CN102512545B - Submicron powder bazheng powder normal temperature preparation method and special bidirectional airflow sieving machine thereof - Google Patents
Submicron powder bazheng powder normal temperature preparation method and special bidirectional airflow sieving machine thereof Download PDFInfo
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Abstract
The invention discloses a submicron powder bazheng powder normal temperature preparation method, which comprises choosing technical materials of akebiaquinata, dianthus superbus, polygonum aviculare, liquorice, fried jasmine, rheum officinale, juncos communis medicinal slices, soapstone and plantain seed raw materials in proportion; drying and smashing to obtain coarse powder; extracting plantain seed oil in the plantain seed coarse powder to be reserved; evenly mixing the rest of coarse powder and the plantain seed dregs in a rod mill to be smashed to be sent into a special bidirectional airflow sieving machine for 500 sieves to obtain powder materials with the grain diameter equal to or smaller than 25 micrometers; achieving bazheng powder submicron powder by collecting powder materials conveyed to a cyclone material collector by air airflow generated by an air induced fan; collecting the powder material not sieved for 500 sieves to be conveyed into the rod mill through a pipeline to be smashed repeatedly; and evenly mixing the collected bazheng powder submicron powder and the plantain seed oil to obtain submicron powder bazheng powder end products. The submicron powder bazheng powder normal temperature preparation method has the advantages of performing the whole process at the normal temperature. The special bidirectional airflow sieving machine simplifies preparation process of the submicron powder bazheng powder.
Description
Technical field
The present invention relates to the veterinary drug preparation field, especially relate to superfine powder BAZHENG SAN normal temperature preparation method; The invention still further relates to the special-purpose two-way airflow screening machine for this method.
Background technology
Chinese herbal medicine is the culture rarity of China, first Shennong's Herbal that the works relevant with natural drug is China in the world, Chinese herbal medicine is carrying out having the incomparable superiority of other chemical synthetic drugs aspect the prevention and treatment of diseases: safe, toxic and side effects is little, effective ingredient is many, hazard residue is few, action target spot is many, can bring into play combined effect, be difficult for producing drug resistance, scalable immunity of organisms, enhancing body resistance against diseases in anti-bacteria and anti-virus.More and more emphasize food safety in the our times various countries, call under green, the ecological overall background, apply prevention and the control that herbal medicine carries out Animal diseases and be of great practical significance.
The present invention adopts the prescription of " People's Republic of China's veterinary drug allusion quotation " in 2010 two BAZHENG SAN of recording of version.The BAZHENG SAN that is applied to fowl poultry kind at present mostly is the powder of coarse pulverization, there are deficiencies such as dosage is big, dosage form thick, appearance poor, effective ingredient can not fully discharge, bioavailability is low, Chinese medicine quality and clinical therapeutic efficacy have been had a strong impact on, and can not evenly mix with pellet, can not directly add drinking-water and use.
The broken technology of Chinese medicine ultra-fine powder is renewal and the development to traditional crushing technology; it had both kept the advantage of Chinese medicine technology of preparing; injected new vitality for the modern production of Chinese medicine again; have a extensive future, but remain in actual production in some problems and a difficult problem: (1) production efficiency is low, the power consumption height is the principal element of restriction Chinese medicine ultra-fine powder large-scale production for animals.Rod mill is in traditional closed circuit method crushing process, when most of material has reached fineness requirement, always there is the small part coarse powder to be mixed in wherein, make this part coarse powder further be crushed to the granularity that requires need prolong the pulverizing time significantly, make crush efficiency reduce, power consumption significantly increases; (2) it is poor that there are the material particular diameter uniformity after the classification in selecting crude drugs with winnower classification and grading wheel classification, influenced the quality of production of herbal medicine compound recipe superfine powder greatly, especially when being applied to the use of animal drinking-water, because a small amount of not existence of breaking cellular wall cell is difficult to reach instructions for use.(3) traditional one-way gas flow is sieved, because Chinese medicine is when carrying out micronizing, along with reducing of particle diameter, material particles surface area and surface energy increase, adsorptivity increases, and mobile variation easily is gathered into bulky grain etc. and causes the sieve classification of crossing that surpasses 200 order fineness medicated powder to be difficult to carry out.The existence of above-mentioned factor has had a strong impact on standardization, the large-scale production of herbal medicine superfine powder, and the popularization on veterinary clinic and use.
