CN102596095A - 具有改进芯部的多孔植入器具 - Google Patents
具有改进芯部的多孔植入器具 Download PDFInfo
- Publication number
- CN102596095A CN102596095A CN2010800500159A CN201080050015A CN102596095A CN 102596095 A CN102596095 A CN 102596095A CN 2010800500159 A CN2010800500159 A CN 2010800500159A CN 201080050015 A CN201080050015 A CN 201080050015A CN 102596095 A CN102596095 A CN 102596095A
- Authority
- CN
- China
- Prior art keywords
- core
- utensil
- processed
- zone
- implant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007943 implant Substances 0.000 title abstract description 100
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 24
- 210000004872 soft tissue Anatomy 0.000 claims abstract description 24
- 239000011148 porous material Substances 0.000 claims abstract description 22
- 238000002513 implantation Methods 0.000 claims description 26
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 claims description 23
- 238000000576 coating method Methods 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 14
- 229910052715 tantalum Inorganic materials 0.000 claims description 13
- 239000011248 coating agent Substances 0.000 claims description 12
- 239000004053 dental implant Substances 0.000 claims description 9
- 229910052751 metal Inorganic materials 0.000 claims description 6
- 239000002184 metal Substances 0.000 claims description 6
- 230000015572 biosynthetic process Effects 0.000 claims description 5
- 238000005530 etching Methods 0.000 claims description 5
- 238000007788 roughening Methods 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 3
- 239000000560 biocompatible material Substances 0.000 claims description 3
- 230000008878 coupling Effects 0.000 claims description 3
- 238000010168 coupling process Methods 0.000 claims description 3
- 238000005859 coupling reaction Methods 0.000 claims description 3
- 230000000975 bioactive effect Effects 0.000 claims 1
- 238000004873 anchoring Methods 0.000 description 23
- 230000008468 bone growth Effects 0.000 description 13
- 210000004195 gingiva Anatomy 0.000 description 11
- 230000012010 growth Effects 0.000 description 9
- 230000008569 process Effects 0.000 description 8
- 238000012545 processing Methods 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 6
- 230000004888 barrier function Effects 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 238000000465 moulding Methods 0.000 description 5
- 230000001054 cortical effect Effects 0.000 description 4
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 4
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 230000008467 tissue growth Effects 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 3
- 238000005299 abrasion Methods 0.000 description 3
- 238000005422 blasting Methods 0.000 description 3
- 238000005229 chemical vapour deposition Methods 0.000 description 3
- 210000000981 epithelium Anatomy 0.000 description 3
- 238000000227 grinding Methods 0.000 description 3
- 238000011068 loading method Methods 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 150000002739 metals Chemical class 0.000 description 3
- 210000000963 osteoblast Anatomy 0.000 description 3
- 229920006260 polyaryletherketone Polymers 0.000 description 3
- 238000005480 shot peening Methods 0.000 description 3
- 238000003466 welding Methods 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 206010055001 Hypodontia Diseases 0.000 description 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 2
- 229910001257 Nb alloy Inorganic materials 0.000 description 2
- 206010051937 Osteorrhagia Diseases 0.000 description 2
- 239000004696 Poly ether ether ketone Substances 0.000 description 2
- 229920000954 Polyglycolide Polymers 0.000 description 2
- 102000013275 Somatomedins Human genes 0.000 description 2
- 206010002583 anodontia Diseases 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 230000005213 hypodontia Effects 0.000 description 2
- 230000008595 infiltration Effects 0.000 description 2
- 238000001764 infiltration Methods 0.000 description 2
- 239000004531 microgranule Substances 0.000 description 2
- RHDUVDHGVHBHCL-UHFFFAOYSA-N niobium tantalum Chemical compound [Nb].[Ta] RHDUVDHGVHBHCL-UHFFFAOYSA-N 0.000 description 2
- 210000002997 osteoclast Anatomy 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- UQGPCEVQKLOLLM-UHFFFAOYSA-N pentaneperoxoic acid Chemical compound CCCCC(=O)OO UQGPCEVQKLOLLM-UHFFFAOYSA-N 0.000 description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
- 229920002530 polyetherether ketone Polymers 0.000 description 2
- 239000004633 polyglycolic acid Substances 0.000 description 2
- 239000004926 polymethyl methacrylate Substances 0.000 description 2
- 238000010079 rubber tapping Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 201000006680 tooth agenesis Diseases 0.000 description 2
- 206010049244 Ankyloglossia congenital Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 244000188472 Ilex paraguariensis Species 0.000 description 1
- 229920002732 Polyanhydride Polymers 0.000 description 1
- 229920002873 Polyethylenimine Polymers 0.000 description 1
- 229920000491 Polyphenylsulfone Polymers 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 229910001069 Ti alloy Inorganic materials 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 229910000771 Vitallium Inorganic materials 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 239000011358 absorbing material Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004523 agglutinating effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 210000004534 cecum Anatomy 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 210000004513 dentition Anatomy 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 210000001513 elbow Anatomy 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 210000004394 hip joint Anatomy 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- -1 niobium Chemical class 0.000 description 1
- 229910052758 niobium Inorganic materials 0.000 description 1
- 239000010955 niobium Substances 0.000 description 1
- GUCVJGMIXFAOAE-UHFFFAOYSA-N niobium atom Chemical compound [Nb] GUCVJGMIXFAOAE-UHFFFAOYSA-N 0.000 description 1
- 238000010883 osseointegration Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 229920001610 polycaprolactone Polymers 0.000 description 1
- 239000004632 polycaprolactone Substances 0.000 description 1
- 229920001601 polyetherimide Polymers 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 229910052573 porcelain Inorganic materials 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 230000008521 reorganization Effects 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000002832 shoulder Anatomy 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 230000036346 tooth eruption Effects 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- 239000000602 vitallium Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
- A61C8/0013—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy with a surface layer, coating
- A61C8/0015—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy with a surface layer, coating being a conversion layer, e.g. oxide layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0003—Not used, see subgroups
- A61C8/0004—Consolidating natural teeth
- A61C8/0006—Periodontal tissue or bone regeneration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0018—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0018—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the shape
- A61C8/0022—Self-screwing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0048—Connecting the upper structure to the implant, e.g. bridging bars
- A61C8/005—Connecting devices for joining an upper structure with an implant member, e.g. spacers
- A61C8/006—Connecting devices for joining an upper structure with an implant member, e.g. spacers with polygonal positional means, e.g. hexagonal or octagonal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0048—Connecting the upper structure to the implant, e.g. bridging bars
- A61C8/005—Connecting devices for joining an upper structure with an implant member, e.g. spacers
- A61C8/0074—Connecting devices for joining an upper structure with an implant member, e.g. spacers with external threads
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/84—Preparations for artificial teeth, for filling teeth or for capping teeth comprising metals or alloys
Landscapes
- Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dentistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Engineering & Computer Science (AREA)
- Ceramic Engineering (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Biomedical Technology (AREA)
- Developmental Biology & Embryology (AREA)
- Dental Prosthetics (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
植入器具具有外侧部分,所述外侧部分形成植入体的外部表面。外侧部分由多孔材料制成,所述多孔材料限定穿过外侧部分的通道。内侧部分具有外表面,所述外表面具有被处理区域,所述被处理区域是穿过通道经由外部表面可触及。被处理区域具有处理部,用于与骨骼或软组织直接附着。
Description
本申请要求于2009年11月24日提交的美国专利申请12/624,608的权益,并是其继续申请,其内容通过引用完全包括在这里。
技术领域
本发明涉及一种多孔植入体,特别是一种将多孔材料安装在芯部上的植入体。
背景技术
牙植入体通常用于将牙修复体或假牙锚固在病人牙齿列中的一个或多个缺齿部位上,所述缺齿部位上的病人原有牙齿已经掉落或损坏。典型地,牙植入体被螺旋拧入或压配到孔洞中,所述孔洞被钻在病人缺牙部位处的下颌骨或上颌骨上。通常地,牙植入器具被设置为单体式或双体式。对于双体式的牙植入器具而言,锚固件或植入体支撑着单独的冠状牙齿基台(abutment),所述基台反过来在植入体和牙修复体之间提供的接口界面。对于单体式的一体牙植入器具而言,其具有相对于牙植入器具的植入体区段成冠状的基台区段。在任一情况下,修复体通常是根据现有方法成型的瓷制冠型。
对于双体式的牙植入器具,具有两段式外科植入体(也称作骨内植入体,“endosseous implant”),所述植入体仅上升到下颌骨或上颌骨的顶部。在这种情况下,外科手术经常分两个阶段进行。在最初阶段,在病人缺牙侧的牙龈里进行切口,并且在缺牙部位的下颌骨或上颌骨内钻孔,接下来使用合适的驱动器将牙植入体螺旋拧入或撞击到孔洞中。此后,将帽体装配在所述植入体上,以封闭植入体的基台联结结构,并且牙龈被缝合在植入体上。经过几个月的时间,病人的颌骨在植入体周围生长,以牢固地将植入体锚固在周围的骨骼中,这个过程被称为骨结合(“osseointegration”)。
在骨结合之后的第二个阶段的过程中,牙医再次打开植入体部位的牙龈,并且将基台(和可选地临时修复体或临时愈合性构件)紧固在植入体上。然后,合适的永久性修复体或齿冠例如由一个或多个印模来成型,所述印模由基台和周围的牙龈组织及齿系得到。所述临时修复体或愈合性构件被移除,并且由永久性修复体代替,所述永久性修复体例如通过接合剂或紧固件被附连到基台上。
可选地,一段式外科双体植入体(也称作穿龈植入体)在单个阶段中被放入,因为所述植入体贯穿牙龈以与基台相附连。单体式植入体也在单个阶段中被放置入颌骨中。
