CN103342695A - 1’,3’-二取代的-4-苯基-3,4,5,6-四氢-2h,1’h-[1,4’]二吡啶-2’-酮 - Google Patents
1’,3’-二取代的-4-苯基-3,4,5,6-四氢-2h,1’h-[1,4’]二吡啶-2’-酮 Download PDFInfo
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- CN103342695A CN103342695A CN2013102505203A CN201310250520A CN103342695A CN 103342695 A CN103342695 A CN 103342695A CN 2013102505203 A CN2013102505203 A CN 2013102505203A CN 201310250520 A CN201310250520 A CN 201310250520A CN 103342695 A CN103342695 A CN 103342695A
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- VNJQMLBHELLWTR-UHFFFAOYSA-N OC(C=CN1CC2CC2)=CC1=O Chemical compound OC(C=CN1CC2CC2)=CC1=O VNJQMLBHELLWTR-UHFFFAOYSA-N 0.000 description 1
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
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- Hematology (AREA)
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- Urology & Nephrology (AREA)
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Abstract
Description
Claims (18)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07116390 | 2007-09-14 | ||
EP07116390.1 | 2007-09-14 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2008801071350A Division CN101801951B (zh) | 2007-09-14 | 2008-09-12 | 1’,3’-二取代的-4-苯基-3,4,5,6-四氢-2h,1’h-[1,4’]二吡啶-2’-酮 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103342695A true CN103342695A (zh) | 2013-10-09 |
CN103342695B CN103342695B (zh) | 2015-04-22 |
Family
ID=39930548
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2008801071350A Active CN101801951B (zh) | 2007-09-14 | 2008-09-12 | 1’,3’-二取代的-4-苯基-3,4,5,6-四氢-2h,1’h-[1,4’]二吡啶-2’-酮 |
CN201310250520.3A Active CN103342695B (zh) | 2007-09-14 | 2008-09-12 | 1’,3’-二取代的-4-苯基-3,4,5,6-四氢-2h,1’h-[1,4’]二吡啶-2’-酮 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2008801071350A Active CN101801951B (zh) | 2007-09-14 | 2008-09-12 | 1’,3’-二取代的-4-苯基-3,4,5,6-四氢-2h,1’h-[1,4’]二吡啶-2’-酮 |
Country Status (30)
Country | Link |
---|---|
US (6) | US9114138B2 (zh) |
EP (1) | EP2203439B1 (zh) |
JP (1) | JP5133416B2 (zh) |
KR (2) | KR101520086B1 (zh) |
CN (2) | CN101801951B (zh) |
AR (1) | AR068511A1 (zh) |
AT (1) | ATE496906T1 (zh) |
AU (1) | AU2008297878B2 (zh) |
BR (1) | BRPI0816767B8 (zh) |
CA (1) | CA2696948C (zh) |
CL (1) | CL2008002745A1 (zh) |
CY (1) | CY1111219T1 (zh) |
DE (1) | DE602008004794D1 (zh) |
DK (1) | DK2203439T3 (zh) |
EA (1) | EA017648B1 (zh) |
ES (1) | ES2356032T3 (zh) |
HK (2) | HK1143820A1 (zh) |
HR (1) | HRP20110278T1 (zh) |
IL (2) | IL204032A (zh) |
MX (1) | MX2010002536A (zh) |
MY (1) | MY152078A (zh) |
NZ (1) | NZ584145A (zh) |
PL (1) | PL2203439T3 (zh) |
PT (1) | PT2203439E (zh) |
RS (1) | RS51660B (zh) |
SI (1) | SI2203439T1 (zh) |
TW (2) | TWI445532B (zh) |
UA (1) | UA100126C2 (zh) |
WO (1) | WO2009033704A1 (zh) |
ZA (1) | ZA201001151B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107108608A (zh) * | 2014-12-11 | 2017-08-29 | 詹森药业有限公司 | 1,2,4‑***并[4,3‑a]吡啶化合物及其作为mGluR2受体的正向别构调节剂的用途 |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
BRPI0816767B8 (pt) | 2007-09-14 | 2021-05-25 | Addex Pharmaceuticals Sa | composto 4-fenil-3,4,5,6-tetra-hidro-2h,1'h-[1,4']bipiridi¬nil-2'-onas 1',3'-dissubstituídas, composição farmacêutica e uso dos mesmos |
US8252937B2 (en) * | 2007-09-14 | 2012-08-28 | Janssen Pharmaceuticals, Inc. | 1,3-disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones |
AU2008297877C1 (en) | 2007-09-14 | 2013-11-07 | Addex Pharma S.A. | 1,3-disubstituted-4-phenyl-1 H-pyridin-2-ones |
US8785486B2 (en) | 2007-11-14 | 2014-07-22 | Janssen Pharmaceuticals, Inc. | Imidazo[1,2-A]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
ES2439291T3 (es) | 2008-09-02 | 2014-01-22 | Janssen Pharmaceuticals, Inc. | Derivados de 3-azabiciclo[3.1.0]hexilo como moduladores de receptores de glutamato metabotrópicos |
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