BRPI0814797A2 - Inibidores dna-pk - Google Patents
Inibidores dna-pkInfo
- Publication number
- BRPI0814797A2 BRPI0814797A2 BRPI0814797-3A2A BRPI0814797A BRPI0814797A2 BR PI0814797 A2 BRPI0814797 A2 BR PI0814797A2 BR PI0814797 A BRPI0814797 A BR PI0814797A BR PI0814797 A2 BRPI0814797 A2 BR PI0814797A2
- Authority
- BR
- Brazil
- Prior art keywords
- inhibitors
- dna
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95063107P | 2007-07-19 | 2007-07-19 | |
US3656008P | 2008-03-14 | 2008-03-14 | |
PCT/GB2008/002459 WO2009010761A1 (en) | 2007-07-19 | 2008-07-18 | Dna pk inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0814797A2 true BRPI0814797A2 (pt) | 2015-02-03 |
Family
ID=39791057
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0814797-3A2A BRPI0814797A2 (pt) | 2007-07-19 | 2008-07-18 | Inibidores dna-pk |
Country Status (14)
Country | Link |
---|---|
US (1) | US20090042865A1 (pt) |
EP (1) | EP2176254A1 (pt) |
JP (1) | JP2010533694A (pt) |
KR (1) | KR20100063701A (pt) |
CN (1) | CN101754964A (pt) |
AR (1) | AR067613A1 (pt) |
AU (1) | AU2008277418A1 (pt) |
BR (1) | BRPI0814797A2 (pt) |
CA (1) | CA2693926A1 (pt) |
CL (1) | CL2008002130A1 (pt) |
RU (1) | RU2009149210A (pt) |
TW (1) | TW200918528A (pt) |
UY (1) | UY31232A1 (pt) |
WO (1) | WO2009010761A1 (pt) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0119865D0 (en) * | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
WO2005016919A1 (en) * | 2003-08-13 | 2005-02-24 | Kudos Pharmaceuticals Limited | Aminopyrones and their use as atm inhibitors |
CA2580229A1 (en) * | 2004-09-20 | 2006-03-30 | Kudos Pharmaceuticals Limited | Dna-pk inhibitors |
TW200638938A (en) * | 2005-02-09 | 2006-11-16 | Kudos Pharm Ltd | ATM inhibitors |
AR053358A1 (es) * | 2005-04-15 | 2007-05-02 | Cancer Rec Tech Ltd | Inhibidores de adn - pk |
US7638541B2 (en) | 2006-12-28 | 2009-12-29 | Metabolex Inc. | 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
BRPI0814294A2 (pt) | 2007-07-19 | 2015-02-03 | Metabolex Inc | Agonistas de receptor heterocíclico ligado a n para o tratamento do diabetes e de desordens metabólicas. |
ES2497566T3 (es) | 2009-10-01 | 2014-09-23 | Cymabay Therapeutics, Inc. | Sales de tetrazol-1-il-fenoximetil-tiazol-2-il-piperidinil-pirimidina sustituida |
US20130109687A1 (en) * | 2010-04-30 | 2013-05-02 | Gary J. Nabel | Methods of treating hiv infection: inhibition of dna dependent protein kinase |
WO2011163090A1 (en) | 2010-06-23 | 2011-12-29 | Metabolex, Inc. | Compositions of 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
SG10201704095UA (en) | 2012-04-24 | 2017-06-29 | Vertex Pharma | Dna-pk inhibitors |
CN107200749B (zh) | 2013-03-12 | 2019-09-03 | 沃泰克斯药物股份有限公司 | Dna-pk抑制剂 |
CN104892589A (zh) | 2014-03-07 | 2015-09-09 | 中国科学院上海药物研究所 | 一类杂环化合物、其制备方法和用途 |
JP2019527693A (ja) | 2016-08-03 | 2019-10-03 | サイマベイ・セラピューティクス・インコーポレイテッドCymaBay Therapeutics,Inc. | 炎症性胃腸疾患または胃腸状態を治療するためのオキシメチレンアリール化合物 |
TW201815418A (zh) | 2016-09-27 | 2018-05-01 | Vertex Pharma | 使用dna破壞劑及dna-pk抑制劑之組合治療癌症的方法 |
CN111053903A (zh) * | 2019-12-26 | 2020-04-24 | 深圳市纳诺艾医疗科技有限公司 | 一种携带共振原子的核酸类似物的化合物的应用 |
US20240083917A1 (en) * | 2021-01-05 | 2024-03-14 | Shandong Xuanzhu Pharma Co., Ltd. | Polycyclic Kinase Inhibitor |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0753725B2 (ja) * | 1987-10-08 | 1995-06-07 | 富山化学工業株式会社 | 4h―1―ベンゾピラン―4―オン誘導体およびその塩、それらの製造法並びにそれらを含有する抗炎症剤 |
US5284856A (en) * | 1988-10-28 | 1994-02-08 | Hoechst Aktiengesellschaft | Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives |
US5703075A (en) * | 1988-12-21 | 1997-12-30 | Pharmacia & Upjohn Company | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones |
US5252735A (en) * | 1990-06-29 | 1993-10-12 | The Upjohn Company | Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones |
US5302613A (en) * | 1990-06-29 | 1994-04-12 | The Upjohn Company | Antiatheroscleroic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones |
WO1994023714A1 (en) * | 1993-04-09 | 1994-10-27 | Toyama Chemical Co., Ltd. | Immunomodulator, cell adhesion inhibitor, and agent for treating and preventing autoimmune diseases |
US5733920A (en) * | 1995-10-31 | 1998-03-31 | Mitotix, Inc. | Inhibitors of cyclin dependent kinases |
JP4103968B2 (ja) * | 1996-09-18 | 2008-06-18 | 株式会社半導体エネルギー研究所 | 絶縁ゲイト型半導体装置 |
US6348311B1 (en) * | 1999-02-10 | 2002-02-19 | St. Jude Childre's Research Hospital | ATM kinase modulation for screening and therapies |
US6387640B1 (en) * | 1999-02-10 | 2002-05-14 | St. Jude Children's Research Hospital | ATM kinase modulation for screening and therapies |
US6333180B1 (en) * | 1999-12-21 | 2001-12-25 | International Flavors & Fragrances Inc. | Bioprocess for the high-yield production of food flavor-acceptable jasmonic acid and methyl jasmonate |
WO2002000216A1 (en) * | 2000-06-28 | 2002-01-03 | Teva Pharmaceutical Industries Ltd. | Carvedilol |
GB0119865D0 (en) * | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
GB0119863D0 (en) * | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
US7049313B2 (en) * | 2002-02-25 | 2006-05-23 | Kudos Pharmaceuticals Ltd. | ATM inhibitors |
ES2357057T3 (es) * | 2002-04-30 | 2011-04-15 | Kudos Pharmaceuticals Limited | Derivados de ftalazinona. |
WO2005016919A1 (en) * | 2003-08-13 | 2005-02-24 | Kudos Pharmaceuticals Limited | Aminopyrones and their use as atm inhibitors |
CA2580229A1 (en) * | 2004-09-20 | 2006-03-30 | Kudos Pharmaceuticals Limited | Dna-pk inhibitors |
TW200638938A (en) * | 2005-02-09 | 2006-11-16 | Kudos Pharm Ltd | ATM inhibitors |
AR053358A1 (es) * | 2005-04-15 | 2007-05-02 | Cancer Rec Tech Ltd | Inhibidores de adn - pk |
JP5781720B2 (ja) * | 2008-12-15 | 2015-09-24 | ルネサスエレクトロニクス株式会社 | 半導体装置及び半導体装置の製造方法 |
-
2008
- 2008-07-17 UY UY31232A patent/UY31232A1/es not_active Application Discontinuation
- 2008-07-18 CA CA2693926A patent/CA2693926A1/en not_active Abandoned
- 2008-07-18 AR ARP080103124A patent/AR067613A1/es unknown
- 2008-07-18 TW TW097127524A patent/TW200918528A/zh unknown
- 2008-07-18 AU AU2008277418A patent/AU2008277418A1/en not_active Abandoned
- 2008-07-18 WO PCT/GB2008/002459 patent/WO2009010761A1/en active Application Filing
- 2008-07-18 BR BRPI0814797-3A2A patent/BRPI0814797A2/pt not_active Application Discontinuation
- 2008-07-18 CN CN200880024849A patent/CN101754964A/zh active Pending
- 2008-07-18 JP JP2010516580A patent/JP2010533694A/ja not_active Withdrawn
- 2008-07-18 EP EP08775986A patent/EP2176254A1/en not_active Withdrawn
- 2008-07-18 US US12/175,542 patent/US20090042865A1/en not_active Abandoned
- 2008-07-18 RU RU2009149210/04A patent/RU2009149210A/ru not_active Application Discontinuation
- 2008-07-18 KR KR1020107003763A patent/KR20100063701A/ko not_active Application Discontinuation
- 2008-07-18 CL CL2008002130A patent/CL2008002130A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CN101754964A (zh) | 2010-06-23 |
WO2009010761A1 (en) | 2009-01-22 |
CA2693926A1 (en) | 2009-01-22 |
CL2008002130A1 (es) | 2009-01-02 |
RU2009149210A (ru) | 2011-08-27 |
AU2008277418A1 (en) | 2009-01-22 |
JP2010533694A (ja) | 2010-10-28 |
US20090042865A1 (en) | 2009-02-12 |
UY31232A1 (es) | 2009-03-02 |
TW200918528A (en) | 2009-05-01 |
EP2176254A1 (en) | 2010-04-21 |
KR20100063701A (ko) | 2010-06-11 |
AR067613A1 (es) | 2009-10-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |