CN108849948A - A kind of bactericidal composition containing captan Yu the gloomy copper of thiophene - Google Patents
A kind of bactericidal composition containing captan Yu the gloomy copper of thiophene Download PDFInfo
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- CN108849948A CN108849948A CN201810863851.7A CN201810863851A CN108849948A CN 108849948 A CN108849948 A CN 108849948A CN 201810863851 A CN201810863851 A CN 201810863851A CN 108849948 A CN108849948 A CN 108849948A
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- Prior art keywords
- thiophene
- captan
- gloomy copper
- bactericidal composition
- composition containing
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom
- A01N47/04—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom containing >N—S—C≡(Hal)3 groups
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
A kind of bactericidal composition containing captan Yu the gloomy copper of thiophene, invention has apparent synergistic effect using captan and the gloomy copper of thiophene as the composite bactericide of effective component, delay the generation of key drug resistance, and reduce production and application costs, can be used for the improvement of resistance disease.There is preferable control efficiency to Chinese cabbage gray mold.
Description
Technical field
Present invention relates particularly to technical field of pesticide compounding, and in particular to a kind of sterilization group containing captan Yu the gloomy copper of thiophene
Close object.
Background technique
Captan is called Cape Town, belongs to the organic sulfurcontaining fungicide of conventional multi-bit point, based on protective effect, has concurrently certain
Therapeutic effect, the whole world have nearly 50 years sales histories.Currently, it is that hat imperial agrochemical in Hebei has that earliest enterprise is registered by the country
Limit company, while being also the captan raw medicine export enterprise of first domestic raw medicine and preparation while registered producer, largest domestic.Its
Preparation trade name new trend (50% wettable powder), Mei get Le (80% water dispersible granules).
Captan wide sterilization spectrum, application mode is more various, can be used for foliar spray and prevents and treats a variety of high and low equal fungoid diseases
Evil, potato, peanut seed dressing, it can also be used to soil treatment (punching applies, pouring root, mixes soil and spreads fertilizer over the fields), prevention and treatment various crop root disease
Evil.
The gloomy copper of thiophene is thiazoles organic copper fungicide, mainly prevents and treats bacterial blight of rice, bacterial stripe, the soft corruption of Chinese cabbage
Disease and bacterial wilt of tomato.High-efficiency broad spectrum, toxicity is low, safety and environmental protection, nuisanceless, to bacterial disease special efficacy, to fungal disease
Efficiently, stable in acid condition, it can be with other combined use of pesticides.
Application chemical agent is the most effective means of controlling plant diseases.But it applies to long-term continuous high dose single
Chemical bactericide, the problems such as be easy to causeing the residual of medicament, environmental pollution and drug-resistant fungi to develop.Reasonable chemistry
It is bactericide compounded or it is mixed have expand fungicidal spectrum, improve control efficiency, extend the optimum period for applying fertilizer, reduce dosage, reduce phytotoxicity,
The positive features such as residual, the generation for delaying drug resistance of fungi and development are reduced, bactericide compounded is to solve above-mentioned ask
One of the maximally efficient method of topic.It is constantly soaring to develop new product fungicide price, and in contrast, exploitation with research efficiently,
Low toxicity, low-residual compounding and mixture have small investment, the lead time is short and is paid attention to both at home and abroad, one after another increasing develop
Dynamics.We filter out captan and are compounded with the gloomy copper of thiophene based on the indoor screening and field trials, have apparent
Synergistic effect.And about captan with the bactericidal composition of the gloomy copper of thiophene compounded and using it has not been reported so far.
Summary of the invention
In order to overcome the problems of the above-mentioned prior art, a kind of Bactericidal composite containing captan Yu the gloomy copper of thiophene is provided
Object.
The technical solution that the present invention uses is：A kind of bactericidal composition containing captan Yu the gloomy copper of thiophene, it is described
Bactericidal composition is compounded by captan with the gloomy copper of thiophene, remaining is adjunct ingredient, the quality of the captan and the gloomy copper of thiophene
Than being 1:40-40:1.
The mass ratio of the captan and the gloomy copper of thiophene is 1:2.
The gross mass of the captan and the gloomy copper of thiophene accounts for the 1-30% of entire Bactericidal composite amount of substance.
The gross mass of the captan and the gloomy copper of thiophene accounts for the 30% of entire Bactericidal composite amount of substance.
The bactericidal composition be missible oil, suspending agent, wettable powder, water dispersible granules, aqueous emulsion, microemulsion,
One of granula, microcapsule formulations.
Application of the bactericidal composition of the captan and the gloomy copper of thiophene in prevention and treatment Chinese cabbage gray mold.
