AR102849A1 - Compuesto de piridina bicíclica - Google Patents

Compuesto de piridina bicíclica

Info

Publication number
AR102849A1
AR102849A1 ARP150103899A ARP150103899A AR102849A1 AR 102849 A1 AR102849 A1 AR 102849A1 AR P150103899 A ARP150103899 A AR P150103899A AR P150103899 A ARP150103899 A AR P150103899A AR 102849 A1 AR102849 A1 AR 102849A1
Authority
AR
Argentina
Prior art keywords
group
alkyl
lower alkyl
cycloalkyl
substituents
Prior art date
Application number
ARP150103899A
Other languages
English (en)
Inventor
takamatsu Hajime
Enjo Kentaro
Hiramoto Masashi
Inagaki Yusuke
Kanai Akira
Ishihata Akihiro
Kawaguchi Kenichi
Original Assignee
Astellas Pharma Inc
Kotobuki Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc, Kotobuki Pharmaceutical Co Ltd filed Critical Astellas Pharma Inc
Publication of AR102849A1 publication Critical patent/AR102849A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Abstract

Reivindicación 1: Un compuesto representado por la fórmula (1) o una sal del mismo, donde, X es O ó S; una línea punteada es una unión simple o una unión doble; R¹ es alquilo inferior que opcionalmente tiene entre uno y cuatro sustituyentes que se seleccionan del grupo G¹, cicloalquilo que opcionalmente tiene entre uno y cinco sustituyentes que se seleccionan del grupo G², o -alquileno inferior-(cicloalquilo que opcionalmente tiene entre uno y cinco sustituyentes que se seleccionan del grupo G²); R² y R⁵ son iguales o diferentes entre sí, y son H, alquilo inferior o cicloalquilo; R³ es -alquileno inferior-X³-alquilo inferior, -alquileno inferior-X³-alquileno inferior-(cicloalquilo que opcionalmente tiene entre uno y cinco sustituyentes que se seleccionan del grupo G²), -alquileno inferior-(cicloalquilo que opcionalmente tiene entre uno y cinco sustituyentes que se seleccionan del grupo G²), o -alquileno inferior-X³-(cicloalquilo que opcionalmente tiene entre uno y cinco sustituyentes que se seleccionan del grupo G²); X³ es O ó S(O)ₙ, donde n es 0, 1, ó 2; R⁴ es OH, NH₂, o -O-alquilo inferior y R⁶ es H; o R⁴ y R⁶ están conectados entre sí para formar, junto con -C(=O)-C-O- al cual están unidos, 2,2-di(alquilo inferior)-4-oxo-1,3-dioxolano-5,5-diilo; el grupo G¹ consiste en halógeno, OH, -O-alquilo inferior, -S-alquilo inferior, y -O-(halógenoalquilo inferior); y el grupo G² consiste en alquilo inferior, halógeno, halógenoalquilo inferior, OH, -O-alquilo inferior, -S-alquilo inferior, y -O-halógenoalquilo inferior.
ARP150103899A 2015-03-09 2015-11-26 Compuesto de piridina bicíclica AR102849A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2015046121 2015-03-09

Publications (1)

Publication Number Publication Date
AR102849A1 true AR102849A1 (es) 2017-03-29

Family

ID=56880128

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150103899A AR102849A1 (es) 2015-03-09 2015-11-26 Compuesto de piridina bicíclica

Country Status (23)