虽然现有牙植入体被植入周围骨骼的骨结合已经被证明是合适的,但是还需要对牙植入体的骨结合进行进一步改进。例如,病人会更喜欢从开始治理到植入体被咬合力完全影响控制时的治疗时间最短。此外,还希望给高风险病人(例如为吸烟者,糖尿病患者和/或骨骼生长反常缓慢的人)提供坚固骨结合的植入体。
附图说明
图1是牙植入器具的侧面透视图;
图2是图1所示的牙植入器具的分解透视图;
图3是沿着图1所示的线3-3所剖开的、图1所示牙植入器具的仰视剖切图;
图4是图1所示牙植入器具的多孔材料的局部特写图;
图5是可选的牙植入器具的侧面剖视图;
图6是另一种可选的牙植入器具的侧面局部剖视图;
图7是另一种可选的牙植入器具的侧面剖视图。
具体实施方式
根据图1至图3,为了增进对植入体的骨结合,用于放置入骨骼中的植入器具10具有由多孔材料14制成的外侧部分12,所述骨骼能够生长进入所述多孔材料14内,以改进植入器具的长期稳定性。这样一种多孔材料也可增加即刻加载的短期稳定性,因为所述多孔材料与周围骨骼的摩擦系数较大,就如下面更加详细的解释那样。外侧部分12可以被放置在内侧部分或芯部16的上面或周围,所述芯部16支撑着外侧部分并且为植入器具10增加强度。所述芯部16可以具有表面处理部18,以进一步增进与骨骼的骨结合,所述骨骼已经生长穿过外侧部分12并且生长至芯部16上。可选地或附加地,所述芯部16也可以具有外部形状或外周边19,所述外周边19被配置成用于限制外侧部分12相对于芯部16的旋转,以将植入体10适当地放置于骨骼的孔洞中以及同时增加长期稳定性和短期稳定性。
现在,如所示实施例中更加具体地显示,植入体10是一个牙植入体,用于***下颌骨或上颌骨内。所述植入体10被用于锚固一个或多个牙假体,并且包括冠状(coronal)头部部分或头部20。内侧部分或芯部16从头部20朝顶部延伸。在一种形式中,头部20和芯部16整体成形,但是它们也可以是单独的部件,而通过螺纹、摩擦配合、焊接(激光焊或电子束焊)等方式彼此紧固。单独的锚固部22(也被称为柄部或根端部分)被配置成接合着芯部16,以使得头部20和锚固部22可协作地在植入体10上、将多孔外侧部分14保持在其间。
对于所示实施例,头部20的冠部末端24被配置成包括阳性或阴性的接合结构,所述接合结构接纳着来自单独基台的相应结构。然而,优选地,头部20可以具有延伸的高度,以贯穿牙龈并且形成单段式植入体,或可以具有一体的基台以形成单件式植入体,而不是所示的两段式植入体10。
头部20具有圆柱形或锥形的外表面26,所述外表面26延伸至顶部末端表面28。芯部16具有相较于外表面26的直径而言更小的外径,并且从头部20的顶部末端表面28朝向顶部地(apically)延伸,以使得顶部末端表面28形成了肩台以将外侧部分12抵靠和保持在芯部16上。在一个特别的形式中,外侧部分12是具有孔洞30的套筒或套管,所述孔洞30接纳着芯部16。在一种形式中,所述套管12具有大约0.03英寸的径向厚度(大约0.75毫米)。外侧部分12的冠部末端32面向和/或紧靠着顶部末端表面28。外侧部分12的顶部末端34面向和/或接合着锚固部22。
锚固部22可以紧固在芯部16的顶部末端部分56上,以将外侧部分12紧固在头部20和锚固部22之间。锚固部22可以具有孔洞36以接纳着芯部16,并且这两个部件可以此后焊接在一起,从而永久性地将外侧部分12紧固在芯部16上。可以理解的是,只要多孔外侧部分12被维持在芯部16附近,还可以设想许多可选的配置结构,例如芯部16和锚固部22通过螺纹或压配合被结合在一起,或芯部16与锚固部22是一体的或是完全地分开的,而不是如上所述地集成到头部20上。
芯部16、头部20和锚固部22(无论单个或多个的这些部件是分开的或整体成型的)由合适的生物相容性材料制成,例如钛、钛合金、不锈钢、锆、钴铬钼合金、聚合物(如聚醚酮酮,PEKK)、陶瓷、和/或复合材料。
头部20及锚固部22的外表面26和37可以具有螺纹38,用于将植入体10螺纹拧入至骨骼的孔洞中,或者是被压配合入孔洞中。如此,外表面26和37可以可选地或附加地具有表面处理部,以促进皮层骨(corticalbone)和/或松质骨(cancellous bone)的生长。头部的外表面26可以附加地或可选地被进行处理,以促进上皮(epithelium)或软组织生成屏障,和/或如果头部20延伸进入牙龈层时,促进软组织生长。在这种情况下,屏障或软组织的生长处理部能够被放置成邻近于软组织或邻近于骨骼和软组织之间的交界面。这样的处理部可以包括宏观或微观攻丝或螺纹,或周向或环向凹槽,或由蚀刻(如酸蚀)所形成其他样式或随机的凹口,喷丸(如沙粒,具有或不具有HA微粒),亦或使用钛氧化物(二氧化钛)或其他会在软组织和生物材料间生成某种粘结的材料涂层。外表面26和37的表面处理部可以、也可以不和下面描述的芯部16的表面处理部相同。
参考图4,形成外侧部分12的多孔材料14可以包括金属,并且其中一种形式是多孔钽部分40,所述多孔钽部分40是高度多孔的生物材料,以作为骨替代材料和/或细胞和组织相容材料。此种材料的示例是使用Trabecular MetalTM技术来生产,所述技术一般可从位于美国印第安纳州的华沙的捷迈公司(Zimmer,Inc.)得到,其中Trabecular MetalTM是捷迈公司的一个商标。此种材料可以由网状玻璃质碳泡沫基底来形成,所述基底通过化学气相沉积(“CVD”)过程被具有生物相容性的金属(例如钽等)渗透和涂覆,所述过程在美国专利5,282,861中详细披露,其公开内容在此引入作为参考。其他金属如铌,或钽铌合金或包括其他金属的钽铌合金也可以被使用。
如图4所示,多孔钽结构40包括大量相互连接的构件、系带、或梁柱42,以限定位于其间的开口空间44,其中每个构件42一般包括碳芯46,所述碳芯46被金属薄膜48(例如钽)覆盖。构件42之间的开口空间或通道44形成了连续不断的通道矩阵(所述通道没有盲端),以使得松质骨的生长可以完全地穿过多孔钽结构40而不受抑制。换言之,骨骼能够从植入体10的外部表面50(所述外部表面由外侧部分12形成)开始生长,大致径向地穿过外侧部分12的通道44,并且生长到芯部16上。
多孔钽在其中可以包括多达75%-85%或更多的空穴。如此,多孔钽是轻巧、坚固的多孔结构,所述多孔结构相当地均匀,并且成分一致,同时和天然松质骨的结构类似,从而提供了松质骨可以生长进入的矩阵结构,以将植入体10锚固至病人颌部的周边骨骼内,从而增加稳定性。这种多孔金属部件12的粗糙外部表面与形成孔洞(所述孔洞接纳着植入体10)的相邻骨骼之间具有相对较大的摩擦系数,以进一步增加初始稳定性,如上文所示。通过限制植入体的运动,这种结构能够产生出众的美学效果。这些植入体能够不通过补充的外科手术过程(如骨移植)而被放置,并且能够被放置到传统的植入体更少成功的区域,例如减少的或被蛀的齿槽区段,或者病人的骨骼生长不正常地缓慢或减少的情况。
更具体而言,多孔材料和骨骼间的高摩擦水平提供了在外科手术之后的即刻稳定性。从材料表面延伸出的钽支柱产生了锉磨作用,所述锉磨作用可以同时刺激骨骼生长以及在放置时锚固植入体。多孔材料由具有极度生物相容性的钽金属制成,所述钽金属使得骨骼可以直接面对所述材料。钽形成了多孔脚手架,所述脚手架让骨骼可以生长进入所述材料,以提供快速的骨结合反应,所述骨结合反应快速地加强了初始机械定位以紧固植入体。具有生长进入骨骼的植入体比同样尺寸的、只具有在表面生长的骨骼的植入体有更好的稳定性。最后,生长进入的骨骼和这种多孔材料的复合物所具有的弹性特性,比实心的金属植入体更加接近骨骼,从而生成了有利于将骨骼维持在植入体附近的加载环境。
就初始稳定性而言,在具有多孔材料的植入体被***骨骼的孔洞或空腔中时,所述多孔材料将通过磨碎、切削和/或剥落骨骼侧壁上的骨碎块以咬入到骨骼内,其中植入器具被放置成贴靠着所述骨骼侧壁。当植入体被***孔洞或空腔中时,这种“锉磨”作用可以在侧壁中形成微小的凹口或凹坑。这可以限制植入器具在孔洞或空腔中的旋转或扭转动作,因为所述植入器具没有空隙来旋出凹坑和在孔洞中旋转。
由于骨骼挤压进入孔隙中,锉磨作用也加速了在植入器具上的和在多孔材料的孔隙内的骨结合。首先,骨骼结构的磨碎引起骨出血,所述骨出血会通过促使有益细胞(如造骨细胞和破骨细胞)的产生以刺激骨骼生长。第二,落入多孔材料上的空隙中的骨碎块协助进行骨骼重新造型。在骨骼重新造型的过程中,造骨细胞将骨碎块作为脚手架使用,并且在骨碎块的周围生成新的骨骼材料。同时,通过分解骨骼并且从骨碎块中释放矿物质(例如钙)并送回血液流内,破骨细胞以再吸收的方式来移除骨碎块。造骨细胞将继续使用位于提取部位内及周围的新的和健康的骨骼,来代替来自空隙的和植入器具周围的被磨碎骨碎块。如此,多孔材料对扭转或旋转的抗性增加,允许被即刻或非常早的加载,并且长期稳定性由于改善的骨结合而得到增加。具有骨骼生长进入的植入体比同样尺寸的、只有骨骼生长到其上的植入体具有更好的稳定性。例如,通常要求长度是16毫米的植入体的加载完全可以使用长度是8毫米的植入体。无论多孔植入体的形式如何,这些优点都可以实现。
多孔钽结构40可被制成具有各种密度,用以选择地调整结构使其适合于特别的应用场合。特别地,所述多孔钽可以被制造出几乎任何想要实现的孔隙度和孔隙尺寸,不论统一均匀的或变化的,并且能够因此与周围的天然骨骼相匹配,从而为骨骼生长进入和矿物化提供改进的矩阵结构。这包括孔隙尺寸在单个植入体上的渐变,以使得孔隙在顶部末端的尺寸更大从而匹配松质骨,同时在冠部末端的尺寸更小以匹配皮层骨,甚至以接纳着软组织的生长进入(ingrowth)。此外,多孔钽能够被制造得更稠密,同时在高机械应力的区域具有更少的孔隙。这也能够通过使所有的或一些的孔隙填充有固体材料实现,而不是通过填充具有更小孔隙的多孔钽来实现。
为了提供附加的初始机械强度和稳定性至多孔结构,所述多孔结构可以被渗入有填充材料,如不可再次吸收的聚合体或可再次吸收的聚合体。用于渗入多孔结构的不可再次吸收聚合物的示例可以包括聚芳醚酮(PAEK),如聚芳醚酮酮(PEKK)、聚醚醚酮(PEEK)、聚醚酮醚酮酮(PEKEKK)、聚甲基丙烯酸甲酯(PMMA)、聚醚酰亚胺、聚砜和聚苯砜。
可再次吸收聚合物的示例可以包括聚乳酸-乙醇酸共聚物(PLGA)、聚乳酸(PLA)、聚乙醇酸(PGA)、聚羟基丁酯(PHB),聚羟基戊酸酯(PHV),和其共聚物,聚已酸内酯,聚酐,聚原酸酯。通过使可再次吸收的填充材料具有附加的初始机械强度和稳定性,钽强化的植入体芯部可以不被要求穿过多孔材料的整个长度。可再次吸收材料将在骨骼生长进入和取代它时再次吸收,这样保持了植入体的强度和稳定性。
又根据图1,表面处理部18被使用或应用在内侧部分或芯部16的外表面52上的被处理区域54,用于直接附着在骨骼上。芯部16的这种坚固附着在骨骼上会增加稳定性。可选地,或附加地,表面处理部的类型可以被选择为在植入体上的芯部贯穿牙龈时(如以下对植入体200和300(图6至图7)所解释的),会促进上皮屏障的生长、软组织屏障的生长、或软组织的生长。
被处理区域54被外侧部分12覆盖,以使得所述被处理区域54是可触及的以便直接接触骨骼,所述被处理区域大致径向地生长穿过外侧部分12。在一种形式中,被处理区域54与外侧部分12相对齐或相对应,以使得被处理区域54仅在外侧部分12下方延伸且不延伸穿过外侧部分12的未被覆盖的地方。在这种情况下,被处理区域54的表面区域和外周边是与外侧部分12的表面区域和外周边相同或大概相同。另一种方法中,被处理区域54可以位于芯部16的部位上,所述芯部16不直接被外侧部分12覆盖。例如,被处理区域54可以覆盖整个芯部16,同时外侧部分12只在冠部到顶部的方向上在芯部16的一部分上方延伸。另外,被处理区域54的表面积可以比外侧部分12的表面积更小,以使得被处理区域54只在外侧部分12的下方延伸,无论被处理区域54的外周边是否与外侧部分12的外周边具有同样的形状。至少,被处理区域54具有至少一部分在外侧部分12的下方延伸,并且从植入体10的外部表面50穿过通道44是可触及的。
优选地,外侧部分12可以只形成植入体10的部分圆周,而不是形成套管或套筒,或可以只位于植入体10的一侧或多侧上。在这种情况下,芯部16的被处理区域54可以被配置成或可以不被配置成只与被外侧部分12所覆盖的区域相对准。
在一种形式中,被处理区域54至少是被粗糙化的。这可以通过喷丸清理或喷砂清理所述被处理区域54完成,用以在芯部16的外表面52上生成随机的凹点图案,其平均粗糙度(Ra)大概是20至50μm。喷砂可以通过喷射羟基磷灰石(HA)或其他具有生物相容性的材料完成。一种方法是,被处理区域54只被喷砂处理,但是可选地,被处理区域能不被喷砂处理而被多种不同的处理方法来处理,或者在除被喷砂处理之外也被多种不同的方法处理。这包括对被处理区域54进行酸蚀,以生成随机的或具有预定图案的粗糙化结果。
在另一个处理部18的示例中,被处理区域54可以具有至少一层生物相容性材料的涂层。所述涂层可以包括具有生物活性的材料,如HA,胶原质,缩氨酸,或其他能促进骨骼生长到芯部16上的生长因子(和/或如果芯部贯穿牙龈的话,则促进软组织生长的生长因子)。可选地或附加地,所述涂层是能够抗菌的和包括过渡金属(如银、铜或锌)离子,其他杀菌的聚合物、抗生素和/或纳米级粗糙度,以防止细菌定植在被处理区域54上。其他涂层可以被应用,以形成可进入涂层内的孔隙度,从而实现更好地附着。这可以包括由捷迈公司提供的松质骨结构钽(CSTi),所述松质骨结构钽(CSTi)包括烧结到芯部16上的钽粉,其形成了穿过涂层的孔隙、以及形成了一定的粗糙度以使固定到骨骼或软组织上的固定性得到提高。可选地或附加地,被处理区域54可以使用它的粗糙处理方式,例如圆周方向粗糙化,如攻丝或环向开槽,或其他样式的粗糙化(无论是在宏观、微观或纳米级尺度上),只要其意图涉及直接附着到骨骼上(或当芯部延伸靠近或贯穿牙龈延伸时,直接附着到软组织上)。
通常地,在植入体被完全装配后,所述植入体被喷砂等方式进行处理,以使得对植入体的暴露区域的处理能够在一个阶段发生。然而,在这种情况下,因为芯部16的外表面52被处理并且而后被覆盖,植入体10的各个部件会在装配前被分开处理。这样,首先是带有芯部16的头部20,多孔的外侧部分12,和锚固部22被如上描述的方式地形成。头部20和芯部16依次被喷砂或被如上描述的其他方式处理,以便直接与骨骼或软组织相接合。在外侧部分12被安装在芯部16上之前,并且在头部20附着在锚固部22之前,头部20和芯部16两者与锚固部22分开地处理。
在一种形式中,整个头部20(包括芯部16的顶部末端部分(apical endportion)56)被喷丸。然而,可以理解的是,芯部16是唯一被处理或喷丸的区域,而头部20的剩余区域被遮掩以免受处理。如下将是优选的,如果植入体10的其他暴露区域接受不同类型的处理,所述处理能被在芯部16处进行的其他处理(如涂层、用不同的微粒或不同尺寸的微粒进行喷砂,带有图案样式的刻蚀等等)所破坏。此外,顶部末端区段56的侧壁57能够被遮掩,因为当植入体10装配时,它在锚固部22内没有暴露,或侧壁57能在需要的时候提供光滑的连接表面。
一旦被处理区域54已经完成,外侧部分12被安装在芯部16上,然后锚固部22被安装在芯部16上,并且通过激光焊接、螺纹连接或其他永久性连接方式紧固在上面。在图示的形式中,当芯部16的顶部末端区段56被放置入锚固部22上的孔洞36内后,两者沿着在锚固部22的顶部末端区段60处的接缝58被激光焊接在一起。当头部20和锚固部22被激光焊接在一起,焊接过程也可能使锚固部22上的粗糙处理部分不理想地变得平滑,从而可能需要在被焊接影响的区域再次对锚固部22进行喷砂。
根据植入体10的另一方面,芯部16被成形为限制头部20和外侧部分12之间的旋转。如果在植入体10被***骨骼的孔洞中时外侧部分12能够相对于芯部16和头部20旋转,所述外侧部分12可能会不如所愿地与骨骼相连接(头部20仍旋转),以使得植入体10不能合适地一直***到骨骼的孔洞中。另外,当在嘴里的多孔外侧部分12的位置不能够在咬合力起作用时发生显著变化(例如通过在植入体上转动)、从而维持初始脆弱的骨骼生长穿过外侧部分12时,骨结合能更好地发生。这使得植入体10具有更多的长期稳定性和短期稳定性。为了完成这些目标,在外侧部分12和芯部16之间形成有反旋转(或抗旋转)的连接装置。
详细地,植入体10一般地限定了纵向轴L,同时芯部16的外周边19在垂直于纵向L的横截面上延伸,并且外侧部分12一般具有圆筒壁62,所述圆筒壁62限定了外侧部分12的孔洞30并且围绕L轴延伸。
芯部16的外表面52具有至少一个大致纵向延伸的槽口或凹槽68。在图示形式中,外表面52在芯部16周围形成一个圆周方向列阵的凹槽68。这样,所述凹槽68在外周边19上形成多个侧面,从而使外周边19具有大致多边形的形状,并带有尖锐角部或边缘64,其中当外侧部分12被轴向***到芯部16上时,所述尖锐边缘64切入到外侧部分12的壁62内。每个凹槽68具有半径为r的凹入曲面66,这使得边缘64被成形为相对尖锐。这样,在一种形式中,芯部16至少具有两个邻接的凹入曲面66,以使得所述两个凹入曲面66的会合部形成了用于接合着套筒的尖端或边缘64。这大致使边缘64紧固在外侧部分12的壁62之中,使套筒12相对于芯部16在旋转方向得到紧固。
凹入表面66的半径r被设定为足够小,使得芯部16保持足够的质量以具有充分吸收咬合力的强度。半径r也足够大,以使得尖端64具有尖锐的边缘,从而在芯部16和套筒12之间提供坚固的、不可旋转的连接。在一种形式中,外周边19具有在6个到12个之间变化的凹入表面66,所述凹入表面66根据想要实现的植入体尺寸,直径d(从边缘到边缘)大约在0.060到0.230英寸之间,并且半径r大约在0.031到0.250英寸之间。在图示形式中,芯部16的8个侧面66的半径大约是0.0625英寸,并且由边缘到边缘的直径大约是0.120英寸。壁62的内直径大约是0.114英寸,以使得每个边缘64切入壁62内至少有0.003英寸。制造公差可以使得切入深度在大约0.002英寸和0.006英寸之间。在一种形式中,边缘64切入壁62的深度应该至少大约为0.002英寸,以形成坚固的阻止旋转的接合。
可以理解的,所有侧面66的半径r是相同的,以保持切入多孔外侧部分12内的切入深度大体均匀,或半径r也可以根据需要发生变化。这可以使边缘沿径向延伸得更远,并且仅在外周边19周围的一些点上(如芯部16的2个或4个对立侧面处)更深一些地切入壁62内,以形成相对坚固的保持。
在另一种可选的形式中,外周边19可以是其他的非圆形状,同时壁62保持为圆形。这创造了芯部16的具有变化半径的区段,所述这些区段没有间隙来相对于外侧部分12进行旋转,反之亦然。在这种情况下,外周边19可以是平面侧的多边形(无论是规则的还是不规则的)或大致椭圆的(例如椭圆形,卵形,长圆形等等),或可以是其他一些曲面和平面侧的结合。其他可选地,壁62和外周边19具有不同的非圆形状,以更好地减少芯部16和壁62之间的旋转,例如通过具有卵形外周边和六边形横截面的壁。在这些情况下,壁62相对于外周边19的初始旋转,是通过摩擦或通过芯部16的切入壁62内的一部分,来使得壁62相对于芯部16得到固定。
在又另一种可选的形式中,植入体可以具有相反的配置方式,其中芯部16的外表面52是圆柱形的,同时外侧部分12的壁62是非圆的,以在这两者之间形成摩擦配合。
在又另一种可选的形式中,外周边19可以具有非圆形状,其对应于壁62的非圆形状,以限制这两个组件之间的旋转。例如,外周边19或芯部16可以具有外表面52,所述外表面52具有至少一个平面侧或部分,其与壁62的平面部分相重合且接合以阻碍旋转。在一种形式中,芯部16和壁62可以具有对准的多边形横截面。
需要注意的是,尽管植入体10具有大致为圆柱形的外表面50,植入体10也可以是莫尔斯型的锥形,以使得植入体10的直径随着其朝向顶部延伸(extend apically)而减小,以在植入体10被压入或螺旋拧入骨骼的孔洞中时进一步增加其与周围骨骼的摩擦。植入体10的外周边也可以是非圆柱形状,以生成其与骨骼中的圆形孔洞之间的更多摩擦。
根据图5,可选的植入体100可以具有多孔的外侧部分102,所述外侧部分102覆盖着芯部106的顶部末端104,以形成袋状体108,并且在这个示例中是锥形的、大致呈子弹状的袋状体108。在这种情况下,芯部106的外表面110具有处理部112,如同上文所述的植入体10的处理部18,用以直接附着在骨骼上(或如果芯部106延伸邻近或贯穿牙龈的话,则附着在软组织上),所述处理部112通过通道44(图4)完全地贯穿多孔的外侧部分102。
根据图6,其他植入体形式可以被用于多孔的外侧部分和在植入体上的芯部,从而除了接纳骨骼之外(或额外地)也接纳着软组织。例如,植入体200是具有穿过齿龈的喇叭形端部202的一段式植入体,所述喇叭形端部202从植入体200的骨结合部分212冠向地延伸。在这种情况下,在喇叭形端部202上的外侧部分204可以表现为全部的或部分的环,所述环安装在芯部206的周围。处理部210被施加在芯部206的外表面208上,如同植入体10那样。
根据图7,在又另一种形式中,基台300具有多孔的外侧部分或环302,所述环302安装在基台上的芯部304周围,从而当基台安装在单独的两段式牙植入体上时接纳着软组织。芯部302具有包括处理部308的外表面306,如同上述植入体10那样。
在另一种方法中,这里提到的被处理区域是多个区间的,并且每个植入体可以具有许多区间,每个区间具有被选择实现不同目的的处理部。在一种形式中,沿植入体的纵向至少具有两个不同的区间,无论这些区间是否邻近或远离彼此。在一种情况下,一个或多个区间可以被植入在骨骼中,并且其处理方式是为了骨骼生长,同时其他一个或多个区间在软组织之间延伸,并且它们的处理方式是为了软组织生长(或如上所述建立屏障)。位于骨骼中的多个区间可以被特别选择,以用于生长皮层骨或松质骨。在一种形式中,植入体10可以例如为骨骼生长而具有许多轴向分隔的局部或完整的环。在图示的示例中,植入体200也可具有为软组织生长的一个或多个区间214,并且具有为骨骼生长的一个或多个多孔的或被处理的区间216(如图6的虚线所示)。类似的,基台300也可以具有一个或多个区间,并且可以被具有一个或多个区间的植入体所支撑。
可以理解的是,除了使用在牙植入体上之外,用于覆盖内侧部分的被处理区域用的多孔外侧部分的结合也可以被使用在骨结合的植入体上,包括沿着骨长度方向的植入体,或在关节处(如膝盖、髋关节、肩膀、肘、脊柱等)的植入体上。
虽然本发明被描述为优选的设计,但是本发明能够进一步按照所揭示内容的精神和范围作修改。因此,本申请意在覆盖使用本发明基本原理的本发明任何变化、使用或改编。此外,本申请意在覆盖使用本领域已知或习惯的技术而产生的相对于本发明的偏差,本发明包括所述技术并且所述技术落入附加的权利要求限制范围内。
Claims (24)
1.一种植入器具,包括:
外侧部分,所述外侧部分形成了植入器具的外部表面,并且由多孔材料制成,所述多孔材料限定了穿过外侧部分的通道;和
内侧部分,所述内侧部分包括具有被处理区域的外表面,所述被处理区域可穿过通道从外部表面触及,所述被处理区域具有用于直接附连到骨骼或软组织上的处理部。
2.如权利要求1所述的植入器具,其特征在于:处理部至少包括外表面的粗糙化部分。
3.如权利要求1所述的植入器具,其特征在于:处理部至少包括使用生物活性材料对外表面进行涂覆的涂层。
4.如权利要求1所述的植入器具,其特征在于:处理部所包括的被处理区域具有以下特征中的至少之一:
螺纹,
环形凹槽,
表面凹口,
至少一个生物相容性涂层,和
至少一个多孔涂层。
5.如权利要求1所述的植入器具,其特征在于还包括头部部分,所述头部部分相对于外侧部分成冠状地进行设置;并且包括芯部部分,其布置于外侧部分的下面;所述处理部被施加于芯部部分上。
6.如权利要求5所述的植入器具,其特征在于:位于芯部部分处的处理部不同于施加于头部部分上的处理部。
7.如权利要求5所述的植入器具,其特征在于:处理部只施加于芯部部分。
8.如权利要求1所述的植入器具,其特征在于包括沿植入器具、在轴向上隔开的至少两个被处理区域,其中一个被处理区域被设置成贯穿软组织,同时另一个被处理区域被设置成贯穿骨骼。
9.如权利要求1所述的植入器具,其特征在于:所述植入器具包括被放置于上颌骨或下颌骨中的牙植入体。
10.如权利要求1所述的植入器具,其特征在于:外侧部分由金属制成。
11.如权利要求1所述的植入器具,其特征在于:外侧部分由钽制成。
12.一种植入器具,包括:
纵向轴,其大致由植入器具所限定;
套筒,其被构造成可放置在骨骼的孔洞中,且具有多孔材料;和
芯部,其被接纳在套筒中,且在垂直于所述纵向轴延伸的横截面上具有非圆的外周边,以接合着套筒,并且可旋转地将套筒紧固到芯部上。
13.如权利要求12所述的植入器具,其特征在于:外周边包括至少一个用于接合套筒的平坦表面。
14.如权利要求12所述的植入器具,其特征在于:外周边是以下的至少之一:
多边形的;
曲线形的;
椭圆形的。
15.如权利要求12所述的植入器具,其特征在于:外周边包括至少一个凹入的曲面。
16.如权利要求15所述的植入器具,其特征在于:芯部具有至少两个凹入的曲面,其在会合部处相邻接,所述会合部形成了接合套筒用的尖端。
17.如权利要求16所述的植入器具,其特征在于:尖端形成了用于切入套筒内的边缘。
18.如权利要求12所述的植入器具,其特征在于:芯部具有外表面,其形成了至少一个大致纵向延伸的沟槽。
19.如权利要求18所述的植入器具,其特征在于:外表面包括在芯部周围沿周向排列的多个沟槽。
20.如权利要求12所述的植入器具,其特征在于:套筒包括由多孔材料形成的多个通道,其全部地和大致径向地贯穿套筒;并且,芯部进一步包括具有被处理区域的表面,所述被处理区域被套筒覆盖并且被处理以直接附着到骨骼或软组织上。
21.如权利要求20所述的植入器具,其特征在于:被处理区域是被粗糙化处理,或具有至少一层生物相容性材料涂层。
22.一种形成植入器具的方法,包括:
对芯部进行处理用于与骨骼或软组织相直接接合;并且
将外侧多孔部分紧固在芯部的被处理区域上。
23.如权利要求22所述的方法,其特征在于:所述处理步骤包括在将外侧多孔部分组装到芯部上之前对芯部进行处理。
24.如权利要求22所述的方法,其特征在于:所述处理步骤包括在芯部上形成以下至少之一:
螺纹,
环形凹槽,
表面凹口图案,
随机布置的表面凹口,
通过酸蚀形成的表面凹口,
通过喷砂法形成的表面凹口,
至少一层的生物相容性涂层,和
至少一层的生物活性涂层。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/624,608 | 2009-11-24 | ||
US12/624,608 US8602782B2 (en) | 2009-11-24 | 2009-11-24 | Porous implant device with improved core |
PCT/US2010/055975 WO2011066098A1 (en) | 2009-11-24 | 2010-11-09 | Porous implant device with improved core |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102596095A true CN102596095A (zh) | 2012-07-18 |
CN102596095B CN102596095B (zh) | 2015-08-05 |
Family
ID=43629715
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201080050015.9A Expired - Fee Related CN102596095B (zh) | 2009-11-24 | 2010-11-09 | 具有改进芯部的多孔植入器具 |
Country Status (6)
Country | Link |
---|---|
US (5) | US8602782B2 (zh) |
EP (1) | EP2503953B1 (zh) |
JP (1) | JP5932657B2 (zh) |
CN (1) | CN102596095B (zh) |
CA (1) | CA2773224C (zh) |
WO (1) | WO2011066098A1 (zh) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8602782B2 (en) | 2009-11-24 | 2013-12-10 | Zimmer Dental, Inc. | Porous implant device with improved core |
CN106456291A (zh) * | 2014-03-28 | 2017-02-22 | 植体B有限公司 | 可更新的牙科植体 |
CN106999217A (zh) * | 2014-11-04 | 2017-08-01 | 海普瑞万迅公司 | 用于稳固断骨或非断骨的植入物 |
CN107847253A (zh) * | 2015-05-22 | 2018-03-27 | 卡燕医疗股份有限公司 | 用于修复软组织的***和方法 |
CN113440276A (zh) * | 2021-06-12 | 2021-09-28 | 杭州口腔医院集团有限公司 | 一种口腔内种植体及其数字化加工方法 |
CN113712694A (zh) * | 2021-09-08 | 2021-11-30 | 琅泰美康医疗器械有限公司 | 组配式种植体 |
CN115740495A (zh) * | 2022-11-02 | 2023-03-07 | 大博医疗科技股份有限公司 | 一种3d打印骨小梁口腔种植体的方法 |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6610067B2 (en) | 2000-05-01 | 2003-08-26 | Arthrosurface, Incorporated | System and method for joint resurface repair |
US8388624B2 (en) | 2003-02-24 | 2013-03-05 | Arthrosurface Incorporated | Trochlear resurfacing system and method |
US8684734B1 (en) | 2003-02-27 | 2014-04-01 | Philip Scott Lyren | Dental implant with porous body |
US8821582B1 (en) * | 2003-05-27 | 2014-09-02 | Philip Scott Lyren | Hip implant with porous body |
EP1765201A4 (en) | 2004-06-28 | 2013-01-23 | Arthrosurface Inc | SYSTEM FOR THE BENDING AREA |
CA2686814A1 (en) | 2006-12-11 | 2008-06-19 | Arthrosurface Incorporated | Retrograde resection apparatus and method |
US10945743B2 (en) | 2009-04-17 | 2021-03-16 | Arthrosurface Incorporated | Glenoid repair system and methods of use thereof |
WO2010121250A1 (en) | 2009-04-17 | 2010-10-21 | Arthrosurface Incorporated | Glenoid resurfacing system and method |
US9707058B2 (en) * | 2009-07-10 | 2017-07-18 | Zimmer Dental, Inc. | Patient-specific implants with improved osseointegration |
CA2792048A1 (en) | 2010-03-05 | 2011-09-09 | Arthrosurface Incorporated | Tibial resurfacing system and method |
KR101134342B1 (ko) * | 2010-04-22 | 2012-04-09 | 주식회사 메가젠임플란트 | 치과용 임플란트의 픽스츄어 및 그를 구비하는 임플란트 시술용 세트 |
EP3738544B1 (de) | 2010-05-05 | 2023-10-18 | Nobel Biocare Services AG | Dentalimplantat |
DE102010051176A1 (de) * | 2010-11-15 | 2012-05-16 | Urs Brodbeck | Dental-Implantatsystem und Verfahren zur Herstellung eines Dental-Implantatsystems |
EP2640318B1 (en) | 2010-11-18 | 2016-08-31 | Zimmer, Inc. | Resistance welding a porous metal layer to a metal substrate |
US10427235B2 (en) * | 2010-11-18 | 2019-10-01 | Zimmer, Inc. | Resistance welding a porous metal layer to a metal substrate |
US9433480B2 (en) * | 2010-12-21 | 2016-09-06 | Zimmer Dental, Inc. | Implant with porous sleeve including anti-rotation features |
DE102011009906A1 (de) | 2011-01-31 | 2012-08-02 | Holger Zipprich | Dental- Implantatsystem |
EP2502600A1 (de) | 2011-03-21 | 2012-09-26 | Biodenta Swiss AG | Dental-Implantatsystem |
JP2013085577A (ja) | 2011-10-13 | 2013-05-13 | Matsumoto Shika Univ | インプラント構造体 |
JP5976486B2 (ja) * | 2011-10-20 | 2016-08-23 | 医療法人メディカル・ライフクォリティ | 対象表面の処理方法 |
US20130165982A1 (en) | 2011-12-22 | 2013-06-27 | Arthrosurface Incorporated | System and Method for Bone Fixation |
US9168110B2 (en) | 2012-05-29 | 2015-10-27 | Biomet 3I, Llc | Dental implant system having enhanced soft-tissue growth features |
DE112013003358T5 (de) | 2012-07-03 | 2015-03-19 | Arthrosurface, Inc. | System und Verfahren für Gelenkoberflächenersatz und -reparatur |
EA022319B1 (ru) * | 2012-07-12 | 2015-12-30 | Закрытое Акционерное Общество "Алтимед" | Зубной имплантат |
US20140205971A1 (en) * | 2013-01-18 | 2014-07-24 | The Trustees Of The Stevens Institute Of Technology | Modification of root form dental implants for accelerated tissue regeneration |
DE102013201885A1 (de) * | 2013-02-05 | 2014-08-07 | Urs Brodbeck | Keramikkörper, insbesondere zur Verwendung in einem Knochenimplantat, insbesondere als Dentalimplantat |
US20140277183A1 (en) * | 2013-03-15 | 2014-09-18 | Smed-Ta/Td, Llc | Fixation of orthopaedic devices |
US9492200B2 (en) | 2013-04-16 | 2016-11-15 | Arthrosurface Incorporated | Suture system and method |
ITTO20130409A1 (it) * | 2013-05-21 | 2013-08-20 | Anna Maria Bonelli | Vite implantabile emergente parzialmente sinterizzata. |
ES2534810B1 (es) * | 2013-05-31 | 2015-11-10 | Josep Soler Cegarra | Implante dental |
FI2835653T3 (fi) * | 2013-08-06 | 2023-01-13 | Näytepidike AFM:lle | |
CN104665913B (zh) | 2013-11-26 | 2017-06-06 | 财团法人工业技术研究院 | 仿生固定装置与其拔出装置 |
CN104665906B (zh) | 2013-11-26 | 2017-09-08 | 财团法人工业技术研究院 | 仿生固定装置 |
CN104665905B (zh) | 2013-11-26 | 2018-04-06 | 财团法人工业技术研究院 | 仿生固定装置 |
US11607319B2 (en) | 2014-03-07 | 2023-03-21 | Arthrosurface Incorporated | System and method for repairing articular surfaces |
US9931219B2 (en) | 2014-03-07 | 2018-04-03 | Arthrosurface Incorporated | Implant and anchor assembly |
US10624748B2 (en) | 2014-03-07 | 2020-04-21 | Arthrosurface Incorporated | System and method for repairing articular surfaces |
CN104352285B (zh) * | 2014-11-25 | 2017-07-07 | 上海交通大学医学院附属第九人民医院 | 一种个体化3d打印种植体的设计与制作方法 |
EP3034033A1 (en) | 2014-12-16 | 2016-06-22 | Nobel Biocare Services AG | Dental implant |
US10426580B2 (en) * | 2015-01-21 | 2019-10-01 | Kwang Seob Kim | Implant unit |
US10980617B2 (en) * | 2015-02-23 | 2021-04-20 | Maurice Valen | Implantable surgical screw for bone reconstruction |
AU2016229795B2 (en) * | 2015-03-10 | 2020-11-19 | Hubbell Incorporated | Temperature monitoring of high voltage distribution system components |
WO2017129869A1 (fr) * | 2016-01-28 | 2017-08-03 | Yeung Research | Système et dispositifs pour la fixation d'implants dentaires sur le maxillaire supérieur |
FR3047164A1 (fr) * | 2016-01-28 | 2017-08-04 | Yeung Res | Systeme et dispositifs pour la fixation d'implants dentaires sur le maxillaire superieur |
US10595916B2 (en) | 2017-01-09 | 2020-03-24 | Zimmer, Inc. | Poly-axial fixation posts |
US11160663B2 (en) | 2017-08-04 | 2021-11-02 | Arthrosurface Incorporated | Multicomponent articular surface implant |
USD913840S1 (en) * | 2018-09-13 | 2021-03-23 | Patrick Bernhard Albert Lachapelle | Fastener for bracelet |
PL234106B1 (pl) * | 2018-12-27 | 2020-01-31 | Jezewska Elzbieta Promet Plast Spolka Cywilna Elzbieta Jezewska Andrzej Jezewski | Elektrownia wiatrowa i sposób sterowania elektrownią wiatrową |
GB2609338B (en) | 2019-03-12 | 2023-06-14 | Arthrosurface Inc | Humeral and glenoid articular surface implant systems and methods |
US11255370B2 (en) * | 2019-10-01 | 2022-02-22 | The Boeing Company | Ceramic fastener assembly for high temperatures |
ES2933723T3 (es) * | 2019-12-19 | 2023-02-13 | Smed Ta Td Llc | Implante dental con material poroso de crecimiento interior |
US11786343B2 (en) | 2020-07-09 | 2023-10-17 | Southern Implants (Pty) Ltd | Dental implants with stepped threads and systems and methods for making the same |
US11484396B1 (en) * | 2021-06-21 | 2022-11-01 | Identical, Inc. | Root-analog dental implants and systems, devices, and methods for designing and manufacturing same |
ES2938069A1 (es) * | 2021-10-04 | 2023-04-04 | Gonzalo Manuel Valle | Implantes hexagonales externos e internos para senos maxilares en maxilares atroficos con altura osea de 3 a 7 mm y protocolo quirurgico asociado |
WO2023057673A1 (es) * | 2021-10-04 | 2023-04-13 | ZARAZAGA MASSETTI, Sebastián | Implantes hexagonales externos e internos aplicados al maxilar superior como al inferior para altura ósea de 3 a 7 mm y para sectores posteriores atróficos con 2-3 mm de hueso a piso de seno maxilar, que incorporan un elemento de fijación auxiliar o aditamento protético para el anclaje inicial o estabilidad primaria y protocolo quirúrgico asociado |
ES2953361A1 (es) * | 2022-03-28 | 2023-11-10 | Gonzalo Manuel Valle | Implantes hexagonales externos e internos aplicados al maxilar superior como al inferior que incorporan un elemento de fijacion auxiliar o aditamento protetico para el anclaje inicial o estabilidad primaria a partir de principios traumatologicos como la reduccion de fracturas |
US20230372067A1 (en) * | 2022-05-20 | 2023-11-23 | Dustin Shin | Dental implant for preserving bone and improving osseointegration |
CN115089328B (zh) * | 2022-06-17 | 2023-05-12 | 汪晓晖 | 一种表面梯度微孔结构的牙种植体***及其制备方法 |
US11872105B1 (en) * | 2022-12-01 | 2024-01-16 | Robert Parker | Dental implant device for regeneration of dental pulp and dentin |
US11931224B1 (en) | 2022-12-19 | 2024-03-19 | Robert Parker | Tooth pod |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4872840A (en) * | 1987-07-15 | 1989-10-10 | Team Incorporated | Dental implant and method |
US5002488A (en) * | 1988-04-12 | 1991-03-26 | Hadaco, Ltd. | Dental implants with resorption preventing means |
US5049074A (en) * | 1989-03-29 | 1991-09-17 | Sugio Otani | Dental implant |
US6095817A (en) * | 1999-02-24 | 2000-08-01 | Sulzer Calcitek Inc. | Dental implant having multiple textured surfaces |
US20090011384A1 (en) * | 2005-08-30 | 2009-01-08 | Michael Collins | Dental implant for a jaw with reduced bone volume and improved osseointegration features |
US20090061387A1 (en) * | 2007-08-30 | 2009-03-05 | Matthew Lomicka | Multiple root implant |
CN101505678A (zh) * | 2006-08-01 | 2009-08-12 | 维特利·邦达 | 植牙***及方法 |
Family Cites Families (349)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2721387A (en) | 1953-07-13 | 1955-10-25 | Edward S Ashuckian | Artificial tooth |
US3314420A (en) * | 1961-10-23 | 1967-04-18 | Haeger Potteries Inc | Prosthetic parts and methods of making the same |
US3423526A (en) | 1965-01-21 | 1969-01-21 | Hughes Aircraft Co | Narrow-band television |
US3423830A (en) * | 1965-10-01 | 1969-01-28 | Dentists Supply Co | Porcelain and resin tooth with silicon bonding agent |
US3423831A (en) * | 1966-06-27 | 1969-01-28 | Dentists Supply Co | Composite artificial tooth |
US3435526A (en) | 1967-02-13 | 1969-04-01 | Heli Coil Corp | Device for securing an artificial tooth to the bone structure of a human jaw |
US3497953A (en) * | 1968-11-01 | 1970-03-03 | Bernard Weissman | Dental prosthetic structure holding device |
US3685115A (en) | 1970-05-25 | 1972-08-22 | Warren J Scott | Method for making dental coping |
US3849887A (en) | 1970-06-01 | 1974-11-26 | Vitredent Corp | Dental implant |
US3797113A (en) * | 1970-06-01 | 1974-03-19 | Vitredent Corp | Dental implant |
US3713860A (en) * | 1970-08-31 | 1973-01-30 | Atomic Energy Commission | Bone substitute |
US3740851A (en) * | 1971-01-13 | 1973-06-26 | B Weissman | Jacketed dental anchor |
JPS5635844B2 (zh) | 1972-12-07 | 1981-08-20 | ||
US3992725A (en) | 1973-11-16 | 1976-11-23 | Homsy Charles A | Implantable material and appliances and method of stabilizing body implants |
US3919773A (en) | 1973-12-20 | 1975-11-18 | Sybron Corp | Direct moldable implant material |
US3906550A (en) | 1973-12-27 | 1975-09-23 | William Rostoker | Prosthetic device having a porous fiber metal structure |
DE2403211C3 (de) | 1974-01-23 | 1981-12-24 | Etablissement Dentaire Ivoclar, Schaan | Werkstoff für Dentalzwecke |
US3905109A (en) | 1974-03-22 | 1975-09-16 | Crysta Dent Inc | Dental implant member |
US3896547A (en) | 1974-05-02 | 1975-07-29 | Sterndent Corp | Prosthetic article and method for manufacture |
JPS5223514B2 (zh) * | 1974-09-25 | 1977-06-24 | ||
US3934347A (en) * | 1975-01-14 | 1976-01-27 | Lash Oral Implants | Dental prosthetic structure and method |
DE2501683C3 (de) | 1975-01-17 | 1979-11-29 | Ernst Leitz Wetzlar Gmbh, 6300 Wetzlar | Polymeres Verbundmaterial für prothetische Zwecke und Verfahren zu seiner Herstellung |
DE2615116A1 (de) * | 1975-04-07 | 1976-10-28 | Kyoto Ceramic | Implantierbare vorrichtung |
US5934906A (en) | 1975-09-19 | 1999-08-10 | Shopvest, Inc. | Working model for prosthodontic preparation of a tooth for installation of an implant fixture |
US4011602A (en) * | 1975-10-06 | 1977-03-15 | Battelle Memorial Institute | Porous expandable device for attachment to bone tissue |
US4199864A (en) * | 1975-12-22 | 1980-04-29 | Arthur Ashman | Endosseous plastic implant method |
GB1526780A (en) | 1975-12-30 | 1978-09-27 | Matsumoto Dental College | Investment casting process of chromium-cobalt and/or nickel alloys |
SE411613B (sv) * | 1976-03-16 | 1980-01-21 | Ehrnford Lars Edgar Martin | Forstyvnings- och forsterkningselement och/eller retentionselement |
SE414399B (sv) * | 1976-03-16 | 1980-07-28 | Hans Scheicher | Keramiskt material for anvendning inom medicinen, i synnerhet for framstellning av implantat, fremst odontologiska implantat samt sett for framstellning av materialet |
US4097935A (en) | 1976-07-21 | 1978-07-04 | Sterling Drug Inc. | Hydroxylapatite ceramic |
US4122605A (en) | 1976-09-22 | 1978-10-31 | Kyoto Ceramic Kabushiki Kaisha | Somatic element of single crystalline sapphire ceramics |
US4259072A (en) * | 1977-04-04 | 1981-03-31 | Kyoto Ceramic Co., Ltd. | Ceramic endosseous implant |
DE2733394C3 (de) | 1977-07-23 | 1984-10-25 | Riess, Guido, Prof. Dr.med.dent., 8100 Garmisch-Partenkirchen | Kunstzahn mit implantierbarer Zahnwurzel |
DE2824118B2 (de) * | 1978-06-01 | 1980-07-10 | Guido Dr.Med.Dent. 8100 Garmisch-Partenkirchen Riess | Dentales Implantat |
IL56141A (en) * | 1977-12-23 | 1981-10-30 | Sterling Drug Inc | Whitlockite ceramic and its manufacture |
US4229170A (en) | 1978-05-04 | 1980-10-21 | Perez Richard D | Pontic having an internal ceramic core |
US4244689A (en) * | 1978-06-27 | 1981-01-13 | Arthur Ashman | Endosseous plastic implant |
DE3071095D1 (en) * | 1979-07-13 | 1985-10-24 | Corning Glass Works | Dental constructs and tools and production thereof |
JPS5645814A (en) * | 1979-09-25 | 1981-04-25 | Kureha Chem Ind Co Ltd | Hydroxyapatite, its ceramic material and its manufacture |
US4252525A (en) * | 1979-12-17 | 1981-02-24 | Child Frank W | Dental implant |
DE3039664C2 (de) * | 1980-10-21 | 1986-07-17 | Kulzer & Co Gmbh, 6380 Bad Homburg | Röntgenopakes Dentalmaterial mit Füllstoff auf Silicat-Basis |
JPS5775646A (en) | 1980-10-29 | 1982-05-12 | Nippon Kogaku Kk | Dental implant |
US4536158A (en) | 1980-12-08 | 1985-08-20 | Medical Biological Sciences, Inc. | Oral prosthesis and method for producing same |
US4478904A (en) | 1981-04-08 | 1984-10-23 | University Of Florida | Metal fiber reinforced bioglass composites |
US4531915A (en) | 1981-08-14 | 1985-07-30 | Tatum Jr O Hilt | Dental implant |
FR2508307A1 (fr) * | 1981-09-16 | 1982-12-31 | Lonca Philippe | Nouveaux implants dentaires et materiel ancillaire pour leur mise en place |
US4439152A (en) * | 1982-03-04 | 1984-03-27 | Small Irwin A | Method of jawbone abutment implant for dental prostheses and implant device |
JPS5911843A (ja) | 1982-07-12 | 1984-01-21 | 日本特殊陶業株式会社 | 義歯装着用歯科インプラント |
US4475892A (en) | 1982-10-13 | 1984-10-09 | Jaff Investment Company | Microcellular ceramic material and process for manufacture thereof |
US4492577A (en) * | 1982-10-25 | 1985-01-08 | Farris Edward T | Surgical implants with solid interiors and porous surfaces |
US4531916A (en) | 1983-07-08 | 1985-07-30 | W. L. Gore & Associates, Inc. | Dental implant with expanded PTFE gingival interface |
US4556534A (en) | 1983-12-20 | 1985-12-03 | Dentsply Research & Development Corp. | Nickel based casting alloy |
JPS60186455A (ja) | 1984-03-06 | 1985-09-21 | 株式会社ニコン | アパタイトコンポジツトセラミクス |
US4828495A (en) | 1984-04-03 | 1989-05-09 | Denpac Corp. | Sintered alloy dental prosthetic devices and method |
EP0180247B1 (de) | 1984-11-09 | 1989-07-26 | IMPLANTO-LOcK Gesellschaft mit beschränkter Haftung für Implantatforschung und Entwicklung | Enossales Implantat zur Befestigung von festsitzendem oder abnehmbarem Zahnersatz |
US4744757A (en) | 1985-03-20 | 1988-05-17 | Corning Glass Works | Fixed partial dentures and method of making |
JPH0712365B2 (ja) | 1985-04-04 | 1995-02-15 | オリンパス光学工業株式会社 | 人工歯根 |
JPS61275205A (ja) | 1985-05-30 | 1986-12-05 | Kuraray Co Ltd | 歯牙表面処理剤 |
US4743260A (en) * | 1985-06-10 | 1988-05-10 | Burton Charles V | Method for a flexible stabilization system for a vertebral column |
US4820157A (en) | 1985-11-22 | 1989-04-11 | Salvo Christopher A | Dental bridge |
US4744759A (en) | 1986-05-13 | 1988-05-17 | American Dental Association Health Foundation | Inserts for composite dental restorations |
US5344457A (en) | 1986-05-19 | 1994-09-06 | The University Of Toronto Innovations Foundation | Porous surfaced implant |
US4737411A (en) * | 1986-11-25 | 1988-04-12 | University Of Dayton | Controlled pore size ceramics particularly for orthopaedic and dental applications |
JPH0616800B2 (ja) | 1986-12-05 | 1994-03-09 | 春幸 川原 | メッシュ構造の骨内インプラント部材 |
US5575652A (en) | 1987-01-30 | 1996-11-19 | Colgate Palmolive Company | Process for applying antibacterial oral composition to dental implant areas |
US4960733A (en) | 1987-02-28 | 1990-10-02 | Hoya Corporation | Inorganic biomaterial and process for producing the same |
JPS63270061A (ja) | 1987-04-28 | 1988-11-08 | Hoya Corp | 無機生体材料の表面改質方法 |
US5076789A (en) | 1987-05-13 | 1991-12-31 | Tanaka Dental Enterprises | Metal-porcelain dental restorations, dental veneers, dental bridges and metal foil for use therein and methods for making dental appliances |
US5186626A (en) * | 1987-05-13 | 1993-02-16 | Asami Tanaka Dental Enterprises | Metal-porcelain dental bridges |
JP2555077B2 (ja) | 1987-05-21 | 1996-11-20 | 株式会社クラレ | 複合インプラント |
US5087200B1 (en) * | 1987-06-12 | 1996-05-07 | Nobelpharma Ab | Spacer for dental implants |
SE457769B (sv) | 1987-06-12 | 1989-01-30 | Nobelpharma Ab | Distansorgan foer tandimplantat |
