EA200870517A1 - Новые антагонисты мсн-рецепторов - Google Patents

Новые антагонисты мсн-рецепторов

Info

Publication number
EA200870517A1
EA200870517A1 EA200870517A EA200870517A EA200870517A1 EA 200870517 A1 EA200870517 A1 EA 200870517A1 EA 200870517 A EA200870517 A EA 200870517A EA 200870517 A EA200870517 A EA 200870517A EA 200870517 A1 EA200870517 A1 EA 200870517A1
Authority
EA
Eurasian Patent Office
Prior art keywords
mch receptors
new antagonists
present
antagonists
new
Prior art date
Application number
EA200870517A
Other languages
English (en)
Other versions
EA015127B1 (ru
Inventor
Маклин Брайан Арнольд
Ен Дао
Кевин Мэттью Гардинир
Дэвид Джозеф Гармен
Стивен Джеймс Грин
Эрик Джеймс Хембр
Цзяньлян Лу
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA200870517A1 publication Critical patent/EA200870517A1/ru
Publication of EA015127B1 publication Critical patent/EA015127B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

В настоящем изобретении предложен антагонист рецепторов меланин-концентрирующего гормона, представляющий собой соединение формулы (I)где R, R, R, R, L, R, Rи Rопределены в описании настоящего изобретения, или фармацевтически приемлемая соль, энантиомер, диастереомер или смесь диастереомеров указанного соединения, подходящие для лечения ожирения и связанных с ним заболеваний.
EA200870517A 2006-06-08 2007-06-08 Антагонисты мсн-рецепторов EA015127B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81184106P 2006-06-08 2006-06-08
PCT/US2007/070662 WO2007146758A2 (en) 2006-06-08 2007-06-08 Novel mch receptor antagonists

Publications (2)

Publication Number Publication Date
EA200870517A1 true EA200870517A1 (ru) 2009-04-28
EA015127B1 EA015127B1 (ru) 2011-06-30

Family

ID=38651254

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200870517A EA015127B1 (ru) 2006-06-08 2007-06-08 Антагонисты мсн-рецепторов

Country Status (10)

Country Link
US (2) US8263772B2 (ru)
EP (1) EP2029609A2 (ru)
JP (1) JP5198439B2 (ru)
CN (1) CN101454328A (ru)
AU (1) AU2007257922A1 (ru)
BR (1) BRPI0712680A2 (ru)
CA (1) CA2652385A1 (ru)
EA (1) EA015127B1 (ru)
MX (1) MX2008015662A (ru)
WO (1) WO2007146758A2 (ru)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2367823A1 (en) 2008-12-23 2011-09-28 Abbott Laboratories Anti-viral compounds
ES2567047T3 (es) 2008-12-23 2016-04-19 Abbvie Inc. Derivados de pirimidina anti-virales
CN102300850A (zh) 2008-12-24 2011-12-28 辛根塔有限公司 制备杀真菌剂的方法
CA2758484A1 (en) * 2009-04-15 2010-10-21 David A. Degoey Anti-viral compounds
CN103819459B (zh) * 2009-06-11 2017-05-17 艾伯维巴哈马有限公司 抗病毒化合物
US8937150B2 (en) 2009-06-11 2015-01-20 Abbvie Inc. Anti-viral compounds
US8716454B2 (en) 2009-06-11 2014-05-06 Abbvie Inc. Solid compositions
US9394279B2 (en) 2009-06-11 2016-07-19 Abbvie Inc. Anti-viral compounds
NZ605440A (en) 2010-06-10 2014-05-30 Abbvie Bahamas Ltd Solid compositions comprising an hcv inhibitor
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
US9034832B2 (en) 2011-12-29 2015-05-19 Abbvie Inc. Solid compositions
WO2013149940A1 (en) 2012-04-02 2013-10-10 Basf Se Acrylamide compounds for combating invertebrate pests
BR112014027133A2 (pt) 2012-05-09 2017-06-27 Basf Se compostos, composição agrícola ou veterinária, método para o controle das pragas de invertebrados, material de propagação dos vegetais e método para o tratamento ou proteção de um animal.
US11484534B2 (en) 2013-03-14 2022-11-01 Abbvie Inc. Methods for treating HCV
EP2970205B1 (en) 2013-03-14 2019-05-08 Tolero Pharmaceuticals, Inc. Jak2 and alk2 inhibitors and methods for their use
EP3089757A1 (en) 2014-01-03 2016-11-09 AbbVie Inc. Solid antiviral dosage forms
AR102849A1 (es) * 2015-03-09 2017-03-29 Astellas Pharma Inc Compuesto de piridina bicíclica
WO2016205590A1 (en) * 2015-06-18 2016-12-22 Cephalon, Inc. Substituted 4-benzyl and 4-benzoyl piperidine derivatives
KR20180026459A (ko) 2015-06-18 2018-03-12 세파론, 인코포레이티드 1,4-치환된 피페리딘 유도체
MX2021000977A (es) 2018-07-26 2021-04-12 Sumitomo Pharma Oncology Inc Metodos para tratar enfermedades asociadas con expresion anormal de receptor de activina a tipo 1 (acvr1) e inhibidores de acvr1 para uso en los mismos.
BR112021007982A2 (pt) 2018-10-30 2021-08-03 Nuvation Bio Inc. compostos heterocíclicos como inibidores de bet
EP3997070A4 (en) * 2019-07-02 2023-07-26 Nuvation Bio Inc. HETEROCYCLIC COMPOUNDS USED AS BET INHIBITORS
WO2024020034A1 (en) * 2022-07-20 2024-01-25 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002003370A (ja) * 1999-09-20 2002-01-09 Takeda Chem Ind Ltd メラニン凝集ホルモン拮抗剤
US20020099073A1 (en) * 2000-07-07 2002-07-25 Andersen Henrik Sune Modulators of protein tyrosine phosphatases (PTPases)
GB0124627D0 (en) * 2001-10-15 2001-12-05 Smithkline Beecham Plc Novel compounds
CA2521832A1 (en) * 2003-04-11 2004-10-28 Smithkline Beecham Corporation Heterocyclic mchr1 antagonists
JP2007509158A (ja) * 2003-10-23 2007-04-12 グラクソ　グループ　リミテッド 肥満、糖尿病、うつ病及び不安を治療するためのｍｃｈｒ１アンタゴニストとしての３−（４−アミノフェニル）チエノピリミド−４−オン誘導体
US20050176738A1 (en) * 2003-11-07 2005-08-11 Neurocrine Biosciences, Inc. Melanin-concentrating hormone receptor antagonists and compositions and methods related thereto
US7521455B2 (en) * 2004-02-13 2009-04-21 Banyu Pharmaceutical Co. Ltd. Fused ring 4-oxopyrimidine derivative
WO2005103039A1 (en) * 2004-04-15 2005-11-03 Neurocrine Biosciences, Inc. 2- (3-aminopyrrolidin-1-yl) pyridines as melanin-concentrating hormone receptor an tagonists
RU2007101705A (ru) 2004-06-18 2008-07-27 Биолипокс Аб (Se) Индолы, полезные для лечения воспаления
EP1828207B1 (en) * 2004-12-17 2009-10-28 Eli Lilly And Company Thiazolopyridinone derivates as mch receptor antagonists
CA2636617A1 (en) * 2006-02-15 2007-08-23 Lothar Schwink Novel aminoalcohol-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments
TW200800908A (en) * 2006-02-15 2008-01-01 Sanofi Aventis Novel azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments

Also Published As

Publication number Publication date
US20090093456A1 (en) 2009-04-09
US20120302547A1 (en) 2012-11-29
CA2652385A1 (en) 2007-12-21
WO2007146758A2 (en) 2007-12-21
AU2007257922A1 (en) 2007-12-21
BRPI0712680A2 (pt) 2012-11-20
WO2007146758A3 (en) 2008-02-07
JP2009539875A (ja) 2009-11-19
US8263772B2 (en) 2012-09-11
MX2008015662A (es) 2009-01-12
JP5198439B2 (ja) 2013-05-15
EA015127B1 (ru) 2011-06-30
CN101454328A (zh) 2009-06-10
EP2029609A2 (en) 2009-03-04

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU