CN103539868A - 一种制备羧甲基壳聚糖的方法 - Google Patents
一种制备羧甲基壳聚糖的方法 Download PDFInfo
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- CN103539868A CN103539868A CN201310536202.3A CN201310536202A CN103539868A CN 103539868 A CN103539868 A CN 103539868A CN 201310536202 A CN201310536202 A CN 201310536202A CN 103539868 A CN103539868 A CN 103539868A
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- Prior art keywords
- chitosan
- sodium salt
- preparing
- chitin
- quality
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- 229920001661 Chitosan Polymers 0.000 title claims abstract description 151
- 238000000034 method Methods 0.000 title claims abstract description 37
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 title claims abstract description 18
- 159000000000 sodium salts Chemical class 0.000 claims abstract description 51
- 238000003381 deacetylation reaction Methods 0.000 claims abstract description 24
- 229920002101 Chitin Polymers 0.000 claims abstract description 23
- 238000006467 substitution reaction Methods 0.000 claims abstract description 19
- 238000006243 chemical reaction Methods 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 238000006473 carboxylation reaction Methods 0.000 claims abstract description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 29
- 230000006196 deacetylation Effects 0.000 claims description 22
- 239000007864 aqueous solution Substances 0.000 claims description 20
- 238000003756 stirring Methods 0.000 claims description 19
- FOCAUTSVDIKZOP-UHFFFAOYSA-N chloroacetic acid Chemical compound OC(=O)CCl FOCAUTSVDIKZOP-UHFFFAOYSA-N 0.000 claims description 12
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 11
- 230000018044 dehydration Effects 0.000 claims description 11
- 238000006297 dehydration reaction Methods 0.000 claims description 11
- 238000001035 drying Methods 0.000 claims description 10
- 238000013019 agitation Methods 0.000 claims description 9
- 238000004090 dissolution Methods 0.000 claims description 9
- 229960004756 ethanol Drugs 0.000 claims description 9
- 230000003252 repetitive effect Effects 0.000 claims description 9
- 238000005201 scrubbing Methods 0.000 claims description 9
- 239000003513 alkali Substances 0.000 claims description 6
- 230000007935 neutral effect Effects 0.000 claims description 5
- 230000021523 carboxylation Effects 0.000 abstract 1
- 238000012668 chain scission Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 238000009776 industrial production Methods 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 33
- 238000005516 engineering process Methods 0.000 description 16
- 239000000243 solution Substances 0.000 description 12
- 239000003814 drug Substances 0.000 description 10
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 239000002253 acid Substances 0.000 description 2
- 239000003929 acidic solution Substances 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000008065 acid anhydrides Chemical class 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 229940089960 chloroacetate Drugs 0.000 description 1
- FOCAUTSVDIKZOP-UHFFFAOYSA-M chloroacetate Chemical compound [O-]C(=O)CCl FOCAUTSVDIKZOP-UHFFFAOYSA-M 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Landscapes
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Cosmetics (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
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CN201310536202.3A CN103539868B (zh) | 2013-11-01 | 2013-11-01 | 一种制备羧甲基壳聚糖的方法 |
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CN201310536202.3A CN103539868B (zh) | 2013-11-01 | 2013-11-01 | 一种制备羧甲基壳聚糖的方法 |
Publications (2)
Publication Number | Publication Date |
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CN103539868A true CN103539868A (zh) | 2014-01-29 |
CN103539868B CN103539868B (zh) | 2016-05-04 |
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CN201310536202.3A Active CN103539868B (zh) | 2013-11-01 | 2013-11-01 | 一种制备羧甲基壳聚糖的方法 |
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Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111363064A (zh) * | 2020-04-28 | 2020-07-03 | 东华大学 | 一种高取代度和高分子量的羧甲基壳聚糖的制备方法 |
CN112125984A (zh) * | 2020-11-03 | 2020-12-25 | 江苏金壳生物医药科技有限公司 | 一种羧甲基壳聚糖的制备方法 |
CN112813527A (zh) * | 2020-12-28 | 2021-05-18 | 江苏品创纺织科技有限公司 | 甲壳素纤维混纺防霉织物 |
US11123438B2 (en) | 2016-08-19 | 2021-09-21 | Ampsource Biopharma Shanghai Inc. | Linker peptide for constructing fusion protein |
