CR20120158A - Compuestos de diòxido de iminotiadiazina como inhibidores de bace, composiciones y su uso. - Google Patents
Compuestos de diòxido de iminotiadiazina como inhibidores de bace, composiciones y su uso.Info
- Publication number
- CR20120158A CR20120158A CR20120158A CR20120158A CR20120158A CR 20120158 A CR20120158 A CR 20120158A CR 20120158 A CR20120158 A CR 20120158A CR 20120158 A CR20120158 A CR 20120158A CR 20120158 A CR20120158 A CR 20120158A
- Authority
- CR
- Costa Rica
- Prior art keywords
- compounds
- iminotiadiazine
- diòxide
- compositions
- bace inhibitors
- Prior art date
Links
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
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- C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
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- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/26—Radicals substituted by halogen atoms or nitro radicals
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- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
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- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
- C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms
Abstract
En sus muchas realizaciones, la presente invención proporciona ciertos compuestos de dióxido de iminotiadiazina, incluyendo los compuestos de la fórmula (I).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24968509P | 2009-10-08 | 2009-10-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20120158A true CR20120158A (es) | 2012-08-27 |
Family
ID=43857101
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20120158A CR20120158A (es) | 2009-10-08 | 2012-03-29 | Compuestos de diòxido de iminotiadiazina como inhibidores de bace, composiciones y su uso. |
Country Status (39)
Country | Link |
---|---|
US (6) | US8729071B2 (es) |
EP (2) | EP3034080B1 (es) |
JP (4) | JP5592494B2 (es) |
KR (3) | KR101646424B1 (es) |
CN (2) | CN104744403A (es) |
AR (1) | AR078534A1 (es) |
AU (1) | AU2010303591B2 (es) |
BR (1) | BR112012008014B1 (es) |
CA (1) | CA2774579C (es) |
CL (1) | CL2012000872A1 (es) |
CR (1) | CR20120158A (es) |
DK (1) | DK2485736T3 (es) |
DO (1) | DOP2012000067A (es) |
EA (1) | EA025120B1 (es) |
EC (1) | ECSP12011857A (es) |
ES (2) | ES2773908T3 (es) |
GE (1) | GEP20156366B (es) |
HK (2) | HK1167608A1 (es) |
HN (1) | HN2012000612A (es) |
HR (1) | HRP20160185T1 (es) |
HU (1) | HUE028672T2 (es) |
IL (3) | IL218712A (es) |
MA (1) | MA33726B1 (es) |
ME (1) | ME02366B (es) |
MX (1) | MX2012004148A (es) |
MY (1) | MY163744A (es) |
NI (1) | NI201200044A (es) |
NZ (1) | NZ598694A (es) |
PE (1) | PE20141935A1 (es) |
PL (1) | PL2485736T3 (es) |
PT (1) | PT2485736E (es) |
RS (1) | RS54587B1 (es) |
SG (1) | SG10201406365WA (es) |
SI (1) | SI2485736T1 (es) |
TN (1) | TN2012000112A1 (es) |
TW (3) | TWI477502B (es) |
UA (1) | UA108363C2 (es) |
WO (1) | WO2011044181A1 (es) |
ZA (2) | ZA201202517B (es) |
Families Citing this family (126)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
ES2572263T3 (es) | 2005-10-25 | 2016-05-31 | Shionogi & Co | Derivados de dihidrooxazina y tetrahidropirimidina como inhibidores de BACE 1 |
JP5383483B2 (ja) | 2007-04-24 | 2014-01-08 | 塩野義製薬株式会社 | アルツハイマー症治療用医薬組成物 |
ES2476605T3 (es) | 2007-04-24 | 2014-07-15 | Shionogi & Co., Ltd. | Derivados de aminohidrotiazina sustituidos con grupos cíclicos |
CN102119161B (zh) | 2008-06-13 | 2015-07-08 | 盐野义制药株式会社 | 具有β分泌酶抑制作用的含硫杂环衍生物 |
EP2360155A4 (en) | 2008-10-22 | 2012-06-20 | Shionogi & Co | 2-AMINOPYRIDIN-4-ON AND 2-AMINOPYRIDINE DERIVATIVE WITH BACE1-HEMDERING EFFECT |
TW201020244A (en) | 2008-11-14 | 2010-06-01 | Astrazeneca Ab | New compounds |
US8569310B2 (en) * | 2009-10-08 | 2013-10-29 | Merck Sharp & Dohme Corp. | Pentafluorosulfur imino heterocyclic compounds as BACE-1 inhibitors, compositions and their use |
UA108363C2 (uk) * | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування | |
EP2485590B1 (en) | 2009-10-08 | 2015-01-07 | Merck Sharp & Dohme Corp. | Pentafluorosulfur imino heterocyclic compounds as bace-1 inhibitors, compositions, and their use |
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US8338413B1 (en) | 2012-03-07 | 2012-12-25 | Novartis Ag | Oxazine derivatives and their use in the treatment of neurological disorders |
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