CY1115925T1 - Παραγωγα πυριδαζινονης - Google Patents

Παραγωγα πυριδαζινονης

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Publication number
CY1115925T1
CY1115925T1 CY20151100033T CY151100033T CY1115925T1 CY 1115925 T1 CY1115925 T1 CY 1115925T1 CY 20151100033 T CY20151100033 T CY 20151100033T CY 151100033 T CY151100033 T CY 151100033T CY 1115925 T1 CY1115925 T1 CY 1115925T1
Authority
CY
Cyprus
Prior art keywords
pyridazinonine
producers
tumors
kinase
inhibitors
Prior art date
Application number
CY20151100033T
Other languages
English (en)
Inventor
Dieter Dorsch
Frank Stieber
Oliver Schadt
Andree Blaukat
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of CY1115925T1 publication Critical patent/CY1115925T1/el

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

Οι ενώσεις του τύπου (I), όπου τα R1, R2, R3, R4, R4' έχουν έκαστο τη σημασία που του αποδίδεται στην αξίωση 1, είναι αναστολείς των κινασών τυροσίνης, ιδίως της Met-κινάσης και δύνανται να χρησιμοποιηθούν, μεταξύ άλλων, για τη θεραπευτική αντιμετώπιση όγκων.
CY20151100033T 2007-07-12 2015-01-15 Παραγωγα πυριδαζινονης CY1115925T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007032507A DE102007032507A1 (de) 2007-07-12 2007-07-12 Pyridazinonderivate
EP08758359.7A EP2164843B1 (de) 2007-07-12 2008-04-29 Pyridazinonderivate

Publications (1)

Publication Number Publication Date
CY1115925T1 true CY1115925T1 (el) 2017-01-25

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Family Applications (3)

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CY20121100840T CY1113137T1 (el) 2007-07-12 2012-09-13 Παραγωγα πυριμιδινυλ-πυριδαζινονης
CY20151100033T CY1115925T1 (el) 2007-07-12 2015-01-15 Παραγωγα πυριδαζινονης
CY20171100120T CY1118498T1 (el) 2007-07-12 2017-01-26 Παραγωγα πυριδαζινονης

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CY20121100840T CY1113137T1 (el) 2007-07-12 2012-09-13 Παραγωγα πυριμιδινυλ-πυριδαζινονης

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CY20171100120T CY1118498T1 (el) 2007-07-12 2017-01-26 Παραγωγα πυριδαζινονης

Country Status (36)

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US (8) US8580781B2 (el)
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CY1113137T1 (el) 2016-04-13
PT2164844E (pt) 2012-08-31
CN101687857B (zh) 2013-07-17
SI2164844T1 (sl) 2012-10-30
ZA201001023B (en) 2010-11-24
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EP2164843A1 (de) 2010-03-24
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US9403799B2 (en) 2016-08-02
US20120295908A1 (en) 2012-11-22
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AU2008274534A1 (en) 2009-01-15
NL301176I2 (nl) 2022-11-03
BRPI0814616A2 (pt) 2015-01-27
CA2693600C (en) 2015-10-06
IL203091A (en) 2013-10-31
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US9062029B2 (en) 2015-06-23
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CN101687857A (zh) 2010-03-31
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BRPI0814616B1 (pt) 2022-04-19
CA2693600A1 (en) 2009-01-15
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US8927540B2 (en) 2015-01-06
BRPI0813707B1 (pt) 2022-02-22
US20130184260A1 (en) 2013-07-18
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FR22C1024I2 (fr) 2023-03-24
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ECSP109953A (es) 2010-03-31
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US20130184261A1 (en) 2013-07-18
AU2008274670B2 (en) 2013-03-14
PL2164844T3 (pl) 2012-10-31
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SI2164843T1 (sl) 2015-02-27
NO2022015I1 (no) 2022-05-13
CL2008001392A1 (es) 2009-01-23
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WO2009007074A1 (de) 2009-01-15
CY1118498T1 (el) 2017-07-12
LTPA2022009I1 (el) 2022-06-10
AU2008274534B2 (en) 2013-05-30
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