EA201591960A1 - Ингибиторы акк и их применение - Google Patents

Ингибиторы акк и их применение

Info

Publication number
EA201591960A1
EA201591960A1 EA201591960A EA201591960A EA201591960A1 EA 201591960 A1 EA201591960 A1 EA 201591960A1 EA 201591960 A EA201591960 A EA 201591960A EA 201591960 A EA201591960 A EA 201591960A EA 201591960 A1 EA201591960 A1 EA 201591960A1
Authority
EA
Eurasian Patent Office
Prior art keywords
application
acc inhibitors
acc
inhibitors
compositions
Prior art date
Application number
EA201591960A
Other languages
English (en)
Other versions
EA030942B1 (ru
Inventor
Джереми Роберт Гринвуд
Джеральдин С. Харриман
Джордж Борг
Крейг Е. Массе
Original Assignee
Нимбус Аполло, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51867753&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201591960(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Нимбус Аполло, Инк. filed Critical Нимбус Аполло, Инк.
Publication of EA201591960A1 publication Critical patent/EA201591960A1/ru
Publication of EA030942B1 publication Critical patent/EA030942B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Abstract

Согласно настоящему изобретению предложены соединения, подходящие для применения в качестве ингибиторов ацетил-КоА-карбоксилазы (АКК), их композиции и способы применения таких соединений.
EA201591960A 2013-05-10 2014-05-08 Ингибиторы акк и их применение EA030942B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361821828P 2013-05-10 2013-05-10
PCT/US2014/037363 WO2014182945A1 (en) 2013-05-10 2014-05-08 Acc inhibitors and uses thereof

Publications (2)

Publication Number Publication Date
EA201591960A1 true EA201591960A1 (ru) 2016-06-30
EA030942B1 EA030942B1 (ru) 2018-10-31

Family

ID=51867753

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201591960A EA030942B1 (ru) 2013-05-10 2014-05-08 Ингибиторы акк и их применение

Country Status (14)

