DK1476162T3 - Kontrolleret syntese af ziprasidone - Google Patents

Kontrolleret syntese af ziprasidone

Info

Publication number: DK1476162T3
Authority: DK; Denmark
Prior art keywords: ziprasidone; controlled synthesis; synthesis; controlled
Prior art date: 2002-02-20

Application number

DK03702918T

Other languages

Danish (da)

English (en)

Inventor

Adam Worth Grobin

Frank Robert Busch

Harry Ralph Howard Jr

Kyle Robert Leeman

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-20

Filing date

2003-02-17

Publication date

2007-07-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27761437&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1476162(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-02-17 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2007-07-02 Application granted granted Critical

2007-07-02 Publication of DK1476162T3 publication Critical patent/DK1476162T3/da

Links

230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
MVWVFYHBGMAFLY-UHFFFAOYSA-N ziprasidone Chemical compound C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 0.000 title 1
229960000607 ziprasidone Drugs 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Ophthalmology & Optometry (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Liquid Crystal Substances (AREA)
Indole Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Medical Preparation Storing Or Oral Administration Devices (AREA)

DK03702918T 2002-02-20 2003-02-17 Kontrolleret syntese af ziprasidone DK1476162T3 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US35880602P	2002-02-20	2002-02-20
US35903802P	2002-02-21	2002-02-21
US36045902P	2002-02-27	2002-02-27
PCT/IB2003/000642 WO2003070246A1 (en)	2002-02-20	2003-02-17	Controlled synthesis of ziprasidone and compositions thereof

Publications (1)

Publication Number	Publication Date
DK1476162T3 true DK1476162T3 (da)	2007-07-02

Family

ID=27761437

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK03702918T DK1476162T3 (da)	2002-02-20	2003-02-17	Kontrolleret syntese af ziprasidone

Country Status (41)

Country	Link
EP (1)	EP1476162B1 (de)
JP (1)	JP4554938B2 (de)
KR (1)	KR100773622B1 (de)
CN (2)	CN101735212A (de)
AP (1)	AP2004003103A0 (de)
AR (1)	AR038563A1 (de)
AT (1)	ATE359787T1 (de)
AU (2)	AU2003206035A1 (de)
BR (1)	BR0307833A (de)
CA (1)	CA2475302C (de)
CO (1)	CO5611138A2 (de)
CY (1)	CY1106467T1 (de)
DE (1)	DE60313289T2 (de)
DK (1)	DK1476162T3 (de)
EA (1)	EA007866B1 (de)
EC (1)	ECSP045239A (de)
ES (1)	ES2283745T3 (de)
GE (1)	GEP20074030B (de)
GT (1)	GT200300040A (de)
HR (1)	HRP20040711A2 (de)
IL (1)	IL163277A (de)
IS (1)	IS7344A (de)
MA (1)	MA27177A1 (de)
MX (1)	MXPA04006993A (de)
MY (1)	MY139523A (de)
NO (2)	NO20043902L (de)
NZ (1)	NZ534443A (de)
OA (1)	OA12774A (de)
PA (1)	PA8567001A1 (de)
PE (1)	PE20030942A1 (de)
PL (1)	PL372238A1 (de)
PT (1)	PT1476162E (de)
RS (1)	RS60404A (de)
SI (1)	SI1476162T1 (de)
SV (1)	SV2004001485A (de)
TN (1)	TNSN04159A1 (de)
TW (1)	TW200307546A (de)
UA (1)	UA77057C2 (de)
UY (1)	UY27668A1 (de)
WO (1)	WO2003070246A1 (de)
ZA (1)	ZA200406276B (de)