FI78232C (fi) | 1987-06-15 | 1989-07-10 | Trident Oy | Implantat, som ersaetter en tand eller en del av benvaevnaden med syntetiskt material. |
JPS6485644A (en) | 1987-09-28 | 1989-03-30 | Asahi Optical Co Ltd | Preparation of ceramics composite |
JPH0191853A (ja) | 1987-10-02 | 1989-04-11 | Jishi Toushi Kogyo Kk | 人工歯 |
US5152687A (en) | 1987-10-30 | 1992-10-06 | Kyocera Corporation | Composite implant member |
US5192325A (en) * | 1988-02-08 | 1993-03-09 | Mitsubishi Kasei Corporation | Ceramic implant |
EP0328041B1 (en) * | 1988-02-08 | 1994-09-07 | Mitsubishi Chemical Corporation | Ceramic implant and process for its production |
DE68904665T2 (de) | 1988-03-17 | 1993-09-02 | Kuraray Co | Haertbare harzzusammensetzung. |
US4880610A (en) | 1988-04-20 | 1989-11-14 | Norian Corporation | In situ calcium phosphate minerals--method and composition |
US5062798A (en) | 1988-04-27 | 1991-11-05 | Ngk Spark Plug Co., Ltd. | SiC based artificial dental implant |
IT1217801B (it) | 1988-06-08 | 1990-03-30 | Honeywell Rull Italia S P A | Apparato per rimozione/inserzione a caldo su un bus di connessione di unita, di registrazione magnetica a supporto non rimovibile |
DE3819777A1 (de) | 1988-06-10 | 1989-12-21 | Bayer Ag | Fuellstoffhaltige, polymerisierbare massen und deren verwendung |
JP2829318B2 (ja) | 1988-06-10 | 1998-11-25 | 春幸 川原 | フレームレス,コアレス多孔質骨内インプラント |
US4877400A (en) | 1988-06-24 | 1989-10-31 | Holsclaw Linda A | Dental bridge and method |
BE1002350A3 (fr) * | 1988-08-02 | 1991-01-08 | Dury Georges Emile Ladislas | Implant. |
JPH0716500B2 (ja) * | 1988-08-12 | 1995-03-01 | 而至陶歯工業株式会社 | 前歯部用人工歯 |
US20020095213A1 (en) | 1988-09-02 | 2002-07-18 | Dirkjan Bakker | Prosthetic devices formed from materials having bone-bonding properties and uses therefor |
US20010051832A1 (en) | 1988-09-02 | 2001-12-13 | Dirkjan Bakker | Prosthetic devices formed from materials having bone-bonding properties and uses therefor |
US5009709A (en) * | 1988-09-15 | 1991-04-23 | Den-Mat Corporation | Strong dental porcelain and method for its manufacture |
US5180303A (en) * | 1988-09-21 | 1993-01-19 | Regents Of The University Of California | Retrievable dental prothesis apparatus and method of fabrication |
US4906190A (en) | 1988-10-11 | 1990-03-06 | Michna Claus G | Dental prosthesis |
DE58904485D1 (de) | 1988-10-24 | 1993-07-01 | Univ Chemnitz Tech | Metallspongiosa und verfahren zu ihrer herstellung. |
JPH02255135A (ja) | 1989-03-29 | 1990-10-15 | Takashi Miyazaki | 歯科用補綴物 |
SE465571B (sv) | 1989-04-10 | 1991-09-30 | Stiftelsen Ct Foer Dentaltekni | Saett att framstaella ett sammansatt keramiskt material med bioaktiva egenskaper |
US5123844A (en) * | 1989-06-20 | 1992-06-23 | Agency Of Industrial Science And Technology | Living hard tissue replacement prepared by superplastic forming of a calcium phosphate base |
EP0405556B1 (en) | 1989-06-30 | 1996-05-22 | TDK Corporation | Living hard tissue replacement, its preparation, and preparation of integral body |
US5232878A (en) | 1989-06-30 | 1993-08-03 | Hoya Corporation | Process for producing inorganic biomaterial |
US4957554A (en) | 1989-08-16 | 1990-09-18 | Minnesota Mining And Manufacturing Company | Dimensionally-controlled ceramics |
US5007835A (en) * | 1989-08-17 | 1991-04-16 | Maurice Valen | Dental implant |
WO1991003213A1 (en) * | 1989-08-30 | 1991-03-21 | Tdk Corporation | Artificial dental root |
FR2651439B1 (fr) | 1989-09-06 | 1994-09-23 | Fbfc International Sa Nv | Materiau bioreactif pour prothese ou implants composites. |
US5236458A (en) | 1989-09-06 | 1993-08-17 | S.A. Fbfc International | Bioreactive material for a prosthesis or composite implants |
US5254005A (en) | 1989-11-14 | 1993-10-19 | Max Zuest | Dental implant system and method |
US5169309A (en) * | 1990-01-12 | 1992-12-08 | Attachments International, Inc. | Abutment for dental appliances and the like |
DK0438048T3 (da) * | 1990-01-15 | 1994-06-20 | Friatec Keramik Kunststoff | Tandimplantat |
US5350302A (en) | 1990-07-05 | 1994-09-27 | Marlin Gerald M | Implant collar and post system |
US5135395A (en) | 1990-07-05 | 1992-08-04 | Marlin Gerald M | Implant collar and post system |
US5562733A (en) | 1990-07-24 | 1996-10-08 | Dentsply G.M.B.H. | Dental ceramic, coated titanium prosthesis |
US5004421A (en) * | 1990-07-27 | 1991-04-02 | Sargon Lazarof | Dental implant and method of using same |
US5125839A (en) | 1990-09-28 | 1992-06-30 | Abraham Ingber | Dental implant system |
DE4042402C1 (zh) * | 1990-10-03 | 1992-09-03 | Degussa Ag, 6000 Frankfurt, De | |
US5288232A (en) * | 1990-12-18 | 1994-02-22 | American Thermocraft Corporation Subsidiary Of Jeneric/Pentron Incorporated | Dental porcelain for titanium and titanium alloys |
US5176747A (en) * | 1990-12-18 | 1993-01-05 | American Thermocraft Corporation | Dental porcelain for titanium and titanium alloys |
US5314334A (en) * | 1990-12-18 | 1994-05-24 | American Thermocraft Corporation Subsidiary Of Jeneric/Pentron Incorporated | Dental procelain bond layer for titanium and titanium alloy copings |
EP0498923B1 (en) | 1991-02-14 | 1995-05-17 | Heraeus Kulzer Gmbh | Implant supported prothesis |
JPH0755224B2 (ja) | 1991-02-20 | 1995-06-14 | 勇 池原 | 作業用模型の製作方法 |
US5194001A (en) * | 1991-08-02 | 1993-03-16 | Salvo Christopher A | Reinforced dental bridge |
US5458488A (en) | 1991-12-30 | 1995-10-17 | Wellesley Research Associates, Inc. | Dental implant and post construction |
US5282861A (en) * | 1992-03-11 | 1994-02-01 | Ultramet | Open cell tantalum structures for cancellous bone implants and cell and tissue receptors |
DE4209569C2 (de) | 1992-03-25 | 1994-11-10 | Hahn Rainer | Prothesenbasis |
FR2690069A1 (fr) | 1992-04-21 | 1993-10-22 | Perisse Jean | Implant dentaire multibloc perfectionné et accessoires. |
FI91713C (fi) * | 1992-04-23 | 1994-08-10 | Axidental Oy | Uusia bioaktiivisia pinnotteita ja niiden valmistus ja käyttö |
US5366756A (en) | 1992-06-15 | 1994-11-22 | United States Surgical Corporation | Method for treating bioabsorbable implant material |
US5316476B1 (en) * | 1992-06-19 | 1996-06-18 | Jack T Krauser | Dental implant with a longitudinally grooved cylindrical surface |
SE470346B (sv) | 1992-06-23 | 1994-01-31 | Sandvik Ab | Metod för framställning av keramiska artificiella tandrestaurationer |
US5310343A (en) * | 1992-10-14 | 1994-05-10 | Jiro Hasegawa | Endo-osseous implant |
US5425640A (en) | 1992-10-22 | 1995-06-20 | Scharf; Jonathan | Method and product for improved ceramic fiber reinforced and filled thermoplastic and thermosetting resin systems |
DE59309022D1 (de) | 1992-11-25 | 1998-11-05 | Rauter Vita Zahnfabrik | Verfahren zur Herstellung von Zahnersatz auf Keramikbasis |
SE500657C2 (sv) | 1992-12-07 | 1994-08-01 | Nobelpharma Ab | Metod och anordning för preparering av implantatytor med användning av gasurladdningsplasma |
US5415546A (en) * | 1993-03-23 | 1995-05-16 | Cox, Sr.; Ronald W. | Radiopaque dental composite and materials |
US5312254A (en) * | 1993-03-26 | 1994-05-17 | Rosenlicht Joel L | Sterile application of implants in bone |
US5338196A (en) | 1993-04-08 | 1994-08-16 | Implant Innovations, Inc. | Dental laboratory components and procedures for anatomical restoration on artificial root fixtures |
US6696585B1 (en) | 1993-04-13 | 2004-02-24 | Southwest Research Institute | Functionalized nanoparticles |
US5346397A (en) | 1993-06-15 | 1994-09-13 | Braiman Kenneth S | Process for making ceramic dental crowns |
US5502087A (en) | 1993-06-23 | 1996-03-26 | Dentsply Research & Development Corp. | Dental composition, prosthesis, and method for making dental prosthesis |
AU683050B2 (en) | 1993-06-24 | 1997-10-30 | Dentsply Gmbh | Dental prosthesis |
EP0630639A1 (de) * | 1993-06-25 | 1994-12-28 | Vita Zahnfabrik H. Rauter GmbH & Co KG | Dentalkeramische Restauration mit einem mehrschichtigen Aufbau |
FR2709413B1 (fr) | 1993-09-03 | 1995-11-17 | Arnaud Delahaye | Prothèse dentaire, et matériau pour sa réalisation. |
FR2710256B1 (fr) * | 1993-09-24 | 1997-08-01 | Gilles Billet | Prothèse dentaire à coque de support composite et revêtement en résine, pièce de tissu préimprégné, procédé et machine de fabrication de cette prothèse. |
US6419491B1 (en) | 1993-11-02 | 2002-07-16 | Bio-Lok International, Inc. | Dental implant system with repeating microgeometric surface patterns |
US6454569B1 (en) | 1993-11-02 | 2002-09-24 | Biolok International, Inc. | Dental implant having a dual bio-affinity collar |
US5468544A (en) | 1993-11-15 | 1995-11-21 | The Trustees Of The University Of Pennsylvania | Composite materials using bone bioactive glass and ceramic fibers |
US5344318A (en) | 1993-11-30 | 1994-09-06 | Wilson Richard S | Aesthetic intramobile element for dental implants |
US5449291A (en) | 1993-12-21 | 1995-09-12 | Calcitek, Inc. | Dental implant assembly having tactile feedback |
US5873721A (en) | 1993-12-23 | 1999-02-23 | Adt Advanced Dental Technologies, Ltd. | Implant abutment systems, devices, and techniques |
JP3362267B2 (ja) | 1993-12-29 | 2003-01-07 | 日本特殊陶業株式会社 | 生体インプラント材料及びその製造方法 |
US5443515A (en) | 1994-01-26 | 1995-08-22 | Implex Corporation | Vertebral body prosthetic implant with slidably positionable stabilizing member |
JP2547953B2 (ja) | 1994-02-07 | 1996-10-30 | 克成 西原 | 人工歯根 |
US5572652A (en) | 1994-04-04 | 1996-11-05 | The United States Of America As Represented By The Secretary Of The Navy | System and method for monitoring and controlling one or more computer sites |
US5947893A (en) | 1994-04-27 | 1999-09-07 | Board Of Regents, The University Of Texas System | Method of making a porous prothesis with biodegradable coatings |
US5425639A (en) | 1994-05-03 | 1995-06-20 | Anders; Irving | Dental implant with shock absorbent cushioned interface |
US6485849B2 (en) | 1994-05-31 | 2002-11-26 | Tec Ventures, Inc. | Method for molding dental restorations and related apparatus |
US5685714A (en) | 1994-06-16 | 1997-11-11 | Implant Innovations, Inc. | Support post for use in dental implant system |
DE4423794C1 (de) | 1994-07-01 | 1996-02-08 | Ivoclar Ag | Zr0¶2¶-haltige Glaskeramik, Verfahren zu deren Herstellung sowie deren Verwendung |
DE4423793C1 (de) | 1994-07-01 | 1996-02-22 | Ivoclar Ag | Leucithaltige Phosphosilikat-Glaskeramik, Verfahren zu deren Herstellung und deren Verwendung |
US5639402A (en) * | 1994-08-08 | 1997-06-17 | Barlow; Joel W. | Method for fabricating artificial bone implant green parts |
AU3460695A (en) * | 1994-08-26 | 1996-03-22 | Dental Illusions | Anterior tooth characterization guide and process for selecting characterizations and fabricating a characterized anterior tooth prosthesis |
DK0701808T3 (da) | 1994-09-19 | 2003-03-24 | Univ Boston | Infunderet keramisk netværk til fremstilling af odontoforme og dentale restaureringer |
US6159417A (en) | 1994-09-19 | 2000-12-12 | Trustees Of Boston University | Method for fabricating ceramic network material |
US6881488B2 (en) | 1994-09-19 | 2005-04-19 | Trustees Of Boston University | Method for fabricating endodontic, orthodontic, and direct restorations having infused ceramic network |
US5470230A (en) | 1994-09-30 | 1995-11-28 | Daftary; Fereidoun | Anatomical dental implant with expandable root |
FR2725358B1 (fr) | 1994-10-05 | 1997-01-17 | Sadoun Michele Tyszblat | Procede de realisation d'une prothese dentaire fixee sur un implant et piece intermediaire pour la mise en oeuvre de ce procede |
US5785524A (en) | 1994-10-06 | 1998-07-28 | Metaux Precieux Sa Metalor | Securing device for tooth implants |
US5899695A (en) | 1994-11-08 | 1999-05-04 | Lazzara; Richard J. | Anatomic interchangeable healing abutment and impression coping |
US5915967A (en) | 1994-11-14 | 1999-06-29 | Mcgill University | Implant assembly |
US5674069A (en) | 1995-01-13 | 1997-10-07 | Osorio; Julian | Customized dental abutment |
FI101129B (sv) * | 1995-01-13 | 1998-04-30 | Vivoxid Oy | Nya bioaktiva glas och deras användning |
US5961328A (en) | 1995-01-23 | 1999-10-05 | Somborac; Milan | Dental implant |
US5621035A (en) * | 1995-02-08 | 1997-04-15 | M.E.D. Usa | Ceramic fused fiber enhanced dental materials |
US6291547B1 (en) | 1995-02-08 | 2001-09-18 | Materials Evolution And Development Usa Inc. | Bone cement compositions comprising fused fibrous compounds |
US5683249A (en) | 1995-03-22 | 1997-11-04 | Den-Mat Corporation | Dental implant process and treated prosthetic |
US7183334B2 (en) | 1995-04-26 | 2007-02-27 | Reinforced Polymers, Inc. | Low temperature molding compositions with solid thermoplastic elastomer thickeners and fiber reinforcement |
US5676976A (en) | 1995-05-19 | 1997-10-14 | Etex Corporation | Synthesis of reactive amorphous calcium phosphates |
US6027742A (en) * | 1995-05-19 | 2000-02-22 | Etex Corporation | Bioresorbable ceramic composites |
US6287341B1 (en) | 1995-05-19 | 2001-09-11 | Etex Corporation | Orthopedic and dental ceramic implants |
US6117456A (en) | 1995-05-19 | 2000-09-12 | Etex Corporation | Methods and products related to the physical conversion of reactive amorphous calcium phosphate |
US5989026A (en) | 1995-05-25 | 1999-11-23 | Implant Innovations, Inc. | Ceramic two-piece dental abutment |
WO1996039974A1 (en) * | 1995-06-07 | 1996-12-19 | Implex Corporation | Femoral head core channel filling prosthesis |
US5676745A (en) | 1995-06-07 | 1997-10-14 | The United States Of America, As Represented By The Secretary Of Commerce | Pre-ceramic polymers in fabrication of ceramic composites |
US5727943A (en) * | 1995-07-18 | 1998-03-17 | Implant Innovations, Inc. | Self-tapping, screw-type dental implant |
DE19529036A1 (de) | 1995-08-08 | 1997-03-13 | Huels Chemische Werke Ag | Biokompatibler Verbundwerkstoff und Verfahren zu seiner Herstellung |
US5614330A (en) * | 1995-08-18 | 1997-03-25 | American Thermocraft Corporation | Porcelain coating compositions for low expansion porcelain cores and the resulting all-ceramic dental restorations |
EP0798992B1 (en) | 1995-12-08 | 2008-11-26 | Zimmer Dental Inc. | Dental implant having multiple textured surfaces |
US5681167A (en) | 1996-01-05 | 1997-10-28 | Lazarof; Sargon | Dental assembly and process for preparing a tooth prosthesis |
US5951295A (en) | 1996-02-08 | 1999-09-14 | Materials Evolution And Development Usa, Inc. | Ceramic fused fiber enhanced dental materials |
US5713994A (en) * | 1996-06-10 | 1998-02-03 | Ceramco Inc. | Low-fusing temperature porcelain, compositions, prostheses, methods and kits |
US6087553A (en) | 1996-02-26 | 2000-07-11 | Implex Corporation | Implantable metallic open-celled lattice/polyethylene composite material and devices |
DE19610300C2 (de) | 1996-03-15 | 1998-07-02 | Fraunhofer Ges Forschung | Hochfeste transluzente Glimmer-Glaskeramiken, Verfahren zu ihrer Herstellung und Verwendung |
WO1997041809A1 (fr) | 1996-05-03 | 1997-11-13 | Bmp S.A. | Implant intra-osseux |
EP0806211B1 (en) | 1996-05-10 | 2002-10-23 | IsoTis N.V. | Implant material and process for producing it |
ATE281126T1 (de) | 1996-05-17 | 2004-11-15 | Brandestini Marco | Verfahren zur herstellung dentaler rekonstruktionen und rohling zur durchführung des verfahrens |
JPH1025480A (ja) | 1996-07-10 | 1998-01-27 | Nippon Steel Corp | コークス炉蓋のプラグ保持構造 |
JP2847239B2 (ja) | 1996-07-11 | 1999-01-13 | 旭中部資材株式会社 | 建物躯体に対する壁パネルの取付工法及びこれに使用する取付治具 |
JPH1025840A (ja) | 1996-07-11 | 1998-01-27 | Fujita Corp | プレキャスト耐震壁を有する建物躯体の構築方法 |
SI0912155T1 (en) | 1996-07-19 | 2002-06-30 | Division Kft Dentavantgart | Use of novel glass compositions in preparing dental glass pillars and support pillars, and method for producing the glass pillars |
US5833464A (en) | 1996-07-26 | 1998-11-10 | Ivoclar A.G. | Method for manufacturing a ceramic dental replacement |
US5759036A (en) | 1996-07-29 | 1998-06-02 | Hinds; Kenneth F. | Complete dental implant system and method |
US5775912A (en) | 1996-08-16 | 1998-07-07 | American Thermocraft Corporation | Method of producing a dental restoration using CAD/CAM |
KR100203378B1 (ko) | 1996-08-31 | 1999-06-15 | 박원훈 | 도재내관의 제조방법 |
US5968856A (en) | 1996-09-05 | 1999-10-19 | Ivoclar Ag | Sinterable lithium disilicate glass ceramic |
US6953594B2 (en) | 1996-10-10 | 2005-10-11 | Etex Corporation | Method of preparing a poorly crystalline calcium phosphate and methods of its use |
US5833463A (en) | 1996-12-09 | 1998-11-10 | Hurson; Steven M. | Titanium surface treated dental screw for attaching a prosthetic component to an implant |
EP1018971A1 (en) | 1997-01-07 | 2000-07-19 | Technology A/S Reipur | A method of fastening an implant to a bone and an implant therefor |
US6013591A (en) * | 1997-01-16 | 2000-01-11 | Massachusetts Institute Of Technology | Nanocrystalline apatites and composites, prostheses incorporating them, and method for their production |
JPH10201771A (ja) | 1997-01-20 | 1998-08-04 | Injietsukusu:Kk | 歯冠修復物 |
US6056547A (en) * | 1997-03-05 | 2000-05-02 | Medentech, Inc. | Impression and foundation system for implant-supported prosthesis |
US6666684B1 (en) | 1997-03-05 | 2003-12-23 | Curtis D. Names | Impression and foundation system for implant-supported prosthesis |
US6045361A (en) * | 1997-03-05 | 2000-04-04 | Biohorizons Implant Systems, Inc. | Ball-topped screw for facilitating the making of an impression of a dental implant and method of using the same |
US5772438A (en) | 1997-03-07 | 1998-06-30 | Deom Design Inc. | Method for installing a permanent bridge between a pair of abutment teeth |
US6280863B1 (en) | 1997-06-12 | 2001-08-28 | Ivoclar Ag | Translucent apatite glass ceramic |
US6121175A (en) | 1997-06-12 | 2000-09-19 | Ivoclar Ag | Alkali silicate glass |
US6200137B1 (en) * | 1997-06-12 | 2001-03-13 | Ivoclar Ag | Chemically stable translucent apatite glass ceramic |
US6168436B1 (en) * | 1997-06-18 | 2001-01-02 | O'brien Gary | Universal dental implant abutment system |
EP0891984A3 (en) | 1997-06-20 | 2000-01-19 | Smithkline Beecham Corporation | Nucleic acid encoding streptococcus pneumoniae response regulator |
US5964592A (en) | 1997-07-21 | 1999-10-12 | Hites; Andras A. | Nonmetallic dental post and method |
IT1295751B1 (it) | 1997-10-15 | 1999-05-27 | Luigi Ardizio | Procedimento per la produzione di protesi dentali fisse in resina, inserti per le stesse e protesi fisse cosi' ottenute |
US6514453B2 (en) | 1997-10-21 | 2003-02-04 | Nanoproducts Corporation | Thermal sensors prepared from nanostructureed powders |
US5931674A (en) | 1997-12-09 | 1999-08-03 | Hanosh; Frederick N. | Expanding dental implant |
EP1037569A4 (en) | 1997-12-10 | 2006-06-21 | Debbie Llc | PROVISIONAL DENTAL PROSTHESIS |
US6214049B1 (en) * | 1999-01-14 | 2001-04-10 | Comfort Biomedical, Inc. | Method and apparatus for augmentating osteointegration of prosthetic implant devices |
US6345984B2 (en) | 1998-04-13 | 2002-02-12 | Jeneric/Pentron, Inc. | Prefabricated components for dental appliances |
US5971760A (en) | 1998-02-27 | 1999-10-26 | Letcher; William F. | Method of installing a replacement of a patient's deteriorated tooth |
US6048205A (en) * | 1998-03-12 | 2000-04-11 | Wright; Cynthia K. | Biocompatible dental restoration system using layers of high strength ceramic, gold, and porcelain |
US6362250B1 (en) | 1998-03-17 | 2002-03-26 | Jeneric/Pentron Incorporated | Dental bridges comprising fiber reinforced frameworks with fiber or particulate reinforced veneers |
FR2776502B1 (fr) | 1998-03-25 | 2000-06-16 | Gilles Billet | Armature en materiau composite pour une prothese dentaire adjointe, et procede de fabrication |
US6267597B1 (en) | 1998-04-03 | 2001-07-31 | Chang Yeal Kim | Tooth restoration using fibre-reinforced composite material |
US20040241614A1 (en) | 1998-04-13 | 2004-12-02 | Goldberg A. Jon | Prefabricated components for dental appliances |
EP0950421B1 (en) | 1998-04-14 | 2006-10-18 | Tranquil Prospects Ltd. | Implantable material and method for its preparation |
US6159010A (en) | 1998-04-23 | 2000-12-12 | Implant Innovations, Inc. | Fenestrated dental coping |
DE59910666D1 (de) | 1998-04-27 | 2004-11-04 | Urs Brodbeck | Vorrichtung zur rekonstruktion von zähnen |
US6039568A (en) * | 1998-06-02 | 2000-03-21 | Hinds; Kenneth F. | Tooth shaped dental implants |
US6048203A (en) * | 1998-06-08 | 2000-04-11 | Rosenberg; Jeffrey M | Method and device for forming and attaching a non-metal dental prosthesis |
US20050023710A1 (en) | 1998-07-10 | 2005-02-03 | Dmitri Brodkin | Solid free-form fabrication methods for the production of dental restorations |
US6354836B1 (en) | 1998-08-20 | 2002-03-12 | Jeneric/Pentron, Inc. | Methods of producing dental restorations using CAD/CAM and manufactures thereof |
US6322728B1 (en) | 1998-07-10 | 2001-11-27 | Jeneric/Pentron, Inc. | Mass production of dental restorations by solid free-form fabrication methods |
US6808659B2 (en) | 1998-07-10 | 2004-10-26 | Jeneric/Pentron Incorporated | Solid free-form fabrication methods for the production of dental restorations |
US6821462B2 (en) | 1998-07-10 | 2004-11-23 | Jeneric/Pentron, Inc. | Mass production of shells and models for dental restorations produced by solid free-form fabrication methods |
US6250922B1 (en) | 1998-07-30 | 2001-06-26 | Sulzer Dental Inc. | Two-piece dental abutment with removable cuff |
US6497573B2 (en) | 1998-07-30 | 2002-12-24 | Centerpulse Dental Inc. | Composite dental abutment |
US6012923A (en) * | 1998-07-30 | 2000-01-11 | Sulzer Calcitek Inc. | Two-piece dental abutment with removable cuff |
US6168633B1 (en) * | 1998-08-10 | 2001-01-02 | Itzhak Shoher | Composite surface composition for an implant structure |
US6186791B1 (en) * | 1998-08-11 | 2001-02-13 | Jeneric/Pentron Incorporated | Fiber reinforced composite post |
DE19846556A1 (de) | 1998-10-09 | 2000-04-13 | Degussa | Dentalwerkstoff aufweisend poröse Glaskeramiken, poröse Glaskeramiken, Verfahren und Verwendung |
CA2249948C (en) | 1998-10-09 | 2006-04-04 | Donald R. Johnson | Bone implant |
US6063442A (en) * | 1998-10-26 | 2000-05-16 | Implex Corporation | Bonding of porous materials to other materials utilizing chemical vapor deposition |
US6168435B1 (en) | 1998-10-26 | 2001-01-02 | Implant Innovations, Inc. | Ceramic dental abutments with a metallic core |
US6450813B1 (en) | 1998-11-10 | 2002-09-17 | Dentsply Research & Development Corp. | Repair porcelain product, composition and method |
DE19852516A1 (de) | 1998-11-13 | 2000-05-25 | Degussa | Keramische Dentalrestauration |
US6146423A (en) | 1999-01-28 | 2000-11-14 | Implex Corporation | Patella replacement apparatus |
US6299448B1 (en) | 1999-02-17 | 2001-10-09 | Ivanka J. Zdrahala | Surgical implant system for restoration and repair of body function |
ES2216871T3 (es) | 1999-04-16 | 2004-11-01 | KALTENBACH & VOIGT GMBH & CO. KG | Procedimiento para fabricar piezas medicas, odontologicas, de tecnica dental y tecnicas de ceramica. |
US6270347B1 (en) | 1999-06-10 | 2001-08-07 | Rensselaer Polytechnic Institute | Nanostructured ceramics and composite materials for orthopaedic-dental implants |
US6193516B1 (en) | 1999-06-18 | 2001-02-27 | Sulzer Calcitek Inc. | Dental implant having a force distribution shell to reduce stress shielding |
JP3072373B1 (ja) | 1999-07-05 | 2000-07-31 | 工業技術院長 | 汚濁物質、雑菌付着抑制機能および耐酸性を有する人工歯根ならびに製造方法 |
FR2796265B1 (fr) | 1999-07-16 | 2005-08-26 | Daniel Cantaloube | Implant dentaire a deux materiaux biocompatibles et de rapide osteo-intergration |
DE19934367C2 (de) | 1999-07-22 | 2003-08-21 | Binzel Alexander Gmbh Co Kg | Verfahren zum Kühlen eines Schweiß- oder Schneidbrenners sowie Kühlsystem hierfür |
US6135775A (en) | 1999-08-03 | 2000-10-24 | Weisman; Bernard | Longitudinally centrally convergant dental post |
US20030031984A1 (en) | 1999-08-26 | 2003-02-13 | Richard P. Rusin | Ceramic dental mill blanks |
EP1124500A1 (en) | 1999-09-02 | 2001-08-22 | JENERIC/PENTRON Incorporated | Method for manufacturing dental restorations |
US6394806B1 (en) | 1999-09-14 | 2002-05-28 | Nobel Biocare Usa, Inc | Snap-in healing cap |
US6503625B1 (en) | 1999-10-08 | 2003-01-07 | W.R. Grace & Co. - Conn. | Fibers for reinforcing matrix materials |
US6183256B1 (en) * | 1999-10-12 | 2001-02-06 | Tommie W. Fisher | Dental crown |
AU8017300A (en) | 1999-10-14 | 2001-04-23 | Robert L. Schroering | Dental implant having a dual-textured exterior surface |
US6206192B1 (en) | 1999-10-18 | 2001-03-27 | Dendek Dental Products | Dental emergency kit |
US6342203B2 (en) | 1999-10-27 | 2002-01-29 | Dakota Dental Development, Inc. | Compositions for dentistry comprising an oil, to repair, restore, adhere to, or protect the surface of a tooth |
ATE362777T1 (de) | 1999-11-01 | 2007-06-15 | Osteobiologics Inc | Biologisch abbaubares polymer-/keramik- implantatmaterial mit bimodalemzersetzungsprofil |
JP4860868B2 (ja) | 1999-12-07 | 2012-01-25 | ツェ.ノヴェイション ゲーエムベーハー | セラミック製の高強度歯科修復物の製造方法 |
US6679701B1 (en) | 2000-03-23 | 2004-01-20 | Gordon D. Blacklock | Anchor having threads opposing unthreading |
FR2806903B1 (fr) | 2000-03-31 | 2003-05-02 | Jean Claude Yeung | Prothese dentaire |
AU2001261689A1 (en) | 2000-05-16 | 2001-11-26 | Rensselaer Polytechnic Institute | Electrically conducting nanocomposite materials for biomedical applications |
US6669476B2 (en) | 2000-06-27 | 2003-12-30 | David Michael Prestipino | Nanophase dental prosthetics and method |
US6689202B2 (en) | 2000-07-21 | 2004-02-10 | Jeneric/Pentron Incorporated | Molds for the manufacture of a dental restoration and methods of making dental restorations |
US6787584B2 (en) | 2000-08-11 | 2004-09-07 | Pentron Corporation | Dental/medical compositions comprising degradable polymers and methods of manufacture thereof |
US6482284B1 (en) | 2000-08-31 | 2002-11-19 | 3M Innovative Properties Company | Method of making a dental mill blank and support stub assembly |
WO2002026157A1 (en) | 2000-09-29 | 2002-04-04 | Biohex Corporation | Dental implant system and additional methods of attachment |
US6447549B1 (en) | 2000-10-06 | 2002-09-10 | Sulzer Orthopedics Inc. | Modular knee prosthesis system |
JP2002126071A (ja) | 2000-10-13 | 2002-05-08 | Itzhak Shoher | インプラント構築物用の複合材料表面組成物 |
CA2324613A1 (en) | 2000-10-26 | 2002-04-26 | Victor Eduardovich Gjunter | Dental implant |
SE517725C2 (sv) | 2000-11-03 | 2002-07-09 | Mattias Molin | Protetisk anordning och förfarande för dess framställning. |
US6386876B1 (en) | 2000-11-29 | 2002-05-14 | Kenneth K. S. Lee | Universal tissue emergence profile shaping healing abutment, provisional and restoration abutments, impression coping and ceramic crown base system |
PL204442B1 (pl) | 2001-02-06 | 2010-01-29 | Lippo Lassila | Polimeryzowalny wielofunkcyjny kompozyt polimerowy i kompozycja polimerowa, sposób wytwarzania takiego kompozytu lub kompozycji i ich zastosowanie |
FI20010222A0 (fi) | 2001-02-06 | 2001-02-06 | Yli Urpo Antti | Lääketieteellisesti hammashoidolliset polymeerikomposiitit ja -koostumukset |
DE10105398A1 (de) | 2001-02-07 | 2002-08-08 | Ulrich Leicht | Zahnärztliches Implantat |
ITRM20010023U1 (it) | 2001-02-14 | 2002-08-14 | D A P | Resina epossidica trasparente per modelli odontotecnici e odontoiatrici. |
US20020115742A1 (en) | 2001-02-22 | 2002-08-22 | Trieu Hai H. | Bioactive nanocomposites and methods for their use |
US6949251B2 (en) | 2001-03-02 | 2005-09-27 | Stryker Corporation | Porous β-tricalcium phosphate granules for regeneration of bone tissue |
US6987136B2 (en) | 2001-07-13 | 2006-01-17 | Vita Special Purpose Corporation | Bioactive spinal implant material and method of manufacture thereof |
FR2828090B1 (fr) | 2001-08-03 | 2003-11-21 | Andre Benhamou | Implant a usage dentaire ou analogue, comprenant un noyau et un manchon en ceramique relies l'un a l'autre par collage |
US20030068598A1 (en) | 2001-10-10 | 2003-04-10 | Pekka Vallittu | Dental or medical device |
US20030148247A1 (en) | 2001-11-21 | 2003-08-07 | Sicurelli Robert J. | Application and energy applying methods for root canal sealing material |
US6648643B2 (en) * | 2001-12-19 | 2003-11-18 | Biolock International, Inc. | Dental implant/abutment interface and system having prong and channel interconnections |
US6878456B2 (en) | 2001-12-28 | 2005-04-12 | 3M Innovative Properties Co. | Polycrystalline translucent alumina-based ceramic material, uses, and methods |
US20050028424A1 (en) | 2002-01-04 | 2005-02-10 | Poinski Michael M. | Scent dispensing system for fishing lure |
EP1499267A4 (en) | 2002-02-05 | 2008-10-29 | Depuy Mitek Inc | BIOREGRADABLE OSTEOCONDUCTIVE COMPOSITIONS FOR BONE REGENERATION |
AUPS038802A0 (en) | 2002-02-08 | 2002-02-28 | Portland Orthopaedics Pty Limited | Modulear prosthesis with adjustable taper |
GB0205868D0 (en) | 2002-03-13 | 2002-04-24 | Univ Nottingham | Polymer composite with internally distributed deposition matter |
DE10216590B4 (de) | 2002-04-14 | 2007-06-14 | Paul Dr. Weigl | Verfahren zur maschinellen Fertigung von zahnärztlichen Restaurationen aus Keramik |
US7514249B2 (en) | 2002-04-18 | 2009-04-07 | The University Of Florida Research Foundation, Inc. | Biomimetic organic/inorganic composites |
US20050100724A1 (en) | 2002-05-02 | 2005-05-12 | Victrex Manufacturing Limited | Composite material |
GB0210786D0 (en) | 2002-05-10 | 2002-06-19 | Plasma Coatings Ltd | Orthopaedic and dental implants |
US6932606B2 (en) | 2002-06-04 | 2005-08-23 | Zimmer Dental Inc. | Abutment screw with gold spring-washer |
US6986660B2 (en) | 2002-06-04 | 2006-01-17 | Zimmer Dental, Inc. | Retaining screw with rententive feature |
US7918382B2 (en) | 2002-06-18 | 2011-04-05 | Zimmer Technology, Inc. | Method for attaching a porous metal layer to a metal substrate |
