MX2010001636A - Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos. - Google Patents
Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos.Info
- Publication number
- MX2010001636A MX2010001636A MX2010001636A MX2010001636A MX2010001636A MX 2010001636 A MX2010001636 A MX 2010001636A MX 2010001636 A MX2010001636 A MX 2010001636A MX 2010001636 A MX2010001636 A MX 2010001636A MX 2010001636 A MX2010001636 A MX 2010001636A
- Authority
- MX
- Mexico
- Prior art keywords
- diazo bicyclic
- smac mimetics
- mimetics
- bicyclic smac
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
La presente invención está dirigida a derivados de pirazolo[3,4-d]pirimidina novedosos de fórmula (I), y sales y ésteres farmacéuticamente aceptables de los mismos, donde R, el Anillo A, L y el anillo B son como se describe aquí. Esos compuestos y sus sales y ésteres farmacéuticamente aceptables inhiben la Raf cinasa y tienen actividad antiproliferativa. Por lo tanto, son útiles en el tratamiento o control de trastornos proliferativos como el cáncer, en particular tumores sólidos, de manera más particular tumor de mama, tumor de colón, tumor de pulmón, tumor de próstata y melanoma. También se describe una composición y una formulación de dosis unitaria que comprende ese compuesto, o una sal o éster farmacéuticamente aceptable del mismo para producir esos compuestos, y métodos para usar esos compuestos, o sus sales o ésteres farmacéuticamente aceptables, en el tratamiento de trastornos proliferativos. (Ver fórmula I).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95565307P | 2007-08-14 | 2007-08-14 | |
| PCT/US2008/060215 WO2008128171A2 (en) | 2007-04-13 | 2008-04-14 | Diazo bicyclic smac mimetics and the uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010001636A true MX2010001636A (es) | 2010-03-15 |
Family
ID=39760502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010001636A MX2010001636A (es) | 2007-08-14 | 2008-04-14 | Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7968554B2 (es) |
| EP (1) | EP2188290B1 (es) |
| JP (1) | JP5296790B2 (es) |
| KR (1) | KR20100038431A (es) |
| CN (1) | CN101965349B (es) |
| AT (1) | ATE512152T1 (es) |
| AU (1) | AU2008288538A1 (es) |
| BR (1) | BRPI0815334A2 (es) |
| CA (1) | CA2694666C (es) |
| ES (1) | ES2366268T3 (es) |
| MX (1) | MX2010001636A (es) |
| WO (1) | WO2009021869A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9408885B2 (en) | 2011-12-01 | 2016-08-09 | Vib Vzw | Combinations of therapeutic agents for treating melanoma |
| JP7341060B2 (ja) | 2017-02-10 | 2023-09-08 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | Ｍａｐｋ経路の活性化に関連付けられる癌の処置のための方法及び医薬組成物 |
| US11725185B2 (en) | 2017-12-28 | 2023-08-15 | University Of Houston System | Stem cell culture systems for columnar epithelial stem cells, and uses related thereto |
| EP3952997A1 (en) * | 2019-04-10 | 2022-02-16 | Cellestia Biotech AG | Compounds for the treatment of oncovirus induced cancer and methods of use thereof |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2732970B1 (fr) | 1995-04-14 | 1997-05-16 | Hoechst Schering Agrevo Sa | Nouveaux derives de l'acide beta-methoxy acrylique, leur procede de preparation et leur application comme pesticides |
| US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| UA60365C2 (uk) | 1998-06-04 | 2003-10-15 | Пфайзер Продактс Інк. | Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця |
| JP4876239B2 (ja) * | 1999-01-11 | 2012-02-15 | プリンストン ユニバーシティー | 標的確認のための高親和性阻害剤およびその使用 |
| HN2000000051A (es) | 1999-05-19 | 2001-02-02 | Pfizer Prod Inc | Derivados heterociclicos utiles como agentes anticancerosos |
| EA005859B1 (ru) | 2000-11-28 | 2005-06-30 | Пфайзер Продактс Инк. | Соли изотиазол-4-карбоксамида и их применение в качестве антигиперпролиферативных агентов |
| MXPA04009541A (es) | 2002-03-29 | 2005-01-25 | Chiron Corp | Benzazoles sustituidos y uso de los mismos como inhibidores de cinasa raf. |
| US7199119B2 (en) | 2002-10-31 | 2007-04-03 | Amgen Inc. | Antiinflammation agents |
| EP1620094A4 (en) | 2003-05-06 | 2010-04-28 | Glaxosmithkline Llc | NEW CHEMICAL COMPOUNDS |
| US7202363B2 (en) | 2003-07-24 | 2007-04-10 | Abbott Laboratories | Thienopyridine and furopyridine kinase inhibitors |
| US20050026944A1 (en) | 2003-07-24 | 2005-02-03 | Patrick Betschmann | Thienopyridine and furopyridine kinase inhibitors |
| US20050020619A1 (en) | 2003-07-24 | 2005-01-27 | Patrick Betschmann | Thienopyridine kinase inhibitors |
| US7119102B2 (en) | 2003-12-05 | 2006-10-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses |
| US20060025383A1 (en) * | 2004-02-03 | 2006-02-02 | Neil Wishart | Aminobenzoxazoles as therapeutic agents |
| US20050256154A1 (en) | 2004-05-04 | 2005-11-17 | Kin-Chun Luk | 4-Amino-thieno[3,2-c]pyridine-7-carboxylic acid amides |
| US7405220B2 (en) | 2004-06-09 | 2008-07-29 | Hoffmann-La Roche Inc. | Pyrazolopyrimidines |
| JP2008520744A (ja) | 2004-11-19 | 2008-06-19 | ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | 抗炎症性ピラゾロピリミジン |
| BRPI0610863A2 (pt) | 2005-05-20 | 2010-08-03 | Array Biopharma Inc | compostos inibidores de raf e métodos para sua utilização |
| SI2395004T1 (sl) * | 2005-06-22 | 2016-05-31 | Plexxikon Inc. | Derivati piro (2,3-b) piridina kot inhibitorji proteinske kinaze |
| AR057455A1 (es) * | 2005-07-22 | 2007-12-05 | Merck & Co Inc | Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica |
| KR100968099B1 (ko) * | 2005-09-15 | 2010-07-06 | 에프. 호프만-라 로슈 아게 | 4-아미노-티에노[3,2-ｃ]피리딘-7-카르복실산 유도체 |
| EP1968979A2 (en) * | 2005-12-08 | 2008-09-17 | Abbott Laboratories | 9-membered heterobicyclic compounds as inhibitors of protein kinases |
| WO2007075554A2 (en) | 2005-12-19 | 2007-07-05 | Osi Pharmaceuticals, Inc. | Combination of igfr inhibitor and anti-cancer agent |
-
2008
- 2008-04-14 MX MX2010001636A patent/MX2010001636A/es not_active Application Discontinuation
- 2008-07-18 US US12/175,562 patent/US7968554B2/en not_active Expired - Fee Related
- 2008-08-04 JP JP2010520530A patent/JP5296790B2/ja not_active Expired - Fee Related
- 2008-08-04 EP EP08786828A patent/EP2188290B1/en not_active Not-in-force
- 2008-08-04 AT AT08786828T patent/ATE512152T1/de not_active IP Right Cessation
- 2008-08-04 BR BRPI0815334A patent/BRPI0815334A2/pt not_active IP Right Cessation
- 2008-08-04 ES ES08786828T patent/ES2366268T3/es active Active
- 2008-08-04 CN CN200880102683.4A patent/CN101965349B/zh not_active Expired - Fee Related
- 2008-08-04 CA CA2694666A patent/CA2694666C/en not_active Expired - Fee Related
- 2008-08-04 WO PCT/EP2008/060215 patent/WO2009021869A1/en active Application Filing
- 2008-08-04 KR KR1020107002618A patent/KR20100038431A/ko not_active Application Discontinuation
- 2008-08-04 AU AU2008288538A patent/AU2008288538A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010535835A (ja) | 2010-11-25 |
| CN101965349B (zh) | 2016-05-04 |
| WO2009021869A1 (en) | 2009-02-19 |
| AU2008288538A1 (en) | 2009-02-19 |
| KR20100038431A (ko) | 2010-04-14 |
| BRPI0815334A2 (pt) | 2019-09-24 |
| EP2188290B1 (en) | 2011-06-08 |
| CA2694666A1 (en) | 2009-02-19 |
| EP2188290A1 (en) | 2010-05-26 |
| US7968554B2 (en) | 2011-06-28 |
| CN101965349A (zh) | 2011-02-02 |
| ES2366268T3 (es) | 2011-10-18 |
| ATE512152T1 (de) | 2011-06-15 |
| CA2694666C (en) | 2015-07-14 |
| JP5296790B2 (ja) | 2013-09-25 |
| US20090048274A1 (en) | 2009-02-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |