AR103406A1 - Sal de tosilato - Google Patents

Sal de tosilato

Info

Publication number
AR103406A1
AR103406A1 ARP160100076A ARP160100076A AR103406A1 AR 103406 A1 AR103406 A1 AR 103406A1 AR P160100076 A ARP160100076 A AR P160100076A AR P160100076 A ARP160100076 A AR P160100076A AR 103406 A1 AR103406 A1 AR 103406A1
Authority
AR
Argentina
Prior art keywords
salt
tosilate
tetrahydropyrrolo
fluoropyrimidin
thiazin
Prior art date
Application number
ARP160100076A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR103406A1 publication Critical patent/AR103406A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

La presente se refiere a una sal de tosilato de N-[3-[(4aR,7aS)-2-amino-6-(5-fluoropirimidin-2-il)-4,4a,5,7-tetrahidropirrolo[3,4-d][1,3]tiazin-7a-il]-4-fluoro-fenil]-5-metoxi-pirazina-2-carboxamida. Composiciones farmacéuticas. Reivindicación 1: Un compuesto caracterizado porque es una sal de tosilato de N-[3-[(4aR,7aS)-2-amino-6-(5-fluoropirimidin-2-il)-4,4a,5,7-tetrahidropirrolo[3,4-d][1,3]tiazin-7a-il]-4-fluoro-fenil]-5-metoxi-pirazina-2-carboxamida.
ARP160100076A 2015-01-30 2016-01-13 Sal de tosilato AR103406A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562109733P 2015-01-30 2015-01-30

Publications (1)

Publication Number Publication Date
AR103406A1 true AR103406A1 (es) 2017-05-10

Family

ID=55275232

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160100076A AR103406A1 (es) 2015-01-30 2016-01-13 Sal de tosilato

Country Status (41)

Country Link
US (1) US10080758B2 (es)
EP (1) EP3250575B1 (es)
JP (2) JP6723250B2 (es)
KR (1) KR101950129B1 (es)
CN (1) CN107108657B (es)
AR (1) AR103406A1 (es)
AU (1) AU2016211827B2 (es)
BR (1) BR112017012149A2 (es)
CA (1) CA2969475C (es)
CL (1) CL2017001899A1 (es)
CO (1) CO2017007810A2 (es)
CR (1) CR20170287A (es)
CY (1) CY1122548T1 (es)
DK (1) DK3250575T3 (es)
DO (1) DOP2017000159A (es)
EA (1) EA031330B1 (es)
EC (1) ECSP17048768A (es)
ES (1) ES2768782T3 (es)
GT (1) GT201700166A (es)
HR (1) HRP20192240T1 (es)
HU (1) HUE048029T2 (es)
IL (1) IL252754A0 (es)
LT (1) LT3250575T (es)
MA (1) MA41420B1 (es)
MD (1) MD3250575T2 (es)
ME (1) ME03581B (es)
MX (1) MX2017009713A (es)
NZ (1) NZ732381A (es)
PE (1) PE20171333A1 (es)
PH (1) PH12017501356A1 (es)
PL (1) PL3250575T3 (es)
PT (1) PT3250575T (es)
RS (1) RS59730B1 (es)
SG (1) SG11201706038PA (es)
SI (1) SI3250575T1 (es)
SV (1) SV2017005478A (es)
TN (1) TN2017000332A1 (es)
TW (1) TWI574969B (es)
UA (1) UA119581C2 (es)
WO (1) WO2016122968A1 (es)
ZA (1) ZA201703937B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI574969B (zh) * 2015-01-30 2017-03-21 美國禮來大藥廠 甲苯磺酸鹽
WO2019094608A1 (en) 2017-11-08 2019-05-16 Denali Therapeutics Inc. Anti-bace1 antibodies and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT401651B (de) * 1994-06-14 1996-11-25 Biochemie Gmbh 7-(2-(2-aminothiazol-4-yl)-2-(z)- hydroximinoacetamido)-3-n,n- dimethylcarbamoyloxymethyl-3-cephem-4-
EP2231630B1 (en) * 2007-12-07 2012-11-07 Pfizer Inc. Tosylate salt of trans-n-isobutyl-3-fluoro-3- [3-flu0r0-4- (pyrrolidin-1-yl-methyl) -phenyl]cyclobut anecarboxamide
PE20091438A1 (es) * 2008-01-18 2009-09-26 Eisai Randd Man Co Ltd Derivados fusionados de aminodihidrotiazina
TWI593692B (zh) * 2013-03-12 2017-08-01 美國禮來大藥廠 四氫吡咯并噻嗪化合物
TWI570127B (zh) * 2014-09-15 2017-02-11 美國禮來大藥廠 結晶型N-[3-[(4aR,7aS)-2-胺基-6-(5-氟嘧啶-2-基)-4,4a,5,7-四氫吡咯并[3,4-d][1,3]噻嗪-7a-基]-4-氟-苯基]-5-甲氧基-吡嗪-2-甲醯胺、其用途及醫藥組合物
TWI574969B (zh) * 2015-01-30 2017-03-21 美國禮來大藥廠 甲苯磺酸鹽

Also Published As

Publication number Publication date
MD3250575T2 (ro) 2020-03-31
PL3250575T3 (pl) 2020-06-01
PH12017501356A1 (en) 2017-12-11
IL252754A0 (en) 2017-08-31
SG11201706038PA (en) 2017-08-30
BR112017012149A2 (pt) 2018-01-02
UA119581C2 (uk) 2019-07-10
MA41420B1 (fr) 2020-02-28
CA2969475C (en) 2019-06-18
GT201700166A (es) 2018-11-23
ME03581B (me) 2020-07-20
CY1122548T1 (el) 2021-01-27
JP2019142902A (ja) 2019-08-29
US20170368071A1 (en) 2017-12-28
HUE048029T2 (hu) 2020-05-28
HRP20192240T1 (hr) 2020-03-06
PT3250575T (pt) 2020-01-16
EP3250575B1 (en) 2019-11-20
CN107108657A (zh) 2017-08-29
EA201791229A1 (ru) 2017-11-30
CR20170287A (es) 2017-07-20
ZA201703937B (en) 2019-01-30
CA2969475A1 (en) 2016-08-04
LT3250575T (lt) 2020-02-10
US10080758B2 (en) 2018-09-25
CN107108657B (zh) 2021-10-08
JP6723250B2 (ja) 2020-07-15
KR20170097782A (ko) 2017-08-28
TWI574969B (zh) 2017-03-21
AU2016211827A1 (en) 2017-06-22
RS59730B1 (sr) 2020-02-28
ECSP17048768A (es) 2017-11-30
MX2017009713A (es) 2017-11-17
CL2017001899A1 (es) 2018-03-23
CO2017007810A2 (es) 2017-10-20
DK3250575T3 (da) 2020-01-20
DOP2017000159A (es) 2017-07-31
EP3250575A1 (en) 2017-12-06
ES2768782T3 (es) 2020-06-23
AU2016211827B2 (en) 2018-04-26
EA031330B1 (ru) 2018-12-28
SI3250575T1 (sl) 2019-12-31
KR101950129B1 (ko) 2019-02-19
SV2017005478A (es) 2018-02-09
NZ732381A (en) 2018-05-25
JP2018503666A (ja) 2018-02-08
WO2016122968A1 (en) 2016-08-04
TW201636354A (zh) 2016-10-16
PE20171333A1 (es) 2017-09-13
TN2017000332A1 (en) 2019-01-16

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