CN113874379A - 作为Cdc7抑制剂的四并环类化合物 - Google Patents
作为Cdc7抑制剂的四并环类化合物 Download PDFInfo
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- CN113874379A CN113874379A CN202080039204.XA CN202080039204A CN113874379A CN 113874379 A CN113874379 A CN 113874379A CN 202080039204 A CN202080039204 A CN 202080039204A CN 113874379 A CN113874379 A CN 113874379A
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Abstract
一类新的作为Cdc7抑制剂的四并环类化合物，具体公开了式(I)所示化合物、其异构体或其药学上可接受的盐。
Description
PCT国内申请，说明书已公开。
Claims (15)
- PCT国内申请，权利要求书已公开。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310266535.2A CN116425770A (zh) | 2019-05-30 | 2020-05-29 | 作为Cdc7抑制剂的四并环类化合物 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910464384 | 2019-05-30 | ||
| CN2019104643845 | 2019-05-30 | ||
| CN201910491339 | 2019-06-06 | ||
| CN2019104913399 | 2019-06-06 | ||
| CN201911128459 | 2019-11-18 | ||
| CN2019111284599 | 2019-11-18 | ||
| PCT/CN2020/093480 WO2020239107A1 (zh) | 2019-05-30 | 2020-05-29 | 作为Cdc7抑制剂的四并环类化合物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310266535.2A Division CN116425770A (zh) | 2019-05-30 | 2020-05-29 | 作为Cdc7抑制剂的四并环类化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113874379A true CN113874379A (zh) | 2021-12-31 |
| CN113874379B CN113874379B (zh) | 2023-03-31 |
Family
ID=73553516
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080039204.XA Active CN113874379B (zh) | 2019-05-30 | 2020-05-29 | 作为Cdc7抑制剂的四并环类化合物 |
| CN202310266535.2A Pending CN116425770A (zh) | 2019-05-30 | 2020-05-29 | 作为Cdc7抑制剂的四并环类化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310266535.2A Pending CN116425770A (zh) | 2019-05-30 | 2020-05-29 | 作为Cdc7抑制剂的四并环类化合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20220235068A1 (zh) |
| EP (1) | EP3978501A4 (zh) |
| JP (1) | JP2022534316A (zh) |
| KR (1) | KR20220027883A (zh) |
| CN (2) | CN113874379B (zh) |
| AU (1) | AU2020281411A1 (zh) |
| BR (1) | BR112021023886A2 (zh) |
| CA (1) | CA3142202A1 (zh) |
| IL (1) | IL288472A (zh) |
| MX (1) | MX2021014629A (zh) |
| SG (1) | SG11202113212YA (zh) |
| WO (1) | WO2020239107A1 (zh) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114127077B (zh) * | 2019-08-20 | 2023-08-01 | 正大天晴药业集团股份有限公司 | 用作Cdc7抑制剂的四并环类化合物 |
| KR20230116005A (ko) * | 2020-11-30 | 2023-08-03 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | Cdc7 억제제로 사용되는 염 형태 및 이의 결정 형태 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060264493A1 (en) * | 2003-02-17 | 2006-11-23 | Ermes Vanotti | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
| CN1993359A (zh) * | 2004-07-27 | 2007-07-04 | 艾文蒂斯药品公司 | 杂环取代的环状脲衍生物、其制备及其作为激酶抑制剂的药物用途 |
| CN102844320A (zh) * | 2010-02-17 | 2012-12-26 | 武田药品工业株式会社 | 杂环化合物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI738748B (zh) * | 2016-03-28 | 2021-09-11 | 日商武田藥品工業有限公司 | 2-[(2s)-1-氮雜雙環[2.2.2]辛-2-基]-6-(3-甲基-1h-吡唑-4-基)噻吩并[3,2-d]嘧啶-4(3h)-酮半水合物之晶形 |
| JP2020508675A (ja) * | 2017-03-01 | 2020-03-26 | 武田薬品工業株式会社 | Ｃｄｃ７阻害剤の効果を予測する方法 |
-
2020
- 2020-05-29 MX MX2021014629A patent/MX2021014629A/es unknown
- 2020-05-29 KR KR1020217043231A patent/KR20220027883A/ko unknown
- 2020-05-29 WO PCT/CN2020/093480 patent/WO2020239107A1/zh unknown
- 2020-05-29 CN CN202080039204.XA patent/CN113874379B/zh active Active
- 2020-05-29 AU AU2020281411A patent/AU2020281411A1/en active Pending
- 2020-05-29 CA CA3142202A patent/CA3142202A1/en active Pending
- 2020-05-29 EP EP20813107.8A patent/EP3978501A4/en active Pending
- 2020-05-29 CN CN202310266535.2A patent/CN116425770A/zh active Pending
- 2020-05-29 US US17/595,869 patent/US20220235068A1/en active Pending
- 2020-05-29 BR BR112021023886A patent/BR112021023886A2/pt unknown
- 2020-05-29 SG SG11202113212YA patent/SG11202113212YA/en unknown
- 2020-05-29 JP JP2021571374A patent/JP2022534316A/ja active Pending
-
2021
- 2021-11-28 IL IL288472A patent/IL288472A/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060264493A1 (en) * | 2003-02-17 | 2006-11-23 | Ermes Vanotti | Tetracyclic pyrazole derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
| CN1993359A (zh) * | 2004-07-27 | 2007-07-04 | 艾文蒂斯药品公司 | 杂环取代的环状脲衍生物、其制备及其作为激酶抑制剂的药物用途 |
| CN102844320A (zh) * | 2010-02-17 | 2012-12-26 | 武田药品工业株式会社 | 杂环化合物 |
Non-Patent Citations (1)
| Title |
|---|
| 李志广 等: "抗人CDC7 单克隆抗体的制备与鉴定", 《中国当代医药》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112021023886A2 (pt) | 2022-01-18 |
| US20220235068A1 (en) | 2022-07-28 |
| CA3142202A1 (en) | 2020-12-03 |
| EP3978501A4 (en) | 2023-05-24 |
| CN116425770A (zh) | 2023-07-14 |
| AU2020281411A1 (en) | 2022-01-06 |
| EP3978501A1 (en) | 2022-04-06 |
| CN113874379B (zh) | 2023-03-31 |
| MX2021014629A (es) | 2022-02-23 |
| JP2022534316A (ja) | 2022-07-28 |
| SG11202113212YA (en) | 2021-12-30 |
| WO2020239107A1 (zh) | 2020-12-03 |
| KR20220027883A (ko) | 2022-03-08 |
| IL288472A (en) | 2022-01-01 |
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