DE3765919D1 - 3-aryloxy-3-substituierte-propanamine. - Google Patents

3-aryloxy-3-substituierte-propanamine.

Info

Publication number
DE3765919D1
DE3765919D1 DE8787311181T DE3765919T DE3765919D1 DE 3765919 D1 DE3765919 D1 DE 3765919D1 DE 8787311181 T DE8787311181 T DE 8787311181T DE 3765919 T DE3765919 T DE 3765919T DE 3765919 D1 DE3765919 D1 DE 3765919D1
Authority
DE
Germany
Prior art keywords
aryloxy
substituted propanamine
propanamine
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8787311181T
Other languages
English (en)
Other versions
DE122005000002I2 (de
Inventor
David Wayne Robertson
David Taiwai Wong
Krushinski, Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of DE3765919D1 publication Critical patent/DE3765919D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms
DE8787311181T 1986-12-22 1987-12-18 3-aryloxy-3-substituierte-propanamine. Expired - Lifetime DE3765919D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94512286A 1986-12-22 1986-12-22

Publications (1)

Publication Number Publication Date
DE3765919D1 true DE3765919D1 (de) 1990-12-06

Family

ID=25482649

Family Applications (3)

Application Number Title Priority Date Filing Date
DE8787311181T Expired - Lifetime DE3765919D1 (de) 1986-12-22 1987-12-18 3-aryloxy-3-substituierte-propanamine.
DE200512000002 Pending DE122005000002I1 (de) 1986-12-22 1987-12-18 Verwendung von Venlafaxin oder eines Aryloxy-Propanaminderivates zur Herstellung eines Medikaments zur Behandlung von Inkontinenz.
DE19873765919 Active DE122005000002I2 (de) 1986-12-22 1987-12-18 3-Aryloxy-3-substituierte-propanamine

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE200512000002 Pending DE122005000002I1 (de) 1986-12-22 1987-12-18 Verwendung von Venlafaxin oder eines Aryloxy-Propanaminderivates zur Herstellung eines Medikaments zur Behandlung von Inkontinenz.
DE19873765919 Active DE122005000002I2 (de) 1986-12-22 1987-12-18 3-Aryloxy-3-substituierte-propanamine

Country Status (27)

Country Link
EP (1) EP0273658B1 (de)
JP (1) JP2549681B2 (de)
KR (2) KR880007433A (de)
CN (1) CN1019113B (de)
AR (1) AR243868A1 (de)
AT (1) ATE57924T1 (de)
AU (1) AU591007B2 (de)
CA (1) CA1302421C (de)
CY (2) CY1682A (de)
DE (3) DE3765919D1 (de)
DK (1) DK174599B1 (de)
EG (1) EG18230A (de)
ES (1) ES2019949B3 (de)
GR (1) GR3001207T3 (de)
HK (1) HK69693A (de)
HU (1) HU206309B (de)
IE (1) IE873449L (de)
IL (1) IL84863A (de)
LU (1) LU91131I2 (de)
MX (1) MX9845A (de)
NL (1) NL300171I2 (de)
NZ (1) NZ222980A (de)
PH (1) PH26556A (de)
PT (1) PT86389B (de)
SG (1) SG114992G (de)
SU (1) SU1598865A3 (de)
ZA (1) ZA879472B (de)