Country Link
US (1) US10023583B2 (es)
EP (1) EP3269721B1 (es)
JP (1) JP6646648B2 (es)
KR (1) KR102446212B1 (es)
CN (1) CN107428768B (es)
AR (1) AR102849A1 (es)
AU (1) AU2015386039B2 (es)
BR (1) BR112017018649B8 (es)
CA (1) CA2976746C (es)
CO (1) CO2017008372A2 (es)
ES (1) ES2869924T3 (es)
IL (1) IL254307B (es)
MX (1) MX370920B (es)
MY (1) MY198083A (es)
PH (1) PH12017501596B1 (es)
PL (1) PL3269721T3 (es)
PT (1) PT3269721T (es)
RU (1) RU2700411C2 (es)
SG (1) SG11201706745PA (es)
TW (1) TWI700285B (es)
UA (1) UA121889C2 (es)
WO (1) WO2016143200A1 (es)
ZA (1) ZA201706038B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3868215A4 (en) 2018-10-16 2022-07-27 Nippon Chemiphar Co., Ltd. MEANS OF IMPROVING SLEEP QUALITY
CN112912070A (zh) 2018-10-17 2021-06-04 日本化学药品株式会社 夜间多尿的治疗或预防剂

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101039690A (zh) 2004-09-09 2007-09-19 霍华德弗洛里实验生理及医药学院 酶抑制剂及其应用
JP5198439B2 (ja) * 2006-06-08 2013-05-15 イーライ リリー アンド カンパニー 新規なｍｃｈ受容体アンタゴニスト
NZ585338A (en) 2007-11-19 2012-08-31 Howard Florey Inst Insulin-regulated aminopeptidase (irap) inhibitors and uses thereof
CN102209718A (zh) 2008-11-06 2011-10-05 安斯泰来制药株式会社 氨基甲酸酯化合物或其盐
JP2013147430A (ja) * 2010-04-28 2013-08-01 Astellas Pharma Inc 夜間頻尿の予防又は治療剤
CN103097383B (zh) * 2010-09-07 2015-09-16 安斯泰来制药株式会社 吡唑并喹啉化合物
CN104902959A (zh) * 2012-07-11 2015-09-09 林伯士艾瑞斯公司 Irak抑制剂和其用途
TWI647227B (zh) 2013-02-28 2019-01-11 日商安斯泰來製藥股份有限公司 ２－醯胺噻唑衍生物或其鹽
AR100646A1 (es) * 2014-05-28 2016-10-19 Astellas Pharma Inc Derivado de piridina

Also Published As

Publication number Publication date
US20180022755A1 (en) 2018-01-25
TWI700285B (zh) 2020-08-01
AU2015386039B2 (en) 2020-05-07
SG11201706745PA (en) 2017-09-28
BR112017018649B8 (pt) 2023-10-03
KR20170124531A (ko) 2017-11-10
TW201636352A (zh) 2016-10-16
ES2869924T3 (es) 2021-10-26
JP6646648B2 (ja) 2020-02-14
PH12017501596A1 (en) 2018-02-12
RU2700411C2 (ru) 2019-09-17
EP3269721A1 (en) 2018-01-17
ZA201706038B (en) 2019-01-30
KR102446212B1 (ko) 2022-09-22
BR112017018649A2 (pt) 2018-04-17
MX370920B (es) 2020-01-09
JPWO2016143200A1 (ja) 2018-02-08
MY198083A (en) 2023-07-31
IL254307A0 (en) 2017-11-30
PH12017501596B1 (en) 2018-02-12
CN107428768A (zh) 2017-12-01
CA2976746C (en) 2023-01-24
EP3269721A4 (en) 2018-08-01
BR112017018649B1 (pt) 2023-07-11
EP3269721B1 (en) 2021-04-07
CA2976746A1 (en) 2016-09-15
CO2017008372A2 (es) 2017-11-30
MX2017010930A (es) 2018-01-23
RU2017134316A (ru) 2019-04-03
US10023583B2 (en) 2018-07-17
UA121889C2 (uk) 2020-08-10
PL3269721T3 (pl) 2021-10-11
WO2016143200A1 (ja) 2016-09-15
IL254307B (en) 2020-11-30
RU2017134316A3 (es) 2019-04-24
PT3269721T (pt) 2021-05-05
CN107428768B (zh) 2020-09-18
AU2015386039A1 (en) 2017-08-10

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