DK1120419T3 - Derivater af isosorbid-mononitrat og deres anvendelse som vasodilaterende midler med formindsket tolerance - Google Patents
Derivater af isosorbid-mononitrat og deres anvendelse som vasodilaterende midler med formindsket toleranceInfo
- Publication number
- DK1120419T3 DK1120419T3 DK99949015T DK99949015T DK1120419T3 DK 1120419 T3 DK1120419 T3 DK 1120419T3 DK 99949015 T DK99949015 T DK 99949015T DK 99949015 T DK99949015 T DK 99949015T DK 1120419 T3 DK1120419 T3 DK 1120419T3
- Authority
- DK
- Denmark
- Prior art keywords
- vasodilators
- isosorbide mononitrate
- diminished
- tolerance
- mononitrate derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009802076A ES2142773B1 (es) | 1998-10-07 | 1998-10-07 | Derivados de mononitrato de isosorbida y su empleo como agentes vasodilatadores con tolerancia desminuida. |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1120419T3 true DK1120419T3 (da) | 2006-07-03 |
Family
ID=8305360
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99949015T DK1120419T3 (da) | 1998-10-07 | 1999-10-04 | Derivater af isosorbid-mononitrat og deres anvendelse som vasodilaterende midler med formindsket tolerance |
Country Status (40)
Country | Link |
---|---|
US (2) | US20010051735A1 (da) |
EP (1) | EP1120419B1 (da) |
JP (1) | JP4659214B2 (da) |
KR (1) | KR100641801B1 (da) |
CN (1) | CN1096465C (da) |
AP (1) | AP1555A (da) |
AR (1) | AR020538A1 (da) |
AT (1) | ATE323707T1 (da) |
AU (1) | AU762724B2 (da) |
BG (1) | BG65135B1 (da) |
BR (1) | BR9914355B1 (da) |
CA (1) | CA2346010C (da) |
CO (1) | CO5180544A1 (da) |
CU (1) | CU23162A3 (da) |
CZ (1) | CZ294551B6 (da) |
DE (2) | DE69930949T2 (da) |
DK (1) | DK1120419T3 (da) |
EA (1) | EA003360B1 (da) |
EE (1) | EE04374B1 (da) |
ES (2) | ES2142773B1 (da) |
GB (1) | GB2359810B (da) |
GE (1) | GEP20043162B (da) |
GT (1) | GT199900173A (da) |
HR (1) | HRP20010256B1 (da) |
HU (1) | HUP0103937A3 (da) |
ID (1) | ID29946A (da) |
IL (2) | IL142391A0 (da) |
IS (1) | IS2312B (da) |
NO (1) | NO328584B1 (da) |
NZ (1) | NZ510855A (da) |
OA (1) | OA11661A (da) |
PA (1) | PA8483901A1 (da) |
PE (1) | PE20001083A1 (da) |
PL (1) | PL200028B1 (da) |
PT (1) | PT1120419E (da) |
RS (1) | RS50112B (da) |
TR (1) | TR200100961T2 (da) |
WO (1) | WO2000020420A1 (da) |
YU (1) | YU25201A (da) |
ZA (1) | ZA200102836B (da) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2258365B1 (es) * | 2003-10-03 | 2007-12-01 | Lacer, S.A. | Derivados de disulfuro, sulfuro, sulfoxido y sulfona de azucares ciclicos y sus usos. |
EP1941876A1 (en) * | 2006-12-28 | 2008-07-09 | Lacer, S.A. | Isosorbide mononitrate derivatives for the treatment of Inflammation and ocular hypertension |
ES2332565B1 (es) * | 2007-01-23 | 2010-10-21 | Lacer, S.A. | Uso de derivados de mononitrato de dianhidrohexita como agentes antiinflamatorios. |
IE20070934A1 (en) | 2007-12-21 | 2009-06-24 | Trinity College Dublin | Efficient aspirin prodrugs |
JP5587790B2 (ja) | 2008-01-09 | 2014-09-10 | アミュラ セラピューティクス リミティド | 化合物 |
ES2393049T3 (es) * | 2008-02-07 | 2012-12-18 | Nicox S.A. | Compuestos donantes de óxido nítrico |
EP2149576A1 (en) * | 2008-07-22 | 2010-02-03 | Lacer, S.A. | Isosorbide Nitrates having vasodilating activity |
