EA201101398A1 - Замещенные пиперидины в качестве антагонистов ccr3 - Google Patents

Замещенные пиперидины в качестве антагонистов ccr3

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Publication number
EA201101398A1
EA201101398A1 EA201101398A EA201101398A EA201101398A1 EA 201101398 A1 EA201101398 A1 EA 201101398A1 EA 201101398 A EA201101398 A EA 201101398A EA 201101398 A EA201101398 A EA 201101398A EA 201101398 A1 EA201101398 A1 EA 201101398A1
Authority
EA
Eurasian Patent Office
Prior art keywords
ccr3
antagonist
substituted piperidine
preparation
pharmaceutically acceptable
Prior art date
Application number
EA201101398A
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English (en)
Other versions
EA021072B1 (ru
Inventor
Марк Грундль
Хорст Доллингер
Риккардо Джованнини
Кристоф Хёнке
Маттиас Хоффманн
Ян Кригль
Домник Мартирес
Георг Раст
Петер Зайтер
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
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Publication date
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA201101398A1 publication Critical patent/EA201101398A1/ru
Publication of EA021072B1 publication Critical patent/EA021072B1/ru

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

В заявке описаны новые замещенные соединения формулы 1в которой A, R, R, Rи Rявляются такими, как определено в описании. В заявке также описано получение антагонистов CCR3, точнее, получение фармацевтических композиций, содержащих фармацевтически приемлемый носитель и по меньшей мере одно соединение, предлагаемое в настоящем изобретении, или его фармацевтически приемлемую соль в терапевтически эффективном количестве.
EA201101398A 2009-04-08 2010-04-01 Замещенные пиперидины в качестве антагонистов ccr3 EA021072B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09157653 2009-04-08
EP09174917 2009-11-03
PCT/EP2010/054396 WO2010115836A1 (en) 2009-04-08 2010-04-01 Substituted piperidines as ccr3 antagonists

Publications (2)

Publication Number Publication Date
EA201101398A1 true EA201101398A1 (ru) 2012-04-30
EA021072B1 EA021072B1 (ru) 2015-03-31

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US (3) US8278302B2 (ru)
EP (1) EP2417120B1 (ru)
JP (1) JP5466246B2 (ru)
KR (1) KR101690979B1 (ru)
CN (1) CN102388032B (ru)
AP (1) AP2989A (ru)
AR (1) AR076228A1 (ru)
AU (1) AU2010233849B2 (ru)
BR (2) BRPI1013821B1 (ru)
CA (1) CA2753151C (ru)
CL (1) CL2011002197A1 (ru)
CO (1) CO6501183A2 (ru)
DK (1) DK2417120T3 (ru)
EA (1) EA021072B1 (ru)
EC (1) ECSP11011427A (ru)
ES (1) ES2613696T3 (ru)
GE (1) GEP20135863B (ru)
HK (1) HK1164295A1 (ru)
HU (1) HUE030787T2 (ru)
IL (1) IL214309A (ru)
MA (1) MA33178B1 (ru)
MX (1) MX2011010584A (ru)
MY (1) MY161903A (ru)
NZ (1) NZ594597A (ru)
PE (1) PE20120135A1 (ru)
PL (1) PL2417120T3 (ru)
PT (1) PT2417120T (ru)
SG (2) SG175079A1 (ru)
TW (1) TWI466880B (ru)
UY (1) UY32547A (ru)
WO (1) WO2010115836A1 (ru)

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EP2417120A1 (en) 2012-02-15
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AR076228A1 (es) 2011-05-26
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USRE45323E1 (en) 2015-01-06
US8653075B2 (en) 2014-02-18
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