DK1337521T3 - Salte af en isothiasol-4-carboxamid og deres anvendelse som antihyperproliferationsmiddel - Google Patents

Salte af en isothiasol-4-carboxamid og deres anvendelse som antihyperproliferationsmiddel

Info

Publication number
DK1337521T3
DK1337521T3 DK01982663T DK01982663T DK1337521T3 DK 1337521 T3 DK1337521 T3 DK 1337521T3 DK 01982663 T DK01982663 T DK 01982663T DK 01982663 T DK01982663 T DK 01982663T DK 1337521 T3 DK1337521 T3 DK 1337521T3
Authority
DK
Denmark
Prior art keywords
isothiazole
carboxamide
salts
hyperproliferative agent
hyperproliferative
Prior art date
Application number
DK01982663T
Other languages
Danish (da)
English (en)
Inventor
Thomas G Gant
Glenn Robert Williams
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of DK1337521T3 publication Critical patent/DK1337521T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK01982663T 2000-11-28 2001-11-19 Salte af en isothiasol-4-carboxamid og deres anvendelse som antihyperproliferationsmiddel DK1337521T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25351300P 2000-11-28 2000-11-28
PCT/IB2001/002193 WO2002044158A1 (fr) 2000-11-28 2001-11-19 Sels d'un isothiazole-4-carboxamide et leur utilisation comme agents anti-hyperproliferatifs

Publications (1)

Publication Number Publication Date
DK1337521T3 true DK1337521T3 (da) 2007-01-29

Family

ID=22960587

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01982663T DK1337521T3 (da) 2000-11-28 2001-11-19 Salte af en isothiasol-4-carboxamid og deres anvendelse som antihyperproliferationsmiddel

Country Status (50)

Country Link
US (1) US6831091B2 (fr)
EP (1) EP1337521B1 (fr)
JP (2) JP2004514714A (fr)
KR (2) KR20050116401A (fr)
CN (1) CN1231474C (fr)
AP (1) AP2001002358A0 (fr)
AR (1) AR031512A1 (fr)
AT (1) ATE340786T1 (fr)
AU (2) AU2002214204B2 (fr)
BG (1) BG107752A (fr)
BR (1) BR0115621A (fr)
CA (1) CA2430065C (fr)
CR (1) CR6963A (fr)
CY (1) CY1106240T1 (fr)
CZ (1) CZ20031315A3 (fr)
DE (1) DE60123461T2 (fr)
DK (1) DK1337521T3 (fr)
DO (1) DOP2001000288A (fr)
EA (1) EA005859B1 (fr)
EC (1) ECSP034628A (fr)
EE (1) EE200300247A (fr)
ES (1) ES2271086T3 (fr)
GE (1) GEP20053652B (fr)
GT (1) GT200100237A (fr)
HK (1) HK1059085A1 (fr)
HN (1) HN2001000268A (fr)
HR (1) HRP20030408A2 (fr)
HU (1) HUP0302553A3 (fr)
IL (1) IL155371A0 (fr)
IS (1) IS6788A (fr)
MA (1) MA26960A1 (fr)
MX (1) MXPA03004714A (fr)
MY (1) MY136686A (fr)
NO (1) NO325187B1 (fr)
NZ (1) NZ525788A (fr)
OA (1) OA12532A (fr)
PA (1) PA8533801A1 (fr)
PE (1) PE20020591A1 (fr)
PL (1) PL362079A1 (fr)
PT (1) PT1337521E (fr)
SI (1) SI1337521T1 (fr)
SK (1) SK5862003A3 (fr)
SV (1) SV2002000748A (fr)
TN (1) TNSN01167A1 (fr)
TW (1) TWI287542B (fr)
UA (1) UA74221C2 (fr)
UY (1) UY27039A1 (fr)
WO (1) WO2002044158A1 (fr)
YU (1) YU36403A (fr)
ZA (1) ZA200303341B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA60365C2 (uk) * 1998-06-04 2003-10-15 Пфайзер Продактс Інк. Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
JP2002534468A (ja) 1999-01-13 2002-10-15 バイエル コーポレイション ｐ３８キナーゼ阻害剤としてのω−カルボキシアリール置換ジフェニル尿素
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US20030216396A1 (en) 2002-02-11 2003-11-20 Bayer Corporation Pyridine, quinoline, and isoquinoline N-oxides as kinase inhibitors
WO2003068228A1 (fr) 2002-02-11 2003-08-21 Bayer Pharmaceuticals Corporation Urees aryliques a activite inhibitrice d'angiogenese
JP4511352B2 (ja) * 2002-07-25 2010-07-28 ファイザー・インク 抗癌薬として有用なイソチアゾール誘導体
AP2005003232A0 (en) * 2002-08-19 2005-03-31 Pfizer Prod Inc Combination therapy for hyperproliferative diseases.
PT1636585E (pt) 2003-05-20 2008-03-27 Bayer Pharmaceuticals Corp Diarilureias com actividade inibidora de cinase
US8637553B2 (en) 2003-07-23 2014-01-28 Bayer Healthcare Llc Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions
ATE517622T1 (de) * 2003-10-27 2011-08-15 Merck Sharp & Dohme Salz eines tetrahydropyranylcyclopentyltetrahydropyridopyr diderivats als ccr-2 antagonisten
JP2007514759A (ja) 2003-12-19 2007-06-07 タケダ サン ディエゴ インコーポレイテッド キナーゼ阻害剤
WO2005102327A1 (fr) * 2004-04-20 2005-11-03 Pfizer Products Inc. Formes posologiques et procedes de traitement utilisant des inhibiteurs vegfr
EP2295427A1 (fr) 2004-04-30 2011-03-16 Bayer HealthCare, LLC Derives de pyrazolyl uree substitues utiles dans le traitement du cancer
TW200538104A (en) * 2004-05-17 2005-12-01 Pfizer Prod Inc Phenyl derivatives for the treatment of abnormal cell growth
US7550598B2 (en) 2004-08-18 2009-06-23 Takeda Pharmaceutical Company Limited Kinase inhibitors
US7713973B2 (en) 2004-10-15 2010-05-11 Takeda Pharmaceutical Company Limited Kinase inhibitors
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
RS52205B2 (sr) 2006-06-16 2021-05-31 H Lundbeck A/S 1-[2-(2,4-dimetilfenilsulfanil)-fenil]piperazin kao jedinjenje sa kombinovanom aktivnošću ponovnog uzimanja serotonina, 5-ht3 i 5-ht1a, za tretman kognitivnih oštećenja
US7932390B2 (en) 2006-06-29 2011-04-26 Hoffman-La Roche Inc. Substituted thieno[3,2-C]pyridine carboxylic acid derivatives
MX2009003793A (es) 2006-10-09 2009-12-14 Takeda Pharmaceutical Inhibidores de cinasa.
MX2010001636A (es) 2007-08-14 2010-03-15 Hoffmann La Roche Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos.
WO2011073521A1 (fr) 2009-12-15 2011-06-23 Petri Salven Méthodes pour l'enrichissement de cellules progénitrices endothéliales adultes et leurs utilisations
CN103261225A (zh) 2010-07-23 2013-08-21 波士顿大学董事会 作为用于抑制病理性血管生成和肿瘤细胞侵袭力的治疗剂以及用于分子成像和靶向递送的抗DEspR抑制剂
KR20210132205A (ko) 2013-03-14 2021-11-03 팬옵티카, 인크. 눈의 후안부로의 약물 전달을 위한 안구용 제제
EP3193867B1 (fr) * 2014-09-17 2021-01-20 PanOptica, Inc. Formulations oculaires permettant l'administration de médicament et la protection du segment antérieur de l'oeil

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA60365C2 (uk) * 1998-06-04 2003-10-15 Пфайзер Продактс Інк. Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця

Also Published As

Publication number Publication date
SV2002000748A (es) 2002-12-02
ECSP034628A (es) 2003-07-25
KR20030059275A (ko) 2003-07-07
EP1337521B1 (fr) 2006-09-27
PA8533801A1 (es) 2002-10-31
JP2004514714A (ja) 2004-05-20
WO2002044158A1 (fr) 2002-06-06
PT1337521E (pt) 2006-12-29
US6831091B2 (en) 2004-12-14
ATE340786T1 (de) 2006-10-15
CR6963A (es) 2003-11-25
IL155371A0 (en) 2003-11-23
HUP0302553A2 (hu) 2003-11-28
ZA200303341B (en) 2004-04-30
AU2002214204B2 (en) 2007-05-24
MA26960A1 (fr) 2004-12-20
MXPA03004714A (es) 2003-08-19
YU36403A (sh) 2006-08-17
JP4971946B2 (ja) 2012-07-11
EP1337521A1 (fr) 2003-08-27
CZ20031315A3 (cs) 2004-04-14
CN1231474C (zh) 2005-12-14
CN1476439A (zh) 2004-02-18
BR0115621A (pt) 2003-09-02
EA005859B1 (ru) 2005-06-30
DOP2001000288A (es) 2002-12-15
US20020151573A1 (en) 2002-10-17
GEP20053652B (en) 2005-11-10
CA2430065A1 (fr) 2002-06-06
ES2271086T3 (es) 2007-04-16
CY1106240T1 (el) 2011-06-08
NO20032388L (no) 2003-07-18
UA74221C2 (uk) 2005-11-15
BG107752A (bg) 2004-01-30
HUP0302553A3 (en) 2009-03-30
EE200300247A (et) 2003-10-15
HRP20030408A2 (en) 2003-08-31
HN2001000268A (es) 2002-01-30
SK5862003A3 (en) 2004-05-04
KR20050116401A (ko) 2005-12-12
TWI287542B (en) 2007-10-01
NO325187B1 (no) 2008-02-11
GT200100237A (es) 2002-07-03
IS6788A (is) 2003-04-14
UY27039A1 (es) 2002-07-31
CA2430065C (fr) 2008-05-20
TNSN01167A1 (fr) 2005-11-10
PE20020591A1 (es) 2002-07-06
NO20032388D0 (no) 2003-05-27
AR031512A1 (es) 2003-09-24
HK1059085A1 (en) 2004-06-18
EA200300424A1 (ru) 2003-10-30
MY136686A (en) 2008-11-28
AU1420402A (en) 2002-06-11
AP2001002358A0 (en) 2001-12-31
DE60123461T2 (de) 2007-02-15
PL362079A1 (en) 2004-10-18
JP2008056692A (ja) 2008-03-13
DE60123461D1 (de) 2006-11-09
NZ525788A (en) 2004-11-26
OA12532A (en) 2006-06-02
SI1337521T1 (sl) 2006-12-31

Similar Documents

Publication Publication Date Title
DK1337521T3 (da) Salte af en isothiasol-4-carboxamid og deres anvendelse som antihyperproliferationsmiddel
DK1335725T3 (da) Anvendelse af CCI-779 som et antineoplastisk middel
DK1133477T3 (da) Substituerede benzimidazoler og deres anvendelse som parpinhibitorer
NO20026010D0 (no) Substituerte quinazolinderivater og deres anvendelse som inhibitorer
DK1498413T3 (da) 4-aminopicolinater og deres anvendelse som herbicider
DK1478629T3 (da) N-aryl-2-oxazolidinon-5-carboxamider og deres derivater og deres anvendelse som antibakterielle midler
DK1339679T3 (da) 3-Aroylindolderivater og deres anvendelse som agonister af CB2-receptorer
DK1480962T3 (da) 5-Phenylthiazol-derivater og deres anvendelse som P1-3-kinaseinhibitorer
DK1223933T3 (da) 5-leddet derivater af heterocyklusser og deres anvendelse som monoaminoxidaseinhibitorer
NO20050476L (no) Kinolinderivater og deres anvendelse som mykobakterielle inhibitorer
NO20013452D0 (no) Benzoheterocykler og deres anvendelse som MEK-inhibitorer
NO20021253L (no) Kinolylpropylpiperidinderivater og deres anvendelse som antibakterielle midler
DK1347955T3 (da) Nye mandelsyrederivater og deres anvendelse som throbin-hæmmere
NO20014135L (no) Nye sulfonamidforbindelser og deres anvendelse
DK1345937T3 (da) Quinuclidincarbamatderivater og deres anvendelse som M3-antagonister
NO20024742L (no) Heterocykliske forbindelser, deres fremstilling og anvendelse
DK1341779T3 (da) Heterocyklisk sulfonamid-inhibitorer af beta-amyloidproduktion
NO20025357L (no) Antranylamider og deres anvendelse som legemidler
NO20025150L (no) 2-acylindolderivater og deres anvendelse som antitumormidler
DK0989121T3 (da) Substituerede benzamider og deres anvendelse som immunmodulatorer
DK1274709T3 (da) Salte af bicykliske, N-acylerede imidazo-3-aminer og imidazo-5-aminer
NO20042719L (no) Substituerte 2-amino-cykloalkankarboksamider og deres anvendelse som protease-inhibitorer
NO20034995D0 (no) Aromatiske sulfonhydroksymater og deres anvendelse som proteaseinhibitorer
DK1600441T3 (da) Krystallinsk form af elrcanidipinhydrochlorid til anvendelse som et antihypertensivt middel
DK1120419T3 (da) Derivater af isosorbid-mononitrat og deres anvendelse som vasodilaterende midler med formindsket tolerance