CN113599391A (zh) * | 2021-08-24 | 2021-11-05 | 上海陶盛生物技术有限公司 | 羧甲基壳聚糖用于促进皮肤伤口愈合、修复皮肤屏障的用途 |
EP3981798A1 (en) | 2020-10-10 | 2022-04-13 | Shandong Eton New Material Co., Ltd. | Modified chitosan, preparation method thereof, and additive for tile adhesive and use thereof |
US11471513B2 (en) | 2016-08-19 | 2022-10-18 | Ampsource Biopharma Shanghai Inc. | Highly glycosylated human blood-clotting factor VIII fusion protein, and manufacturing method and application of same |
US11472863B2 (en) | 2016-08-19 | 2022-10-18 | Ampsource Biopharma Shanghai Inc. | Human coagulation factor IX (FIX) fusion protein, preparation method therefor, and use thereof |
US11981718B2 (en) | 2020-05-27 | 2024-05-14 | Ampsource Biopharma Shanghai Inc. | Dual-function protein for lipid and blood glucose regulation |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4619995A (en) * | 1984-12-24 | 1986-10-28 | Nova Chem Limited | N,O-carboxymethyl chitosan and preparative method therefor |
CN1271580A (zh) * | 2000-04-20 | 2000-11-01 | 中国科学院地理研究所 | 治疗和预防铅中毒的药物及其制法 |
FR2865210A1 (fr) * | 2004-01-20 | 2005-07-22 | Oreal | Procede de preparation de derives de chitosane, derives obtenus, compositions les comprenant et procede de traitement |
CN102716073A (zh) * | 2012-06-20 | 2012-10-10 | 石家庄亿生堂医用品有限公司 | 医用羧甲基壳聚糖防粘连剂及其制备方法 |
CN103374080A (zh) * | 2012-04-16 | 2013-10-30 | 扬州鸿信生物制品有限公司 | 一种制备羧甲基壳聚糖的方法 |
-
2013
- 2013-11-01 CN CN201310536202.3A patent/CN103539868B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4619995A (en) * | 1984-12-24 | 1986-10-28 | Nova Chem Limited | N,O-carboxymethyl chitosan and preparative method therefor |
CN1271580A (zh) * | 2000-04-20 | 2000-11-01 | 中国科学院地理研究所 | 治疗和预防铅中毒的药物及其制法 |
FR2865210A1 (fr) * | 2004-01-20 | 2005-07-22 | Oreal | Procede de preparation de derives de chitosane, derives obtenus, compositions les comprenant et procede de traitement |
CN103374080A (zh) * | 2012-04-16 | 2013-10-30 | 扬州鸿信生物制品有限公司 | 一种制备羧甲基壳聚糖的方法 |
CN102716073A (zh) * | 2012-06-20 | 2012-10-10 | 石家庄亿生堂医用品有限公司 | 医用羧甲基壳聚糖防粘连剂及其制备方法 |
Non-Patent Citations (1)
Title |
---|
刘长霞,等: "一锅连续法制备羧甲基壳聚糖工艺研究", 《高分子材料科学与工程》 * |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11123438B2 (en) | 2016-08-19 | 2021-09-21 | Ampsource Biopharma Shanghai Inc. | Linker peptide for constructing fusion protein |
US11471513B2 (en) | 2016-08-19 | 2022-10-18 | Ampsource Biopharma Shanghai Inc. | Highly glycosylated human blood-clotting factor VIII fusion protein, and manufacturing method and application of same |
US11472863B2 (en) | 2016-08-19 | 2022-10-18 | Ampsource Biopharma Shanghai Inc. | Human coagulation factor IX (FIX) fusion protein, preparation method therefor, and use thereof |
US11833212B2 (en) | 2016-08-19 | 2023-12-05 | Ampsource Biopharma Shanghai Inc. | Linker peptide for constructing fusion protein |
CN111363064A (zh) * | 2020-04-28 | 2020-07-03 | 东华大学 | 一种高取代度和高分子量的羧甲基壳聚糖的制备方法 |
CN111363064B (zh) * | 2020-04-28 | 2022-03-15 | 东华大学 | 一种高取代度和高分子量的羧甲基壳聚糖的制备方法 |
US11981718B2 (en) | 2020-05-27 | 2024-05-14 | Ampsource Biopharma Shanghai Inc. | Dual-function protein for lipid and blood glucose regulation |
EP3981798A1 (en) | 2020-10-10 | 2022-04-13 | Shandong Eton New Material Co., Ltd. | Modified chitosan, preparation method thereof, and additive for tile adhesive and use thereof |
CN112125984A (zh) * | 2020-11-03 | 2020-12-25 | 江苏金壳生物医药科技有限公司 | 一种羧甲基壳聚糖的制备方法 |
CN112813527A (zh) * | 2020-12-28 | 2021-05-18 | 江苏品创纺织科技有限公司 | 甲壳素纤维混纺防霉织物 |
CN113599391A (zh) * | 2021-08-24 | 2021-11-05 | 上海陶盛生物技术有限公司 | 羧甲基壳聚糖用于促进皮肤伤口愈合、修复皮肤屏障的用途 |
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Publication number | Publication date |
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CN103539868B (zh) | 2016-05-04 |
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Owner name: SHANGHAI CHUNLU BIOCHEMISTRY CO., LTD. Free format text: FORMER OWNER: XU YUFAN Effective date: 20140408 |
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Free format text: CORRECT: ADDRESS; FROM: 201800 JIADING, SHANGHAI TO: 201814 JIADING, SHANGHAI |
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Effective date of registration: 20140408 Address after: 201814 Shanghai Jiading District Anting town Baoan Road East ring junction Applicant after: Shanghai Chunlu Biochemistry Co., LTD. Address before: 201800, room 77, No. 3885, Lane 801, Shanghai Yi Road, Shanghai, Jiading District Applicant before: Xu Yufan |
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