EP2149577B1 (en) | 2008-07-22 | 2011-04-27 | Lacer, S.A. | New stereospecific method for the preparation of dioxa-bicyclooctane compounds |
EP2177216A1 (en) * | 2008-10-13 | 2010-04-21 | Lacer, S.A. | Use of dianhydrohexite mononitrate derivatives as healing agents |
WO2010055138A1 (en) * | 2008-11-14 | 2010-05-20 | Lacer, S.A. | New stereospecific method for the preparation of dioxa-bicyclooctane compounds |
EP2199294A1 (en) | 2008-12-19 | 2010-06-23 | Lacer, S.A. | New stereospecific method for the preparation of dioxa bicyclooctane nitrate compounds |
ES2423939T3 (es) * | 2009-09-10 | 2013-09-25 | Cognis Ip Management Gmbh | Derivados de isosorburo gliceril éter y su empleo en aplicaciones de uso doméstico |
DK2515899T3 (da) | 2009-12-23 | 2016-08-15 | Arca Biopharma Inc | Fremgangsmåder og sammensætninger til kardiovaskulære sygdomme og tilstande |
CN102241687A (zh) * | 2011-05-23 | 2011-11-16 | 中国人民解放军第四军医大学 | 抗缺血/再灌注损伤的药物 |
WO2013060673A1 (en) | 2011-10-24 | 2013-05-02 | Nicox S.A. | Quinone based nitric oxide donating compounds |
KR20150123324A (ko) * | 2013-03-05 | 2015-11-03 | 아처 다니엘 미드랜드 캄파니 | 이소헥시드 모노트리플레이트 및 이의 합성 방법 |
WO2014169976A1 (en) | 2013-04-18 | 2014-10-23 | Nicox Science Ireland | Quinone based nitric oxide donating compounds |
CN104650108B (zh) * | 2013-11-18 | 2017-05-24 | 富力 | 连翘脂素硫酸酯及其衍生物、制备方法及其应用 |
CN105461731B (zh) * | 2014-08-07 | 2017-05-24 | 富力 | 连翘脂素布洛芬酯、其制备及其应用 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1356374A (fr) | 1963-02-12 | 1964-03-27 | Machine à fonctions multiples pour le travail du bois | |
GB1356374A (en) | 1971-04-29 | 1974-06-12 | American Home Prod | Mononitrate esters of 1,3 3,6-dianhydro-d-glucitol |
US3886196A (en) | 1973-02-07 | 1975-05-27 | Phillips Petroleum Co | Magnesium-aluminum-silicate-phosphate catalysts for ammonialytic cleavage of lactams to form omega-aminonitriles |
DE3028289C2 (de) * | 1980-07-25 | 1986-11-27 | Dr. Willmar Schwabe GmbH & Co, 7500 Karlsruhe | 2-O- und 5-O-substituierte 1.4;3.6-Dianhydro-hexit-mononitrate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen |
DE3248548A1 (de) * | 1982-12-29 | 1984-07-05 | Heinrich Mack Nachf., 7918 Illertissen | Acylderivate von 1,4:3,6-dianhydro-hexiten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
DE3421072A1 (de) | 1984-06-06 | 1985-12-12 | Heinrich Mack Nachf., 7918 Illertissen | 1,4:3,6-dianhydro-hexit-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
DE3602067A1 (de) | 1986-01-24 | 1987-07-30 | Mack Chem Pharm | 2,6-dioxabicyclo(3.3.0)octan-derivate, ihre herstellung und verwendung als arzneimittel |
DE3606634A1 (de) | 1986-02-28 | 1987-09-03 | Mack Chem Pharm | Isohexid-nucleoside, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
IT1204571B (it) * | 1987-05-08 | 1989-03-10 | Chiesi Farma Spa | Esteri di 1,4:3,6-dianidrosorbitolo-2-mononitrato e 5-mononitrato,loro procedimento di preparazione e loro composizioni farmaceutiche |
DE3741005A1 (de) | 1987-12-03 | 1989-06-15 | Mack Chem Pharm | Aminopropanol-derivate von 1,4:3,6-dianhydro-hexit-nitraten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
JP2628756B2 (ja) * | 1988-09-15 | 1997-07-09 | シュバルツファルマ アクチェンゲゼルシャフト | 新規有機ニトレート及びそれらの製造方法 |
US5428061A (en) | 1988-09-15 | 1995-06-27 | Schwarz Pharma Ag | Organic nitrates and method for their preparation |
US4891373A (en) * | 1988-11-23 | 1990-01-02 | Pfizer Inc. | Aminopropanol derivatives of 1,4:3,6-dianhydrohexitol nitrates, processes for their preparation and their use as medicaments |
CA2014520C (en) | 1989-04-17 | 1996-07-16 | Fumio Suzuki | Hexitol derivatives |
NL9001955A (nl) * | 1990-09-05 | 1992-04-01 | Cedona Pharm Bv | Nieuwe thiazolidinederivaten. |
FR2680173A1 (fr) * | 1991-08-07 | 1993-02-12 | Hoechst Lab | Nitrates organiques, leurs procedes de preparation et leur utilisation dans le traitement de maladies cardiovasculaires . |
DE69321596T2 (de) * | 1992-07-30 | 1999-04-22 | Cal International Ltd | Ester und kombinationen von einem organischen nitrat und einem salicyclat |
IL120531A (en) | 1997-03-26 | 2006-12-31 | Yissum Res Dev Co | Nitric oxide donors and pharmaceutical compositions containing them |
-
1998
- 1998-10-07 ES ES009802076A patent/ES2142773B1/es not_active Expired - Fee Related
-
1999
- 1999-09-30 AR ARP990104928A patent/AR020538A1/es active IP Right Grant
- 1999-10-04 IL IL14239199A patent/IL142391A0/xx active IP Right Grant
- 1999-10-04 EP EP99949015A patent/EP1120419B1/en not_active Expired - Lifetime
- 1999-10-04 ES ES99949015T patent/ES2257871T3/es not_active Expired - Lifetime
- 1999-10-04 YU YU25201A patent/YU25201A/sh unknown
- 1999-10-04 TR TR2001/00961T patent/TR200100961T2/xx unknown
- 1999-10-04 CN CN99811802A patent/CN1096465C/zh not_active Expired - Fee Related
- 1999-10-04 CA CA002346010A patent/CA2346010C/en not_active Expired - Fee Related
- 1999-10-04 PT PT99949015T patent/PT1120419E/pt unknown
- 1999-10-04 AT AT99949015T patent/ATE323707T1/de not_active IP Right Cessation
- 1999-10-04 EE EEP200100207A patent/EE04374B1/xx not_active IP Right Cessation
- 1999-10-04 JP JP2000574532A patent/JP4659214B2/ja not_active Expired - Fee Related
- 1999-10-04 DE DE69930949T patent/DE69930949T2/de not_active Expired - Lifetime
- 1999-10-04 AU AU62041/99A patent/AU762724B2/en not_active Ceased
- 1999-10-04 EA EA200100422A patent/EA003360B1/ru not_active IP Right Cessation
- 1999-10-04 DE DE19983612T patent/DE19983612T1/de not_active Ceased
- 1999-10-04 NZ NZ510855A patent/NZ510855A/xx not_active IP Right Cessation
- 1999-10-04 OA OA1200100085A patent/OA11661A/en unknown
- 1999-10-04 WO PCT/ES1999/000316 patent/WO2000020420A1/es not_active Application Discontinuation
- 1999-10-04 PL PL347030A patent/PL200028B1/pl not_active IP Right Cessation
- 1999-10-04 GE GEAP19995886A patent/GEP20043162B/en unknown
- 1999-10-04 GB GB0111172A patent/GB2359810B/en not_active Expired - Fee Related
- 1999-10-04 PE PE1999001005A patent/PE20001083A1/es not_active Application Discontinuation
- 1999-10-04 KR KR1020017004374A patent/KR100641801B1/ko not_active IP Right Cessation
- 1999-10-04 BR BRPI9914355-0A patent/BR9914355B1/pt not_active IP Right Cessation
- 1999-10-04 DK DK99949015T patent/DK1120419T3/da active
- 1999-10-04 ID IDW00200101008A patent/ID29946A/id unknown
- 1999-10-04 HU HU0103937A patent/HUP0103937A3/hu unknown