The beneficial effects of the invention are as follows：The present invention provides a kind of bactericidal composition containing captan Yu the gloomy copper of thiophene, hair
It is bright that there is apparent synergistic effect using captan and the gloomy copper of thiophene as the composite bactericide of effective component, delay the production of key drug resistance
It is raw, and production and application costs are reduced, it can be used for the improvement of resistance disease.Have to Chinese cabbage gray mold preferable anti-
Control effect.
Specific embodiment
The present invention will now be described in detail with reference to examples, and the examples are only preferred embodiments of the present invention,
It is not limitation of the invention.
Test objective
Captan and the gloomy copper single dose of thiophene are tested to great Bai using Plating by the commission of Zhejiang east wind Chemical Co., Ltd.
The indoor bactericidal activity of dish gray mold carries out verifying screening, provides foundation for field trial and next step research and development.
Experimental condition
For trying pathogen
Chinese cabbage ash arrhizus bacteria (strain is that culture saves strain from generation to generation for a long time in this laboratory).
Instrument and equipment
Sartorius BP211D 0.01mg electronic balance, 100-1000 μ l of eppendorf research, liquid relief
Rifle, microscope, pipette, conical flask, graduated cylinder, beaker, punch, slide calliper rule, culture dish, stainless steel medicine spoon, electric heating air blast are dry
Dry case, incubator etc..
Isolated test condition
Using PSA culture medium, i.e. potato 20-25%, sucrose 2%, agar powder 1.2% and water.PH is naturally, by potato
Peeling, is cut into small pieces, boils in water-bath half an hour, and double gauze filtering adds sucrose, agar powder, constant volume after dissolution.Triangle is dispensed to burn
Bottle, 121 DEG C, high pressure sterilization 25-30 minutes, is poured into plate, every ware 10ml, and access test bacteria strain, sets 25 DEG C -26 after solidification
DEG C or so incubator culture after it is spare.
Experimental design
Reagent agent
95% captan TC；
The gloomy copper TC of 92% thiophene (offer of Zhejiang east wind Chemical Co., Ltd.).
Other reagents
N,N-dimethylformamide, acetone.
Test dose design
Specific test dose design is shown in Table l.
Processing mode
Testing time
On May 16th, 2018
Handle the time
On May 18th, 2018
Administrated method
Plating
Test method
Reference《Farm-chemical indoor determination test rule fungicide part 2：Inhibit disease fungus mycelia growth test flat
Ware method》Method carry out bioassay：I.e. inoculation test bacterium, bacteria cake diameter 5mm are subsequently placed on configured toxic medium
It is cultivated in 24.3 DEG C or so of incubator.
Investigation method：
Investigation method：Measurement colony growth diameter (mm) is measured with slide calliper rule after cultivating 3 days in the incubator,
Each bacterium colony diameter is measured perpendicularly using the crisscross method, takes its average value, calculates after deducting bacteria cake diameter
The diameter of bacterium colony growth.
Data statistic analysis：
Calculation method
According to investigation result, each concentration for the treatment of is calculated to for examination target bacterium by formula (1), (2)
Mycelial growth inhibition rate, unit are percentage (%), and calculated result retains 2 significant digits.
D=Dl-D2............. (1)
In formula：D- bacterium colony increases diameter；Mono- colony diameter of D1；Mono- bacteria cake diameter of D2.
I=(D0-Dt) × 100/D0............. (2)
In formula：Mono- mycelial growth inhibition rate of I；Mono- blank control mycelia growth diameter of D0；Mono- chemicals treatment bacterium colony of Dt increases
Diameter.
Statistical disposition
Make regression analysis according to each drug concentration logarithm and corresponding mycelial growth inhibition rate probit value, each medicament
EC50、EC90, 95% confidence limit.The total poison system (CTC) of mixture is calculated according still further to Sun Yunpei's Method.The performance of the compounding agent of CTC >=100 increases
Effect；The compounding agent of CTC≤80 shows antagonism：80<CTC<100 compounding agents show as being added.Specific formula for calculation is as follows：
ATI=S × 100/M.............. (3)
The toxicity index that mono- mixture of ATI is surveyed in formula；The EC50 of mono- standard agent of S, unit are milligrams per liter (mg/L)；M
One for try mixture EC50, unit be milligrams per liter (mg/L).
TTI=TIA × PA+TIB × PB....... (4)
The theoretical toxicity index of TTI- mixture in formula；TIA-A medicament toxicity index；Percentage of the PA-A medicament in intermixture
Content, unit are percentage (%)；TIB-B medicament toxicity index；Percentage composition of the PB-B medicament in intermixture, unit hundred
Divide rate (%).
CTC=ATI × 100/TTI....... (5)
CTC- co-toxicity coefficient in formula；ATI- mixture surveys toxicity index；TTI- mixtures theoretical toxicity index.
