CN104770373A - Sterilization composition containing quinolinone and metconazole - Google Patents
Sterilization composition containing quinolinone and metconazole Download PDFInfo
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- CN104770373A CN104770373A CN201510183719.8A CN201510183719A CN104770373A CN 104770373 A CN104770373 A CN 104770373A CN 201510183719 A CN201510183719 A CN 201510183719A CN 104770373 A CN104770373 A CN 104770373A
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- metconazole
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Abstract
The invention provides a sterilization composition containing active components including quinolinone and metconazole. The weight ratio of quinolinone to metconazole ranges from (1:15) to (15:1). The sterilization composition can be prepared into water dispersible granule, wettable powder or a suspending agent with agriculturally proper auxiliary agents. The sterilization composition provided by the invention has reasonable components, and has treatment and protection effects, good sterilization effect and low drug use cost; the activity and the sterilization effect are not the simple superposition of all the components, and the sterilization composition has a remarkable synergistic effect, has good crop safety and meets the safety requirements of pesticide preparations; and the sterilization composition has a relatively prevention and treatment effect on apple alternaria leaf spot.
Description
Technical field
The present invention relates to pesticide field, particularly bactericide field, particularly, the present invention relates to a kind of containing copper 8-hydroxyquinolinate and the metconazole bactericidal composition as active component.
Background technology
Copper 8-hydroxyquinolinate is typical organic chelated copper systemic fungicide, there is extremely strong adhesion strength and resistance of rainwater washing against ability, in addition copper 8-hydroxyquinolinate also possesses that safety is high, fungicidal spectrum is wide, the lasting period is long, the features such as cost is low, to control bacterial disease, there is special efficacy, also have efficient to fungal disease control, alternative conventional Inorganic Copper series bactericidal agent, for preventing and treating various bacillary and fungal disease on fruit tree, vegetables.Copper 8-hydroxyquinolinate has the feature of organic quinolines and mantoquita concurrently, there is double sterilization activity, its mechanism of action that has its source in is unique: organic quinolines suppresses the metabolism of germ spore, control cell again divide and break up, chelated copper ion is absorbed by the pathogeny bacterium spore sprouted simultaneously, directly kill spore cell in pathogeny bacterium inside, thus reach the effect of diseases prevention; All to be had by fungi, bacterial multiple diseases crop and kill significantly and inhibitory action, and can the activity of various enzyme in stimulating plant body, there is raising photosynthesis, growth promoting effects, purification fruit face, increase yield, the effects such as oil recovery enhancement.
Metconazole (Metconazole); chemical name: 5-(4-chlorobenzyl)-2; 2-dimethyl-1 (1H-1; 2; 4-triazole-1-ylmethyl) cyclopentanol, be a kind of New-type wide-spectrum systemic fungicide, have excellent protection and therapeutic action concurrently; can do cauline leaf process and can make seed treatment again, be C-14 demethylation enzyme inhibitor in sterol biosynthesis.Although the mechanism of action is the same with other triazole bactericidal agents, activity profile then difference is comparatively large, and two kinds of isomer have bactericidal activity, and wherein Cis activity is higher than trans.The antifungal spectrum of metconazole is widely, and active splendid, compares with conventional sterilants, and dosage is extremely low and prevent and treat cereal to plant disease scope very wide, is mainly used in preventing and treating cereal crop, as wheat, paddy rice, to Septoria and rust superior activity.To vegetables, fruit tree etc., also there is good control efficiency.
The same with many bactericide that is efficient, wide spectrum, the single agricultural chemicals of uses a large amount of for a long time, all can make disease develop immunity to drugs, and increases amount of application, strengthens cost accounting, also produces a series of environmental problem simultaneously and cause certain threat to the safety problem of food.Use the bactericide of the different mechanism of action to carry out composite, this method can not only reduce applications of pesticide amount, improve practical function effect, increasing action site, and expanding prevention crop and object spectrum, can also delay the generation of viral resistance.
Summary of the invention
The object of the present invention is to provide a kind of component reasonable, synergistic effect is remarkable, and bactericidal effect is good, and drug cost is low, and can delay pesticide resistance and agricultural bactericidal composition to crop safety.