Summary of the invention
The object of the invention is to provide a kind of rapid-action, good effect, bioavailability height, superfine powder BAZHENG SAN normal temperature preparation method that the clinical application amount is few.
Another purpose of the present invention is to provide a kind of special-purpose two-way airflow screening machine that is applied to superfine powder BAZHENG SAN normal temperature preparation method.
Superfine powder BAZHENG SAN normal temperature preparation method of the present invention comprises the steps:
The first step, choose the decoction pieces of crude drug Caulis Akebiae, Herba Dianthi, Herba Polygoni Avicularis, Radix Glycyrrhizae, Fructus Gardeniae (parched), Radix et Rhizoma Rhei (stir-fried with wine), Medulla Junci and Talcum, Semen Plantaginis raw material successively according to the weight portion ratio of 6:6:6:5:6:6:3:12:6, through natural drying or dry to moisture≤10%;
Second goes on foot, under 20 ℃～25 ℃ temperature the above-mentioned raw materials medicine is pulverized respectively, obtains granularity 60～80 purpose Chinese medicine coarse powder; The Herba Plantaginis seed oil that extracts in the Semen Plantaginis coarse powder is standby;
The 3rd the step, with Caulis Akebiae, Herba Dianthi, Herba Polygoni Avicularis, Radix Glycyrrhizae, Fructus Gardeniae (parched), Radix et Rhizoma Rhei (stir-fried with wine), Medulla Junci, Talcum coarse powder and Semen Plantaginis medicinal residues mix homogeneously;
The 4th step, with the 3rd step gained coarse powder place pulverize in the rod mill after, be fed into special-purpose two-way airflow screening machine by wind and cross 500 mesh sieves, the air-flow that the powder that obtains particle diameter≤25 micron of sieving is produced by air-introduced machine is transported to collect in the tornado feeder set and namely gets the BAZHENG SAN superfine powder; The powder of not crossing 500 mesh sieves arrives circulation pulverizing again in the described rod mill through the funnel collection and by line transportation;
The 5th step, with the Herba Plantaginis seed oil of the 4th BAZHENG SAN superfine powder collected of step and the second step gained with the abundant mixing of intensive mixer, can obtain superfine powder BAZHENG SAN finished product.
Special-purpose two-way airflow screening machine of the present invention comprises casing and the downward screen drum of chamber intermediate openings that sets within it, the order number of described screen drum 〉=500 orders; The nozzle of screen drum is connected mutually with the funnel upper shed that is arranged on the casing bottom; Chassis cavity is connected with air-introduced machine by the negative pressure chamber on top; Be provided with the door font rotary jet pipe that is constituted by transverse tube and standpipe in the zone between screen drum and casing, the puff prot of described door font rotary jet pipe is for axially being opened in groove on its tube wall along described transverse tube and standpipe respectively, described groove is offered towards the screen drum direction respectively, the groove width 0.5-2 millimeter of groove, the middle part of transverse tube and drive motors driving coupling; Be provided with blast pipe in the screen drum centre position, the air outlet of described blast pipe passes that screen drum is connected with the transverse tube middle part of door font rotary jet pipe and rolls by rolling bearing and is connected; The air inlet of blast pipe extends outside the described hopper side walls and is connected with the blast orifice of aerator; Be provided with feed pipe in screen drum, be provided with the buffering umbrella above the discharging opening of described feed pipe, the charging aperture of feed pipe extends outside the hopper side walls and is communicated with powder conveying fan air outlet through wind stopping device.
The air inducing of described air-introduced machine is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The rotating speed of described drive motors is 155 rev/mins; The blast pressure of described aerator is 33kpa, and the blow rate required is 320m
3/ h; The wind pressure that goes out of described powder conveying fan is 24kpa, and air output is 150m
3/ h; The sidewall of described screen drum and roof respectively with corresponding standpipe and transverse tube between distance be 25 millimeters.
The invention has the advantages that whole process of preparation all carries out at normal temperatures, do not need low temperature or special additional conditions; Final drug particle diameter≤25 micron of preparation, cell wall breaking rate (sporoderm-broken rate reaches more than 95%) and bioavailability have been improved greatly, strengthened pharmacological action, thereby reduced treatment disease dosage, saved medical material, abnormal smells from the patient and the mouthfeel of medicine have also been improved simultaneously, make and directly adopt the water way administration to be achieved, changed the deficiency that Chinese powder medicine can only spice can not be drunk water and takes, the BAZHENG SAN of ultra micro powder can evenly stick on the animal pellet feed simultaneously, has solved particulate material and can not mix the problem of using with Chinese medicine; The two-way airflow screening machine that uses in the inventive method has been simplified the preparation technology of superfine powder BAZHENG SAN greatly, has realized the purpose that the Chinese powder medicine quality standard is controlled, be suitable for large-scale industrial production.