Country Link
US (1) US10208063B2 (ru)
EP (1) EP2994139B1 (ru)
JP (1) JP6434498B2 (ru)
KR (1) KR20160006762A (ru)
CN (1) CN105358154A (ru)
AR (1) AR096242A1 (ru)
AU (1) AU2014262638A1 (ru)
BR (1) BR112015028152A2 (ru)
CA (1) CA2911932A1 (ru)
CL (1) CL2015003315A1 (ru)
EA (1) EA030942B1 (ru)
HK (2) HK1221411A1 (ru)
MX (1) MX2015015422A (ru)
WO (1) WO2014182945A1 (ru)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014182943A1 (en) 2013-05-10 2014-11-13 Nimbus Apollo, Inc. Acc inhibitors and uses thereof
US10208044B2 (en) 2013-05-10 2019-02-19 Gilead Apollo, Llc ACC inhibitors and uses thereof
EP2994128B1 (en) 2013-05-10 2019-01-30 Gilead Apollo, LLC Acc inhibitors and uses thereof
US10150728B2 (en) 2013-10-17 2018-12-11 Shionogi & Co., Ltd. Alkylene derivatives
JP6668253B2 (ja) 2014-11-26 2020-03-18 武田薬品工業株式会社 二環性化合物
CN107106873A (zh) * 2015-01-09 2017-08-29 吉利德阿波罗公司 用于治疗非酒精性脂肪肝病的acc抑制剂组合治疗
AR106472A1 (es) 2015-10-26 2018-01-17 Gilead Apollo Llc Inhibidores de acc y usos de los mismos
ES2855348T3 (es) 2015-11-25 2021-09-23 Gilead Apollo Llc Inhibidores de éster ACC y usos de los mismos
EP3379933B1 (en) 2015-11-25 2023-02-15 Gilead Apollo, LLC Fungicidal compositions containing derivatives of 2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidine
SI3380480T1 (sl) 2015-11-25 2023-04-28 Gilead Apollo, Llc Pirazolni inhibitorji ACC in uporabe le-teh
CN108349994B (zh) 2015-11-25 2021-06-22 吉利德阿波罗公司 ***acc抑制剂及其用途
CN110431143B (zh) * 2017-03-24 2022-08-12 浙江海正药业股份有限公司 杂芳基并嘧啶酮类衍生物及其制备方法和用途
WO2018171699A1 (zh) * 2017-03-24 2018-09-27 浙江海正药业股份有限公司 氰基取代的杂芳基并嘧啶酮类衍生物及其制备方法和用途
CA3124702A1 (en) 2019-01-15 2020-07-23 Gilead Sciences, Inc. Fxr (nr1h4) modulating compounds
AR119594A1 (es) 2019-08-09 2021-12-29 Gilead Sciences Inc Derivados de tienopirimidina como inhibidores acc y usos de los mismos
EP4058144A1 (en) 2019-11-15 2022-09-21 Gilead Sciences, Inc. Triazole carbamate pyridyl sulfonamides as lpa receptor antagonists and uses thereof
CN114746426B (zh) * 2019-12-05 2023-12-01 漳州片仔癀药业股份有限公司 作为acc1和acc2抑制剂的晶型及其制备方法和应用
CN114787166B (zh) * 2019-12-05 2023-09-19 漳州片仔癀药业股份有限公司 噻吩并[2,3-c]哒嗪-4(1H)-酮类化合物的晶型及其制备方法和应用
US11478533B2 (en) 2020-04-27 2022-10-25 Novo Nordisk A/S Semaglutide for use in medicine
KR20230019880A (ko) 2020-06-03 2023-02-09 길리애드 사이언시즈, 인코포레이티드 Lpa 수용체 길항제 및 이의 용도
TW202344504A (zh) 2020-06-03 2023-11-16 美商基利科學股份有限公司 Lpa受體拮抗劑及其用途
JP2024517016A (ja) 2021-05-11 2024-04-18 ギリアード サイエンシーズ， インコーポレイテッド Ｌｐａ受容体アンタゴニスト及びそれらの使用
AU2022273702A1 (en) 2021-05-13 2023-11-02 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof
US11939318B2 (en) 2021-12-08 2024-03-26 Gilead Sciences, Inc. LPA receptor antagonists and uses thereof
CN116267361A (zh) * 2023-05-10 2023-06-23 沈阳农业大学 一种防治十字花科作物根肿病的方法

Family Cites Families (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3060084A (en) 1961-06-09 1962-10-23 Du Pont Improved homogeneous, readily dispersed, pesticidal concentrate
US3299566A (en) 1964-06-01 1967-01-24 Olin Mathieson Water soluble film containing agricultural chemicals
US3325503A (en) 1965-02-18 1967-06-13 Diamond Alkali Co Polychloro derivatives of mono- and dicyano pyridines and a method for their preparation
US3296272A (en) 1965-04-01 1967-01-03 Dow Chemical Co Sulfinyl- and sulfonylpyridines
FR1453897A (fr) 1965-06-16 1966-07-22 Dérivés du thiophène et de thiéno pyridazines
US4144050A (en) 1969-02-05 1979-03-13 Hoechst Aktiengesellschaft Micro granules for pesticides and process for their manufacture
US3920442A (en) 1972-09-18 1975-11-18 Du Pont Water-dispersible pesticide aggregates
US4172714A (en) 1976-12-20 1979-10-30 E. I. Du Pont De Nemours And Company Dry compactible, swellable herbicidal compositions and pellets produced therefrom
GB2095558B (en) 1981-03-30 1984-10-24 Avon Packers Ltd Formulation of agricultural chemicals
US5304732A (en) 1984-03-06 1994-04-19 Mgi Pharma, Inc. Herbicide resistance in plants
GB8524663D0 (en) 1985-10-07 1985-11-13 Fujisawa Pharmaceutical Co Quinazoline derivatives
FR2629098B1 (fr) 1988-03-23 1990-08-10 Rhone Poulenc Agrochimie Gene chimerique de resistance herbicide
US5180587A (en) 1988-06-28 1993-01-19 E. I. Du Pont De Nemours And Company Tablet formulations of pesticides
ATE241699T1 (de) 1989-03-24 2003-06-15 Syngenta Participations Ag Krankheitsresistente transgene pflanze
DK0777964T3 (da) 1989-08-30 2002-03-11 Kynoch Agrochemicals Proprieta Fremgangsmåde til fremstilling af et doseringssystem
JPH0747582B2 (ja) 1989-12-11 1995-05-24 杏林製薬株式会社 キナゾリン―３―アルカン酸誘導体とその塩およびその製造法
US5372989A (en) 1990-03-12 1994-12-13 E. I. Du Pont De Nemours And Company Water-dispersible or water-soluble pesticide grandules from heat-activated binders
AU655197B2 (en) 1990-06-25 1994-12-08 Monsanto Technology Llc Glyphosate tolerant plants
DE69122201T2 (de) 1990-10-11 1997-02-06 Sumitomo Chemical Co Pestizide Zusammensetzung
UA48104C2 (ru) 1991-10-04 2002-08-15 Новартіс Аг Фрагмент днк, содержащий последовательность, которая кодирует инсектицидный протеин, оптимизированную для кукурузы, фрагмент днк, обеспечивающий направленную желательную для сердцевины стебля экспрессию связанного с ней структурного гена в растении, фрагмент днк, обеспечивающий специфическую для пыльцы экспрессию связанного с ней структурного гена в растении, рекомбинантная молекула днк, способ получения оптимизированной для кукурузы кодирующей последовательности инсектицидного протеина, способ защиты растений кукурузы по меньшей мере от одного насекомого-вредителя
US6069298A (en) 1993-02-05 2000-05-30 Regents Of The University Of Minnesota Methods and an acetyl CoA carboxylase gene for conferring herbicide tolerance and an alteration in oil content of plants
US6303181B1 (en) 1993-05-17 2001-10-16 Electrochemicals Inc. Direct metallization process employing a cationic conditioner and a binder
US5530195A (en) 1994-06-10 1996-06-25 Ciba-Geigy Corporation Bacillus thuringiensis gene encoding a toxin active against insects
US5773704A (en) 1996-04-29 1998-06-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Herbicide resistant rice
WO1998002527A1 (en) 1996-07-17 1998-01-22 Michigan State University Imidazolinone herbicide resistant sugar beet plants
US5773702A (en) 1996-07-17 1998-06-30 Board Of Trustees Operating Michigan State University Imidazolinone herbicide resistant sugar beet plants
DE19650197A1 (de) 1996-12-04 1998-06-10 Bayer Ag 3-Thiocarbamoylpyrazol-Derivate
TW460476B (en) 1997-04-14 2001-10-21 American Cyanamid Co Fungicidal trifluoromethylalkylamino-triazolopyrimidines
CA2304270A1 (en) 1997-09-18 1999-03-25 Basf Aktiengesellschaft Benzamidoxim derivatives, intermediate products and methods for preparing and using them as fungicides
DE19750012A1 (de) 1997-11-12 1999-05-20 Bayer Ag Isothiazolcarbonsäureamide
EP1035772A4 (en) 1997-12-04 2001-03-28 Dow Agrosciences Llc FUNGICIDAL COMPOSITIONS AND METHODS, AND COMPOUNDS AND METHODS FOR THEIR PRODUCTION
GB9817623D0 (en) 1998-08-13 1998-10-07 Glaxo Group Ltd Pharmaceutical compounds
US6348643B1 (en) 1998-10-29 2002-02-19 American Cyanamid Company DNA sequences encoding the arabidopsis acetohydroxy-acid synthase small subunit and methods of use
DE69927516T2 (de) 1998-11-17 2006-03-16 Kumiai Chemical Industry Co., Ltd. Pyrimidinylbenzimidazol- und triazinylbenzimidazol-derivate und fungizide für landwirtschaft/gartenbau
JP3417862B2 (ja) 1999-02-02 2003-06-16 新東工業株式会社 酸化チタン光触媒高担持シリカゲルおよびその製造方法
US6586617B1 (en) 1999-04-28 2003-07-01 Sumitomo Chemical Takeda Agro Company, Limited Sulfonamide derivatives
DE10021412A1 (de) 1999-12-13 2001-06-21 Bayer Ag Fungizide Wirkstoffkombinationen
WO2001054501A2 (en) 2000-01-25 2001-08-02 Syngenta Participations Ag Herbicidal composition
US6376548B1 (en) 2000-01-28 2002-04-23 Rohm And Haas Company Enhanced propertied pesticides
CA2407396C (en) 2000-04-28 2013-12-31 Basf Aktiengesellschaft Use of the maize x112 mutant ahas 2 gene and imidazolinone herbicides for selection of transgenic monocots
WO2002015701A2 (en) 2000-08-25 2002-02-28 Syngenta Participations Ag Bacillus thuringiensis crystal protein hybrids
AU2002211233A1 (en) 2000-09-18 2002-03-26 E.I. Du Pont De Nemours And Company Pyridinyl amides and imides for use as fungicides
AU2002228640B2 (en) 2000-11-17 2005-11-10 Dow Agrosciences Llc Compounds having fungicidal activity and processes to make and use same
US6548738B2 (en) 2000-12-26 2003-04-15 Research Development Foundation ACC2-knockout mice and uses thereof
JP5034142B2 (ja) 2001-04-20 2012-09-26 住友化学株式会社 植物病害防除剤組成物
DE10136065A1 (de) 2001-07-25 2003-02-13 Bayer Cropscience Ag Pyrazolylcarboxanilide
FR2828196A1 (fr) 2001-08-03 2003-02-07 Aventis Cropscience Sa Derives de chromone a action fongicide, procede de preparation et application dans le domaine de l'agriculture
BR0211809A (pt) 2001-08-09 2004-09-08 Univ Saskatchewan Plantas de trigo tendo resistência aumentada a herbicidas de imidazolinona e método de produção da mesma
US7528297B2 (en) 2001-08-09 2009-05-05 Northwest Plant Breeding Company Wheat plants having increased resistance to imidazolinone herbicides
ATE527363T1 (de) 2001-08-09 2011-10-15 Univ Saskatchewan Weizenpflanzen mit erhöhter resistenz gegenüber imidazolinon-herbiziden
CA2457575C (en) 2001-08-17 2010-12-21 Sankyo Agro Company, Limited 3-phenoxy-4-pyridazinol derivatives and herbicidal composition containing the same
US7230167B2 (en) 2001-08-31 2007-06-12 Syngenta Participations Ag Modified Cry3A toxins and nucleic acid sequences coding therefor
