SG11201706038PA - Tosylate salt of n-[3-[(4ar,7as)-2-amino-6-(5-fluoropyrimidin-2-yl)-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7a-yl]-4-fluoro-phenyl]-5-methoxy-pyrazine-2-carboxamide - Google Patents

Tosylate salt of n-[3-[(4ar,7as)-2-amino-6-(5-fluoropyrimidin-2-yl)-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7a-yl]-4-fluoro-phenyl]-5-methoxy-pyrazine-2-carboxamide

Info

Publication number: SG11201706038PA
Authority: SG; Singapore
Prior art keywords: tetrahydropyrrolo; fluoropyrimidin; thiazin; pyrazine; carboxamide
Prior art date: 2015-01-30

Application number

SG11201706038PA

Inventor

David Andrew Coates

Craig Daniel Wolfangel

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-01-30

Filing date

2016-01-22

Publication date

2017-08-30

2016-01-22 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2017-08-30 Publication of SG11201706038PA publication Critical patent/SG11201706038PA/en

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

SG11201706038PA 2015-01-30 2016-01-22 Tosylate salt of n-[3-[(4ar,7as)-2-amino-6-(5-fluoropyrimidin-2-yl)-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7a-yl]-4-fluoro-phenyl]-5-methoxy-pyrazine-2-carboxamide SG11201706038PA (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201562109733P	2015-01-30	2015-01-30
PCT/US2016/014423 WO2016122968A1 (en)	2015-01-30	2016-01-22	Tosylate salt of n-[3-[(4ar,7as)-2-amino-6-(5-fluoropyrimidin-2-yl)-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7a-yl]-4-fluoro-phenyl]-5-methoxy-pyrazine-2-carboxamide

Publications (1)

Publication Number	Publication Date
SG11201706038PA true SG11201706038PA (en)	2017-08-30

Family

ID=55275232

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG11201706038PA SG11201706038PA (en)	2015-01-30	2016-01-22	Tosylate salt of n-[3-[(4ar,7as)-2-amino-6-(5-fluoropyrimidin-2-yl)-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7a-yl]-4-fluoro-phenyl]-5-methoxy-pyrazine-2-carboxamide

Country Status (41)

Country	Link
US (1)	US10080758B2 (en)
EP (1)	EP3250575B1 (en)
JP (2)	JP6723250B2 (en)
KR (1)	KR101950129B1 (en)
CN (1)	CN107108657B (en)
AR (1)	AR103406A1 (en)
AU (1)	AU2016211827B2 (en)
BR (1)	BR112017012149A2 (en)
CA (1)	CA2969475C (en)
CL (1)	CL2017001899A1 (en)
CO (1)	CO2017007810A2 (en)
CR (1)	CR20170287A (en)
CY (1)	CY1122548T1 (en)
DK (1)	DK3250575T3 (en)
DO (1)	DOP2017000159A (en)
EA (1)	EA031330B1 (en)
EC (1)	ECSP17048768A (en)
ES (1)	ES2768782T3 (en)
GT (1)	GT201700166A (en)
HR (1)	HRP20192240T1 (en)
HU (1)	HUE048029T2 (en)
IL (1)	IL252754A0 (en)
LT (1)	LT3250575T (en)
MA (1)	MA41420B1 (en)
MD (1)	MD3250575T2 (en)
ME (1)	ME03581B (en)
MX (1)	MX2017009713A (en)
NZ (1)	NZ732381A (en)
PE (1)	PE20171333A1 (en)
PH (1)	PH12017501356A1 (en)
PL (1)	PL3250575T3 (en)
PT (1)	PT3250575T (en)
RS (1)	RS59730B1 (en)
SG (1)	SG11201706038PA (en)
SI (1)	SI3250575T1 (en)
SV (1)	SV2017005478A (en)
TN (1)	TN2017000332A1 (en)
TW (1)	TWI574969B (en)
UA (1)	UA119581C2 (en)
WO (1)	WO2016122968A1 (en)
ZA (1)	ZA201703937B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI574969B (en) *	2015-01-30	2017-03-21	美國禮來大藥廠	Tosylate salt
WO2019094608A1 (en)	2017-11-08	2019-05-16	Denali Therapeutics Inc.	Anti-bace1 antibodies and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT401651B (en) *	1994-06-14	1996-11-25	Biochemie Gmbh	7- (2- (2-AMINOTHIAZOL-4-YL) -2- (Z) - HYDROXIMINOACETAMIDO) -3-N, N- DIMETHYLCARBAMOYLOXYMETHYL-3-CEPHEM-4-
RU2451016C2 (en) *	2007-12-07	2012-05-20	Пфайзер Инк.	Tosylate salt of trans-n-isobutyl-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]cyclobutane carboxamide
KR101564634B1 (en) *	2008-01-18	2015-10-30	에자이 알앤드디 매니지먼트 가부시키가이샤	Condensed aminodihydrothiazine derivative
TWI593692B (en)	2013-03-12	2017-08-01	美國禮來大藥廠	Tetrahydropyrrolothiazine compounds
TWI570127B (en) *	2014-09-15	2017-02-11	美國禮來大藥廠	Crystalline n-[3- [(4ar,7as)-2-amino-6-(5-fluoropyrimidin-2-yl)-4,4a,5,7- tetrahydropyrrolo [3,4-d] [ 1 ,3]thiazin-7a-yl] -4-fluoro-phenyl] -5 -methoxy- pyrazine-2-carboxamide, and use and pharmaceutical composition thereof
TWI574969B (en) *	2015-01-30	2017-03-21	美國禮來大藥廠	Tosylate salt

