ATE239008T1 - Verfahren zur herstellung von (+/-) calanolide a und zwischenprodukte dafür - Google Patents

Verfahren zur herstellung von (+/-) calanolide a und zwischenprodukte dafür

Info

Publication number
ATE239008T1
ATE239008T1 AT95929365T AT95929365T ATE239008T1 AT E239008 T1 ATE239008 T1 AT E239008T1 AT 95929365 T AT95929365 T AT 95929365T AT 95929365 T AT95929365 T AT 95929365T AT E239008 T1 ATE239008 T1 AT E239008T1
Authority
AT
Austria
Prior art keywords
calanolide
producing
intermediate products
products therefor
therefor
Prior art date
Application number
AT95929365T
Other languages
English (en)
Inventor
Michael T Flavin
Ze-Qi Xu
John D Rizzo
Alla Kucherenko
Albert Khilevich
Abram Kivovich Sheinkman
Vilayphone Vilaychak
Lin Lin
Wei Chen
William A Boulanger
Original Assignee
Sarawak Medichem Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sarawak Medichem Pharmaceuticals Inc filed Critical Sarawak Medichem Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE239008T1 publication Critical patent/ATE239008T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Fats And Perfumes (AREA)
AT95929365T 1994-08-03 1995-08-02 Verfahren zur herstellung von (+/-) calanolide a und zwischenprodukte dafür ATE239008T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/285,655 US5489697A (en) 1994-08-03 1994-08-03 Method for the preparation of (+)-calanolide A and intermediates thereof
PCT/US1995/009804 WO1996004263A1 (en) 1994-08-03 1995-08-02 Method for the preparation of (±)-calanolide a and intermediates thereof

Publications (1)

Publication Number Publication Date
ATE239008T1 true ATE239008T1 (de) 2003-05-15

Family

ID=23095160

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95929365T ATE239008T1 (de) 1994-08-03 1995-08-02 Verfahren zur herstellung von (+/-) calanolide a und zwischenprodukte dafür

Country Status (9)

Country Link
US (1) US5489697A (de)
EP (3) EP1308448A1 (de)
JP (1) JP3043813B2 (de)
AT (1) ATE239008T1 (de)
AU (1) AU704247B2 (de)
CA (1) CA2196656C (de)
DE (1) DE69530592T2 (de)
MY (1) MY118279A (de)
WO (1) WO1996004263A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6774141B1 (en) * 1992-03-31 2004-08-10 The United States Of America As Represented By The Secretary Of Health And Human Services Calanolide and related antiviral compounds, compositions, and uses thereof
WO1994014789A1 (en) * 1992-12-23 1994-07-07 Smithkline Beecham Corporation Coumarin derivatives as retroviral inhibitors
US6277879B1 (en) 1994-08-03 2001-08-21 Sarawak Medichem Pharmaceuticals, Inc. Calanolide analogues and methods of their use
US6303652B1 (en) 1998-08-21 2001-10-16 Hughes Institute BTK inhibitors and methods for their identification and use
EP1071658B1 (de) * 1998-04-17 2004-06-16 Parker Hughes Institute Btk inhibitoren und verfahren zur identifizierung und verwendung
US6306897B1 (en) * 1999-03-19 2001-10-23 Parker Hughes Institute Calanolides for inhibiting BTK
AU4491800A (en) 1999-04-26 2000-11-10 Sarawak Medichem Pharmaceuticals, Inc. Methods for preparing antiviral calanolide compounds
JP2002193971A (ja) * 2000-12-22 2002-07-10 Kuraray Co Ltd カラノリドａおよびその中間体の製造方法
AU2002254206A1 (en) 2001-03-16 2002-10-03 Sarawak Medichem Pharmaceuticals, Inc. Pyranocoumarin compounds as a novel pharmacophore with anti-tb activity
WO2003070159A2 (en) * 2001-11-16 2003-08-28 Sarawak Medichem Pharmaceuticals Novel coumarin and chromene compounds and methods of treating or preventing viral infections
WO2003076444A1 (en) * 2002-03-08 2003-09-18 Kuraray Co., Ltd. Intermediates for production of (+)-calanolide a, processes for production of the intermediates and process for producing (+)-calanolide a with the same
US6777562B1 (en) * 2003-02-19 2004-08-17 Dow Global Technologies Inc. Preparation of a trans-calanolide ketone intermediate and chiral separation of calanolide alcohols to give racemic calanolide A
AU2004224191A1 (en) 2003-03-24 2004-10-07 F. Hoffmann-La Roche Ag Non-nucleoside reverse transcriptase inhibitors
JP2005314260A (ja) * 2004-04-28 2005-11-10 Japan Science & Technology Agency フラボンｃ配糖体の製法
EP1773802A1 (de) * 2004-07-23 2007-04-18 Pharmacia & Upjohn Company LLC Enantioselektives verfahren zur trennung substituierter 2-trifluormethyl-2h-chromen-3-carbonsäurederivate
KR20080056220A (ko) 2005-10-19 2008-06-20 에프. 호프만-라 로슈 아게 페닐-아세트아마이드 ｎｎｒｔ 저해제
PT2057125E (pt) 2006-08-16 2011-05-31 Hoffmann La Roche Inibidores n?o nucle?sidos de transcriptase inversa
ES2550152T3 (es) 2006-12-13 2015-11-04 F. Hoffmann-La Roche Ag Derivados de 2-(piperidin-4-il)-4-fenoxi-o fenilamino-pirimidina como inhibidores no nucleósidos de transcriptasa inversa
WO2008145562A1 (en) 2007-05-30 2008-12-04 F. Hoffmann-La Roche Ag Non-nucleoside reverse transcriptase inhibitors
MX2010004992A (es) * 2007-11-05 2010-12-21 Inst Of Mataria Medica Compuestos de dipirano-cumarina tetraciclicos con actividades anti-virus de la inmunodeficiencia humana y anti-mycobacterium tuberculosis.
WO2009080534A1 (en) 2007-12-21 2009-07-02 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
WO2011077100A1 (en) 2009-12-24 2011-06-30 Cipla Limited Antiretroviral composition
RU2458944C1 (ru) * 2011-03-15 2012-08-20 Государственное образовательное учреждение высшего профессионального образования Кемеровский технологический институт пищевой промышленности Способ получения коллодиевой пленки центробежным методом

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994014789A1 (en) * 1992-12-23 1994-07-07 Smithkline Beecham Corporation Coumarin derivatives as retroviral inhibitors

Also Published As

Publication number Publication date
US5489697A (en) 1996-02-06
EP0775130A1 (de) 1997-05-28
MY118279A (en) 2004-09-30
JP3043813B2 (ja) 2000-05-22
JPH09512829A (ja) 1997-12-22
CA2196656A1 (en) 1996-02-15
EP1308448A1 (de) 2003-05-07
WO1996004263A1 (en) 1996-02-15
AU704247B2 (en) 1999-04-15
DE69530592T2 (de) 2004-03-18
DE69530592D1 (de) 2003-06-05
EP0775130B1 (de) 2003-05-02
CA2196656C (en) 2010-03-23
AU3274695A (en) 1996-03-04
EP1054007A2 (de) 2000-11-22
MX9700782A (es) 1997-09-30
EP1054007A3 (de) 2000-11-29

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