04-17 | Pfizer Inc | Selective azole pde10a inhibitor compounds |
US7951818B2 (en) | 2006-12-01 | 2011-05-31 | Galapagos Nv | Imidazolopyridine compounds useful for the treatment of degenerative and inflammatory diseases |
WO2008082490A2 (en) | 2006-12-20 | 2008-07-10 | Schering Corporation | Novel jnk inhibitors |
AU2008214372A1 (en) | 2007-02-08 | 2008-08-14 | Merck Sharp & Dohme Corp. | Therapeutic agents |
WO2008100412A1 (en) | 2007-02-12 | 2008-08-21 | Merck & Co., Inc. | Piperidine derivatives |
EP2121633A2 (en) | 2007-02-12 | 2009-11-25 | Merck & Co., Inc. | Piperazine derivatives for treatment of ad and related conditions |
RU2009144998A (ru) | 2007-05-07 | 2011-06-20 | Шеринг Корпорейшн (US) | Модуляторы гамма-секретазы |
BRPI0811993A2 (pt) | 2007-05-11 | 2014-11-18 | Hoffmann La Roche | " hetarilanilinas como moduladores para beta-amiloide ". |
EP2166854A4 (en) | 2007-06-13 | 2012-05-16 | Merck Sharp & Dohme | TRIAZOLE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND ASSOCIATED STATES |
WO2009005729A1 (en) | 2007-06-29 | 2009-01-08 | Schering Corporation | Gamma secretase modulators |
CA2693138A1 (en) * | 2007-07-16 | 2009-01-22 | Wyeth Llc | Aminoalkylazole derivatives as histamine-3 antagonists |
US7935815B2 (en) | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
CA2698341A1 (en) | 2007-09-06 | 2009-03-12 | Schering Corporation | Gamma secretase modulators |
GB0720444D0 (en) | 2007-10-18 | 2007-11-28 | Glaxo Group Ltd | Novel compounds |
KR20100094554A (ko) | 2007-12-06 | 2010-08-26 | 쉐링 코포레이션 | 감마 세크레타제 조절인자 |
WO2009076352A1 (en) * | 2007-12-11 | 2009-06-18 | Schering Corporation | Gamma secretase modulators |
CA2713716A1 (en) | 2008-02-22 | 2009-08-27 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
US20100137320A1 (en) | 2008-02-29 | 2010-06-03 | Schering Corporation | Gamma secretase modulators |
WO2010010188A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases. |
US20120129846A1 (en) | 2008-11-06 | 2012-05-24 | Zhaoning Zhu | Gamma secretase modulators |
KR101293421B1 (ko) | 2008-11-10 | 2013-08-05 | 에프. 호프만-라 로슈 아게 | 헤테로사이클릭 감마 분비효소 조절제 |
CA2744152A1 (en) | 2008-12-03 | 2010-06-10 | Via Pharmaceuticals, Inc. | Inhibitors of diacylglycerol acyltransferase |
PA8854101A1 (es) | 2008-12-18 | 2010-07-27 | Ortho Mcneil Janssen Pharm | Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa |
TW201030002A (en) | 2009-01-16 | 2010-08-16 | Bristol Myers Squibb Co | Bicyclic compounds for the reduction of beta-amyloid production |
AP2011005779A0 (en) | 2009-02-06 | 2011-08-31 | Ortho Mcneil Janssen Pharm | Novel susbstituted bicyclic heterocyclic compoundsas gamma secretase modulators. |
TWI461425B (zh) | 2009-02-19 | 2014-11-21 | Janssen Pharmaceuticals Inc | 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類 |
CN102333777B (zh) | 2009-02-26 | 2014-06-25 | 卫材R&D管理有限公司 | 含氮的稠合杂环化合物及其作为β淀粉样蛋白生成抑制剂的用途 |
JP2012051807A (ja) | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | アリールイミダゾール化合物 |
JP2012051806A (ja) | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | イミダゾリルピラジン誘導体 |
US20120053165A1 (en) | 2009-03-03 | 2012-03-01 | Pfizer Inc. | Novel Phenyl Imidazoles and Phenyl Triazoles As Gamma-Secretase Modulators |
US20110299830A1 (en) | 2009-03-16 | 2011-12-08 | Panasonic Corporation | Application running device |
EP2424866A1 (en) | 2009-04-27 | 2012-03-07 | High Point Pharmaceuticals, LLC | Substituted imidazo[1,2-a]pyridine derivatives, pharmaceutical compositions, and methods of use as -secretase inhibitors |
NZ596843A (en) | 2009-05-07 | 2012-12-21 | Janssen Pharmaceuticals Inc | Novel substituted indazole and aza-indazole derivatives as gamma secretase modulators |
JP2010274429A (ja) | 2009-05-26 | 2010-12-09 | Ihi Corp | アライメントステージ |
EP2454239B1 (en) | 2009-07-15 | 2014-08-13 | Janssen Pharmaceuticals Inc. | Substituted triazole and imidazole derivatives as gamma secretase modulators |
BR112012017310A2 (pt) | 2010-01-15 | 2016-04-19 | Janssen Pharmaceuticals Inc | derivados de triazol substituídos como moduladores de gama secretase |
KR20140047032A (ko) | 2011-03-24 | 2014-04-21 | 얀센 파마슈티칼즈, 인코포레이티드 | 감마 세크레타제 조정제로서의 신규 치환 트리아졸릴 피페라진 및 트리아졸릴 피페리딘 유도체 |
WO2012131539A1 (en) | 2011-03-31 | 2012-10-04 | Pfizer Inc. | Novel bicyclic pyridinones |
IN2014MN00258A (es) | 2011-07-15 | 2015-09-25 | Janssen Pharmaceuticals Inc |
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2010
- 2010-07-13 EP EP10734963.1A patent/EP2454239B1/en active Active
- 2010-07-13 AU AU2010272578A patent/AU2010272578B2/en not_active Ceased
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- 2010-07-13 CA CA2778517A patent/CA2778517A1/en not_active Abandoned
- 2010-07-13 CN CN2010800332416A patent/CN102482227A/zh active Pending
- 2010-07-13 BR BR112012000915A patent/BR112012000915A2/pt not_active IP Right Cessation
- 2010-07-13 MX MX2012000763A patent/MX2012000763A/es active IP Right Grant
- 2010-07-13 AP AP2011006034A patent/AP2011006034A0/xx unknown
- 2010-07-13 KR KR1020127003902A patent/KR20120050450A/ko not_active Application Discontinuation
- 2010-07-13 EA EA201270166A patent/EA021047B1/ru not_active IP Right Cessation
- 2010-07-13 JP JP2012520010A patent/JP2012532912A/ja active Pending
- 2010-07-13 US US13/382,659 patent/US8946266B2/en not_active Expired - Fee Related
- 2010-07-13 ES ES10734963.1T patent/ES2519565T3/es active Active
- 2010-07-13 WO PCT/EP2010/060083 patent/WO2011006903A1/en active Application Filing
- 2010-07-13 SG SG2012002473A patent/SG177644A1/en unknown
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Also Published As
Publication number | Publication date |
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AP2011006034A0 (en) | 2011-12-31 |
BR112012000915A2 (pt) | 2019-09-24 |
US20120135981A1 (en) | 2012-05-31 |
AU2010272578B2 (en) | 2015-03-05 |
ZA201200285B (en) | 2014-06-25 |
IL217491A0 (en) | 2012-02-29 |
CN102482227A (zh) | 2012-05-30 |
WO2011006903A1 (en) | 2011-01-20 |
SG177644A1 (en) | 2012-03-29 |
IL217491A (en) | 2015-08-31 |
EP2454239B1 (en) | 2014-08-13 |
EP2454239A1 (en) | 2012-05-23 |
ES2519565T3 (es) | 2014-11-07 |
JP2015129147A (ja) | 2015-07-16 |
AU2010272578A1 (en) | 2012-01-19 |
TW201109316A (en) | 2011-03-16 |
CA2778517A1 (en) | 2011-01-20 |
KR20120050450A (ko) | 2012-05-18 |
JP2012532912A (ja) | 2012-12-20 |
EA201270166A1 (ru) | 2012-06-29 |
EA021047B1 (ru) | 2015-03-31 |
NZ597505A (en) | 2013-05-31 |
US8946266B2 (en) | 2015-02-03 |
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