US7304070B2 (en) 2001-11-09 2007-12-04 Cv Therapeutics, Inc. A2B adenosine receptor antagonists
US6977300B2 (en) 2001-11-09 2005-12-20 Cv Therapeutics, Inc. A2B adenosine receptor antagonists
WO2003052073A2 (en) 2001-12-17 2003-06-26 Syngenta Participations Ag Novel corn event
WO2003053145A1 (fr) 2001-12-21 2003-07-03 Nissan Chemical Industries, Ltd. Composition bactericide
TWI327462B (en) 2002-01-18 2010-07-21 Sumitomo Chemical Co Condensed heterocyclic sulfonyl urea compound, a herbicide containing the same, and a method for weed control using the same
DE10204390A1 (de) 2002-02-04 2003-08-14 Bayer Cropscience Ag Disubstituierte Thiazolylcarboxanilide
CA2477931C (en) 2002-03-05 2011-02-01 Josef Ehrenfreund O-cyclopropyl-carboxanilides and their use as fungicides
BR0311697A (pt) 2002-06-06 2005-03-22 Eisai Co Ltd Novos derivados condensados de imidazol
CA2492167C (en) 2002-07-10 2015-06-16 The Department Of Agriculture, Western Australia Wheat plants having increased resistance to imidazolinone herbicides
GB0227966D0 (en) 2002-11-29 2003-01-08 Syngenta Participations Ag Organic Compounds
DE602004020052D1 (de) 2003-01-06 2009-04-30 Israel State Pflanzliche acetyl-coa carboxylase-hemmende herbizide als pestizide
WO2004083193A1 (ja) 2003-03-17 2004-09-30 Sumitomo Chemical Company, Limited アミド化合物およびこれを含有する殺菌剤組成物
WO2004098520A2 (en) 2003-05-01 2004-11-18 Irm Llc Compounds and compositions as protein kinase inhibitors
AU2004243416B2 (en) 2003-05-28 2009-06-11 Basf Se Wheat plants having increased tolerance to imidazolinone herbicides
HUE035897T2 (en) 2003-06-23 2018-05-28 Pioneer Hi Bred Int Incorporating the green-capability of a single gene-controlled option into the plant
EP2982240B1 (en) 2003-08-29 2019-07-31 Instituto Nacional de Tecnologia Agropecuaria Rice plants having increased tolerance to imidazolinone herbicides
TWI355894B (en) 2003-12-19 2012-01-11 Du Pont Herbicidal pyrimidines
JP2007527886A (ja) 2004-03-10 2007-10-04 ビーエーエスエフ　アクチェンゲゼルシャフト ５，６−ジアルキル−７−アミノトリアゾロピリミジン、その調製、および有害真菌を防除するためのその使用、ならびにそれらの化合物を含む組成物
SI1725561T1 (sl) 2004-03-10 2010-09-30 Basf Se Dialkil amino triazolopirimidini postopek za njihovo proizvodnjo njihova uporaba za nadzor patogenih gljiv in agensi vsebujoči omenjeno spojino
US20080020999A1 (en) 2004-06-03 2008-01-24 Klapproth Michael C Fungicidal Mixtures Of Amidinylphenyl Compounds
CN1968935A (zh) 2004-06-18 2007-05-23 巴斯福股份公司 N－(邻苯基)－1－甲基－3－三氟甲基吡唑－4－甲酰苯胺及其作为杀真菌剂的用途
WO2005123690A1 (de) 2004-06-18 2005-12-29 Basf Aktiengesellschaft 1-methyl-3-difluormethyl-pyrazol-4-carbonsäure-(ortho-phenyl)-anilide und ihre verwendung als fungizid
US7947691B2 (en) 2004-07-21 2011-05-24 Athersys, Inc. Cyclic n-hydroxy imides as inhibitors of flap endonuclease and uses thereof
GB0418048D0 (en) 2004-08-12 2004-09-15 Syngenta Participations Ag Method for protecting useful plants or plant propagation material
JP2006131559A (ja) 2004-11-05 2006-05-25 Takeda Chem Ind Ltd 含窒素複素環化合物
ES2308726T3 (es) 2005-02-16 2008-12-01 Basf Se 5-alcoxiaquil-6-alquil-7-amino-azolopirimidinas, procedimiento para su obtencion y su empleo para la lucha contra hongos dañinos asi como agentes que las contienen.
DE102005007160A1 (de) 2005-02-16 2006-08-24 Basf Ag Pyrazolcarbonsäureanilide, Verfahren zu ihrer Herstellung und sie enthaltende Mittel zur Bekämpfung von Schadpilzen
DE102005009458A1 (de) 2005-03-02 2006-09-07 Bayer Cropscience Ag Pyrazolylcarboxanilide
JP2009504592A (ja) 2005-08-10 2009-02-05 スミスクライン・ビーチャム・コーポレイション 選択的ｈｍ７４ａアゴニストとしてのキサンチン誘導体
CA2626103C (en) 2006-01-13 2013-07-30 Dow Agrosciences Llc 6-(poly-substituted aryl)-4-aminopicolinates and their use as herbicides
EP1983832A2 (en) 2006-02-09 2008-10-29 Syngeta Participations AG A method of protecting a plant propagation material, a plant, and/or plant organs
WO2007095603A2 (en) 2006-02-15 2007-08-23 Abbott Laboratories Novel acetyl-coa carboxylase (acc) inhibitors and their use in diabetes, obesity and metabolic syndrome
CA2644996A1 (en) 2006-03-02 2007-09-13 Cv Therapeutics, Inc. A2a adenosine receptor antagonists
RS52626B (en) 2006-07-25 2013-06-28 Cephalon Inc. PYRIDIZINONA DERIVATIVES
TW200823225A (en) 2006-11-01 2008-06-01 Astrazeneca Ab New compounds
PE20081559A1 (es) * 2007-01-12 2008-11-20 Merck & Co Inc DERIVADOS DE ESPIROCROMANONA SUSTITUIDOS COMO INHIBIDORES DE ACETIL CoA CARBOXILASA
WO2008103354A2 (en) 2007-02-20 2008-08-28 Cropsolution, Inc. Modulators of acetyl-coenzyme a carboxylase and methods of use thereof
AU2008256717B2 (en) 2007-05-25 2013-11-21 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
CN101481380B (zh) 2008-01-08 2012-10-17 浙江医药股份有限公司新昌制药厂 噻吩并哒嗪类化合物及其制备方法、药物组合物及其用途
JP5592360B2 (ja) 2008-07-02 2014-09-17 アベキサ・リミテッド イミダゾピリミジノンおよびその使用
WO2010022236A2 (en) 2008-08-20 2010-02-25 The University Of Medicine And Dentistry Of New Jersey Inhibiting obesity progression by inhibiting adipocyte differentiation with a pre-adipocyte autophagy inhibitor
JP5535931B2 (ja) 2008-10-27 2014-07-02 武田薬品工業株式会社 二環性化合物
US20100113473A1 (en) * 2008-10-30 2010-05-06 Player Mark R Aryl amide compound as an acetyl coenzyme a carboxylase inhibitor
US20100280067A1 (en) 2009-04-30 2010-11-04 Pakala Kumara Savithru Sarma Inhibitors of acetyl-coa carboxylase
US8697739B2 (en) * 2010-07-29 2014-04-15 Novartis Ag Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof
US8729102B2 (en) * 2010-11-30 2014-05-20 Takeda Pharmaceutical Company Limited Bicyclic compound
PL2699576T3 (pl) 2011-04-22 2016-05-31 Pfizer Pochodne pirazolospiroketonu do zastosowania jako inhibitory karboksylazy acetylo-COA
JPWO2013035827A1 (ja) 2011-09-09 2015-03-23 塩野義製薬株式会社 新規オレフィン誘導体
US20130116241A1 (en) 2011-11-09 2013-05-09 Abbvie Inc. Novel inhibitor compounds of phosphodiesterase type 10a
CN104105485B (zh) 2011-11-11 2017-04-12 吉利德阿波罗公司 Acc抑制剂和其用途
EP2994128B1 (en) 2013-05-10 2019-01-30 Gilead Apollo, LLC Acc inhibitors and uses thereof
US10208044B2 (en) 2013-05-10 2019-02-19 Gilead Apollo, Llc ACC inhibitors and uses thereof
WO2014182943A1 (en) 2013-05-10 2014-11-13 Nimbus Apollo, Inc. Acc inhibitors and uses thereof

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EP2994139B1 (en) 2019-04-10
MX2015015422A (es) 2016-06-21
BR112015028152A2 (pt) 2017-07-25
US10208063B2 (en) 2019-02-19
CN105358154A (zh) 2016-02-24
KR20160006762A (ko) 2016-01-19
US20160108061A1 (en) 2016-04-21
AU2014262638A1 (en) 2015-11-26
EP2994139A1 (en) 2016-03-16
JP2016520063A (ja) 2016-07-11
EP2994139A4 (en) 2016-11-30
HK1221411A1 (zh) 2017-06-02
AR096242A1 (es) 2015-12-16
CL2015003315A1 (es) 2016-07-15
EA030942B1 (ru) 2018-10-31
HK1221661A1 (zh) 2017-06-09
JP6434498B2 (ja) 2018-12-05

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