CO2017007810A2 - Sal de tosilato de n-[3-[4ar,7as)-2-amino-6-(5-fluoropirimidin-2-il)-4,4a,5,7-tetrahidropirrolo[3,4-d][1,3]tiazin-7a-il-4-fluoro-fenil]-5-metoxi-pirazina-2-carboxamida - Google Patents

Sal de tosilato de n-[3-[4ar,7as)-2-amino-6-(5-fluoropirimidin-2-il)-4,4a,5,7-tetrahidropirrolo[3,4-d][1,3]tiazin-7a-il-4-fluoro-fenil]-5-metoxi-pirazina-2-carboxamida

Info

Publication number
CO2017007810A2
CO2017007810A2 CONC2017/0007810A CO2017007810A CO2017007810A2 CO 2017007810 A2 CO2017007810 A2 CO 2017007810A2 CO 2017007810 A CO2017007810 A CO 2017007810A CO 2017007810 A2 CO2017007810 A2 CO 2017007810A2
Authority
CO
Colombia
Prior art keywords
tetrahydropyrrolo
fluoropyrimidin
thiazin
pyrazine
carboxamide
Prior art date
Application number
CONC2017/0007810A
Other languages
English (en)
Inventor
David Andrew Coates
Craig Daniel Wolfangel
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CO2017007810A2 publication Critical patent/CO2017007810A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

La invención presente invención se refiere a una sal de tosilato de N-[3-[(4aR,7aS)-2-amino-6-(5-fluoropirimidin-2-il)-4,4a,5,7-tetrahidropirrolo[3,4-d][1,3]tiazin-7a-il]-4-fluoro-fenil]-5-metoxi-pirazina-2-carboxamida.
CONC2017/0007810A 2015-01-30 2017-08-01 Sal de tosilato de n-[3-[4ar,7as)-2-amino-6-(5-fluoropirimidin-2-il)-4,4a,5,7-tetrahidropirrolo[3,4-d][1,3]tiazin-7a-il-4-fluoro-fenil]-5-metoxi-pirazina-2-carboxamida CO2017007810A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562109733P 2015-01-30 2015-01-30
PCT/US2016/014423 WO2016122968A1 (en) 2015-01-30 2016-01-22 Tosylate salt of n-[3-[(4ar,7as)-2-amino-6-(5-fluoropyrimidin-2-yl)-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7a-yl]-4-fluoro-phenyl]-5-methoxy-pyrazine-2-carboxamide

Publications (1)

Publication Number Publication Date
CO2017007810A2 true CO2017007810A2 (es) 2017-10-20

Family

ID=55275232

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2017/0007810A CO2017007810A2 (es) 2015-01-30 2017-08-01 Sal de tosilato de n-[3-[4ar,7as)-2-amino-6-(5-fluoropirimidin-2-il)-4,4a,5,7-tetrahidropirrolo[3,4-d][1,3]tiazin-7a-il-4-fluoro-fenil]-5-metoxi-pirazina-2-carboxamida

Country Status (41)

Country Link
US (1) US10080758B2 (es)
EP (1) EP3250575B1 (es)
JP (2) JP6723250B2 (es)
KR (1) KR101950129B1 (es)
CN (1) CN107108657B (es)
AR (1) AR103406A1 (es)
AU (1) AU2016211827B2 (es)
BR (1) BR112017012149A2 (es)
CA (1) CA2969475C (es)
CL (1) CL2017001899A1 (es)
CO (1) CO2017007810A2 (es)
CR (1) CR20170287A (es)
CY (1) CY1122548T1 (es)
DK (1) DK3250575T3 (es)
DO (1) DOP2017000159A (es)
EA (1) EA031330B1 (es)
EC (1) ECSP17048768A (es)
ES (1) ES2768782T3 (es)
GT (1) GT201700166A (es)
HR (1) HRP20192240T1 (es)
HU (1) HUE048029T2 (es)
IL (1) IL252754A0 (es)
LT (1) LT3250575T (es)
MA (1) MA41420B1 (es)
MD (1) MD3250575T2 (es)
ME (1) ME03581B (es)
MX (1) MX2017009713A (es)
NZ (1) NZ732381A (es)
PE (1) PE20171333A1 (es)
PH (1) PH12017501356A1 (es)
PL (1) PL3250575T3 (es)
PT (1) PT3250575T (es)
RS (1) RS59730B1 (es)
SG (1) SG11201706038PA (es)
SI (1) SI3250575T1 (es)
SV (1) SV2017005478A (es)
TN (1) TN2017000332A1 (es)
TW (1) TWI574969B (es)
UA (1) UA119581C2 (es)
WO (1) WO2016122968A1 (es)
ZA (1) ZA201703937B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR103406A1 (es) * 2015-01-30 2017-05-10 Lilly Co Eli Sal de tosilato
WO2019094608A1 (en) 2017-11-08 2019-05-16 Denali Therapeutics Inc. Anti-bace1 antibodies and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT401651B (de) * 1994-06-14 1996-11-25 Biochemie Gmbh 7-(2-(2-aminothiazol-4-yl)-2-(z)- hydroximinoacetamido)-3-n,n- dimethylcarbamoyloxymethyl-3-cephem-4-
NZ585671A (en) * 2007-12-07 2012-06-29 Pfizer Tosylate salt of trans-n-isobutyl-3-fluoro-3- [3-fluoro-4- (pyrrolidin-1-yl-methyl) -phenyl] cyclobut anecarboxamide
EP2233474B1 (en) * 2008-01-18 2015-08-05 Eisai R&D Management Co., Ltd. Condensed aminodihydrothiazine derivative
TWI593692B (zh) * 2013-03-12 2017-08-01 美國禮來大藥廠 四氫吡咯并噻嗪化合物
TWI570127B (zh) * 2014-09-15 2017-02-11 美國禮來大藥廠 結晶型N-[3-[(4aR,7aS)-2-胺基-6-(5-氟嘧啶-2-基)-4,4a,5,7-四氫吡咯并[3,4-d][1,3]噻嗪-7a-基]-4-氟-苯基]-5-甲氧基-吡嗪-2-甲醯胺、其用途及醫藥組合物
AR103406A1 (es) * 2015-01-30 2017-05-10 Lilly Co Eli Sal de tosilato

Also Published As

Publication number Publication date
KR101950129B1 (ko) 2019-02-19
MA41420B1 (fr) 2020-02-28
ME03581B (me) 2020-07-20
ES2768782T3 (es) 2020-06-23
SI3250575T1 (sl) 2019-12-31
EA031330B1 (ru) 2018-12-28
DOP2017000159A (es) 2017-07-31
PL3250575T3 (pl) 2020-06-01
CA2969475A1 (en) 2016-08-04
AU2016211827B2 (en) 2018-04-26
CA2969475C (en) 2019-06-18
CN107108657A (zh) 2017-08-29
CL2017001899A1 (es) 2018-03-23
EP3250575B1 (en) 2019-11-20
GT201700166A (es) 2018-11-23
PT3250575T (pt) 2020-01-16
AU2016211827A1 (en) 2017-06-22
SV2017005478A (es) 2018-02-09
JP2019142902A (ja) 2019-08-29
RS59730B1 (sr) 2020-02-28
ZA201703937B (en) 2019-01-30
EA201791229A1 (ru) 2017-11-30
EP3250575A1 (en) 2017-12-06
BR112017012149A2 (pt) 2018-01-02
MX2017009713A (es) 2017-11-17
SG11201706038PA (en) 2017-08-30
JP6723250B2 (ja) 2020-07-15
NZ732381A (en) 2018-05-25
PE20171333A1 (es) 2017-09-13
ECSP17048768A (es) 2017-11-30
AR103406A1 (es) 2017-05-10
US20170368071A1 (en) 2017-12-28
TW201636354A (zh) 2016-10-16
TN2017000332A1 (en) 2019-01-16
JP2018503666A (ja) 2018-02-08
CR20170287A (es) 2017-07-20
PH12017501356A1 (en) 2017-12-11
KR20170097782A (ko) 2017-08-28
UA119581C2 (uk) 2019-07-10
CY1122548T1 (el) 2021-01-27
HRP20192240T1 (hr) 2020-03-06
DK3250575T3 (da) 2020-01-20
TWI574969B (zh) 2017-03-21
MD3250575T2 (ro) 2020-03-31
HUE048029T2 (hu) 2020-05-28
CN107108657B (zh) 2021-10-08
LT3250575T (lt) 2020-02-10
US10080758B2 (en) 2018-09-25
WO2016122968A1 (en) 2016-08-04
IL252754A0 (en) 2017-08-31

Similar Documents

Publication Publication Date Title
MA47123A (fr) Dérivés de benzooxazole en tant qu'mmunomodulateurs
MA42990A (fr) Composés utiles en tant qu'immunomodulateurs
MA40587A (fr) Composés d'aminopyrimidinyle en tant qu'inhibiteurs de jak
BR112016026942A2 (pt) geração de visualizações de direção curva por curva.
MA41542A (fr) Nouveaux dérivés de n-acyl-arylsulfonamide utilisés en tant qu'inhibiteurs d'aminoacyl-arnt synthétase
MX2016014765A (es) Incremento del rendimiento utilizando soforolipidos.
DK3397621T3 (da) Fremgangsmåde til fremstilling af 1,1,3-trioxo-1,2-benzothiazol-6-carboxamid
CO2017007810A2 (es) Sal de tosilato de n-[3-[4ar,7as)-2-amino-6-(5-fluoropirimidin-2-il)-4,4a,5,7-tetrahidropirrolo[3,4-d][1,3]tiazin-7a-il-4-fluoro-fenil]-5-metoxi-pirazina-2-carboxamida
MA41174A (fr) Dérivés d'imidazopyridazine utilisés en tant qu'inhibiteurs de pi3kbeta
CL2017000645A1 (es) Síntesis de ent-progesterona e intermediarios de la misma
DK3397620T3 (da) Fremgangsmåde til fremstilling af 1,1,3-Trioxo-1,2-benzothiazol-6-carboxamid
CO2017001927A2 (es) Formas cristalinas de n-[3-[(4ar,7as)-2-amino-6-(5- fluoropirimidin-2-il)-4,4a,5,7-tetrahidropirrolo[3,4-d][1,3]tiazin-7a-il]-4-fluoro-fenil]-5-metoxi-pirazin-2-carboxamida como inhibidores de bace
BR112019002828A2 (pt) método de preparação de derivados de estireno substituído
DOP2017000016A (es) Nueva sal de disoproxilo de tenofovir
MA45184A (fr) Procédé de préparation de l'éluxadoline .
TH182870B (th) เกลือทอซิเลทของ n-[3-[(4ar,7as)-2-อะมิโน-6-(5-ฟลูออโรพิริมิดิน-2-อิล)-4,4a,5,7-เททระไฮโดรพิร์โรโล[3,4-d][1,3]ไธอะซิน-7a-อิล]-4-ฟลูออโร-เฟนิล]-5-เมธอกซิ-ไพแรซีน-2-คาร์บอกแซมีด
TH182897B (th) อุปกรณ์สำหรับยึดแกนกระดุม
TH183362B (th) "สิ่งเข้มข้นปรุงแต่งรสชาติที่มีรูปร่าง"
TH1601005811B (th) โครงสร้างส่วนประดับด้านหน้าของรถจักรยานยนต์
ES1149559Y (es) Tendal de ropa
TH1401007488B (th) โครงสร้างด้านหน้าของจักรยานยนต์
UA93238U (uk) Комплексний препарат "глуцисаргін"