Technical scheme involved in the present invention is as follows:
A kind of bactericidal composition, it is characterized in that, described composition comprises active component copper 8-hydroxyquinolinate and metconazole, and the weight ratio of the two is 1:15-15:1.
Preferably, the weight ratio of the two is 1:0-10:1; Be more preferably 1:5-5:1, most preferably be 1:2-2:1.
A kind of bactericide, is characterized in that, 5 ~ 90 % by weight above-mentioned bactericidal compositions that described bactericide comprises and agriculturally suitable auxiliary agent.Be preferably 8 ~ 75 % by weight.
Described bactericide is water dispersible granules, wetting powder, suspending agent according to the preparation formulation that method known in those skilled in the art can be prepared.
For water dispersible granules, those skilled in the art are familiar with the corresponding auxiliary agent of use and complete the present invention very much.Dispersant as in polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate one or more; Wetting agent as in alkyl sulfate, alkylsulfonate, naphthalene sulfonate one or more; Disintegrant as in ammonium sulfate, urea, sucrose, glucose one or more; Binding agent is as one or more in diatomite, corn starch, PVA, carboxymethyl (ethyl) cellulose family; Filler as diatomite, kaolin, white carbon, fine particle calcium carbonate, talcum powder, attapulgite, potter's clay one or more.
To wetting powder, spendable auxiliary agent has: dispersant as in polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate one or more; Wetting agent as in alkyl sulfate, alkylsulfonate, naphthalene sulfonate one or more; Filler as ammonium sulfate, urea, sucrose, glucose, diatomite, kaolin, white carbon, fine particle calcium carbonate, talcum powder, attapulgite, potter's clay one or more.
To suspending agent, spendable auxiliary agent has: dispersant such as polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate (dispersing agent NNO), Huntsman Corporation of the TERSPERSE 2020(U.S. produce, alkyl naphthalene sulfonic acid salt) in one or more; Emulsifier is as Nongru-700 #(common name: alkyl phenol formaldehyde resin polyoxyethylene ether), agriculture breast 2201, this dish-60#(common name: Span60), Tween-60 #(common name: polyoxyethylene sorbitan stearate), agriculture breast 1601#(common name: triphenoethyl benzene phenol polyoxyethylene polyoxypropylene block polymer), Huntsman Corporation of the TERSPERSE 4894(U.S. produces) in one or more; Wetting agent such as alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate, alkylphenol-polyethenoxy base ether phosphate, phenethyl phenol polyethenoxy base ether phosphate, alkyl sulfate, alkylsulfonate, naphthalene sulfonate, Huntsman Corporation of the TERSPERSE 2500(U.S. produce) in one or more; Thickener as in xanthans, polyvinyl alcohol, bentonite, aluminium-magnesium silicate one or more; Preservative as in formaldehyde, benzoic acid, Sodium Benzoate one or more; Defoamer is as organic silicon defoamer; Antifreezing agent as ethylene glycol, propane diols, glycerine, urea, inorganic salts as in sodium chloride one or more; Water is deionized water.
Another object of the present invention is to provide above-mentioned bactericidal composition or the application of bactericide on control alternaria leaf spot of apple.
Beneficial effect: instant component is reasonable, treatment adds protective effect, and bactericidal effect is good; drug cost is low, and its activity and bactericidal effect are not the simple superposition of each composition activity, but has significant synergistic effect; good to crop safety, meet the security requirement of pesticidal preparations.The present invention has good control efficiency to alternaria leaf spot of apple.
Embodiment
In order to prevent and treat the alternaria leaf spot of apple in agricultural production, inventor has carried out composite synergy research with copper 8-hydroxyquinolinate and metconazole, and concrete grammar is:
Subjects be respectively alternaria leaf spot of apple (
alternaria mali), former medicine is mixed with the test medicine of needs, test method is with reference to " People's Republic of China's agricultural industry criteria NY/T1156.2-2006 ".First single dose and Mixed Pharmacy are arranged 5 variable concentrations gradients (on the basis of preliminary experiment result, different with proportioning according to different agents combination, concentration gradient arranges also different, and bacteriostasis rate sets by geometric progression in the scope of 5% ~ 90%).If clear water contrasts, repeat 3 times.Adopt mycelial growth rate method, by cultured pathogen, be aseptically 5 mm card punch with diameter, cut bacterium cake from colony edge, with transfer needle, bacterium cake is connected on the culture medium flat plate of different agents concentration, put 27 DEG C, cultivate in saturated humidity incubator; When control group bacterium colony covers with, measure colony diameter, calculate the percentage that each chemicals treatment suppresses mycelial growth, by the linear regression analysis between the probit value of inhibiting rate and the logarithm value of series concentration, obtain the EC50 value of each medicament, calculate the co-toxicity coefficient (CTC) of mixture by the abundant method of Sun Yun, evaluate the activity of reagent agent to germ with this.
The co-toxicity coefficient (CTC) >=120 of complex preparation shows as synergistic effect; CTC≤80 show as antagonism; 80 < CTC < 120 show as summation action.Test and result of calculation are as shown in table 1.
The Toxicity Determination of table 1 Alternaria mali
| Chemicals treatment | Virulence regression equation | Correlation coefficient (r) | EC 50（mg/L） | Co-toxicity coefficient (CTC) |
| Copper 8-hydroxyquinolinate (A) | Y=-0.754+2.564X | 0.9834 | 1.969 | - |
| Metconazole (B) | Y=-0.949+1.841X | 0.9985 | 3.274 | - |
| A:B=15:1 | Y=-0.578+2.672X | 0.9925 | 1.646 | 122.7 |
| A:B=10:1 | Y=-0.481+2.850X | 0.9905 | 1.475 | 138.5 |
| A:B=5:1 | Y=-0.365+3.318X | 0.9869 | 1.288 | 163.8 |
| A:B=2:1 | Y=-0.253+3.571X | 0.9955 | 1.177 | 192.9 |
| A:B=1:1 | Y=-0.381+3.219X | 0.9965 | 1.313 | 187.3 |
| A:B=1:2 | Y=-0.525+2.783X | 0.9859 | 1.543 | 173.8 |
| A:B=1:5 | Y=-0.799+2.919X | 0.9955 | 1.878 | 157.0 |
| A:B=1:10 | Y=-0.799+2.919X | 0.9925 | 2.14 | 144.3 |
| A:B=1:15 | Y=-0.876+2.301X | 0.9889 | 2.403 | 130.8 |
Toxicity Determination result shows: copper 8-hydroxyquinolinate and metconazole take weight ratio as 1:15 ~ 15: 1 mixedly has good virulence to Alternaria mali, all has significant synergistic effect, wherein 2:1-1:2 best results.
Below in conjunction with example of formulations and biological Examples, content of the present invention is described further.
Example of formulations 1
Take 30% copper 8-hydroxyquinolinate, 3% metconazole, 2% calcium lignosulfonate, 2% dispersing agent NNO, 1% Nekal BX, 1%K-12, attapulgite add to 100% weight portion.Above-mentioned raw materials, through mixing, obtains 33% copper 8-hydroxyquinolinate metconazole wetting powder after air-flow crushing.
Example of formulations 2
Take 50% copper 8-hydroxyquinolinate, 10% metconazole, 5% calcium lignosulfonate, 2% Nekal BX, 2%K-12,5% White Carbon black, kaolin adds to 100% weight portion.Above-mentioned raw materials, through mixing, obtains 60% copper 8-hydroxyquinolinate metconazole wetting powder after air-flow crushing.
Example of formulations 3
Take 30% copper 8-hydroxyquinolinate, 15% metconazole, 5%TERSPERSE 4894,2%TERSPERSE 2500,3%TERSPERSE 2020,0.2% xanthans, 5% propane diols, 0.5% benzoic acid, 0.5% silicone defoaming agent, deionized water add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear dispersion 30min, with 45% copper 8-hydroxyquinolinate metconazole suspending agent obtained after sand mill sand milling.