Toxicity test
2 captan of table and the gloomy copper single dose of thiophene and compounding are with comparison Chinese cabbage gray mold plate measurement result
As can be seen from Table 2 captan and thiophene gloomy copper compounding with the EC50 value for comparing Chinese cabbage gray mold be 8.7788~
13.8363mg/L, EC90 value are 48.0271~113.5185mg/L.
Synergy evaluation
3 captan of table and the gloomy copper compounding of thiophene are with the synergy evaluation for comparing Chinese cabbage gray mold
The 1 of captan and thiophene gloomy copper compounding as can be seen from Table 3：2 with compare Chinese cabbage gray mold co-toxicity coefficient be
115.87 all having synergistic effect.
Conclusion
Captan and the gloomy copper of thiophene have good bacteriostatic activity to Chinese cabbage gray mold.There is apparent increase after the two compounding
Effect effect.In conjunction with indexs such as EC50 and co-toxicity coefficients, the proportion 1 of captan and the gloomy copper of thiophene that enterprise provides:2 have reasonability,
It can further research and develop.
4 captan of table, the gloomy copper of thiophene and the gloomy copper (1 of captan thiophene:2) Chinese cabbage gray mold result (after medicine 2 days) are prevented and treated
The above is only a preferred embodiment of the present invention, protection scope of the present invention is not limited merely to above-mentioned implementation
Example, all technical solutions belonged under thinking of the present invention all belong to the scope of protection of the present invention.It should be pointed out that for the art
Those of ordinary skill for, several improvements and modifications without departing from the principles of the present invention, these improvements and modifications
It should be regarded as protection scope of the present invention.
Claims (6)
1. a kind of bactericidal composition containing captan Yu the gloomy copper of thiophene, which is characterized in that the bactericidal composition is by captan
It is compounded with the gloomy copper of thiophene, remaining is adjunct ingredient, and the mass ratio of the captan and the gloomy copper of thiophene is 1:40-40:1.
2. a kind of bactericidal composition containing captan Yu the gloomy copper of thiophene according to claim 1, which is characterized in that described
The mass ratio of captan and the gloomy copper of thiophene is 1:2.
3. a kind of bactericidal composition containing captan Yu the gloomy copper of thiophene according to claim 1, which is characterized in that described
The gross mass of captan and the gloomy copper of thiophene accounts for the 1-30% of entire Bactericidal composite amount of substance.
4. a kind of bactericidal composition containing captan Yu the gloomy copper of thiophene according to claim 3, which is characterized in that described
The gross mass of captan and the gloomy copper of thiophene accounts for the 30% of entire Bactericidal composite amount of substance.
5. a kind of bactericidal composition containing captan Yu the gloomy copper of thiophene according to claim 1, which is characterized in that described
Bactericidal composition is missible oil, in suspending agent, wettable powder, water dispersible granules, aqueous emulsion, microemulsion, granule, microcapsule formulations
One kind.
6. a kind of bactericidal composition containing captan Yu the gloomy copper of thiophene according to claim 1, which is characterized in that described
Application of the bactericidal composition of captan and the gloomy copper of thiophene in prevention and treatment Chinese cabbage gray mold.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810863851.7A CN108849948A (en) | 2018-08-01 | 2018-08-01 | A kind of bactericidal composition containing captan Yu the gloomy copper of thiophene |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810863851.7A CN108849948A (en) | 2018-08-01 | 2018-08-01 | A kind of bactericidal composition containing captan Yu the gloomy copper of thiophene |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4066760A (en) * | 1976-03-29 | 1978-01-03 | Kumiai Chemical Industries Ltd. | Agricultural and horticultural fungicidal compositions |
| CN105851058A (en) * | 2015-01-21 | 2016-08-17 | 陕西汤普森生物科技有限公司 | Sterilization composition containing captan and copper preparation |
| CN108244128A (en) * | 2018-03-13 | 2018-07-06 | 陕西康禾立丰生物科技药业有限公司 | A kind of bactericidal composition containing fenbendazole and copper agent |
-
2018
- 2018-08-01 CN CN201810863851.7A patent/CN108849948A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4066760A (en) * | 1976-03-29 | 1978-01-03 | Kumiai Chemical Industries Ltd. | Agricultural and horticultural fungicidal compositions |
| CN105851058A (en) * | 2015-01-21 | 2016-08-17 | 陕西汤普森生物科技有限公司 | Sterilization composition containing captan and copper preparation |
| CN108244128A (en) * | 2018-03-13 | 2018-07-06 | 陕西康禾立丰生物科技药业有限公司 | A kind of bactericidal composition containing fenbendazole and copper agent |
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Application publication date: 20181123 |
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