The clinical therapeutic efficacy of preparation of the present invention is verified by following test:
Test example one, BAZHENG SAN ultrafine preparation are to the therapeutic effect of chicken gout
Test drug and material:
The BAZHENG SAN superfine powder adopts the present invention's preparation.
BAZHENG SAN: according to two ones of " Chinese veterinary drug allusion quotation " versions in 2010, manufacture experimently at laboratory.
Experimental animal: adopt 120 age in days Sanhuang chicken of Yanjin County, Henan Province natural occurrence, select 150.According to incidence, in conjunction with clinical symptoms, cut open inspection variation, laboratory diagnosis etc. and be diagnosed as gout, isolated rearing is also fed and is not contained the complete feed of medicine.
The test grouping: experimental animal is divided into 5 groups at random, every group of 30 chickens.
The I group adopts BAZHENG SAN superfine powder high-dose therapy, feeds by 3% spice;
The II group adopts dosage treatment in the BAZHENG SAN superfine powder, feeds by 1.5% spice;
The III group adopts BAZHENG SAN superfine powder low dose treatment, feeds by 0.75% spice;
The IV group adopts the BAZHENG SAN treatment, feeds by 3% spice;
The V group is for infecting matched group, and morbidity is not treated;
The VI group is the blank group, and morbidity is not treated.
Trial drug evenly sneaked in the feedstuff by above-mentioned variable concentrations feed, be used in conjunction 5 days, therapeutic effect sees Table 1.
Table 1 variable concentrations BAZHENG SAN superfine powder is to the therapeutic effect of chicken gout
| Group | Cure rate (%) | Obvious effective rate (%) | Effective percentage (%) | Inefficiency (%) |
| Ⅰ | 93.3 | 3.3 | 96.6 | 3.4 |
| Ⅱ | 86.6 | 3.3 | 89.9 | 10.1 |
| Ⅲ | 80.0 | 3.3 | 83.3 | 16.7 |
| Ⅳ | 80.0 | 6.7 | 86.7 | 13.3 |
| Ⅴ | 0 | 10 | 10 | 90.0 |
| Ⅵ | 100 | 100 | 200 | 0 |
Criterion:
Cure: clinical symptoms complete obiteration after the medication treatment, spirit and appetite recover normal for curing;
Produce effects: clinical symptoms obviously alleviates after the medication treatment, and spirit and appetite transfer the treatment produce effects well to;
Effectively: be cure rate and obvious effective rate sum;
Invalid: symptom does not disappear after medication, the state of an illness do not take a turn for the better and treat during because of primary disease death be invalid.
Result of the test shows: the BAZHENG SAN superfine powder of different treatment consumptions all has the obvious treatment effect to the chicken goat, and the more big effect of consumption is more good.The therapeutic effect of high dose and middle dosage superfine powder all is better than the therapeutic effect of BAZHENG SAN, and low dosage superfine powder therapeutic effect slightly is worse than BAZHENG SAN.This shows, compare with coarse powder when the BAZHENG SAN superfine powder uses at equal or the dosage that reduces by half, the chicken goat to be had better clinical effect.
Test example two,
The BAZHENG SAN ultrafine preparation is to the clinical efficacy of sow urine retention in puerperal
Test drug and material:
The BAZHENG SAN superfine powder adopts the present invention's preparation.
BAZHENG SAN: according to two ones of " Chinese veterinary drug allusion quotation " versions in 2010, manufacture experimently at laboratory.
Experimental animal: adopt the sick sow of large-scale pig farm, Hebei province 6 hairs, farrow and urinate after three days under the sound of rain pattering difficulty, it is not obvious to inject the antibiotics curative effect.Disease sees that this pig haunch exerts duty, makes to urinate posture again and again, and swelling of external genitals is opened a business, and flows filthy mucus, and urine is measured red few, drenches under the puckery difficulty, and there is pain in palpation bladder portion, and 39.5 ℃ of body temperature are diagnosed as the urine retention in puerperal.
The test grouping: experimental animal is divided into 2 groups at random, every group of 3 pigs.The I group adopts the treatment of BAZHENG SAN superfine powder, feeds by the 30g/d/ head; The II group adopts the BAZHENG SAN treatment, feeds by the 60g/d/ head; Trial drug evenly sneaked in the feedstuff by above-mentioned variable concentrations feed, be used in conjunction 3 days, therapeutic effect sees Table 2.
Criterion:
Cure: clinical symptoms complete obiteration after the medication treatment, spirit and appetite recover normal for curing;
Produce effects: clinical symptoms obviously alleviates after the medication treatment, and spirit and appetite transfer the treatment produce effects well to;
Effectively: be cure rate and obvious effective rate sum;
Invalid: symptom does not disappear after medication, the state of an illness do not take a turn for the better and treat during because of primary disease death be invalid.
Table 2 variable concentrations BAZHENG SAN superfine powder is to the therapeutic effect of sow urine retention in puerperal
| Group | Cure rate (%) | Obvious effective rate (%) | Effective percentage (%) | Inefficiency (%) |
| Ⅰ | 66.7 | 33.3 | 100 | 0 |
| Ⅱ | 33.3 | 66.7 | 100 | 0 |
Result of the test shows: medication is after 3 days, and BAZHENG SAN superfine powder and BAZHENG SAN all have better curative effect to sow urine retention in puerperal, and effective percentage is all 100%.But the cure rate of BAZHENG SAN superfine powder is respectively 66.7% and 33.3% apparently higher than BAZHENG SAN.This shows, compare with the BAZHENG SAN coarse powder that the BAZHENG SAN superfine powder is under the operating position that reduces by half, and is better to the curative effect of sow urine retention in puerperal, can use at clinical expansion.
Description of drawings
Fig. 1 is the production equipment system figure of the method for the invention.
Fig. 2 is the structural representation of special-purpose two-way airflow screening machine of the present invention.
The specific embodiment
As shown in Figure 1, 2, superfine powder BAZHENG SAN normal temperature preparation method of the present invention comprises the steps:
The first step, choose the decoction pieces of crude drug Caulis Akebiae, Herba Dianthi, Herba Polygoni Avicularis, Radix Glycyrrhizae, Fructus Gardeniae (parched), Radix et Rhizoma Rhei (stir-fried with wine), Medulla Junci and Talcum, Semen Plantaginis raw material successively according to the weight portion ratio of 6:6:6:5:6:6:3:12:6, through natural drying or dry to moisture≤10%;
Second goes on foot, under 20 ℃～25 ℃ temperature the above-mentioned raw materials medicine is pulverized respectively, obtains granularity 60～80 purpose Chinese medicine coarse powder; Extract the oil in the Semen Plantaginis coarse powder, Herba Plantaginis seed oil and medicinal residues are standby;
The 3rd the step, with Caulis Akebiae, Herba Dianthi, Herba Polygoni Avicularis, Radix Glycyrrhizae, Fructus Gardeniae (parched), Radix et Rhizoma Rhei (stir-fried with wine), Medulla Junci, Talcum coarse powder and Semen Plantaginis medicinal residues mix homogeneously;
The 4th goes on foot, at first opens powder conveying fan 15, air-introduced machine 5, aerator 11, drive motors 8.The blow pressure of powder conveying fan 15 is 24kpa, and the blowing amount is 150m
3/ h; The air inducing of air-introduced machine 5 is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The blast pressure of aerator 11 is 33kpa, blow rate required 320m
3/ h; The rotating speed of drive motors 8 is 155 rev/mins;
1, the 3rd step gained coarse powder is placed pulverize in the rod mill 16 after, powder body to be fractionated are arranged in the downward screen drum 2 of casing 1 inner chamber intermediate openings being brought into by high velocity air through wind stopping device 14, feed pipe 12 under the power of the blowing effect of powder conveying fan 15 in the rod mill 16, and by the impulsive force of buffering umbrella 13 reduction powder body to be fractionated in screen drum 2, powder body to be fractionated is disperseed in screen drum 2; The order number of screen drum 2 is 500 orders;
2, the powder body to be fractionated that disperses in the screen drum 2 carries out classification by screen drum 2 under air-introduced machine 5 effects, and fine powder negative pressure chamber 4 through casing 1 top under the negative-pressure air-flow effect that air-introduced machine 5 produces of passing screen drum 2 is transported to collect in the tornado feeder set 17 and namely gets the BAZHENG SAN superfine powder.The powder body by screen drum 2 does not sink through collecting with the funnel 3 that screen drum 2 under sheds are connected mutually and being transported to circulation pulverizing again in the described rod mill 16 by pipeline 18;
3, door font rotary jet pipe rotates by rolling bearing 10 under drive motors 8 drives, the wind that aerator 11 is sent is in blast pipe 9 enters described transverse tube 6 and standpipe 7, and through be opened in the puff prot ejection that has the groove structure on transverse tube 6 and standpipe 7 tube walls respectively vertically towards screen drum 2 directions, form even blowback air-flow in screen drum 2 at screen drum 2 end faces and side, powder body in the screen drum 2 is further atomized, stop powder body to stop up sieve screen apertures at screen drum 2 caking simultaneously, make not powder body by screen drum 2 along with the air-flow whirlpool that forms sinks to entering in the funnel 3.The groove width that is opened in groove on transverse tube 6 and standpipe 7 tube walls is respectively vertically selected between 0.5 millimeter-2 millimeters as required, between the roof of transverse tube 6 and standpipe 7 and corresponding screen drum 2 and the sidewall apart from being respectively 25 millimeters.
The 5th step, with the Herba Plantaginis seed oil of the 4th BAZHENG SAN superfine powder collected of step and the second step gained with the abundant mixing of intensive mixer, can obtain superfine powder BAZHENG SAN finished product.
The superfine powder BAZHENG SAN finished product of gained is sub-packed in the aluminium foil bag, every bag of 500g or 1000g storage.
Claims (2)
1. a superfine powder BAZHENG SAN normal temperature preparation method is characterized in that: comprise the steps:
The first step, choose the decoction pieces of crude drug Caulis Akebiae, Herba Dianthi, Herba Polygoni Avicularis, Radix Glycyrrhizae, Fructus Gardeniae (parched), Radix et Rhizoma Rhei (stir-fried with wine), Medulla Junci and Talcum, Semen Plantaginis raw material successively according to the weight portion ratio of 6:6:6:5:6:6:3:12:6, through natural drying or dry to moisture≤10%;
Second goes on foot, under 20 ℃～25 ℃ temperature the above-mentioned raw materials medicine is pulverized respectively, obtains granularity 60～80 purpose Chinese medicine coarse powder; The Herba Plantaginis seed oil that extracts in the Semen Plantaginis coarse powder is standby;
The 3rd the step, with Caulis Akebiae, Herba Dianthi, Herba Polygoni Avicularis, Radix Glycyrrhizae, Fructus Gardeniae (parched), Radix et Rhizoma Rhei (stir-fried with wine), Medulla Junci, Talcum coarse powder and Semen Plantaginis medicinal residues mix homogeneously;
The 4th step, with the 3rd step gained coarse powder place pulverize in the rod mill (16) after, be fed into special-purpose two-way airflow screening machine by wind and cross 500 mesh sieves, the air-flow that the powder that obtains particle diameter≤25 micron of sieving is produced by air-introduced machine (5) is transported to that collection namely gets the BAZHENG SAN superfine powder in the tornado feeder set (17); The powder of not crossing 500 mesh sieves is transported to circulation pulverizing again in the described rod mill (16) through funnel (3) collection and by pipeline (18);
The 5th step, with the abundant mixing of Herba Plantaginis seed oil of the 4th BAZHENG SAN superfine powder collected of step and the second step gained, can obtain superfine powder BAZHENG SAN finished product;
Described special-purpose two-way airflow screening machine is characterized in that: comprise casing (1) and the downward screen drum of chamber intermediate openings (2) that sets within it, the order number of described screen drum (2) 〉=500 orders; The nozzle of screen drum (2) is connected mutually with funnel (3) upper shed that is arranged on casing (1) bottom; Casing (1) inner chamber is connected with air-introduced machine (5) by the negative pressure chamber (4) on top; Be provided with the door font rotary jet pipe that is constituted by transverse tube (6) and standpipe (7) in the zone that is positioned between screen drum (2) and the casing (1), the puff prot of described door font rotary jet pipe is for axially being opened in groove on its tube wall along described transverse tube (6) and standpipe (7) respectively, described groove is offered towards screen drum (2) direction respectively, the groove width 0.5-2 millimeter of groove, the middle part of transverse tube (6) and drive motors (8) driving coupling; Be provided with blast pipe (9) in screen drum (2) centre position, the air outlet of described blast pipe (9) passes screen drum (2) and is connected with transverse tube (6) middle part of door font rotary jet pipe and is connected by rolling bearing (10) rolling; The air inlet of blast pipe (9) extends outside described funnel (3) sidewall and is connected with the blast orifice of aerator (11); In screen drum (2), be provided with feed pipe (12), be provided with buffering umbrella (13) in the discharging opening of described feed pipe (12) top, the charging aperture of feed pipe (12) extends outside funnel (3) sidewall and is communicated with powder conveying fan (15) air outlet through wind stopping device (14).
2. superfine powder BAZHENG SAN normal temperature preparation method according to claim 1 is characterized in that: the air inducing of described air-introduced machine (5) is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The rotating speed of described drive motors (8) is 155 rev/mins; The blast pressure of described aerator (11) is 33kpa, and the blow rate required is 320m
3/ h; The wind pressure that goes out of described powder conveying fan (15) is 24kpa, and air output is 150m
3/ h; The sidewall of described screen drum (2) and roof respectively with corresponding standpipe (7) and transverse tube (6) between distance be 25 millimeters.
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| CN102397452B (en) * | 2011-11-28 | 2013-09-25 | 河南省康星药业股份有限公司 | Submicron powder cough powder normal temperature preparation method |
| CN102429937B (en) * | 2011-11-28 | 2013-10-23 | 河南省康星药业股份有限公司 | Superfine powder purslane powder normal-temperature preparation method and special double-direction air flow screening machine thereof |
| CN102429992B (en) * | 2011-11-28 | 2013-10-16 | 河南省康星药业股份有限公司 | Superfine powder houttuynia herb normal-temperature preparation method |
| CN102406675B (en) * | 2011-11-28 | 2013-09-25 | 河南省康星药业股份有限公司 | Room-temperature preparation method of ultramicro powder angelica |
| CN102423333B (en) * | 2011-11-28 | 2013-12-04 | 河南省康星药业股份有限公司 | Ultramicro powder epimedium constant-temperature preparation method |
| CN102406672B (en) * | 2011-11-28 | 2013-08-28 | 河南省康星药业股份有限公司 | Room-temperature preparation method of ultramicro powder pomegranate rind pulvis and special two-way airflow screening machine thereof |
| CN102397370B (en) * | 2011-11-28 | 2013-08-28 | 河南省康星药业股份有限公司 | Submicron powder Jinfang Baidu San normal temperature preparation method and special two-way airflow screen grader |
| CN102397163B (en) * | 2011-11-28 | 2014-02-12 | 河南省康星药业股份有限公司 | Method for preparing ultrafine medicine terminalia fruit, gardenia and szechwan chinaberry fruit powder at normal temperature |
| CN102397347B (en) * | 2011-11-28 | 2013-08-28 | 河南省康星药业股份有限公司 | Submicron powder pulvis rhei normal temperature preparation method and special two-way airflow screen grader |
| CN102406830B (en) * | 2011-11-28 | 2013-08-28 | 河南省康星药业股份有限公司 | Room-temperature preparation method for submicron powder Qingshu powder and special bidirectional airflow screening machine |
| CN102397380B (en) * | 2011-11-28 | 2013-08-28 | 河南省康星药业股份有限公司 | Normal temperature preparation method of submicron powder Huanlian Jiedusan and special two-way airflow screen grader |
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Address after: 451464, No. 2, Hing Road, Baisha Industrial Park, Zhongmu County, Henan, Zhengzhou Applicant after: Henan Health Star Pharmaceutical Co., Ltd. Address before: 451464, No. 2, Hing Road, Baisha Industrial Park, Zhongmu County, Henan, Zhengzhou Applicant before: Henan Kangxing Pharmaceutical Co., Ltd. |
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Inventor after: Xing Yujuan Inventor after: Shen Yanmin Inventor after: Liu Yonglu Inventor after: Ma Zhongbin Inventor after: Yu Rui Inventor after: Cao Lingjie Inventor before: Shen Yanmin Inventor before: Liu Yonglu Inventor before: Ma Zhongbin Inventor before: Yu Rui Inventor before: Cao Lingjie |
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