US6945448B2 (en) | 2002-06-18 | 2005-09-20 | Zimmer Technology, Inc. | Method for attaching a porous metal layer to a metal substrate |
US6797006B2 (en) | 2002-06-18 | 2004-09-28 | Zimmer Technology, Inc. | Porous unicondylar knee |
US6840960B2 (en) | 2002-09-27 | 2005-01-11 | Stephen K. Bubb | Porous implant system and treatment method |
US20040068320A1 (en) | 2002-10-04 | 2004-04-08 | Robie Bruce H. | Prosthetic disc and vertebral body replacement device having pyrolytic carbon bearing members |
US6916177B2 (en) | 2002-10-24 | 2005-07-12 | Jiin-Huey Chern Lin | Dental implant with hardened calcium phosphate cement inside |
US6976999B2 (en) | 2002-11-19 | 2005-12-20 | Zimmer Technology, Inc. | Prosthetic device and method of making the same |
CA2506845A1 (en) | 2002-12-13 | 2004-07-01 | Stefan Neumeyer | Abutment for a tooth implant, tooth implant with such an abutment and process for manufacturing a dental prothesis using the tooth implant |
US6984261B2 (en) | 2003-02-05 | 2006-01-10 | 3M Innovative Properties Company | Use of ceramics in dental and orthodontic applications |
US7291012B2 (en) | 2003-02-27 | 2007-11-06 | Lyren Philip S | Dental implant with porous body |
US20090233256A1 (en) * | 2008-03-14 | 2009-09-17 | Robert Schroering | Band of Connective Tissue Grooves for Use with a Dental Implant or a Separate Abutment for a Dental Implant |
DE10315563A1 (de) | 2003-04-05 | 2004-10-28 | Bego Medical Ag | Verfahren zur Herstellung von Implantataufbauten für Dentalimplantate sowie Implantataufbau für Dentalimplantat |
WO2004103203A2 (en) | 2003-05-16 | 2004-12-02 | Nobel Biocare Services Ag | Dental implant system |
US6994726B2 (en) | 2004-05-25 | 2006-02-07 | Calcitec, Inc. | Dual function prosthetic bone implant and method for preparing the same |
US8029755B2 (en) | 2003-08-06 | 2011-10-04 | Angstrom Medica | Tricalcium phosphates, their composites, implants incorporating them, and method for their production |
US7179089B2 (en) | 2003-10-20 | 2007-02-20 | Prosthosolve, Llc | Abutment system and method for preparing the same |
US20050084821A1 (en) | 2003-10-20 | 2005-04-21 | Sims Lawrence O. | Abutment system |
US20050096652A1 (en) | 2003-10-31 | 2005-05-05 | Burton Charles V. | Integral flexible spine stabilization device and method |
EP1691852A2 (en) | 2003-11-10 | 2006-08-23 | Angiotech International AG | Medical implants and fibrosis-inducing agents |
US7001672B2 (en) | 2003-12-03 | 2006-02-21 | Medicine Lodge, Inc. | Laser based metal deposition of implant structures |
US20050136378A1 (en) * | 2003-12-19 | 2005-06-23 | Elmekki Ennajimi | Implant system and method of installation thereof |
US20060075826A1 (en) | 2004-05-05 | 2006-04-13 | Roberts Jack C | Synthetic cortical bone for ballistic testing |
ATE380518T1 (de) | 2004-05-19 | 2007-12-15 | Straumann Holding Ag | Einstückiges dentalimplantat und verfahren zu dessen herstellung |
US20050261795A1 (en) | 2004-05-21 | 2005-11-24 | Eastman Kodak Company | Method of making ceramic dental restorations |
GB0417790D0 (en) | 2004-08-10 | 2004-09-15 | Chandler Colin E | Dental implant system |
KR100617128B1 (ko) * | 2004-11-17 | 2006-08-31 | 엘지전자 주식회사 | 디지털 방송 방법 및 장치 |
US20090036908A1 (en) | 2005-03-30 | 2009-02-05 | Ron Zokol | Biologic Barrier for Implants That Pass Through Mucosal or Cutaneous Tissue |
US20060235542A1 (en) | 2005-04-15 | 2006-10-19 | Zimmer Technology, Inc. | Flexible segmented bearing implant |
US20070111165A1 (en) * | 2005-05-26 | 2007-05-17 | Michael Wallick | Polymer Core Prosthetic Dental Device with an Esthetic Surface |
WO2007027794A1 (en) | 2005-08-30 | 2007-03-08 | Zimmer Dental, Inc. | Dental implant with improved osseointegration features |
US8814567B2 (en) * | 2005-05-26 | 2014-08-26 | Zimmer Dental, Inc. | Dental implant prosthetic device with improved osseointegration and esthetic features |
AU2006249942B2 (en) * | 2005-05-26 | 2011-07-07 | Zimmer Dental, Inc. | Prosthetic dental device |
US7281926B2 (en) | 2005-12-23 | 2007-10-16 | Meir Yakir | Modular dental implants with extensions |
US7462392B2 (en) | 2006-02-03 | 2008-12-09 | W. R. Grace & Co.-Conn. | Bi-tapered reinforcing fibers |
EP1967157A1 (en) * | 2007-03-05 | 2008-09-10 | Ziterion GmbH | Hybrid two-part dental implant |
JP4850119B2 (ja) * | 2007-04-18 | 2012-01-11 | 川崎重工業株式会社 | 車両の排気装置 |
US20090061388A1 (en) * | 2007-08-30 | 2009-03-05 | Michael Collins | Dental prosthetic device with soft tissue barrier promotion material |
US20090098511A1 (en) * | 2007-10-16 | 2009-04-16 | Kai Zhang | Method of making a dental implant and prosthetic device |
US20090098510A1 (en) * | 2007-10-16 | 2009-04-16 | Kai Zhang | Dental implant and prosthetic device preparation kit |
US8057230B1 (en) * | 2008-02-20 | 2011-11-15 | Folsom Jr Aubrey C | Ceramic and metal composite dental implant |
US8231387B2 (en) * | 2008-07-02 | 2012-07-31 | Zimmer, Inc. | Porous implant with non-porous threads |
US8899982B2 (en) * | 2008-07-02 | 2014-12-02 | Zimmer Dental, Inc. | Implant with structure for securing a porous portion |
US8562348B2 (en) * | 2008-07-02 | 2013-10-22 | Zimmer Dental, Inc. | Modular implant with secured porous portion |
US20100114314A1 (en) * | 2008-11-06 | 2010-05-06 | Matthew Lomicka | Expandable bone implant |
FR2943241B1 (fr) | 2009-03-18 | 2011-06-24 | Vital Implant Sa | Implant dentaire biocompatible a structure poreuse trabeculaire |
US8602782B2 (en) | 2009-11-24 | 2013-12-10 | Zimmer Dental, Inc. | Porous implant device with improved core |
-
2009
- 2009-11-24 US US12/624,608 patent/US8602782B2/en not_active Expired - Fee Related
-
2010
- 2010-11-09 WO PCT/US2010/055975 patent/WO2011066098A1/en active Application Filing
- 2010-11-09 JP JP2012539941A patent/JP5932657B2/ja not_active Expired - Fee Related
- 2010-11-09 CN CN201080050015.9A patent/CN102596095B/zh not_active Expired - Fee Related
- 2010-11-09 EP EP10779179.0A patent/EP2503953B1/en active Active
- 2010-11-09 CA CA2773224A patent/CA2773224C/en not_active Expired - Fee Related
-
2013
- 2013-09-19 US US14/031,608 patent/US9439738B2/en active Active
-
2016
- 2016-09-08 US US15/259,454 patent/US9901424B2/en active Active
-
2018
- 2018-01-16 US US15/872,147 patent/US10687919B2/en not_active Expired - Fee Related
-
2020
- 2020-05-20 US US16/879,438 patent/US20200275998A1/en not_active Abandoned
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4872840A (en) * | 1987-07-15 | 1989-10-10 | Team Incorporated | Dental implant and method |
US5002488A (en) * | 1988-04-12 | 1991-03-26 | Hadaco, Ltd. | Dental implants with resorption preventing means |
US5049074A (en) * | 1989-03-29 | 1991-09-17 | Sugio Otani | Dental implant |
US6095817A (en) * | 1999-02-24 | 2000-08-01 | Sulzer Calcitek Inc. | Dental implant having multiple textured surfaces |
US20090011384A1 (en) * | 2005-08-30 | 2009-01-08 | Michael Collins | Dental implant for a jaw with reduced bone volume and improved osseointegration features |
CN101505678A (zh) * | 2006-08-01 | 2009-08-12 | 维特利·邦达 | 植牙***及方法 |
US20090061387A1 (en) * | 2007-08-30 | 2009-03-05 | Matthew Lomicka | Multiple root implant |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9439738B2 (en) | 2009-11-24 | 2016-09-13 | Zimmer Dental, Inc. | Porous implant device with improved core |
US8602782B2 (en) | 2009-11-24 | 2013-12-10 | Zimmer Dental, Inc. | Porous implant device with improved core |
US9901424B2 (en) | 2009-11-24 | 2018-02-27 | Zimmer Dental, Inc. | Porous implant device with improved core |
US10687919B2 (en) | 2009-11-24 | 2020-06-23 | Zimmer Dental, Inc. | Porous implant device with improved core |
US10426579B2 (en) | 2014-03-28 | 2019-10-01 | Implant B Ltd. | Renewable dental implant |
CN106456291A (zh) * | 2014-03-28 | 2017-02-22 | 植体B有限公司 | 可更新的牙科植体 |
CN106456291B (zh) * | 2014-03-28 | 2019-08-06 | 植体B有限公司 | 可更新的牙科植体 |
CN106999217A (zh) * | 2014-11-04 | 2017-08-01 | 海普瑞万迅公司 | 用于稳固断骨或非断骨的植入物 |
CN106999217B (zh) * | 2014-11-04 | 2021-04-13 | 海普瑞万迅公司 | 用于稳固断骨或非断骨的植入物 |
CN107847253A (zh) * | 2015-05-22 | 2018-03-27 | 卡燕医疗股份有限公司 | 用于修复软组织的***和方法 |
CN113440276A (zh) * | 2021-06-12 | 2021-09-28 | 杭州口腔医院集团有限公司 | 一种口腔内种植体及其数字化加工方法 |
CN113712694A (zh) * | 2021-09-08 | 2021-11-30 | 琅泰美康医疗器械有限公司 | 组配式种植体 |
CN115740495A (zh) * | 2022-11-02 | 2023-03-07 | 大博医疗科技股份有限公司 | 一种3d打印骨小梁口腔种植体的方法 |
Also Published As
Publication number | Publication date |
---|---|
US20170049536A1 (en) | 2017-02-23 |
CN102596095B (zh) | 2015-08-05 |
US9439738B2 (en) | 2016-09-13 |
CA2773224C (en) | 2016-11-08 |
WO2011066098A1 (en) | 2011-06-03 |
US10687919B2 (en) | 2020-06-23 |
US20140017633A1 (en) | 2014-01-16 |
EP2503953A1 (en) | 2012-10-03 |
JP2013512006A (ja) | 2013-04-11 |
US8602782B2 (en) | 2013-12-10 |
US9901424B2 (en) | 2018-02-27 |
US20200275998A1 (en) | 2020-09-03 |
EP2503953B1 (en) | 2016-04-27 |
US20110123951A1 (en) | 2011-05-26 |
US20180200028A1 (en) | 2018-07-19 |
CA2773224A1 (en) | 2011-06-03 |
JP5932657B2 (ja) | 2016-06-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102596095B (zh) | 具有改进芯部的多孔植入器具 | |
US10265143B1 (en) | Dental implant with an interface that connects a porous bone fixation body to a metal coronal body | |
EP1764061B1 (en) | Intraosseous dental implantation and method for making the same | |
US9066771B2 (en) | Modular implant with secured porous portion | |
EP0798992B1 (en) | Dental implant having multiple textured surfaces | |
JPH04246360A (ja) | 移植可能な補てつ | |
US8951043B2 (en) | Insertion part of a two-part implant with insertion instrument | |
US20120034577A1 (en) | Dental implant with osteoinductive carrier system | |
CN200973755Y (zh) | 一种微螺纹种植体 | |
JP5680838B2 (ja) | 人工歯根 | |
US8235721B2 (en) | Dental implants for implantation in a human or animal jawbone and methods of manufacturing same | |
RU41972U1 (ru) | Эндопротез вертлужной впадины | |
CN116058987A (zh) | 拟牙根种植体*** |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150805 |