EA200400815A1 - Контролируемый синтез зипразидона и его композиции - Google Patents

Контролируемый синтез зипразидона и его композиции

Info

Publication number
EA200400815A1
EA200400815A1 EA200400815A EA200400815A EA200400815A1 EA 200400815 A1 EA200400815 A1 EA 200400815A1 EA 200400815 A EA200400815 A EA 200400815A EA 200400815 A EA200400815 A EA 200400815A EA 200400815 A1 EA200400815 A1 EA 200400815A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compositions
ziprazidona
controlled synthesis
undechloroziprasidone
synthesis
Prior art date
Application number
EA200400815A
Other languages
English (en)
Other versions
EA007866B1 (ru
Inventor
Фрэнк Роберт Буш
Адам Уорт Гроубин
Гарри Ральф мл. Хауард
Кайл Роберт Лиман
Original Assignee
Пфайзер Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27761437&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200400815(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк.
Publication of EA200400815A1 publication Critical patent/EA200400815A1/ru
Publication of EA007866B1 publication Critical patent/EA007866B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Согласно данному изобретению предложена композиция зипразидона, содержащая не более 1000 млндехлорзипразидона, предпочтительно не более чем приблизительно 500 млндехлорзипразидона и более предпочтительно не более чем приблизительно 100 млндехлорзипразидона. Также предложены способы синтеза и применения таких композиций зипразидона.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200400815A 2002-02-20 2003-02-17 Контролируемый синтез зипразидона и его композиции EA007866B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US35880602P 2002-02-20 2002-02-20
US35903802P 2002-02-21 2002-02-21
US36045902P 2002-02-27 2002-02-27
PCT/IB2003/000642 WO2003070246A1 (en) 2002-02-20 2003-02-17 Controlled synthesis of ziprasidone and compositions thereof

Publications (2)

Publication Number Publication Date
EA200400815A1 true EA200400815A1 (ru) 2004-12-30
EA007866B1 EA007866B1 (ru) 2007-02-27

Family

ID=27761437

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200400815A EA007866B1 (ru) 2002-02-20 2003-02-17 Контролируемый синтез зипразидона и его композиции

Country Status (41)

Country Link
EP (1) EP1476162B1 (ru)
JP (1) JP4554938B2 (ru)
KR (1) KR100773622B1 (ru)
CN (2) CN101735212A (ru)
AP (1) AP2004003103A0 (ru)
AR (1) AR038563A1 (ru)
AT (1) ATE359787T1 (ru)
AU (2) AU2003206035A1 (ru)
BR (1) BR0307833A (ru)
CA (1) CA2475302C (ru)
CO (1) CO5611138A2 (ru)
CY (1) CY1106467T1 (ru)
DE (1) DE60313289T2 (ru)
DK (1) DK1476162T3 (ru)
EA (1) EA007866B1 (ru)
EC (1) ECSP045239A (ru)
ES (1) ES2283745T3 (ru)
GE (1) GEP20074030B (ru)
GT (1) GT200300040A (ru)
HR (1) HRP20040711A2 (ru)
IL (1) IL163277A (ru)
IS (1) IS7344A (ru)
MA (1) MA27177A1 (ru)
MX (1) MXPA04006993A (ru)
MY (1) MY139523A (ru)
NO (2) NO20043902L (ru)
NZ (1) NZ534443A (ru)
OA (1) OA12774A (ru)
PA (1) PA8567001A1 (ru)
PE (1) PE20030942A1 (ru)
PL (1) PL372238A1 (ru)
PT (1) PT1476162E (ru)
RS (1) RS60404A (ru)
SI (1) SI1476162T1 (ru)
SV (1) SV2004001485A (ru)
TN (1) TNSN04159A1 (ru)
TW (1) TW200307546A (ru)
UA (1) UA77057C2 (ru)
UY (1) UY27668A1 (ru)
WO (1) WO2003070246A1 (ru)
ZA (1) ZA200406276B (ru)

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US7253186B2 (en) 2002-06-24 2007-08-07 Carl-Magnus Andersson N-substituted piperidine derivatives as serotonin receptor agents
US7538222B2 (en) 2002-06-24 2009-05-26 Acadia Pharmaceuticals, Inc. N-substituted piperidine derivatives as serotonin receptor agents
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AU2003300814A1 (en) 2002-12-04 2004-06-23 Dr. Reddy's Laboratories Inc. Polymorphic forms of ziprasidone and its hydrochloride
ES2314362T3 (es) 2003-01-16 2009-03-16 Acadia Pharmaceuticals Inc. Agonistas inversos selectivos de los receptores 2a o 2c de serotonina utilizados como agentes terapeuticos contra enfermedades neurodegenerativas.
US7199144B2 (en) 2003-04-21 2007-04-03 Teva Pharmaceuticals Industries, Ltd. Process for the preparation of valsartan and intermediates thereof
DE602004013405T2 (de) 2003-03-17 2009-05-07 Teva Pharmaceutical Industries Ltd. Polymorphe formen von valsartan
EP1618097A1 (en) 2003-04-21 2006-01-25 Teva Pharmaceutical Industries Ltd Process for the preparation of valsartan
KR20080093164A (ko) 2003-06-03 2008-10-20 테바 파마슈티컬 인더스트리즈 리미티드 결정성 지프라시돈 염산염 및 그의 제조 방법
US7667037B2 (en) 2003-10-24 2010-02-23 Teva Pharmaceutical Industries Ltd. Processes for preparation of ziprasidone
EP1592688A2 (en) * 2003-12-18 2005-11-09 Teva Pharmaceutical Industries Ltd. Polymorphic form b2 of ziprasidone base
PT1720867E (pt) 2004-02-27 2010-01-28 Ranbaxy Lab Ltd Processo para a preparação de ziprasidona
CA2467538C (en) 2004-05-14 2010-08-24 Apotex Pharmachem Inc. New amorphous ziprasidone hydrochloride (5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride) and processes to produce the same
US7820695B2 (en) 2004-05-21 2010-10-26 Acadia Pharmaceuticals, Inc. Selective serotonin receptor inverse agonists as therapeutics for disease
CA2471219A1 (en) 2004-06-14 2005-12-14 Apotex Pharmachem Inc. Improved preparation of an anhydrate form of 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride (ziprasidone hydrochloride)
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CN101031548B (zh) 2004-09-27 2011-04-06 阿卡蒂亚药品公司 N-(4-氟苄基)-n-(1-甲基哌啶-4-基)-n'-(4-(2-甲基丙氧基)-苯基甲基)脲的盐及其制备
ES2250001B1 (es) * 2004-09-29 2007-06-01 Medichem, S.A. Proceso para la purificacion de ziprasidona.
ES2250000B1 (es) * 2004-09-29 2007-06-01 Medichem, S.A. Procedimiento para la preparacion de ziprasidona.
WO2006080025A1 (en) * 2005-01-27 2006-08-03 Hetero Drugs Limited Process for ziprasidone using novel intermediates
ITMI20052216A1 (it) * 2005-11-18 2007-05-19 Dipharma Spa Procedimento per la preparazione di ziprasidone
CN100491375C (zh) * 2006-07-01 2009-05-27 浙江美诺华药物化学有限公司 一种齐拉西酮的制备方法
JP2010522198A (ja) 2007-03-19 2010-07-01 アカドイア プハルマセウチカルス インコーポレーテッド ５−ｈｔ２ａインバースアゴニスト及びアンタゴニストの抗精神病薬との併用
CN102234273B (zh) * 2010-04-21 2015-08-05 上海医药工业研究院 甲磺酸齐拉西酮半水合物及其制备方法
CN102234272A (zh) * 2010-04-21 2011-11-09 上海医药工业研究院 盐酸齐拉西酮半水合物的制备方法
CN107848972B (zh) 2015-07-20 2021-06-18 阿卡蒂亚药品公司 用于制备n-(4-氟苄基)-n-(1-甲基哌啶-4-基)-n’-(4-(2-甲基丙氧基)苯基甲基)脲及其酒石酸盐和多晶型c的方法
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WO2017165635A1 (en) 2016-03-25 2017-09-28 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome p450 modulators
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Also Published As

Publication number Publication date
KR100773622B1 (ko) 2007-11-05
CA2475302C (en) 2009-05-12
PL372238A1 (en) 2005-07-11
SI1476162T1 (sl) 2007-08-31
NO20100584L (no) 2004-09-17
JP4554938B2 (ja) 2010-09-29
CN1635892A (zh) 2005-07-06
WO2003070246A1 (en) 2003-08-28
AU2009202008A1 (en) 2009-06-11
GEP20074030B (en) 2007-02-12
EA007866B1 (ru) 2007-02-27
IL163277A (en) 2010-05-31
PT1476162E (pt) 2007-06-25
NO20043902L (no) 2004-09-17
NZ534443A (en) 2007-07-27
EP1476162B1 (en) 2007-04-18
EP1476162A1 (en) 2004-11-17
GT200300040A (es) 2007-01-12
MY139523A (en) 2009-10-30
HRP20040711A2 (en) 2004-12-31
SV2004001485A (es) 2004-05-07
TNSN04159A1 (fr) 2007-03-12
ZA200406276B (en) 2005-09-20
BR0307833A (pt) 2004-12-07
ES2283745T3 (es) 2007-11-01
PA8567001A1 (es) 2003-12-10
RS60404A (en) 2006-10-27
ATE359787T1 (de) 2007-05-15
UA77057C2 (en) 2006-10-16
CA2475302A1 (en) 2003-08-28
IS7344A (is) 2004-07-05
ECSP045239A (es) 2004-09-28
DK1476162T3 (da) 2007-07-02
CO5611138A2 (es) 2006-02-28
AU2003206035A1 (en) 2003-09-09
MA27177A1 (fr) 2005-01-03
DE60313289T2 (de) 2007-12-27
MXPA04006993A (es) 2004-11-10
TW200307546A (en) 2003-12-16
JP2005525347A (ja) 2005-08-25
UY27668A1 (es) 2003-10-31
AR038563A1 (es) 2005-01-19
KR20040086417A (ko) 2004-10-08
OA12774A (en) 2006-07-04
CN101735212A (zh) 2010-06-16
CY1106467T1 (el) 2012-01-25
DE60313289D1 (de) 2007-05-31
PE20030942A1 (es) 2003-11-08
AP2004003103A0 (en) 2004-09-30

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MH4D Revocation of a eurasian patent in part

Designated state(s): RU

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU