CN113197864A - 一种酒石酸泰万菌素可溶性粉及其制备方法 - Google Patents
一种酒石酸泰万菌素可溶性粉及其制备方法 Download PDFInfo
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Abstract
本发明公开一种酒石酸泰万菌素可溶性粉及其制备方法,主要由以下原料组成:酒石酸泰万菌素20‑50份,羟丙基‑β‑环糊精50‑80份,pH调节剂0.1‑1份和纯水。本发明工艺简单高效,制备出的酒石酸泰万菌素可溶性粉溶解度增加,稳定性提高,并能遮盖药物的不良气味,降低药物的刺激性,从而提高药物的生物利用度,增强药效、减轻副作用。通过控制喷雾干燥过程中物料粒径大小,提高了产品的流动性,更适合养殖终端的使用。
Description
技术领域
本发明涉及动物医药技术领域,具体涉及一种酒石酸泰万菌素可溶性粉及其制备方法。
背景技术
传统的酒石酸泰万菌素可溶性粉溶解度和稳定性较差,无法遮盖药物的不良气味,且具备一定的刺激性,从而增加了副作用,不利于养殖终端的使用。
发明内容
本发明的目的在于针对现有技术的缺陷和不足,提供一种酒石酸泰万菌素可溶性粉及其制备方法。
为实现上述目的,本发明采用的技术方案是:一种酒石酸泰万菌素可溶性粉,其创新点在于,主要由以下原料组成:酒石酸泰万菌素20-50份,羟丙基-β-环糊精50-80份,pH调节剂0.1-1份和纯水。
一种酒石酸泰万菌素可溶性粉的制备方法,其创新点在于,包括以下步骤:
S1、称取羟丙基-β-环糊精,常温溶解,与纯水比为1-2:5-8W/V,得到羟丙基-β-环糊***溶液;
S2、再按照比例称取酒石酸泰万菌素,溶于羟丙基-β-环糊***溶液中;
S3、常温包埋,搅拌1-2h,获得溶液;
S4、制得的溶液经喷雾干燥,得酒石酸泰万菌素可溶性粉,喷雾干燥过程中将酒石酸泰万菌素可溶性粉粒径控制在150-200μm。
本发明有益效果为:
本发明工艺简单高效,制备出的酒石酸泰万菌素可溶性粉溶解度增加,稳定性提高,并能遮盖药物的不良气味,降低药物的刺激性,从而提高药物的生物利用度,增强药效、减轻副作用。通过控制喷雾干燥过程中物料粒径大小,提高了产品的流动性,更适合养殖终端的使用。
具体实施方式
下面实施例对本发明作进一步的说明。
为了使本发明的目的、技术方案及优点更加清楚明白,以下结合具体实施例,对本发明进行进一步详细说明。应当理解,此处所描述的具体实施方式仅用以解释本发明,并不用于限定本发明。
实施例1
一种酒石酸泰万菌素可溶性粉的制备方法,包括以下步骤:
S1、称取羟丙基-β-环糊精50份,常温溶解,与纯水比为1:5W/V,得到羟丙基-β-环糊***溶液;
S2、再称取酒石酸泰万菌素20份,溶于羟丙基-β-环糊***溶液中;
S3、常温包埋,搅拌1h,获得溶液;
S4、制得的溶液经喷雾干燥,得酒石酸泰万菌素可溶性粉。喷雾干燥过程中将酒石酸泰万菌素可溶性粉粒径控制在150-200μm。
实施例2
一种酒石酸泰万菌素可溶性粉的制备方法,包括以下步骤:
S1、称取羟丙基-β-环糊精80份,常温溶解,与纯水比为2:8W/V,得到羟丙基-β-环糊***溶液;
S2、再称取酒石酸泰万菌素50份,溶于羟丙基-β-环糊***溶液中;
S3、常温包埋,搅拌2h,获得溶液;
S4、制得的溶液经喷雾干燥,得酒石酸泰万菌素可溶性粉。喷雾干燥过程中将酒石酸泰万菌素可溶性粉粒径控制在150-200μm。
实施例3
一种酒石酸泰万菌素可溶性粉的制备方法,包括以下步骤:
S1、称取羟丙基-β-环糊精70份,常温溶解,与纯水比为2:7W/V,得到羟丙基-β-环糊***溶液;
S2、再称取酒石酸泰万菌素40份,溶于羟丙基-β-环糊***溶液中;
S3、常温包埋,搅拌1.5h,获得溶液;
S4、制得的溶液经喷雾干燥,得酒石酸泰万菌素可溶性粉。喷雾干燥过程中将酒石酸泰万菌素可溶性粉粒径控制在150-200μm。
酒石酸泰万菌素改良前后溶解性对比:
(1)改良前后25%酒石酸泰万菌素溶解效果对比:
(2)改良后的25%酒石酸泰万菌素不同溶解浓度溶解效果对比:
从上表可以看出,本发明改良后的酒石酸泰万菌素在溶解性上优于传统改良强的酒石酸泰万菌素。
以上所述,仅用以说明本发明的技术方案而非限制,本领域普通技术人员对本发明的技术方案所做的其它修改或者等同替换,只要不脱离本发明技术方案的精神和范围,均应涵盖在本发明的权利要求范围当中。
Claims (2)
1.一种酒石酸泰万菌素可溶性粉,其特征在于,主要由以下原料组成:酒石酸泰万菌素20-50份,羟丙基-β-环糊精50-80份,pH调节剂0.1-1份和纯水。
2.一种根据权利要求1所述酒石酸泰万菌素可溶性粉的制备方法,其特征在于,包括以下步骤:
S1、称取羟丙基-β-环糊精,常温溶解,与纯水比为1-2:5-8W/V,得到羟丙基-β-环糊***溶液;
S2、再按照比例称取酒石酸泰万菌素,溶于羟丙基-β-环糊***溶液中;
S3、常温包埋,搅拌1-2h,获得溶液;
S4、制得的溶液经喷雾干燥,得酒石酸泰万菌素可溶性粉,喷雾干燥过程中将酒石酸泰万菌素可溶性粉粒径控制在150-200μm。
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CN114642641A (zh) * | 2022-05-24 | 2022-06-21 | 山东国邦药业有限公司 | 一种酒石酸泰万菌素水溶性颗粒剂及其制备方法 |
CN118021765A (zh) * | 2024-04-15 | 2024-05-14 | 中国农业科学院农业环境与可持续发展研究所 | 酒石酸泰万菌素纳米制剂及其制备方法 |
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CN107213470A (zh) * | 2017-06-01 | 2017-09-29 | 中牧南京动物药业有限公司 | 酒石酸泰万菌素可溶性粉及其制备方法 |
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CN114642641A (zh) * | 2022-05-24 | 2022-06-21 | 山东国邦药业有限公司 | 一种酒石酸泰万菌素水溶性颗粒剂及其制备方法 |
CN114642641B (zh) * | 2022-05-24 | 2022-07-26 | 山东国邦药业有限公司 | 一种酒石酸泰万菌素水溶性颗粒剂及其制备方法 |
CN118021765A (zh) * | 2024-04-15 | 2024-05-14 | 中国农业科学院农业环境与可持续发展研究所 | 酒石酸泰万菌素纳米制剂及其制备方法 |
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