2016
- 2016-01-13 TW TW105100973A patent/TWI574969B/en not_active IP Right Cessation
- 2016-01-13 AR ARP160100076A patent/AR103406A1/en unknown
- 2016-01-22 TN TNP/2017/000332A patent/TN2017000332A1/en unknown
- 2016-01-22 ES ES16702654T patent/ES2768782T3/en active Active
- 2016-01-22 SI SI201630517T patent/SI3250575T1/en unknown
- 2016-01-22 HU HUE16702654A patent/HUE048029T2/en unknown
- 2016-01-22 LT LTEP16702654.1T patent/LT3250575T/en unknown
- 2016-01-22 RS RS20191663A patent/RS59730B1/en unknown
- 2016-01-22 EA EA201791229A patent/EA031330B1/en not_active IP Right Cessation
- 2016-01-22 CA CA2969475A patent/CA2969475C/en not_active Expired - Fee Related
- 2016-01-22 MD MDE20170309T patent/MD3250575T2/en unknown
- 2016-01-22 US US15/535,523 patent/US10080758B2/en active Active
- 2016-01-22 MX MX2017009713A patent/MX2017009713A/en unknown
- 2016-01-22 KR KR1020177020943A patent/KR101950129B1/en active IP Right Grant
- 2016-01-22 PT PT167026541T patent/PT3250575T/en unknown
- 2016-01-22 CR CR20170287A patent/CR20170287A/en unknown
- 2016-01-22 AU AU2016211827A patent/AU2016211827B2/en not_active Ceased
- 2016-01-22 MA MA41420A patent/MA41420B1/en unknown
- 2016-01-22 BR BR112017012149-2A patent/BR112017012149A2/en not_active Application Discontinuation
- 2016-01-22 DK DK16702654.1T patent/DK3250575T3/en active
- 2016-01-22 NZ NZ732381A patent/NZ732381A/en not_active IP Right Cessation
- 2016-01-22 PL PL16702654T patent/PL3250575T3/en unknown
- 2016-01-22 CN CN201680005234.2A patent/CN107108657B/en active Active
- 2016-01-22 ME MEP-2019-347A patent/ME03581B/en unknown
- 2016-01-22 WO PCT/US2016/014423 patent/WO2016122968A1/en active Application Filing
- 2016-01-22 UA UAA201707108A patent/UA119581C2/en unknown
- 2016-01-22 EP EP16702654.1A patent/EP3250575B1/en active Active
- 2016-01-22 SG SG11201706038PA patent/SG11201706038PA/en unknown
- 2016-01-22 PE PE2017001211A patent/PE20171333A1/en unknown
- 2016-01-22 JP JP2017540253A patent/JP6723250B2/en active Active
2017
- 2017-06-07 IL IL252754A patent/IL252754A0/en unknown
- 2017-06-08 ZA ZA2017/03937A patent/ZA201703937B/en unknown
- 2017-07-03 DO DO2017000159A patent/DOP2017000159A/en unknown
- 2017-07-06 SV SV2017005478A patent/SV2017005478A/en unknown
- 2017-07-25 CL CL2017001899A patent/CL2017001899A1/en unknown
- 2017-07-27 GT GT201700166A patent/GT201700166A/en unknown
- 2017-07-28 EC ECIEPI201748768A patent/ECSP17048768A/en unknown
- 2017-07-28 PH PH12017501356A patent/PH12017501356A1/en unknown
- 2017-08-01 CO CONC2017/0007810A patent/CO2017007810A2/en unknown
2019
- 2019-04-10 JP JP2019074951A patent/JP2019142902A/en not_active Ceased
- 2019-12-12 HR HRP20192240TT patent/HRP20192240T1/en unknown
2020
- 2020-01-15 CY CY20201100033T patent/CY1122548T1/en unknown