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WO2001066521A1 (en)	2000-03-06	2001-09-13	Acadia Pharmaceuticals, Inc.	Azacyclic compounds for use in the treatment of serotonin related diseases
WO2003057698A2 (en)	2001-12-28	2003-07-17	Acadia Pharmaceuticals, Inc.	Spiroazacyclic compounds as monoamine receptor modulators
IL165907A0 (en)	2002-06-24	2006-01-15	Acadia Pharm Inc	N-substituted piperidine derivatives as serotonin receptor agents
US7253186B2 (en)	2002-06-24	2007-08-07	Carl-Magnus Andersson	N-substituted piperidine derivatives as serotonin receptor agents
US7538222B2 (en)	2002-06-24	2009-05-26	Acadia Pharmaceuticals, Inc.	N-substituted piperidine derivatives as serotonin receptor agents
WO2004050655A1 (en) *	2002-12-04	2004-06-17	Dr. Reddy's Laboratories Limited	Polymorphic forms of ziprasidone and its hydrochloride
AU2003300814A1 (en)	2002-12-04	2004-06-23	Dr. Reddy's Laboratories Inc.	Polymorphic forms of ziprasidone and its hydrochloride
PT1587789E (pt)	2003-01-16	2008-12-16	Acadia Pharm Inc	Agonistas inversos selectivos para receptores 2a/2c da serotonina como agentes terapêuticos para doenças neurodegenerativas
WO2004083192A1 (en)	2003-03-17	2004-09-30	Teva Pharmaceutical Industries Ltd.	Polymorphis of valsartan
US7199144B2 (en)	2003-04-21	2007-04-03	Teva Pharmaceuticals Industries, Ltd.	Process for the preparation of valsartan and intermediates thereof
WO2004094392A1 (en) *	2003-04-21	2004-11-04	Teva Pharmaceutical Industries Ltd.	Process for the preparation of valsartan
WO2005016325A2 (en)	2003-06-03	2005-02-24	Teva Pharmaceutical Industries Ltd.	CRISTALLINE ZIPRASIDONE HCl AND PROCESSES FOR PREPARATION THEREOF
CA2543805A1 (en)	2003-10-24	2005-05-06	Gideon Pilarsky	Processes for preparation of ziprasidone
US20050197347A1 (en) *	2003-12-18	2005-09-08	Judith Aronhime	Polymorphic form B2 of ziprasidone base
ATE451367T1 (de)	2004-02-27	2009-12-15	Ranbaxy Lab Ltd	Verfahren zur herstellung von ziprasidon
CA2467538C (en)	2004-05-14	2010-08-24	Apotex Pharmachem Inc.	New amorphous ziprasidone hydrochloride (5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride) and processes to produce the same
US7820695B2 (en)	2004-05-21	2010-10-26	Acadia Pharmaceuticals, Inc.	Selective serotonin receptor inverse agonists as therapeutics for disease
CA2471219A1 (en)	2004-06-14	2005-12-14	Apotex Pharmachem Inc.	Improved preparation of an anhydrate form of 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride)
CN101035759B (zh)	2004-09-27	2011-06-15	阿卡蒂亚药品公司	N-(4-氟苄基)-n-(1-甲基哌啶-4-基)-n’-(4-(2-甲基丙氧基)苯基甲基)脲及其酒石酸盐的合成和晶形
US7790899B2 (en)	2004-09-27	2010-09-07	Acadia Pharmaceuticals, Inc.	Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
ES2250000B1 (es) *	2004-09-29	2007-06-01	Medichem, S.A.	Procedimiento para la preparacion de ziprasidona.
ES2250001B1 (es) *	2004-09-29	2007-06-01	Medichem, S.A.	Proceso para la purificacion de ziprasidona.
EP1841764A1 (de) *	2005-01-27	2007-10-10	Hetero Drugs Limited	Verfahren für ziprasidon unter verwendung neuer zwischenprodukte
ITMI20052216A1 (it) *	2005-11-18	2007-05-19	Dipharma Spa	Procedimento per la preparazione di ziprasidone
CN100491375C (zh) *	2006-07-01	2009-05-27	浙江美诺华药物化学有限公司	一种齐拉西酮的制备方法
ES2423485T3 (es)	2007-03-19	2013-09-20	Acadia Pharmaceuticals Inc.	Asociaciones de agonistas y antagonistas inversos 5-HT2A con antipsicóticos
CN102234273B (zh) *	2010-04-21	2015-08-05	上海医药工业研究院	甲磺酸齐拉西酮半水合物及其制备方法
CN102234272A (zh) *	2010-04-21	2011-11-09	上海医药工业研究院	盐酸齐拉西酮半水合物的制备方法
SI3325444T1 (sl)	2015-07-20	2021-11-30	Acadia Pharmaceuticals Inc.	Postopki za pripravo N-(4-fluorobenzil)-N-(1-metilpiperidin-4-il)-N'- (4-(2-metilpropiloksi)fenilmetil)karbamida in njegove tartratne soli in polimorfne oblike C
US10953000B2 (en)	2016-03-25	2021-03-23	Acadia Pharmaceuticals Inc.	Combination of pimavanserin and cytochrome P450 modulators
WO2017165635A1 (en)	2016-03-25	2017-09-28	Acadia Pharmaceuticals Inc.	Combination of pimavanserin and cytochrome p450 modulators
EP3558311A1 (de)	2016-12-20	2019-10-30	Acadia Pharmaceuticals Inc.	Pimavanserin allein oder in kombination zur verwendung in der behandlung von morbus-alzheimer-psychose
CN108239085A (zh) *	2016-12-26	2018-07-03	四川科瑞德凯华制药有限公司	一种甲磺酸齐拉西酮的纯化及制备方法
US11135211B2 (en)	2017-04-28	2021-10-05	Acadia Pharmaceuticals Inc.	Pimavanserin for treating impulse control disorder
US20210077479A1 (en)	2017-08-30	2021-03-18	Acadia Pharmaceuticals Inc.	Formulations of pimavanserin
CN112724066B (zh) *	2021-02-04	2022-10-21	海南鑫开源医药科技有限公司	一种盐酸齐拉西酮中间体中的二卤杂质及其制备方法
CN116046966A (zh) *	2023-01-17	2023-05-02	北京协和建昊医药技术开发有限责任公司	一种流动相配置装置及其配置方法

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CN1071324C (zh)	1995-11-07	2001-09-19	辉瑞大药厂	制备3－(1－哌嗪基)－1,2－苯并异噻唑的方法和中间体
SI0904273T1 (en) *	1996-05-07	2003-08-31	Pfizer Inc.	Mesylate trihydrate salt of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2(1h)-indol-2-one (=ziprasidone), its preparation and its use as dopamine d2 antagonist
TW491847B (en)	1996-05-07	2002-06-21	Pfizer	Mesylate dihydrate salts of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2h-indol-2-one
IL127497A (en) *	1997-12-18	2002-07-25	Pfizer Prod Inc	Medicinal products containing piperazinyl-heterocyclic compounds for the treatment of psychiatric disorders
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2003
- 2003-02-14 UY UY27668A patent/UY27668A1/es not_active Application Discontinuation
- 2003-02-17 JP JP2003569202A patent/JP4554938B2/ja not_active Expired - Fee Related
- 2003-02-17 OA OA1200400216A patent/OA12774A/en unknown
- 2003-02-17 EP EP03702918A patent/EP1476162B1/de not_active Revoked
- 2003-02-17 AP APAP/P/2004/003103A patent/AP2004003103A0/en unknown
- 2003-02-17 AT AT03702918T patent/ATE359787T1/de active
- 2003-02-17 CN CN200910261963A patent/CN101735212A/zh active Pending
- 2003-02-17 PL PL03372238A patent/PL372238A1/xx not_active Application Discontinuation
- 2003-02-17 UA UA20040806969A patent/UA77057C2/uk unknown
- 2003-02-17 KR KR1020047012980A patent/KR100773622B1/ko not_active IP Right Cessation
- 2003-02-17 AU AU2003206035A patent/AU2003206035A1/en not_active Abandoned
- 2003-02-17 PT PT03702918T patent/PT1476162E/pt unknown
- 2003-02-17 RS YU60404A patent/RS60404A/sr unknown
- 2003-02-17 WO PCT/IB2003/000642 patent/WO2003070246A1/en active Application Filing
- 2003-02-17 CA CA002475302A patent/CA2475302C/en not_active Expired - Fee Related
- 2003-02-17 DK DK03702918T patent/DK1476162T3/da active
- 2003-02-17 ES ES03702918T patent/ES2283745T3/es not_active Expired - Lifetime
- 2003-02-17 DE DE60313289T patent/DE60313289T2/de not_active Revoked
- 2003-02-17 MX MXPA04006993A patent/MXPA04006993A/es not_active Application Discontinuation
- 2003-02-17 SI SI200330811T patent/SI1476162T1/sl unknown
- 2003-02-17 EA EA200400815A patent/EA007866B1/ru not_active IP Right Cessation
- 2003-02-17 BR BR0307833-7A patent/BR0307833A/pt not_active IP Right Cessation
- 2003-02-17 CN CNA038042460A patent/CN1635892A/zh active Pending
- 2003-02-17 PE PE2003000168A patent/PE20030942A1/es not_active Application Discontinuation
- 2003-02-17 NZ NZ534443A patent/NZ534443A/en not_active IP Right Cessation
- 2003-02-17 GE GE5684A patent/GEP20074030B/en unknown
- 2003-02-18 TW TW092103292A patent/TW200307546A/zh unknown
- 2003-02-18 AR ARP030100527A patent/AR038563A1/es unknown
- 2003-02-18 GT GT200300040A patent/GT200300040A/es unknown
- 2003-02-18 MY MYPI20030564A patent/MY139523A/en unknown
- 2003-02-19 SV SV2003001485A patent/SV2004001485A/es not_active Application Discontinuation
- 2003-02-20 PA PA20038567001A patent/PA8567001A1/es unknown
2004
- 2004-07-05 IS IS7344A patent/IS7344A/is unknown
- 2004-07-29 IL IL163277A patent/IL163277A/en unknown
- 2004-08-04 HR HRP20040711 patent/HRP20040711A2/xx not_active Application Discontinuation
- 2004-08-05 ZA ZA200406276A patent/ZA200406276B/en unknown
- 2004-08-13 CO CO04079019A patent/CO5611138A2/es unknown
- 2004-08-17 MA MA27827A patent/MA27177A1/fr unknown
- 2004-08-19 TN TNP2004000159A patent/TNSN04159A1/fr unknown
- 2004-08-19 EC EC2004005239A patent/ECSP045239A/es unknown
- 2004-09-17 NO NO20043902A patent/NO20043902L/no not_active Application Discontinuation
2007
- 2007-05-10 CY CY20071100629T patent/CY1106467T1/el unknown
2009
- 2009-05-21 AU AU2009202008A patent/AU2009202008A1/en not_active Ceased
2010
- 2010-04-22 NO NO20100584A patent/NO20100584L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
PA8567001A1 (es)	2003-12-10
NO20043902L (no)	2004-09-17
EA200400815A1 (ru)	2004-12-30
SV2004001485A (es)	2004-05-07
CA2475302A1 (en)	2003-08-28
JP2005525347A (ja)	2005-08-25
ECSP045239A (es)	2004-09-28
TW200307546A (en)	2003-12-16
MY139523A (en)	2009-10-30
ES2283745T3 (es)	2007-11-01
JP4554938B2 (ja)	2010-09-29
GT200300040A (es)	2007-01-12
OA12774A (en)	2006-07-04
KR20040086417A (ko)	2004-10-08
DE60313289D1 (de)	2007-05-31
MA27177A1 (fr)	2005-01-03
AU2009202008A1 (en)	2009-06-11
UA77057C2 (en)	2006-10-16
TNSN04159A1 (fr)	2007-03-12
UY27668A1 (es)	2003-10-31
MXPA04006993A (es)	2004-11-10
IL163277A (en)	2010-05-31
PT1476162E (pt)	2007-06-25
PL372238A1 (en)	2005-07-11
DE60313289T2 (de)	2007-12-27
AR038563A1 (es)	2005-01-19
IS7344A (is)	2004-07-05
KR100773622B1 (ko)	2007-11-05
HRP20040711A2 (en)	2004-12-31
PE20030942A1 (es)	2003-11-08
NO20100584L (no)	2004-09-17
CA2475302C (en)	2009-05-12
GEP20074030B (en)	2007-02-12
AU2003206035A1 (en)	2003-09-09
ZA200406276B (en)	2005-09-20
ATE359787T1 (de)	2007-05-15
WO2003070246A1 (en)	2003-08-28
CO5611138A2 (es)	2006-02-28
AP2004003103A0 (en)	2004-09-30
EP1476162B1 (de)	2007-04-18
BR0307833A (pt)	2004-12-07
SI1476162T1 (sl)	2007-08-31
CY1106467T1 (el)	2012-01-25
EP1476162A1 (de)	2004-11-17
EA007866B1 (ru)	2007-02-27
CN1635892A (zh)	2005-07-06
NZ534443A (en)	2007-07-27
RS60404A (en)	2006-10-27
CN101735212A (zh)	2010-06-16

Publication	Publication Date	Title
DK1476162T3 (da)	2007-07-02	Kontrolleret syntese af ziprasidone
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