EA200901611A1 - Производные 2-оксо-3-бензил-бензоксазол-2-она и родственные соединения в качестве ингибиторов мет киназы для лечения опухолей - Google Patents

Производные 2-оксо-3-бензил-бензоксазол-2-она и родственные соединения в качестве ингибиторов мет киназы для лечения опухолей

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Publication number
EA200901611A1
EA200901611A1 EA200901611A EA200901611A EA200901611A1 EA 200901611 A1 EA200901611 A1 EA 200901611A1 EA 200901611 A EA200901611 A EA 200901611A EA 200901611 A EA200901611 A EA 200901611A EA 200901611 A1 EA200901611 A1 EA 200901611A1
Authority
EA
Eurasian Patent Office
Prior art keywords
treatment
kinase inhibitors
benzoxazol
oxo
meters
Prior art date
Application number
EA200901611A
Other languages
English (en)
Inventor
Оливер Шадт
Дитер Дорш
Франк Штибер
Андрее Блаукат
Original Assignee
Мерк Патент Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of EA200901611A1 publication Critical patent/EA200901611A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

Abstract

Соединения формулы (I)в которой R, R, R, R, R, R', Е, Е', Е" и Е'" имеют значения, указанные в п.1, являются ингибиторами тирозинкиназ, в особенности Met киназы, и могут применяться, в частности, для лечения опухолей.
EA200901611A 2007-06-06 2008-05-08 Производные 2-оксо-3-бензил-бензоксазол-2-она и родственные соединения в качестве ингибиторов мет киназы для лечения опухолей EA200901611A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007026341A DE102007026341A1 (de) 2007-06-06 2007-06-06 Benzoxazolonderivate
PCT/EP2008/003696 WO2008148449A1 (de) 2007-06-06 2008-05-08 2-oxo-3-benzyl-benzoxazol-2-one derivate und verwandte verbindungen als met-kinase inhibitoren zur behandlung von tumoren

Publications (1)

Publication Number Publication Date
EA200901611A1 true EA200901611A1 (ru) 2010-06-30

Family

ID=39739806

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200901611A EA200901611A1 (ru) 2007-06-06 2008-05-08 Производные 2-оксо-3-бензил-бензоксазол-2-она и родственные соединения в качестве ингибиторов мет киназы для лечения опухолей

Country Status (18)

Country Link
US (2) US8071593B2 (ru)
EP (1) EP2150551B1 (ru)
JP (1) JP5662143B2 (ru)
KR (1) KR20100031531A (ru)
CN (1) CN101679401B (ru)
AR (1) AR066892A1 (ru)
AU (1) AU2008258366B2 (ru)
BR (1) BRPI0812293A2 (ru)
CA (1) CA2689554C (ru)
DE (1) DE102007026341A1 (ru)
EA (1) EA200901611A1 (ru)
ES (1) ES2402540T3 (ru)
IL (1) IL202505A (ru)
MX (1) MX2009013077A (ru)
PE (1) PE20090770A1 (ru)
TW (1) TW200848030A (ru)
WO (1) WO2008148449A1 (ru)
ZA (1) ZA201000085B (ru)

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Publication number Publication date
PE20090770A1 (es) 2009-06-24
KR20100031531A (ko) 2010-03-22
US8071593B2 (en) 2011-12-06
CA2689554A1 (en) 2008-12-11
AU2008258366A1 (en) 2008-12-11
US20110263596A1 (en) 2011-10-27
MX2009013077A (es) 2010-01-15
BRPI0812293A2 (pt) 2014-11-25
EP2150551B1 (de) 2013-01-16
AR066892A1 (es) 2009-09-16
EP2150551A1 (de) 2010-02-10
JP2010529051A (ja) 2010-08-26
US8431572B2 (en) 2013-04-30
ES2402540T3 (es) 2013-05-06
JP5662143B2 (ja) 2015-01-28
DE102007026341A1 (de) 2008-12-11
US20100280030A1 (en) 2010-11-04
CN101679401A (zh) 2010-03-24
CN101679401B (zh) 2012-12-12
AU2008258366B2 (en) 2013-02-21
WO2008148449A1 (de) 2008-12-11
CA2689554C (en) 2015-12-01
IL202505A0 (en) 2010-06-30
IL202505A (en) 2014-11-30
TW200848030A (en) 2008-12-16
ZA201000085B (en) 2010-09-29

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