Also Published As

Publication number	Publication date
CN107108657B (en)	2021-10-08
SV2017005478A (en)	2018-02-09
CL2017001899A1 (en)	2018-03-23
WO2016122968A1 (en)	2016-08-04
CA2969475C (en)	2019-06-18
CO2017007810A2 (en)	2017-10-20
PH12017501356A1 (en)	2017-12-11
KR20170097782A (en)	2017-08-28
EA031330B1 (en)	2018-12-28
EP3250575A1 (en)	2017-12-06
LT3250575T (en)	2020-02-10
US10080758B2 (en)	2018-09-25
JP2019142902A (en)	2019-08-29
MX2017009713A (en)	2017-11-17
MD3250575T2 (en)	2020-03-31
PT3250575T (en)	2020-01-16
PL3250575T3 (en)	2020-06-01
CA2969475A1 (en)	2016-08-04
ZA201703937B (en)	2019-01-30
DK3250575T3 (en)	2020-01-20
DOP2017000159A (en)	2017-07-31
AU2016211827B2 (en)	2018-04-26
RS59730B1 (en)	2020-02-28
UA119581C2 (en)	2019-07-10
TN2017000332A1 (en)	2019-01-16
IL252754A0 (en)	2017-08-31
HRP20192240T1 (en)	2020-03-06
SI3250575T1 (en)	2019-12-31
JP6723250B2 (en)	2020-07-15
CN107108657A (en)	2017-08-29
ECSP17048768A (en)	2017-11-30
TWI574969B (en)	2017-03-21
NZ732381A (en)	2018-05-25
KR101950129B1 (en)	2019-02-19
CR20170287A (en)	2017-07-20
MA41420B1 (en)	2020-02-28
EA201791229A1 (en)	2017-11-30
AR103406A1 (en)	2017-05-10
US20170368071A1 (en)	2017-12-28
AU2016211827A1 (en)	2017-06-22
PE20171333A1 (en)	2017-09-13
ES2768782T3 (en)	2020-06-23
CY1122548T1 (en)	2021-01-27
ME03581B (en)	2020-07-20
JP2018503666A (en)	2018-02-08
EP3250575B1 (en)	2019-11-20
GT201700166A (en)	2018-11-23
BR112017012149A2 (en)	2018-01-02
HUE048029T2 (en)	2020-05-28
TW201636354A (en)	2016-10-16

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