DE9422335U1 - Formulierung mit kontrollierter Freisetzung - Google Patents
Formulierung mit kontrollierter FreisetzungInfo
- Publication number
- DE9422335U1 DE9422335U1 DE9422335U DE9422335U DE9422335U1 DE 9422335 U1 DE9422335 U1 DE 9422335U1 DE 9422335 U DE9422335 U DE 9422335U DE 9422335 U DE9422335 U DE 9422335U DE 9422335 U1 DE9422335 U1 DE 9422335U1
- Authority
- DE
- Germany
- Prior art keywords
- preparation
- controlled release
- tramadol
- preparation according
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Description
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Claims (20)
1. Orales Präparat mit kontrollierter Freisetzung, enthaltend Tramadol oder ein phar
mazeutisch annehmbares Salz davon, welches zur Behandlung von gemäßigtem bis starkem
Schmerz über 12 Stunden oder mehr wirksam ist, worin:
- A) das orale Präparat mit kontrollierter Freisetzung das Tramadol oder ein Salz davon um faßt, das in einer Matrix mit kontrollierter Freisetzung inkorporiert ist, welche eines oder mehrere Materialien ausgewählt aus (a) verdaulichen C8-C50-substituierten oder unsubstituierten Kohlenwasserstoffen wie etwa Fettsäuren, Fettalkohole, Glycerylester aus Fettsäuren, Mineral- oder Pflanzenöle oder -wachse und (b) Polyalkylenglykole ent hält; oder
- B) das orale Präparat mit kontrollierter Freisetzung das Tramadol oder ein Salz davon in einer Matrix mit kontrollierter Freisetzung und in Form eines Teilchengemenges um faßt, wobei die Matrix einen hydrophoben schmelzbaren Trägerstoff oder ein Verdün nungsmittel, welches einen Schmelzpunkt von 35°C bis 140°C aufweist, oder eine Ta blette, welche durch Verpressen des Teilchengemenges erhalten wird, einschließt; oder
- C) das orale Präparat mit kontrollierter Freisetzung das Tramadol oder ein Salz davon um faßt, welches in einer Matrix mit normaler Freisetzung inkorporiert ist, die ein, das Tramadol oder ein pharmazeutisch annehmbares Salz davon und ein kugelbildendes Mittel umfassendes Sphäroid ist, wobei das Sphäroid einen Überzug mit kontrollierter Freisetzung aufweist, ausgewählt aus wasserunlöslichen Wachsen, wasserunlöslichen Polymethacrylaten und wasserunlöslichen Cellulosen.
2. Präparat nach Anspruch 1, wobei das Hydrochlorid von Tramadol als das pharma
zeutisch annehmbare Salz eingesetzt wird.
3. Präparat nach Anspruch 1 oder 2, wobei die Menge an Tramadol oder einem phar
mazeutisch annehmbaren Salz im Bereich von 50 mg bis 400 mg (berechnet als Tramadolhy
drochlorid) liegt.
4. Präparat nach Anspruch 1, 2 oder 3, wobei in (A) das Präparat bis zu 60 Gew.-% der
Komponente (a) enthält.
5. Präparat nach Anspruch 4, wobei die Komponente (a) einen Fettalkohol enthält, der
in einer Menge von 5 bis 30 Gew.-%, bezogen auf das Präparat, vorliegt.
6. Präparat nach Anspruch 5, wobei der Fettalkohol aus Laurylalkohol, Myristylalko
hol, Stearylalkohol, Cetylalkohol und Cetostearylalkohol ausgewählt ist.
7. Präparat nach Anspruch 6, wobei der Fettalkohol Cetylalkohol ist.
8. Präparat nach einem der vorangehenden Ansprüche, wobei in (A) die Matrix eine
oder mehrere Alkylcellulosen und einen oder mehrere C12-C36 aliphatische Alkohole enthält.
9. Präparat nach Anspruch 1, wobei in (B) der hydrophobe schmelzbare Trägerstoff
oder das Verdünnungsmittel ein natürliches oder synthetisches Wachs oder Öl ist.
10. Präparat nach Anspruch 9, wobei der hydrophobe schmelzbare Trägerstoff oder das
Verdünnungsmittel ein hydriertes Pflanzenöl, ein hydriertes Rhizinusöl, mikrokristallines
Wachs, Bienenwachs, Carnaubawachs oder Glycerylmonostearat ist.
11. Präparat nach einem der Ansprüche 9 oder 10, wobei die Matrix weiterhin eine
Komponente zur Freisetzungskontrolle enthält, welche ein wasserlösliches schmelzbares Ma
terial oder ein partikuläres lösliches oder unlösliches organisches oder inorganisches Material
umfaßt.
12. Präparat nach Anspruch 1, 2 oder 3, wobei in (C) die Sphäroide andere pharmazeu
tisch annehmbare Inhaltsstoffe, wie etwa ein Bindemittel, einen Füllstoff und/oder ein Färbe
mittel enthalten.
13. Präparat nach Anspruch 12, wobei das Bindemittel ein wasserlösliches Polymer,
eine wasserlösliche Hydroxyalkylcellulose oder ein wasserunlösliches Polymer ist.
14. Präparat nach Anspruch 13, wobei das Bindemittel, welches ein wasserunlösliches
Polymer ist, ebenfalls kontrollierte Freisetzungseigenschaften bewirkt.
15. Präparat nach Anspruch 13, wobei die wasserlösliche Hydroxyalkylcellulose Hy
droxypropylcellulose ist.
16. Präparat nach einem der Ansprüche 12 bis 15, wobei der Füllstoff Lactose ist.
17. Orales Präparat mit kontrollierter Freisetzung nach einem der vorhergehenden An
sprüche, wobei die unter Verwendung der Ph. Eur. Paddle-Methode bei 100 U/min in 900 ml
0,1 N-Salzsäure bei 37°C und mit UV-Nachweis bei 270 nm gemessene in vitro-
Freisetzungsrate von Tramadol ist:
18. Orales Präparat mit kontrollierter Freisetzung nach einem der vorangehenden An
sprüche, wobei die unter Verwendung der Ph. Eur. Paddle-Methode bei 100 U/min in 900 ml
0,1 N-Salzsäure bei 37°C und mit UV-Nachweis bei 270 nm gemessene in vitro-
Freisetzungsrate von Tramadol ist:
19. Orales Präparat mit kontrollierter Freisetzung nach einem der vorangehenden An
sprüche, wobei die unter Verwendung der Ph. Eur. Paddle-Methode bei 100 U/min in 900 ml
0,1 N-Salzsäure bei 37°C und mit UV-Nachweis bei 270 nm gemessene in vitro-
Freisetzungsrate von Tramadol ist:
20. Orales Präparat mit kontrollierter Freisetzung nach einem der vorangehenden An
sprüche, wobei die unter Verwendung der Ph. Eur. Paddle-Methode bei 100 U/min in 900 ml
0,1 N-Salzsäure bei 37°C und mit UV-Nachweis bei 270 nm gemessene in vitro-
Freisetzungsrate von Tramadol ist:
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE9422335U DE9422335U1 (de) | 1993-05-10 | 1994-04-29 | Formulierung mit kontrollierter Freisetzung |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4315525A DE4315525B4 (de) | 1993-05-10 | 1993-05-10 | Pharmazeutische Zusammensetzung |
GB9324045A GB2284760B (en) | 1993-11-23 | 1993-11-23 | A method of preparing pharmaceutical compositions by melt pelletisation |
GB9404544A GB9404544D0 (en) | 1994-03-09 | 1994-03-09 | Controlled release formulation |
GB9404928A GB2287880A (en) | 1994-03-14 | 1994-03-14 | Production of sustained release compositions |
DE9422335U DE9422335U1 (de) | 1993-05-10 | 1994-04-29 | Formulierung mit kontrollierter Freisetzung |
EP95114527A EP0699436B2 (de) | 1993-05-10 | 1994-04-29 | Arzneimittel mit kontrollierter Wirkstoffabgabe |
Publications (1)
Publication Number | Publication Date |
---|---|
DE9422335U1 true DE9422335U1 (de) | 2000-04-13 |
Family
ID=27435744
Family Applications (8)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69435295T Expired - Lifetime DE69435295D1 (de) | 1993-05-10 | 1994-04-29 | Tramadolhaltiges Arzneimittel mit gesteuerter Wirkstoffabgabe |
DE69427472T Expired - Lifetime DE69427472T3 (de) | 1993-05-10 | 1994-04-29 | Arzneimittel mit kontrollierter Wirkstoffabgabe |
DE0729751T Pending DE729751T1 (de) | 1993-05-10 | 1994-04-29 | Tramadolhaltiges Arzneimittel mit verzögerter Wirkstoffabgabe |
DE09004973T Active DE09004973T8 (de) | 1993-05-10 | 1994-04-29 | Formulierung mit gesteuerter Freisetzung |
DE0699436T Pending DE699436T1 (de) | 1993-05-10 | 1994-04-29 | Arzneimittel mit kontrollierter Wirkstoffabgabe |
DE69434479T Expired - Lifetime DE69434479T2 (de) | 1993-05-10 | 1994-04-29 | Tramadolhaltiges Arzneimittel mit gesteuerter Wirkstoffabgabe |
DE69400215T Revoked DE69400215T2 (de) | 1993-05-10 | 1994-04-29 | Tramadol enthaltendes Arzneimittel mit verzögerter Wirkstoffabgabe |
DE9422335U Expired - Lifetime DE9422335U1 (de) | 1993-05-10 | 1994-04-29 | Formulierung mit kontrollierter Freisetzung |
Family Applications Before (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69435295T Expired - Lifetime DE69435295D1 (de) | 1993-05-10 | 1994-04-29 | Tramadolhaltiges Arzneimittel mit gesteuerter Wirkstoffabgabe |
DE69427472T Expired - Lifetime DE69427472T3 (de) | 1993-05-10 | 1994-04-29 | Arzneimittel mit kontrollierter Wirkstoffabgabe |
DE0729751T Pending DE729751T1 (de) | 1993-05-10 | 1994-04-29 | Tramadolhaltiges Arzneimittel mit verzögerter Wirkstoffabgabe |
DE09004973T Active DE09004973T8 (de) | 1993-05-10 | 1994-04-29 | Formulierung mit gesteuerter Freisetzung |
DE0699436T Pending DE699436T1 (de) | 1993-05-10 | 1994-04-29 | Arzneimittel mit kontrollierter Wirkstoffabgabe |
DE69434479T Expired - Lifetime DE69434479T2 (de) | 1993-05-10 | 1994-04-29 | Tramadolhaltiges Arzneimittel mit gesteuerter Wirkstoffabgabe |
DE69400215T Revoked DE69400215T2 (de) | 1993-05-10 | 1994-04-29 | Tramadol enthaltendes Arzneimittel mit verzögerter Wirkstoffabgabe |
Country Status (22)
Country | Link |
---|---|
US (6) | US5591452A (de) |
EP (6) | EP0729751A1 (de) |
JP (3) | JP3045924B2 (de) |
CN (2) | CN1094755C (de) |
AT (5) | ATE201989T1 (de) |
AU (2) | AU6196394A (de) |
CA (1) | CA2123160C (de) |
CZ (1) | CZ288517B6 (de) |
DE (8) | DE69435295D1 (de) |
DK (4) | DK0699436T4 (de) |
ES (5) | ES2088312T3 (de) |
FI (3) | FI942092A (de) |
GR (2) | GR3020084T3 (de) |
HU (1) | HU228177B1 (de) |
ID (1) | ID25988A (de) |
IL (3) | IL119660A (de) |
NO (3) | NO306446B1 (de) |
NZ (1) | NZ260408A (de) |
PT (3) | PT699436E (de) |
SG (1) | SG67347A1 (de) |
SK (2) | SK283143B6 (de) |
TW (1) | TW496736B (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7611730B2 (en) | 2001-02-21 | 2009-11-03 | Grunenthal Gmbh | Tramadol-based medicament |
Families Citing this family (197)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5681585A (en) | 1991-12-24 | 1997-10-28 | Euro-Celtique, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
US5478577A (en) | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
IL119660A (en) | 1993-05-10 | 2002-09-12 | Euro Celtique Sa | Controlled release formulation comprising tramadol |
DE4329794C2 (de) * | 1993-09-03 | 1997-09-18 | Gruenenthal Gmbh | Tramadolsalz enthaltende Arzneimittel mit verzögerter Wirkstofffreisetzung |
US5891471A (en) | 1993-11-23 | 1999-04-06 | Euro-Celtique, S.A. | Pharmaceutical multiparticulates |
KR100354702B1 (ko) | 1993-11-23 | 2002-12-28 | 유로-셀티크 소시에떼 아노뉨 | 약학조성물의제조방법및서방형조성물 |
US5843480A (en) | 1994-03-14 | 1998-12-01 | Euro-Celtique, S.A. | Controlled release diamorphine formulation |
GB9422154D0 (en) * | 1994-11-03 | 1994-12-21 | Euro Celtique Sa | Pharmaceutical compositions and method of producing the same |
US5965161A (en) | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
US5698210A (en) | 1995-03-17 | 1997-12-16 | Lee County Mosquito Control District | Controlled delivery compositions and processes for treating organisms in a column of water or on land |
US6262115B1 (en) * | 1995-05-22 | 2001-07-17 | Alza Coporation | Method for the management of incontinence |
US5912268A (en) * | 1995-05-22 | 1999-06-15 | Alza Corporation | Dosage form and method for treating incontinence |
GB9519363D0 (en) * | 1995-09-22 | 1995-11-22 | Euro Celtique Sa | Pharmaceutical formulation |
IL131713A (en) * | 1997-03-11 | 2004-08-31 | Arakis Ltd | Dosage forms comprising separate portions of r- and s-enantiomers |
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1994
- 1994-04-27 IL IL11966094A patent/IL119660A/en not_active IP Right Cessation
- 1994-04-27 IL IL109460A patent/IL109460A/en not_active IP Right Cessation
- 1994-04-27 NZ NZ260408A patent/NZ260408A/en not_active IP Right Cessation
- 1994-04-29 DE DE69435295T patent/DE69435295D1/de not_active Expired - Lifetime