- 1999-10-04 RS YUP-252/01A patent/RS50112B/sr unknown
- 1999-10-04 CZ CZ20011257A patent/CZ294551B6/cs not_active IP Right Cessation
- 1999-10-04 AP APAP/P/2001/002128A patent/AP1555A/en active
- 1999-10-06 CO CO99063420A patent/CO5180544A1/es not_active Application Discontinuation
- 1999-10-07 GT GT199900173A patent/GT199900173A/es unknown
- 1999-10-07 PA PA19998483901A patent/PA8483901A1/es unknown
-
2001
- 2001-03-29 IS IS5910A patent/IS2312B/is unknown
- 2001-04-03 IL IL142391A patent/IL142391A/en not_active IP Right Cessation
- 2001-04-04 CU CU83A patent/CU23162A3/es not_active IP Right Cessation
- 2001-04-05 ZA ZA200102836A patent/ZA200102836B/xx unknown
- 2001-04-06 NO NO20011778A patent/NO328584B1/no not_active IP Right Cessation
- 2001-04-06 US US09/827,868 patent/US20010051735A1/en not_active Abandoned
- 2001-04-06 HR HR20010256A patent/HRP20010256B1/xx not_active IP Right Cessation
- 2001-04-06 BG BG105417A patent/BG65135B1/bg unknown
-
2003
- 2003-04-28 US US10/424,828 patent/US6858632B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1120419T3 (da) | Derivater af isosorbid-mononitrat og deres anvendelse som vasodilaterende midler med formindsket tolerance | |
NO20024742D0 (no) | Heterocykliske forbindelser, deres fremstilling og anvendelse | |
NO20020683D0 (no) | Arylmetylkarbonylaminotiazolderivater og deres anvendelse som antitumormidler | |
NO20021253L (no) | Kinolylpropylpiperidinderivater og deres anvendelse som antibakterielle midler | |
ATE314072T1 (de) | Antivirale azaindolderivate | |
DK1498413T3 (da) | 4-aminopicolinater og deres anvendelse som herbicider | |
DK1198454T3 (da) | Multilinderivater og deres anvendelse som antibakterielle midler | |
NO20001079D0 (no) | Kopolymerer og deres anvendelse som borehjelpemiddel | |
ATE325807T1 (de) | Purinderivate | |
NO20000627D0 (no) | ForhÕndsbelagte kontrollert - frigjørings - gjødningsmidler og fremgangsmÕter for deres fremstilling | |
ATE267836T1 (de) | Purinderivate | |
NO20025150L (no) | 2-acylindolderivater og deres anvendelse som antitumormidler | |
DK1273575T3 (da) | Diazepan derivater eller salte deraf | |
NO20011436D0 (no) | 2,2,6,6-dietyl-dimetyl-1-alkoksy-piperidin-forbindelser og deres korresponderende 1-oksider | |
DK1337521T3 (da) | Salte af en isothiasol-4-carboxamid og deres anvendelse som antihyperproliferationsmiddel | |
DK1107980T3 (da) | Krystallinske former af EtO2C-CH2-(R)Cgl-Aze-Pab-OH | |
DE50104619D1 (de) | Zündvorrichtung | |
NO995513L (no) | N-triazolyl-2-indolkarboksamider og deres anvendelse som CCK- | |
ATE282038T1 (de) | Kristallin form ii von cabergolin | |
DE60024023D1 (de) | Nockenwellenversteller | |
DK1259515T3 (da) | Thienopyridinderivater og deres anvendelse som antiinflammatoriske midler | |
NO20012802L (no) | Benzofuranderivater, deres fremstilling og anvendelse | |
NO992629D0 (no) | Substituerte benzotiopyransalter og deres anvendelse som herbicider | |
NO20015564D0 (no) | Imidazo-inneholdende heterocykliske forbindelser, deres sammensetninger og anvendelser | |
NO20022844D0 (no) | N-(1-fenyletyl)-5-fenyl-imidazol-2-aminforbindelser, deres sammensetninger og anvendelser |