SG11202113212YA - Tetracyclic compounds as cdc7 inhibitors - Google Patents

Tetracyclic compounds as cdc7 inhibitors

Info

Publication number
SG11202113212YA
SG11202113212YA SG11202113212YA SG11202113212YA SG11202113212YA SG 11202113212Y A SG11202113212Y A SG 11202113212YA SG 11202113212Y A SG11202113212Y A SG 11202113212YA SG 11202113212Y A SG11202113212Y A SG 11202113212YA SG 11202113212Y A SG11202113212Y A SG 11202113212YA
Authority
SG
Singapore
Prior art keywords
tetracyclic compounds
cdc7 inhibitors
cdc7
inhibitors
tetracyclic
Prior art date
Application number
SG11202113212YA
Inventor
Gang Li
Lun Lu
Zhibo Zhang
Lihong Hu
Charles Z Ding
Shuhui Chen
Original Assignee
Chia Tai Tianqing Pharmaceutical Group Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chia Tai Tianqing Pharmaceutical Group Co Ltd filed Critical Chia Tai Tianqing Pharmaceutical Group Co Ltd
Publication of SG11202113212YA publication Critical patent/SG11202113212YA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
SG11202113212YA 2019-05-30 2020-05-29 Tetracyclic compounds as cdc7 inhibitors SG11202113212YA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN201910464384 2019-05-30
CN201910491339 2019-06-06
CN201911128459 2019-11-18
PCT/CN2020/093480 WO2020239107A1 (en) 2019-05-30 2020-05-29 Tetracyclic compounds as cdc7 inhibitors

Publications (1)

Publication Number Publication Date
SG11202113212YA true SG11202113212YA (en) 2021-12-30

Family

ID=73553516

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202113212YA SG11202113212YA (en) 2019-05-30 2020-05-29 Tetracyclic compounds as cdc7 inhibitors

Country Status (12)

Country Link
US (1) US20220235068A1 (en)
EP (1) EP3978501A4 (en)
JP (1) JP2022534316A (en)
KR (1) KR20220027883A (en)
CN (2) CN113874379B (en)
AU (1) AU2020281411A1 (en)
BR (1) BR112021023886A2 (en)
CA (1) CA3142202A1 (en)
IL (1) IL288472A (en)
MX (1) MX2021014629A (en)
SG (1) SG11202113212YA (en)
WO (1) WO2020239107A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114127077B (en) * 2019-08-20 2023-08-01 正大天晴药业集团股份有限公司 Tetrafused ring compounds useful as Cdc7 inhibitors
KR20230116005A (en) * 2020-11-30 2023-08-03 치아타이 티안큉 파마수티컬 그룹 주식회사 Salt forms used as CDC7 inhibitors and crystalline forms thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006517949A (en) * 2003-02-17 2006-08-03 ファルマシア・イタリア・ソシエタ・ペル・アツィオーニ Tetracyclic pyrazole derivatives as kinase inhibitors, methods for producing the derivatives, and pharmaceutical compositions containing the derivatives
EP1621539A1 (en) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Heterocycle -substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
MX353500B (en) * 2010-02-17 2018-01-16 Takeda Pharmaceuticals Co Heterocyclic compound.
TWI738748B (en) * 2016-03-28 2021-09-11 日商武田藥品工業有限公司 Crystalline forms of 2-[(2s)-1-azabicyclo[2.2.2]oct-2-yl]-6-(3-methyl-1h-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3h)-one hemihydrate
JP2020508675A (en) * 2017-03-01 2020-03-26 武田薬品工業株式会社 Methods for predicting the effects of CDC7 inhibitors

Also Published As

Publication number Publication date
BR112021023886A2 (en) 2022-01-18
CN113874379A (en) 2021-12-31
US20220235068A1 (en) 2022-07-28
CA3142202A1 (en) 2020-12-03
EP3978501A4 (en) 2023-05-24
CN116425770A (en) 2023-07-14
AU2020281411A1 (en) 2022-01-06
EP3978501A1 (en) 2022-04-06
CN113874379B (en) 2023-03-31
MX2021014629A (en) 2022-02-23
JP2022534316A (en) 2022-07-28
WO2020239107A1 (en) 2020-12-03
KR20220027883A (en) 2022-03-08
IL288472A (en) 2022-01-01

Similar Documents

Publication Publication Date Title
IL275089A (en) Polycyclic compounds as allosteric shp2 inhibitors
IL268030B (en) Bicyclic compounds as allosteric shp2 inhibitors
ZA202207722B (en) Substituted tricyclic compounds
ZA202206253B (en) Substituted tricyclic compounds
IL290508A (en) Heterocyclic compounds as kinase inhibitors
EP4067359A4 (en) Pyrimidoimidazole compounds used as dna-pk inhibitors
IL289439A (en) Heterocyclic compounds as bet inhibitors
SG11202013016YA (en) Heterocyclic compounds as trk inhibitors
IL289617A (en) Heterocyclic compounds
IL289595A (en) Heterocyclic compounds
GB201819126D0 (en) Inhibitor compounds
IL290087A (en) Inhibitor compounds
IL289389A (en) Heterocyclic compounds as kinase inhibitors
IL287717A (en) Substituted pyrrolopyridines as jak inhibitors
IL288472A (en) Tetracyclic compounds as cdc7 inhibitors
IL288987A (en) New heterocyclic compounds
EP3844166C0 (en) Substituted macrocycles useful as kinase inhibitors
GB201914860D0 (en) Inhibitor compounds
IL271808A (en) New substituted azaindoline derivatives as nik inhibitors
ZA202001503B (en) Tricyclic compounds as histone methyl-transferase inhibitors
EP3641756A4 (en) Tricyclic compounds as cyp1 inhibitors
IL287813A (en) Tricyclic compounds
EP4039331A4 (en) Azepan derivative
IL276887A (en) Chromene derivatives as inhibitors of tcr-nck interaction
SG11202110808SA (en) Organic compounds