Background technology
Chinese herbal medicine is carrying out having the incomparable superiority of other chemical synthetic drugs aspect the prevention and treatment of diseases: safe, toxic and side effects is little, effective ingredient is many, hazard residue is few, action target spot is many, can bring into play combined effect, be difficult for producing drug resistance, scalable immunity of organisms, enhancing body resistance against diseases in anti-bacteria and anti-virus.More and more emphasize food safety in the our times various countries, call under green, the ecological overall background, apply prevention and the control that herbal medicine carries out Animal diseases and be of great practical significance.
The present invention adopts two diffusing prescriptions of the dysentery relieving that records of " People's Republic of China's veterinary drug allusion quotation " in 2010 version.The diffusing prescription of dysentery relieving has good therapeutic effect to piglet pujos blancos.At present used dysentery relieving looses and mostly is the powder of coarse pulverization, has deficiencies such as dosage is big, dosage form thick, appearance poor, and effective ingredient can not fully discharge, bioavailability is low, have a strong impact on Chinese medicine quality and clinical therapeutic efficacy, and can not evenly mix with pellet, can not directly add drinking-water.
The broken technology of Chinese medicine ultra-fine powder is renewal and the development to traditional crushing technology; it had both kept the advantage of Chinese medicine technology of preparing; injected new vitality for the modern production of Chinese medicine again; have a extensive future, but remain in actual production in some problems and a difficult problem: (1) production efficiency is low, the power consumption height is the principal element of restriction Chinese medicine ultra-fine powder large-scale production for animals.Rod mill is in traditional closed circuit method crushing process, when most of material has reached fineness requirement, always there is the small part coarse powder to be mixed in wherein, make this part coarse powder further be crushed to the granularity that requires need prolong the pulverizing time significantly, make crush efficiency reduce, power consumption significantly increases; (2) it is poor that there are the material particular diameter uniformity after the classification in selecting crude drugs with winnower classification and grading wheel classification, influenced the quality of production of herbal medicine compound recipe superfine powder greatly, especially when being applied to the use of animal drinking-water, because a small amount of not existence of breaking cellular wall cell is difficult to reach instructions for use.(3) traditional one-way gas flow is sieved, because Chinese medicine is when carrying out micronizing, along with reducing of particle diameter, material particles surface area and surface energy increase, adsorptivity increases, and mobile variation easily is gathered into bulky grain etc. and causes the sieve classification of crossing that surpasses 200 order fineness medicated powder to be difficult to carry out.The existence of above-mentioned factor has had a strong impact on standardization, the large-scale production of herbal medicine superfine powder, and the popularization on veterinary clinic and use.
Summary of the invention
The object of the invention is to provide a kind of rapid-action, good effect, bioavailability height, superfine powder dysentery relieving that the clinical application amount the is few normal temperature preparation method that looses.
Another purpose of the present invention is to provide a kind of special-purpose two-way airflow screening machine that is applied to the diffusing normal temperature preparation method of superfine powder dysentery relieving.
The superfine powder dysentery relieving of the present invention normal temperature preparation method that looses comprises the steps:
The first step, choose Chinese crude drug Realgar, Herba Pogostemonis decoction pieces and Talcum, through natural drying or dry to moisture≤10%;
Second goes on foot, under 20 ℃~25 ℃ temperature the above-mentioned raw materials medicine is pulverized respectively, obtains granularity 60~80 purpose Chinese medicine coarse powder;
The 3rd step, with above-mentioned raw materials medicine coarse powder according to Realgar: the weight portion ratio mix homogeneously of Herba Pogostemonis: Talcum=4:11:15;
The 4th step, with the 3rd step gained coarse powder place pulverize in the rod mill after, be fed into special-purpose two-way airflow screening machine by wind and cross 500 mesh sieves, the air-flow that the powder that obtains particle diameter≤25 micron of sieving is produced by air-introduced machine is transported to collect in the tornado feeder set and namely gets the superfine powder dysentery relieving finished product that looses; The powder of not crossing 500 mesh sieves arrives circulation pulverizing again in the described rod mill through the funnel collection and by line transportation.Finished product superfine powder dysentery relieving looses and is sub-packed in the aluminium foil bag, and every bag weighs 100g, 200g, 500g, 1000g, 2000g etc.
Special-purpose two-way airflow screening machine of the present invention comprises casing and the downward screen drum of chamber intermediate openings that sets within it, the order number of described screen drum 〉=500 orders; The nozzle of screen drum is connected mutually with the funnel upper shed that is arranged on the casing bottom; Chassis cavity is connected with air-introduced machine by the negative pressure chamber on top; Be provided with the door font rotary jet pipe that is constituted by transverse tube and standpipe in the zone between screen drum and casing, the puff prot of described door font rotary jet pipe is for axially being opened in groove on its tube wall along described transverse tube and standpipe respectively, described groove is offered towards the screen drum direction respectively, the groove width 0.5-2 millimeter of groove, the middle part of transverse tube and drive motors driving coupling; Be provided with blast pipe in the screen drum centre position, the air outlet of described blast pipe passes that screen drum is connected with the transverse tube middle part of door font rotary jet pipe and rolls by rolling bearing and is connected; The air inlet of blast pipe extends outside the described hopper side walls and is connected with the blast orifice of aerator; Be provided with feed pipe in screen drum, be provided with the buffering umbrella above the discharging opening of described feed pipe, the charging aperture of feed pipe extends outside the hopper side walls and is communicated with powder conveying fan air outlet through wind stopping device.
The air inducing of described air-introduced machine is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The rotating speed of described drive motors is 155 rev/mins; The blast pressure of described aerator is 33kpa, and the blow rate required is 320m
3/ h; The wind pressure that goes out of described powder conveying fan is 24kpa, and air output is 150m
3/ h; The sidewall of described screen drum and roof respectively with corresponding standpipe and transverse tube between distance be 25 millimeters.
The invention has the advantages that whole process of preparation all carries out at normal temperatures, do not need low temperature or special additional conditions; Final drug particle diameter≤25 micron of preparation, cell wall breaking rate (sporoderm-broken rate reaches more than 95%) and bioavailability have been improved greatly, strengthened pharmacological action, thereby reduced treatment disease dosage, saved medical material, abnormal smells from the patient and the mouthfeel of medicine have also been improved simultaneously, make and directly adopt the water way administration to be achieved, changed the deficiency that Chinese powder medicine can only spice can not be drunk water and takes, the dysentery relieving of ultra micro powder looses and can evenly stick on the animal pellet feed simultaneously, has solved particulate material and can not mix the problem of using with Chinese medicine; The two-way airflow screening machine that uses in the inventive method has been simplified the preparation technology that the superfine powder dysentery relieving looses greatly, has realized the purpose that the Chinese powder medicine quality standard is controlled, be suitable for large-scale industrial production.
The clinical therapeutic efficacy of preparation of the present invention is verified by following test:
The test example: the dysentery relieving powder ultramicro powder preparation is to the clinical efficacy of piglet pujos blancos
Test drug and material:
The dysentery relieving powder ultramicro powder adopts the present invention's preparation.
The LIJUNJING powder; The 100g/ bag, content: 98.5%, prepared in laboratory
Dysentery relieving looses: according to two ones of " Chinese veterinary drug allusion quotation " versions in 2010, manufacture experimently at laboratory.
Experimental animal: 180 of the long white commodity piglets of 20 ages in days of pig farm, Hua County, Anyang natural occurrence, according to incidence in conjunction with clinical symptoms, cut open inspection variation, laboratory diagnosis etc. and be defined as the piglet pujos blancos disease, isolated rearing is also fed and is not contained the complete feed of medicine.
The test grouping: experimental animal is divided into 6 groups at random, 30 every group.
The I group adopts dysentery relieving powder ultramicro powder high-dose therapy, and consumption is 4g/ days/head;
The II group adopts dosage treatment in the dysentery relieving powder ultramicro powder, and consumption is 2g/ days/head;
The III group adopts dysentery relieving powder ultramicro powder low dose treatment, and consumption is 1g/ days/head;
The IV group adopts the LIJUNJING treated powder, and consumption is 0.5g/kg;
The V group adopts dysentery relieving to loose and treats, and consumption is 4g/ days/head;
The VI group is not treated matched group for morbidity.
Trial drug evenly sneaked in the feedstuff by above-mentioned variable concentrations feed, be used in conjunction 5 days, therapeutic effect sees Table 1.
Criterion:
Cure: clinical symptoms complete obiteration after the medication treatment, appetite, spirit and feces recover normal for curing;
Produce effects: clinical symptoms obviously alleviates after the medication treatment, and appetite, spirit and feces transfer the treatment produce effects well to;
Effectively: be cure rate and obvious effective rate sum;
Invalid: symptom does not disappear after medication, the state of an illness do not take a turn for the better and treat during because of primary disease death be invalid.
Table 1 variable concentrations dysentery relieving powder ultramicro powder is to the therapeutic effect of piglet pujos blancos
Group |
Cure rate (%) |
Obvious effective rate (%) |
Effective percentage (%) |
Inefficiency (%) |
Ⅰ |
96.33 |
3.33 |
99.66 |
0.34 |
Ⅱ |
90.33 |
3.33 |
93.33 |
6.67 |
Ⅲ |
80.0 |
6.67 |
86.67 |
13.33 |
Ⅳ |
70.0 |
10.0 |
80.0 |
20.0 |
Ⅴ |
80.0 |
10.0 |
90.0 |
10.0 |
Ⅵ |
0 |
10.0 |
10.0 |
90.0 |
Result of the test shows: do not treat matched group with morbidity and compare, the dysentery relieving powder ultramicro powder of different treatment consumptions all has the obvious treatment effect to piglet pujos blancos, and the more big effect of consumption is more good, has tangible dose-effect relationship.Compare with coarse powder, the dysentery relieving powder ultramicro powder is when Isodose or the dosage that reduces by half use, and effect obviously is better than coarse powder.The dysentery relieving powder ultramicro powder of minimum amount also is better than the therapeutic effect of LIJUNJING.This shows that the dysentery relieving powder ultramicro powder has LIJUNJING and diffusing drug effect and the advantage that can not be substituted of dysentery relieving when the treatment piglet pujos blancos.
Description of drawings
Fig. 1 is the production equipment system figure of the method for the invention.
Fig. 2 is the structural representation of special-purpose two-way airflow screening machine of the present invention.
The specific embodiment
As shown in Figure 1, 2, the superfine powder dysentery relieving of the present invention normal temperature preparation method that looses comprises the steps:
The first step, choose Chinese crude drug Realgar, Herba Pogostemonis decoction pieces and Talcum, through natural drying or dry to moisture≤10%;
Second goes on foot, under 20 ℃~25 ℃ temperature the above-mentioned raw materials medicine is pulverized respectively, obtains granularity 60~80 purpose Chinese medicine coarse powder;
The 3rd step, with above-mentioned raw materials medicine coarse powder according to Realgar: the weight portion ratio mix homogeneously of Herba Pogostemonis: Talcum=4:11:15;
The 4th goes on foot, at first opens powder conveying fan 15, air-introduced machine 5, aerator 11, drive motors 8.The blow pressure of powder conveying fan 15 is 24kpa, and the blowing amount is 150m
3/ h; The air inducing of air-introduced machine 5 is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The blast pressure of aerator 11 is 33kpa, blow rate required 320m
3/ h; The rotating speed of drive motors 8 is 155 rev/mins;
1, the 3rd step gained coarse powder is placed pulverize in the rod mill 16 after, powder body to be fractionated are arranged in the downward screen drum 2 of casing 1 inner chamber intermediate openings being brought into by high velocity air through wind stopping device 14, feed pipe 12 under the power of the blowing effect of powder conveying fan 15 in the rod mill 16, and by the impulsive force of buffering umbrella 13 reduction powder body to be fractionated in screen drum 2, powder body to be fractionated is disperseed in screen drum 2; The order number of screen drum 2 is 500 orders;
2, the screen drum 2 interior powder body to be fractionated that disperse carry out classification by screen drum 2 under air-introduced machine 5 effects, and fine powder negative pressure chamber 4 through casing 1 top under the negative-pressure air-flow effect that air-introduced machine 5 produces of passing screen drum 2 is transported to collect in the tornado feeder set 17 and namely gets the diffusing finished product of superfine powder dysentery relieving.The powder body by screen drum 2 does not sink through collecting with the funnel 3 that screen drum 2 under sheds are connected mutually and being transported to circulation pulverizing again in the described rod mill 16 by pipeline 18;
3, door font rotary jet pipe rotates by rolling bearing 10 under drive motors 8 drives, the wind that aerator 11 is sent is in blast pipe 9 enters described transverse tube 6 and standpipe 7, and through be opened in the puff prot ejection that has the groove structure on transverse tube 6 and standpipe 7 tube walls respectively vertically towards screen drum 2 directions, form even blowback air-flow in screen drum 2 at screen drum 2 end faces and side, powder body in the screen drum 2 is further atomized, stop powder body to stop up sieve screen apertures at screen drum 2 caking simultaneously, make not powder body by screen drum 2 along with the air-flow whirlpool that forms sinks to entering in the funnel 3.The groove width that is opened in groove on transverse tube 6 and standpipe 7 tube walls is respectively vertically selected between 0.5 millimeter-2 millimeters as required, between the roof of transverse tube 6 and standpipe 7 and corresponding screen drum 2 and the sidewall apart from being respectively 25 millimeters.
The superfine powder dysentery relieving of the preparation finished product that looses is sub-packed in the aluminium foil bag and stores, every bag heavy 500g or 1000g.