- 1994-04-29 AT AT95114527T patent/ATE201989T1/de active
- 1994-04-29 DK DK95114527.5T patent/DK0699436T4/da active
- 1994-04-29 EP EP96101147A patent/EP0729751A1/de not_active Ceased
- 1994-04-29 PT PT95114527T patent/PT699436E/pt unknown
- 1994-04-29 SG SG1996008705A patent/SG67347A1/en unknown
- 1994-04-29 DE DE69427472T patent/DE69427472T3/de not_active Expired - Lifetime
- 1994-04-29 PT PT04030658T patent/PT1527775E/pt unknown
- 1994-04-29 DK DK04030658.1T patent/DK1527775T3/da active
- 1994-04-29 ES ES94303128T patent/ES2088312T3/es not_active Expired - Lifetime
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- 1994-04-29 EP EP95114527A patent/EP0699436B2/de not_active Expired - Lifetime
- 1994-04-29 DK DK04014719T patent/DK1468679T3/da active
- 1994-04-29 EP EP04030658A patent/EP1527775B1/de not_active Expired - Lifetime
- 1994-04-29 EP EP94303128A patent/EP0624366B1/de not_active Revoked
- 1994-04-29 DE DE0729751T patent/DE729751T1/de active Pending
- 1994-04-29 AT AT04030658T patent/ATE468850T1/de active
- 1994-04-29 EP EP04014719A patent/EP1468679B1/de not_active Expired - Lifetime
- 1994-04-29 DK DK94303128.6T patent/DK0624366T3/da active
- 1994-04-29 DE DE09004973T patent/DE09004973T8/de active Active
- 1994-04-29 ES ES09004973T patent/ES2331046T1/es active Pending
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- 1994-04-29 DE DE0699436T patent/DE699436T1/de active Pending
- 1994-04-29 AT AT04014719T patent/ATE303140T1/de active
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- 1994-04-29 EP EP09004973.5A patent/EP2103303B1/de not_active Expired - Lifetime
- 1994-04-29 DE DE69400215T patent/DE69400215T2/de not_active Revoked
- 1994-04-29 DE DE9422335U patent/DE9422335U1/de not_active Expired - Lifetime
- 1994-04-29 PT PT04014719T patent/PT1468679E/pt unknown
- 1994-04-29 ES ES04030658T patent/ES2346651T3/es not_active Expired - Lifetime
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- 1994-05-06 FI FI942092A patent/FI942092A/fi not_active Application Discontinuation
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- 1994-05-09 AU AU61963/94A patent/AU6196394A/en not_active Abandoned
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- 1994-05-10 CN CN94105356A patent/CN1094755C/zh not_active Expired - Lifetime
- 1994-05-10 ID IDP991104D patent/ID25988A/id unknown
- 1994-05-10 SK SK1437-98A patent/SK283143B6/sk not_active IP Right Cessation
- 1994-05-10 SK SK541-94A patent/SK279971B6/sk not_active IP Right Cessation
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- 1994-05-12 TW TW085103273A patent/TW496736B/zh not_active IP Right Cessation
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1995
- 1995-05-24 US US08/449,772 patent/US6326027B1/en not_active Expired - Lifetime
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1996
- 1996-05-30 GR GR960401422T patent/GR3020084T3/el unknown
- 1996-07-10 US US08/677,798 patent/US6254887B1/en not_active Expired - Lifetime
- 1996-11-20 IL IL11966096A patent/IL119660A0/xx unknown
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1997
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1998
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1999
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2001
- 2001-03-06 US US09/800,204 patent/US7074430B2/en not_active Expired - Fee Related
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2003
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2006
- 2006-05-16 US US11/435,015 patent/US20060269603A1/en not_active Abandoned
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2008
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2010
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7611730B2 (en) | 2001-02-21 | 2009-11-03 | Grunenthal Gmbh | Tramadol-based medicament |
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