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US5362886A (en) * 1993-10-12 1994-11-08 Eli Lilly And Company Asymmetric synthesis
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GB0004151D0 (en) 2000-02-23 2000-04-12 Astrazeneca Uk Ltd Novel use
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GB0004149D0 (en) 2000-02-23 2000-04-12 Astrazeneca Uk Ltd Novel compounds
GB0004153D0 (en) * 2000-02-23 2000-04-12 Astrazeneca Uk Ltd Novel use
SE0102640D0 (sv) 2001-07-31 2001-07-31 Astrazeneca Ab Novel compounds
US20030087965A1 (en) * 2001-07-31 2003-05-08 Robertson David W. Treatment of chronic pain with 3-aryloxy-3-phenylpropanamines
EP2266590A3 (de) 2002-02-22 2011-04-20 Shire LLC Wirkstoff-Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Wirkstoffen
WO2003078418A1 (fr) * 2002-03-19 2003-09-25 Mitsubishi Chemical Corporation Compose de 3-hydroxy-3-(2-thienyl)propionamide, procede de fabrication correspondant, et procede de fabrication d'un compose de 3-amino-1-(2-thienly)1-propanol a partir de ce dernier
US7659409B2 (en) 2002-03-19 2010-02-09 Mitsubishi Chemical Corporation 3-Hydroxy-3-(2-thienyl) propionamides and production method thereof, and production method of 3-amino-1-(2-thienyl)-1-propanols using the same
EP1506965A4 (de) * 2002-05-20 2010-11-03 Mitsubishi Rayon Co Propanolaminderivate, verfahren zur herstellung von 3-n-methylamino-1-(2-thienyl)-1-propanolen und verfahren zur herstellung von propanolaminderivaten
DE10235206A1 (de) * 2002-08-01 2004-02-19 Basf Ag Verfahren zur Herstellung von (S)-3-Methylmino-1-(thien-2-yl)propan-1-ol
GB0220581D0 (en) 2002-09-04 2002-10-09 Novartis Ag Organic Compound
GB0229583D0 (en) 2002-12-19 2003-01-22 Cipla Ltd A process for preparing duloxetine and intermediates for use therein
DE10302595A1 (de) 2003-01-22 2004-07-29 Basf Ag 3-Methylamino-1-(2-thienyl)-1-proganon, seine Herstellung und Verwendung
DE10345772A1 (de) 2003-10-01 2005-04-21 Basf Ag Verfahren zur Herstellung von 3-Methylamino-1-(thien-2-yl)-propan-1-ol
DE102004004719A1 (de) 2004-01-29 2005-08-18 Basf Ag Verfahren zur Herstellung von enantiomerenreinen Aminoalkoholen
DK1720852T3 (da) * 2004-02-19 2012-10-22 Lonza Ag Fremgangsmåde til fremstilling af enantiomerrene 1-substituerede 3-aminoalkoholer
DE102004022686A1 (de) 2004-05-05 2005-11-24 Basf Ag Verfahren zur Herstellung optisch aktiver Alkohole
GB0410470D0 (en) * 2004-05-11 2004-06-16 Cipla Ltd Pharmaceutical compound and polymorphs thereof
PE20060437A1 (es) 2004-06-18 2006-06-08 Novartis Ag COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR
GB0415746D0 (en) 2004-07-14 2004-08-18 Novartis Ag Organic compounds
WO2006021564A1 (en) * 2004-08-26 2006-03-02 Neurosearch A/S Novel substituted aryloxy alkylamines and their use as monoamine neurotransmitter re-uptake inhibitors
WO2006071868A2 (en) * 2004-12-23 2006-07-06 Teva Pharmaceutical Industries Ltd. Process for preparing pharmaceutically acceptable salts of duloxetine and intermediates thereof
US7534900B2 (en) 2005-03-14 2009-05-19 Teva Pharmaceutical Industries Ltd Process for the purification of duloxetine hydrochloride
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7956050B2 (en) 2005-07-15 2011-06-07 Albany Molecular Research, Inc. Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
DE102005044736A1 (de) 2005-09-19 2007-03-22 Basf Ag Neue Dehydrogenasen, deren Derivate und ein Verfahren zur Herstellung von optisch aktiven Alkanolen
EP1838692A2 (de) * 2005-09-22 2007-10-03 Teva Pharmaceutical Industries Ltd Dnt-maleat und herstellungsverfahren dafür
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JP5739415B2 (ja) 2009-05-12 2015-06-24 ブリストル−マイヤーズ スクウィブ カンパニー （Ｓ）−７−（［１，２，４］トリアゾロ［１，５−ａ］ピリジン−６−イル）−４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロイソキノリンの結晶形態およびその使用
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SI2558455T1 (sl) 2010-04-13 2017-12-29 Krka, D.D., Novo Mesto Sinteza duloksetina in/ali njegovih farmacevtsko sprejemljivih soli
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PL224543B1 (pl) 2013-08-21 2017-01-31 Pabianickie Zakłady Farm Polfa Spółka Akcyjna Dojelitowa tabletka duloksetyny
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JP2016222628A (ja) * 2015-06-03 2016-12-28 株式会社トクヤマ デュロキセチン塩酸塩の製造方法
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CN106349211B (zh) * 2016-08-26 2020-10-16 江苏恩华药业股份有限公司 2-甲基-3-芳氧基-3-杂芳基丙胺类化合物及应用
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CN114206859A (zh) * 2019-05-16 2022-03-18 上海璃道医药科技有限公司 3-芳氧基-3-五元杂芳基-丙胺类化合物及其晶型和用途

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Also Published As

Publication number Publication date
PT86389B (pt) 1990-11-20
DK174599B1 (da) 2003-07-14
JPS63185946A (ja) 1988-08-01
SG114992G (en) 1993-01-29
HU206309B (en) 1992-10-28
HK69693A (en) 1993-07-30
SU1598865A3 (ru) 1990-10-07
CN87108175A (zh) 1988-07-06
NZ222980A (en) 1989-11-28
GR3001207T3 (en) 1992-07-30
CY2005001I2 (el) 2009-11-04
PT86389A (en) 1988-01-01
ES2019949B3 (es) 1991-07-16
KR960003808B1 (ko) 1996-03-22
DE122005000002I2 (de) 2006-08-24
AU591007B2 (en) 1989-11-23
ATE57924T1 (de) 1990-11-15
MX9845A (es) 1993-12-01
AU8266087A (en) 1988-06-23
NL300171I2 (nl) 2005-06-01
DK664887D0 (da) 1987-12-17
ZA879472B (en) 1989-08-30
DE122005000002I1 (de) 2005-05-12
CN1019113B (zh) 1992-11-18
CY1682A (en) 1993-10-10
EG18230A (en) 1992-10-30
CY2005001I1 (el) 2009-11-04
PH26556A (en) 1992-08-19
HUT47561A (en) 1989-03-28
EP0273658A1 (de) 1988-07-06
IL84863A0 (en) 1988-06-30
LU91131I2 (fr) 2005-03-29
KR880007433A (ko) 1988-08-27
DK664887A (da) 1988-06-23
JP2549681B2 (ja) 1996-10-30
IL84863A (en) 1992-03-29
EP0273658B1 (de) 1990-10-31
NL300171I1 (nl) 2005-04-01
AR243868A1 (es) 1993-09-30
IE873449L (en) 1988-06-22
CA1302421C (en) 1992-06-02

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