BR112017012149A2 - Sal tosilato de n-[3-[(4ar,7as)-2-amino-6-(5- fluoropirimidin-2-il)-4,4a,5,7-tetra-hidropirrolo[3,4- d][1,3]tiazin-7a-il]-4-fluoro-fenil]-5-metóxi-pirazina-2- carboxamida - Google Patents

Sal tosilato de n-[3-[(4ar,7as)-2-amino-6-(5- fluoropirimidin-2-il)-4,4a,5,7-tetra-hidropirrolo[3,4- d][1,3]tiazin-7a-il]-4-fluoro-fenil]-5-metóxi-pirazina-2- carboxamida

Info

Publication number
BR112017012149A2
BR112017012149A2 BR112017012149-2A BR112017012149A BR112017012149A2 BR 112017012149 A2 BR112017012149 A2 BR 112017012149A2 BR 112017012149 A BR112017012149 A BR 112017012149A BR 112017012149 A2 BR112017012149 A2 BR 112017012149A2
Authority
BR
Brazil
Prior art keywords
fluoropyrimidin
carboxamide
fluoro
phenyl
amino
Prior art date
Application number
BR112017012149-2A
Other languages
English (en)
Inventor
Andrew Coates David
Daniel Wolfangel Craig
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of BR112017012149A2 publication Critical patent/BR112017012149A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

a presente invenção refere-se a um sal tosilato de n-[3-[(4ar,7as)-2-amino-6-(5-fluoropirimidin-2-il)-4,4a,5,7-tetra-hidropirrolo[3,4-d][1,3]tiazin-7a-il]-4-fluoro-fenil]-5-metóxi-pirazina-2-carboxamida.
BR112017012149-2A 2015-01-30 2016-01-22 Sal tosilato de n-[3-[(4ar,7as)-2-amino-6-(5- fluoropirimidin-2-il)-4,4a,5,7-tetra-hidropirrolo[3,4- d][1,3]tiazin-7a-il]-4-fluoro-fenil]-5-metóxi-pirazina-2- carboxamida BR112017012149A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562109733P 2015-01-30 2015-01-30
US62/109,733 2015-01-30
PCT/US2016/014423 WO2016122968A1 (en) 2015-01-30 2016-01-22 Tosylate salt of n-[3-[(4ar,7as)-2-amino-6-(5-fluoropyrimidin-2-yl)-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7a-yl]-4-fluoro-phenyl]-5-methoxy-pyrazine-2-carboxamide

Publications (1)

Publication Number Publication Date
BR112017012149A2 true BR112017012149A2 (pt) 2018-01-02

Family

ID=55275232

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017012149-2A BR112017012149A2 (pt) 2015-01-30 2016-01-22 Sal tosilato de n-[3-[(4ar,7as)-2-amino-6-(5- fluoropirimidin-2-il)-4,4a,5,7-tetra-hidropirrolo[3,4- d][1,3]tiazin-7a-il]-4-fluoro-fenil]-5-metóxi-pirazina-2- carboxamida

Country Status (41)

Country Link
US (1) US10080758B2 (pt)
EP (1) EP3250575B1 (pt)
JP (2) JP6723250B2 (pt)
KR (1) KR101950129B1 (pt)
CN (1) CN107108657B (pt)
AR (1) AR103406A1 (pt)
AU (1) AU2016211827B2 (pt)
BR (1) BR112017012149A2 (pt)
CA (1) CA2969475C (pt)
CL (1) CL2017001899A1 (pt)
CO (1) CO2017007810A2 (pt)
CR (1) CR20170287A (pt)
CY (1) CY1122548T1 (pt)
DK (1) DK3250575T3 (pt)
DO (1) DOP2017000159A (pt)
EA (1) EA031330B1 (pt)
EC (1) ECSP17048768A (pt)
ES (1) ES2768782T3 (pt)
GT (1) GT201700166A (pt)
HR (1) HRP20192240T1 (pt)
HU (1) HUE048029T2 (pt)
IL (1) IL252754A0 (pt)
LT (1) LT3250575T (pt)
MA (1) MA41420B1 (pt)
MD (1) MD3250575T2 (pt)
ME (1) ME03581B (pt)
MX (1) MX2017009713A (pt)
NZ (1) NZ732381A (pt)
PE (1) PE20171333A1 (pt)
PH (1) PH12017501356A1 (pt)
PL (1) PL3250575T3 (pt)
PT (1) PT3250575T (pt)
RS (1) RS59730B1 (pt)
SG (1) SG11201706038PA (pt)
SI (1) SI3250575T1 (pt)
SV (1) SV2017005478A (pt)
TN (1) TN2017000332A1 (pt)
TW (1) TWI574969B (pt)
UA (1) UA119581C2 (pt)
WO (1) WO2016122968A1 (pt)
ZA (1) ZA201703937B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR103406A1 (es) * 2015-01-30 2017-05-10 Lilly Co Eli Sal de tosilato
WO2019094608A1 (en) 2017-11-08 2019-05-16 Denali Therapeutics Inc. Anti-bace1 antibodies and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT401651B (de) * 1994-06-14 1996-11-25 Biochemie Gmbh 7-(2-(2-aminothiazol-4-yl)-2-(z)- hydroximinoacetamido)-3-n,n- dimethylcarbamoyloxymethyl-3-cephem-4-
NZ585671A (en) * 2007-12-07 2012-06-29 Pfizer Tosylate salt of trans-n-isobutyl-3-fluoro-3- [3-fluoro-4- (pyrrolidin-1-yl-methyl) -phenyl] cyclobut anecarboxamide
EP2233474B1 (en) * 2008-01-18 2015-08-05 Eisai R&D Management Co., Ltd. Condensed aminodihydrothiazine derivative
TWI593692B (zh) * 2013-03-12 2017-08-01 美國禮來大藥廠 四氫吡咯并噻嗪化合物
TWI570127B (zh) * 2014-09-15 2017-02-11 美國禮來大藥廠 結晶型N-[3-[(4aR,7aS)-2-胺基-6-(5-氟嘧啶-2-基)-4,4a,5,7-四氫吡咯并[3,4-d][1,3]噻嗪-7a-基]-4-氟-苯基]-5-甲氧基-吡嗪-2-甲醯胺、其用途及醫藥組合物
AR103406A1 (es) * 2015-01-30 2017-05-10 Lilly Co Eli Sal de tosilato

Also Published As

Publication number Publication date
KR101950129B1 (ko) 2019-02-19
MA41420B1 (fr) 2020-02-28
ME03581B (me) 2020-07-20
ES2768782T3 (es) 2020-06-23
SI3250575T1 (sl) 2019-12-31
EA031330B1 (ru) 2018-12-28
DOP2017000159A (es) 2017-07-31
PL3250575T3 (pl) 2020-06-01
CA2969475A1 (en) 2016-08-04
AU2016211827B2 (en) 2018-04-26
CA2969475C (en) 2019-06-18
CN107108657A (zh) 2017-08-29
CL2017001899A1 (es) 2018-03-23
EP3250575B1 (en) 2019-11-20
GT201700166A (es) 2018-11-23
PT3250575T (pt) 2020-01-16
AU2016211827A1 (en) 2017-06-22
SV2017005478A (es) 2018-02-09
JP2019142902A (ja) 2019-08-29
RS59730B1 (sr) 2020-02-28
ZA201703937B (en) 2019-01-30
EA201791229A1 (ru) 2017-11-30
EP3250575A1 (en) 2017-12-06
MX2017009713A (es) 2017-11-17
SG11201706038PA (en) 2017-08-30
JP6723250B2 (ja) 2020-07-15
NZ732381A (en) 2018-05-25
PE20171333A1 (es) 2017-09-13
ECSP17048768A (es) 2017-11-30
AR103406A1 (es) 2017-05-10
US20170368071A1 (en) 2017-12-28
TW201636354A (zh) 2016-10-16
TN2017000332A1 (en) 2019-01-16
JP2018503666A (ja) 2018-02-08
CO2017007810A2 (es) 2017-10-20
CR20170287A (es) 2017-07-20
PH12017501356A1 (en) 2017-12-11
KR20170097782A (ko) 2017-08-28
UA119581C2 (uk) 2019-07-10
CY1122548T1 (el) 2021-01-27
HRP20192240T1 (hr) 2020-03-06
DK3250575T3 (da) 2020-01-20
TWI574969B (zh) 2017-03-21
MD3250575T2 (ro) 2020-03-31
HUE048029T2 (hu) 2020-05-28
CN107108657B (zh) 2021-10-08
LT3250575T (lt) 2020-02-10
US10080758B2 (en) 2018-09-25
WO2016122968A1 (en) 2016-08-04
IL252754A0 (en) 2017-08-31

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements