BR112021023886A2 - Compostos tetracíclicos como inibidores de cdc7 - Google Patents

Compostos tetracíclicos como inibidores de cdc7

Info

Publication number
BR112021023886A2
BR112021023886A2 BR112021023886A BR112021023886A BR112021023886A2 BR 112021023886 A2 BR112021023886 A2 BR 112021023886A2 BR 112021023886 A BR112021023886 A BR 112021023886A BR 112021023886 A BR112021023886 A BR 112021023886A BR 112021023886 A2 BR112021023886 A2 BR 112021023886A2
Authority
BR
Brazil
Prior art keywords
tetracyclic compounds
cdc7 inhibitors
cdc7
inhibitors
tetracyclic
Prior art date
Application number
BR112021023886A
Other languages
English (en)
Inventor
Z Ding Charles
Gang Li
Lihong Hu
Lun Lu
Shuhui Chen
Zhibo Zhang
Original Assignee
Chia Tai Tianqing Pharmaceutical Group Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chia Tai Tianqing Pharmaceutical Group Co Ltd filed Critical Chia Tai Tianqing Pharmaceutical Group Co Ltd
Publication of BR112021023886A2 publication Critical patent/BR112021023886A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Abstract

compostos tetracíclicos como inibidores de cdc7. uma nova classe de compostos tetracíclicos atuando como inibidores de cdc7; são especificamente divulgados um composto representado pela fórmula (i), isômeros do mesmo ou sais farmaceuticamente aceitáveis do mesmo.
BR112021023886A 2019-05-30 2020-05-29 Compostos tetracíclicos como inibidores de cdc7 BR112021023886A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN201910464384 2019-05-30
CN201910491339 2019-06-06
CN201911128459 2019-11-18
PCT/CN2020/093480 WO2020239107A1 (zh) 2019-05-30 2020-05-29 作为Cdc7抑制剂的四并环类化合物

Publications (1)

Publication Number Publication Date
BR112021023886A2 true BR112021023886A2 (pt) 2022-01-18

Family

ID=73553516

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021023886A BR112021023886A2 (pt) 2019-05-30 2020-05-29 Compostos tetracíclicos como inibidores de cdc7

Country Status (12)

Country Link
US (1) US20220235068A1 (pt)
EP (1) EP3978501A4 (pt)
JP (1) JP2022534316A (pt)
KR (1) KR20220027883A (pt)
CN (2) CN113874379B (pt)
AU (1) AU2020281411A1 (pt)
BR (1) BR112021023886A2 (pt)
CA (1) CA3142202A1 (pt)
IL (1) IL288472A (pt)
MX (1) MX2021014629A (pt)
SG (1) SG11202113212YA (pt)
WO (1) WO2020239107A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114127077B (zh) * 2019-08-20 2023-08-01 正大天晴药业集团股份有限公司 用作Cdc7抑制剂的四并环类化合物
KR20230116005A (ko) * 2020-11-30 2023-08-03 치아타이 티안큉 파마수티컬 그룹 주식회사 Cdc7 억제제로 사용되는 염 형태 및 이의 결정 형태

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006517949A (ja) * 2003-02-17 2006-08-03 ファルマシア・イタリア・ソシエタ・ペル・アツィオーニ キナーゼ阻害剤としての四環系ピラゾール誘導体、前記誘導体の製造方法、および前記誘導体を含む医薬組成物
EP1621539A1 (en) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Heterocycle -substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
MX353500B (es) * 2010-02-17 2018-01-16 Takeda Pharmaceuticals Co Compuesto heterociclico.
TWI738748B (zh) * 2016-03-28 2021-09-11 日商武田藥品工業有限公司 2-[(2s)-1-氮雜雙環[2.2.2]辛-2-基]-6-(3-甲基-1h-吡唑-4-基)噻吩并[3,2-d]嘧啶-4(3h)-酮半水合物之晶形
JP2020508675A (ja) * 2017-03-01 2020-03-26 武田薬品工業株式会社 Ｃｄｃ７阻害剤の効果を予測する方法

Also Published As

Publication number Publication date
CN113874379A (zh) 2021-12-31
US20220235068A1 (en) 2022-07-28
CA3142202A1 (en) 2020-12-03
EP3978501A4 (en) 2023-05-24
CN116425770A (zh) 2023-07-14
AU2020281411A1 (en) 2022-01-06
EP3978501A1 (en) 2022-04-06
CN113874379B (zh) 2023-03-31
MX2021014629A (es) 2022-02-23
JP2022534316A (ja) 2022-07-28
SG11202113212YA (en) 2021-12-30
WO2020239107A1 (zh) 2020-12-03
KR20220027883A (ko) 2022-03-08
IL288472A (en) 2022-01-01

Similar Documents

Publication Publication Date Title
CL2022001731A1 (es) Inhibidores de egfr.
UY38057A (es) Inhibidores de sarcómero cardíaco
CR20210032A (es) Compuestos
EA201500173A1 (ru) Фунгицидные композиции
MX2021013531A (es) Inhibidores de cdk.
ES2657549T3 (es) Piridopirazinas sustituidas como nuevos inhibidores de SYK
BR112023015976A2 (pt) Compostos de anel aromático de pirimidina
BR112021023886A2 (pt) Compostos tetracíclicos como inibidores de cdc7
MX2018001991A (es) Compuestos triciclicos heterociclicos como inhibidores de fosfoinositol 3-quinasa.
AU2018316542A1 (en) Indole derivatives as histone demethylase inhibitors
CO2021001375A2 (es) Compuestos heterocíclicos antihelmínticos
EA201792320A1 (ru) Способ лечения рака ингибитором пути stat3 и ингибитором киназы
BR112022019888A2 (pt) Compostos tricíclicos como inibidores de egfr
BR112021026556A2 (pt) Composto tricíclico, método de preparação para ele e uso dele
MX2022002839A (es) Nuevo compuesto heterocíclico aromático tricíclico, método de preparación del mismo, composición farmacéutica y aplicación del mismo.
PH12017501404A1 (en) Diaza-benzofluoranthrene compounds
CO2024000221A2 (es) Pirimidinil-pirazoles sustituidos como inhibidores de cdk2
BR112022002107A2 (pt) Inibidor de vmat2 e método de preparação para o mesmo e aplicação do mesmo
EA202091481A1 (ru) Замещенные алкиниленовые соединения в качестве противораковых агентов
BR112023020274A2 (pt) Método de preparo de composto bicíclico e aplicação como agente antifúngico
PH12021550248A1 (en) Borate of azetidine derivative
EA202193248A1 (ru) ТЕТРАЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ Cdc7
UY39625A (es) Derivados tricíclicos útiles como inhibidores de parp7
MX2020001412A (es) Compuestos y métodos para tratar la hiperpotasemia.
BR112023016801A2 (pt) Composto tricíclico como inibidor de hif2a, método de preparação e aplicação do mesmo