TNSN01167A1 - Formes de sels d'amide d'acide 3-(4-bromo-2,6-difluoro-benzyloxy) - 5 [3 - (4 - pyrrolidine - 1 - yl - butyl) ureido] isothiazole - 4 - carboxylique, et procede pour leur production. - Google Patents

Formes de sels d'amide d'acide 3-(4-bromo-2,6-difluoro-benzyloxy) - 5 [3 - (4 - pyrrolidine - 1 - yl - butyl) ureido] isothiazole - 4 - carboxylique, et procede pour leur production.

Info

Publication number
TNSN01167A1
TNSN01167A1 TNTNSN01167A TNSN01167A TNSN01167A1 TN SN01167 A1 TNSN01167 A1 TN SN01167A1 TN TNSN01167 A TNTNSN01167 A TN TNSN01167A TN SN01167 A TNSN01167 A TN SN01167A TN SN01167 A1 TNSN01167 A1 TN SN01167A1
Authority
TN
Tunisia
Prior art keywords
isothiazole
ureido
benzyloxy
difluoro
pyrrolidine
Prior art date
Application number
TNTNSN01167A
Other languages
English (en)
Inventor
G Gant Thomas
Robert Williams Glenn
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of TNSN01167A1 publication Critical patent/TNSN01167A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

L'INVENTION CONCERNE LE CHLORHYDRATE, LE BROMHYDRATE, L'HEMI-CITRATE, L'ACETATE, LE P- TOSYLATE, LE L-TARTRATE, L'HEMI-SUCCINATE ET LE MESYLATE DU COMPOSE DE FORMULE (I) : ELLE CONCERNE EGALEMENT DES PROCEDES POUR LEUR PREPARATION ET DES COMPOSITIONS LES CONTENANT. APPLICATION: UTILISATION DE CES COMPOSES ET COMPOSITIONS POUR LE TRAITEMENT DE MALADIES HYPERPROLIFERATIVES CHEZ DES MAMMIFERES.
TNTNSN01167A 2000-11-28 2001-11-27 Formes de sels d'amide d'acide 3-(4-bromo-2,6-difluoro-benzyloxy) - 5 [3 - (4 - pyrrolidine - 1 - yl - butyl) ureido] isothiazole - 4 - carboxylique, et procede pour leur production. TNSN01167A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25351300P 2000-11-28 2000-11-28

Publications (1)

Publication Number Publication Date
TNSN01167A1 true TNSN01167A1 (fr) 2005-11-10

Family

ID=22960587

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN01167A TNSN01167A1 (fr) 2000-11-28 2001-11-27 Formes de sels d'amide d'acide 3-(4-bromo-2,6-difluoro-benzyloxy) - 5 [3 - (4 - pyrrolidine - 1 - yl - butyl) ureido] isothiazole - 4 - carboxylique, et procede pour leur production.

Country Status (50)

Country Link
US (1) US6831091B2 (fr)
EP (1) EP1337521B1 (fr)
JP (2) JP2004514714A (fr)
KR (2) KR20050116401A (fr)
CN (1) CN1231474C (fr)
AP (1) AP2001002358A0 (fr)
AR (1) AR031512A1 (fr)
AT (1) ATE340786T1 (fr)
AU (2) AU1420402A (fr)
BG (1) BG107752A (fr)
BR (1) BR0115621A (fr)
CA (1) CA2430065C (fr)
CR (1) CR6963A (fr)
CY (1) CY1106240T1 (fr)
CZ (1) CZ20031315A3 (fr)
DE (1) DE60123461T2 (fr)
DK (1) DK1337521T3 (fr)
DO (1) DOP2001000288A (fr)
EA (1) EA005859B1 (fr)
EC (1) ECSP034628A (fr)
EE (1) EE200300247A (fr)
ES (1) ES2271086T3 (fr)
GE (1) GEP20053652B (fr)
GT (1) GT200100237A (fr)
HK (1) HK1059085A1 (fr)
HN (1) HN2001000268A (fr)
HR (1) HRP20030408A2 (fr)
HU (1) HUP0302553A3 (fr)
IL (1) IL155371A0 (fr)
IS (1) IS6788A (fr)
MA (1) MA26960A1 (fr)
MX (1) MXPA03004714A (fr)
MY (1) MY136686A (fr)
NO (1) NO325187B1 (fr)
NZ (1) NZ525788A (fr)
OA (1) OA12532A (fr)
PA (1) PA8533801A1 (fr)
PE (1) PE20020591A1 (fr)
PL (1) PL362079A1 (fr)
PT (1) PT1337521E (fr)
SI (1) SI1337521T1 (fr)
SK (1) SK5862003A3 (fr)
SV (1) SV2002000748A (fr)
TN (1) TNSN01167A1 (fr)
TW (1) TWI287542B (fr)
UA (1) UA74221C2 (fr)
UY (1) UY27039A1 (fr)
WO (1) WO2002044158A1 (fr)
YU (1) YU36403A (fr)
ZA (1) ZA200303341B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA60365C2 (uk) * 1998-06-04 2003-10-15 Пфайзер Продактс Інк. Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
JP2002534468A (ja) 1999-01-13 2002-10-15 バイエル コーポレイション ｐ３８キナーゼ阻害剤としてのω−カルボキシアリール置換ジフェニル尿素
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
WO2003068229A1 (fr) 2002-02-11 2003-08-21 Bayer Pharmaceuticals Corporation N-oxydes de pyridine, de quinoline, et d'isoquinoline en tant qu'inhibiteurs de kinase
EP2324825A1 (fr) 2002-02-11 2011-05-25 Bayer Healthcare LLC Arylurées dotées d'une activité d'inhibition de l'angiogenèse
BR0312798A (pt) * 2002-07-25 2005-05-03 Pfizer Prod Inc Derivados de isotiazol úteis como agentes anticancerìgenos
AP2005003232A0 (en) * 2002-08-19 2005-03-31 Pfizer Prod Inc Combination therapy for hyperproliferative diseases.
ATE366108T1 (de) 2003-05-20 2007-07-15 Bayer Pharmaceuticals Corp Diaryl-harnstoffe für durch pdgfr vermittelte krankheiten
NZ580384A (en) 2003-07-23 2011-03-31 Bayer Pharmaceuticals Corp 4{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide and metabolites for the treatment and prevention of diseases and conditions
RU2317295C1 (ru) * 2003-10-27 2008-02-20 Мерк Энд Ко., Инк. Соль антагониста ccr-2
EP1694686A1 (fr) 2003-12-19 2006-08-30 Takeda San Diego, Inc. Inhibiteurs de kinase
WO2005102327A1 (fr) * 2004-04-20 2005-11-03 Pfizer Products Inc. Formes posologiques et procedes de traitement utilisant des inhibiteurs vegfr
JP2007535565A (ja) 2004-04-30 2007-12-06 バイエル ファーマシューティカルス コーポレーション 癌の治療に有用な置換ピラゾリル尿素誘導体
TW200538104A (en) * 2004-05-17 2005-12-01 Pfizer Prod Inc Phenyl derivatives for the treatment of abnormal cell growth
EP1778669A2 (fr) 2004-08-18 2007-05-02 Takeda San Diego, Inc. Inhibiteurs de kinase
WO2006044687A2 (fr) 2004-10-15 2006-04-27 Takeda San Diego, Inc. Inhibiteurs de kinase
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
SI2044043T2 (sl) 2006-06-16 2021-04-30 H. Lundbeck A/S 1-2(-2,4-dimetilfenilsulfanil)-fenil)piperazin hidrobromid kot spojina s kombinirano aktivnostjo ponovnega privzema serotonina, 5-ht3 in 5-ht1a za zdravljenje kognitivne motnje
US7932390B2 (en) 2006-06-29 2011-04-26 Hoffman-La Roche Inc. Substituted thieno[3,2-C]pyridine carboxylic acid derivatives
BRPI0719883A2 (pt) 2006-10-09 2015-05-05 Takeda Pharmaceutical Inibidores de quinase
MX2010001636A (es) 2007-08-14 2010-03-15 Hoffmann La Roche Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos.
WO2011073521A1 (fr) 2009-12-15 2011-06-23 Petri Salven Méthodes pour l'enrichissement de cellules progénitrices endothéliales adultes et leurs utilisations
CA2806921C (fr) 2010-07-23 2019-11-26 Trustees Of Boston University Inhibiteurs anti-despr comme agents therapeutiques pour l'inhibition de l'angiogenese pathologique et de l'invasivite des cellules tumorales et pour l'imagerie moleculaire et l'administration ciblee
EP2968650B1 (fr) * 2013-03-14 2019-01-16 PanOptica, Inc. Formulations oculaires destinées à l'administration de médicament au segment postérieur de l'oeil
EP3193867B1 (fr) * 2014-09-17 2021-01-20 PanOptica, Inc. Formulations oculaires permettant l'administration de médicament et la protection du segment antérieur de l'oeil

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA60365C2 (uk) * 1998-06-04 2003-10-15 Пфайзер Продактс Інк. Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця

Also Published As

Publication number Publication date
PA8533801A1 (es) 2002-10-31
HRP20030408A2 (en) 2003-08-31
GEP20053652B (en) 2005-11-10
DK1337521T3 (da) 2007-01-29
PE20020591A1 (es) 2002-07-06
DOP2001000288A (es) 2002-12-15
NO20032388L (no) 2003-07-18
IL155371A0 (en) 2003-11-23
WO2002044158A1 (fr) 2002-06-06
MXPA03004714A (es) 2003-08-19
HUP0302553A3 (en) 2009-03-30
CY1106240T1 (el) 2011-06-08
AU1420402A (en) 2002-06-11
BR0115621A (pt) 2003-09-02
NZ525788A (en) 2004-11-26
YU36403A (sh) 2006-08-17
EA005859B1 (ru) 2005-06-30
ECSP034628A (es) 2003-07-25
SV2002000748A (es) 2002-12-02
KR20050116401A (ko) 2005-12-12
PT1337521E (pt) 2006-12-29
JP2008056692A (ja) 2008-03-13
NO20032388D0 (no) 2003-05-27
JP4971946B2 (ja) 2012-07-11
MY136686A (en) 2008-11-28
KR20030059275A (ko) 2003-07-07
HK1059085A1 (en) 2004-06-18
MA26960A1 (fr) 2004-12-20
TWI287542B (en) 2007-10-01
GT200100237A (es) 2002-07-03
DE60123461T2 (de) 2007-02-15
CA2430065C (fr) 2008-05-20
SI1337521T1 (sl) 2006-12-31
CR6963A (es) 2003-11-25
HN2001000268A (es) 2002-01-30
CZ20031315A3 (cs) 2004-04-14
CN1231474C (zh) 2005-12-14
NO325187B1 (no) 2008-02-11
EP1337521A1 (fr) 2003-08-27
CN1476439A (zh) 2004-02-18
SK5862003A3 (en) 2004-05-04
IS6788A (is) 2003-04-14
AR031512A1 (es) 2003-09-24
OA12532A (en) 2006-06-02
UY27039A1 (es) 2002-07-31
HUP0302553A2 (hu) 2003-11-28
AU2002214204B2 (en) 2007-05-24
JP2004514714A (ja) 2004-05-20
CA2430065A1 (fr) 2002-06-06
EA200300424A1 (ru) 2003-10-30
UA74221C2 (uk) 2005-11-15
PL362079A1 (en) 2004-10-18
US6831091B2 (en) 2004-12-14
ZA200303341B (en) 2004-04-30
ES2271086T3 (es) 2007-04-16
EP1337521B1 (fr) 2006-09-27
ATE340786T1 (de) 2006-10-15
AP2001002358A0 (en) 2001-12-31
EE200300247A (et) 2003-10-15
US20020151573A1 (en) 2002-10-17
DE60123461D1 (de) 2006-11-09
BG107752A (bg) 2004-01-30

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