Example of formulations 4
Take 10% copper 8-hydroxyquinolinate, 30% metconazole, this dish of 2%TERSPERSE 2020,2%-60#, 2% Tween-60 #, 1%TERSPERSE 2500,0.5% white carbon, 0.3% xanthans, 5% ethylene glycol, 0.5% benzoic acid, 0.5% silicone defoaming agent, deionized water add to 100% weight portion.Above-mentioned raw materials is through mixing, and high speed shear dispersion 30min, with 40% copper 8-hydroxyquinolinate metconazole suspending agent obtained after sand mill sand milling.
Example of formulations 5
Take 25% copper 8-hydroxyquinolinate, 25% metconazole, 4% TERSPERSE 2700,2% dispersing agent NNO, 2% Nekal BX (nekal), 2%K-12,3% corn starch, 5% ammonium sulfate, attapulgite add to 100% weight portion.Namely the method for above-mentioned raw materials frequent regulation water intaking dispersible granule mixes, ultra micro air-flow crushing, mixing, granulation step produce 50% copper 8-hydroxyquinolinate metconazole water dispersible granules.
Biological Examples: control alternaria leaf spot of apple field trial
Test is located at Fushan District, Yantai City Dong Motang.Trial crops is apple tree, and kind is new Red Star, and controlling object is apple peels and cores (Alternaria mali).Test garden seeding row spacing 2.5 × 3m2, the cultivation condition (soil types, fertility, farming etc.) of all experimental plots is consistent, age of tree life in 18 years, and spot defoliation over the years occurs seriously and evenly.Duration of test apple growth period be autumn growth pumping initial stage ~ autumn growth stop the pumping phase.Every community 3 strain becomes fruit tree in age, if protection row, if blank, random district group arranges.The dispenser first of autumn growth premorbid, about 10 days, later interval once, sprays 3 times altogether.Adopt spray pesticide, the medicine that makes Apple Leaves positive and negative even, till dripping.
Investigation and statistical method
Investigation morbidity radix before medicine, dispenser terminates latter 12 days respectively investigation drug effects.2 strains are investigated in every community.Every strain by east, south, west, north, in 5 orientation fix 5 branches, investigate the incidence of whole blade, record the sick number of sheets at different levels, grade scale is as follows:
0 grade: without scab;
1 grade: lesion area accounts for less than 10% of whole leaf area;
3 grades; Lesion area accounts for 11 ~ 25% of whole leaf area;
5 grades; Lesion area accounts for 26 ~ 40% of whole leaf area;
7 grades; Lesion area accounts for 41 ~ 65% of whole leaf area;
9 grades; Lesion area accounts for more than 65% of whole leaf area.
Drug effect computational methods
Alternaria leaf spot of apple field test results prevented and treated by table 2
Field test results shows: 33% copper 8-hydroxyquinolinate metconazole wetting powder 3000 times, 3200 times, 3400 times, 60% copper 8-hydroxyquinolinate metconazole wetting powder 4500 times, 4700 times, 4900 times, 45% copper 8-hydroxyquinolinate metconazole suspending agent 3200 times, 3400 times, 3600 times, 40% copper 8-hydroxyquinolinate metconazole suspending agent 3000 times, 3200 times, 3400 times, 50% copper 8-hydroxyquinolinate metconazole water dispersible granules 4000 times, 4200 times, 4400 times, more significant control efficiency is had to alternaria leaf spot of apple, obviously be better than 33.5% copper 8-hydroxyquinolinate suspending agent 1000 times, 600 times, 60g/L metconazole water and milk, to the control efficiency of alternaria leaf spot of apple.
The present invention is by employing two kinds of active component compound schemes, create higher synergistic function, compared with existing unitary agent, there is significant bactericidal effect, also delayed the drug-fast generation of pathogen simultaneously, pollution-free to crop, safety is good, meets the security requirement of pesticidal preparations.
A kind of bactericidal composition containing copper 8-hydroxyquinolinate and metconazole of the present invention is described by concrete example, those skilled in the art can use for reference content of the present invention, the links such as suitable feed change, process conditions realize other object corresponding, its relevant change does not all depart from content of the present invention, all similar replacements and change will become apparent to those skilled in the art that and be all deemed to be included within scope of the present invention.
Claims (8)
1. a bactericidal composition, is characterized in that, described composition comprises active component copper 8-hydroxyquinolinate and metconazole, and the weight ratio of the two is 1:15-15:1.
2. bactericidal composition according to claim 1, is characterized in that, the weight ratio of the two is 1:0-10:1.
3. bactericidal composition according to claim 1, is characterized in that, the weight ratio of the two is 1:5-5:1.
4. bactericidal composition according to claim 1, is characterized in that, the weight ratio of the two is 1:2-2:1.
5. a bactericide, is characterized in that, described bactericide comprise 5 ~ 90 % by weight according to the arbitrary described bactericidal composition of Claims 1-4 and the auxiliary agent that is agriculturally suitable for.
6. bactericide according to claim 5, is characterized in that, described bactericide comprise 8 ~ 75 % by weight according to the arbitrary described bactericidal composition of Claims 1-4 and the auxiliary agent that is agriculturally suitable for.
7. bactericide according to claim 5, is characterized in that, described bactericide is mixed with water dispersible granules, wetting powder or suspending agent.
8. the application on control alternaria leaf spot of apple according to the arbitrary described bactericidal composition of Claims 1-4 or the arbitrary described bactericide of claim 5 to 7.
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| CN201510183719.8A CN104770373B (en) | 2015-04-17 | 2015-04-17 | A kind of containing copper 8-hydroxyquinolinate with the bactericidal composition of metconazole |
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| CN201510183719.8A CN104770373B (en) | 2015-04-17 | 2015-04-17 | A kind of containing copper 8-hydroxyquinolinate with the bactericidal composition of metconazole |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106614705A (en) * | 2016-12-30 | 2017-05-10 | 陕西省蒲城美尔果农化有限责任公司 | Sterilization composition containing oxine-copper and flusilazole |
| CN108633890A (en) * | 2018-04-25 | 2018-10-12 | 浙江东风化工有限公司 | A kind of bactericidal composition containing metconazole Yu the gloomy copper of thiophene |
| CN110506747A (en) * | 2019-08-28 | 2019-11-29 | 浙江海正化工股份有限公司 | Using cyproconazole and copper 8-hydroxyquinolinate as the composition pesticide of active constituent and its preparation and application |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04264011A (en) * | 1991-02-18 | 1992-09-18 | Kureha Chem Ind Co Ltd | Disinfectant of seed |
| WO1996001054A1 (en) * | 1994-07-01 | 1996-01-18 | Janssen Pharmaceutica N.V. | Synergistic compositions containing metconazole and another triazole |
-
2015
- 2015-04-17 CN CN201510183719.8A patent/CN104770373B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04264011A (en) * | 1991-02-18 | 1992-09-18 | Kureha Chem Ind Co Ltd | Disinfectant of seed |
| WO1996001054A1 (en) * | 1994-07-01 | 1996-01-18 | Janssen Pharmaceutica N.V. | Synergistic compositions containing metconazole and another triazole |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106614705A (en) * | 2016-12-30 | 2017-05-10 | 陕西省蒲城美尔果农化有限责任公司 | Sterilization composition containing oxine-copper and flusilazole |
| CN108633890A (en) * | 2018-04-25 | 2018-10-12 | 浙江东风化工有限公司 | A kind of bactericidal composition containing metconazole Yu the gloomy copper of thiophene |
| CN110506747A (en) * | 2019-08-28 | 2019-11-29 | 浙江海正化工股份有限公司 | Using cyproconazole and copper 8-hydroxyquinolinate as the composition pesticide of active constituent and its preparation and application |
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Address after: 318000 Zhejiang Province, Taizhou City Road No. 97 Patentee after: Shunyi Co., Ltd Address before: 318000 Zhejiang Province, Taizhou City Road No. 97 Patentee before: Zhejiang Haizheng Chemical Co., Ltd. |