Background technology
Chinese herbal medicine is the culture rarity of China, the works that First is relevant with natural drug in the world is the Shennong's Herbal of China, Chinese herbal medicine is carrying out having the incomparable superiority of other chemical synthetic drugs aspect the prevention and treatment of diseases: safe, toxic and side effect is little, active ingredient is many, hazard residue is few, action target spot is many, can bring into play combined effect, be difficult for producing drug resistance, in anti-bacteria and anti-virus, can regulate immunity of organisms, strengthen body resistance against diseases.More and more emphasize food security in the our times various countries, under Calling for Green, the ecological overall background, apply prevention and the control that herbal medicine carries out Animal diseases and be of great practical significance.
The loose prescription of white dragon that the present invention adopts " People's Republic of China's veterinary drug allusion quotation " in 2010 two ones of version to record, Bai Long is dispersed in the treatment damp-heat dysentery, and the aspects such as toxic-heat and blood stasis have good clinical effectiveness.Be applied at present the loose powder that mostly is coarse crushing of white dragon of fowl poultry kind, there are the deficiencies such as dosage is large, formulation thick, appearance poor, active ingredient can not fully discharge, bioavailability is low, traditional Chinese medicine quality and clinical therapeutic efficacy have been had a strong impact on, and can not evenly mix with pellet, can not directly add drinking-water and use.
The Study on Supermicro-pulverization of Traditional Chinese Drugs technology is to the renewal of traditional crushing technology and development; it had both kept the advantage of traditional Chinese medicine technology of preparing; injected new vitality for the modern production of Chinese medicine again; have a extensive future, but remain in actual production in some problems and a difficult problem: (1) production efficiency is low, the power consumption height is the principal element of restriction veterinary Chinese medicine Ultramicro-powder large-scale production.Rod mill is in traditional closed circuit method crushing process, when most of material has reached fineness requirement, always there is the small part meal to be mixed in wherein, make this part meal further be crushed to institute's granularity that requires needs significantly to prolong grinding time, so that crush efficiency reduces, power consumption significantly increases; (2) it is poor that there are the material particular diameter uniformity after the classification in selection by winnowing classification and grading wheel classification, greatly affected the quality of production of herbal medicine compound Ultramicro-powder, especially when being applied to the drinking water for animals use, because a small amount of not existence of broken wall cell is difficult to reach instructions for use.(3) traditional one-way gas flow screening is because Chinese medicine is when carrying out ultramicro grinding, along with reducing of particle diameter, material particles surface area and surface energy increase, adsorptivity increases, and mobile variation easily is gathered into bulky grain etc. and causes the sieve classification of crossing that surpasses 200 order fineness medicinal powder to be difficult to carry out.The existence of above-mentioned factor has had a strong impact on standardization, the large-scale production of herbal medicine Ultramicro-powder, and the popularization on veterinary clinic and use.
Summary of the invention
The object of the invention is to provide a kind of rapid-action, good effect, bioavilability is high, the clinical application amount is few normal-temperature preparation method of ultramicro Bailong powder.
Another purpose of the present invention is to provide a kind of special bilateral airflow sieving machine that is applied to normal-temperature preparation method of ultramicro Bailong powder.
Normal-temperature preparation method of ultramicro Bailong powder of the present invention comprises the steps:
The first step, choose respectively the Chinese bulbul, rough gentian, coptis medicine materical crude slice by weight, through natural drying or dry to moisture≤10%;
Second step, under 20 ℃~25 ℃ temperature with above-mentioned three the flavor bulk drugs pulverize respectively, obtain granularity 60~80 purpose Chinese medicine meal;
The 3rd step, with above-mentioned raw materials medicine meal by the Chinese bulbul: the weight ratio of rough gentian: the coptis=6:3:1 mixes;
The 4th step, with the 3rd step gained meal place pulverize in the rod mill after, be fed into special bilateral airflow sieving machine by wind and cross 500 mesh sieves, the air-flow that the powder that obtains particle diameter≤25 micron of sieving is produced by air-introduced machine is transported to collect in the tornado feeder set and namely gets the loose finished product of ultra micro whitewash dragon; The powder of not crossing 500 mesh sieves is transported to again circulation pulverizing in the described rod mill through collection funnel and by pipeline.Finished product ultra micro whitewash dragon is loose to be sub-packed in the aluminium foil bag, and every bag weighs 100g, 200g, 500g, 1000g, 2000g etc.
Special bilateral airflow sieving machine of the present invention comprises casing and the downward screen drum of chamber intermediate openings that sets within it, the order number of described screen drum 〉=500 orders; The nozzle of screen drum is connected mutually with the funnel upper shed that is arranged on the casing bottom; Chassis cavity is connected with air-introduced machine by the negative pressure chamber on top; The door font rotation spray tracheae that is made of transverse tube and standpipe is arranged at the region division between screen drum and casing, the puff prot of described door font rotation spray tracheae is for axially being opened in groove on its tube wall along described transverse tube and standpipe respectively, described groove is offered towards the screen drum direction respectively, the groove width 0.5-2 millimeter of groove, the middle part of transverse tube and drive motors driving coupling; Be provided with blast pipe in the screen drum centre position, the air outlet of described blast pipe passes that screen drum is connected with the transverse tube middle part of door font rotation spray tracheae and rolls by rolling bearing and is connected; The air inlet of blast pipe extends outside the described hopper side walls and is connected with the blast orifice of air blast; Be provided with feed pipe in screen drum, be provided with the buffering umbrella above the discharging opening of described feed pipe, the charging aperture of feed pipe extends outside the hopper side walls and is communicated with powder conveying fan air outlet through wind stopping device.
The air inducing of described air-introduced machine is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The rotating speed of described drive motors is 155 rev/mins; The blast pressure of described air blast is 33kpa, and the blow rate required is 320m
3/ h; The wind pressure that goes out of described powder conveying fan is 24kpa, and air output is 150m
3/ h; The sidewall of described screen drum and roof respectively with corresponding standpipe and transverse tube between distance be 25 millimeters.
The invention has the advantages that whole preparation process all carries out at normal temperatures, do not need low temperature or special additional conditions; The final drug particle diameter of preparation≤25 microns, breaking-wall cell rate (sporoderm-broken rate reaches more than 95%) and bioavilability have greatly been improved, strengthened pharmacological action, thereby reduced treatment disease dosage, saved medicinal material, smell and the mouthfeel of medicine have also been improved simultaneously, so that directly adopt the water way administration to be achieved, changed the deficiency that traditional Chinese powder medicine can only spice can not be drunk water and takes, the white dragon of superfine powder is loose simultaneously can evenly stick on the animal pellet feed, has solved particulate material and can not mix with Chinese medicine the problem of using; The bidirectional airflow sieving machine that uses in the inventive method has been simplified the loose preparation technology of ultra micro whitewash dragon greatly, has realized the purpose that the traditional Chinese powder medicine quality standard is controlled, be suitable for large-scale industrial production.
The clinical therapeutic efficacy of preparation of the present invention is verified by following test:
Test example: white imperial powder ultramicro powder preparation is to the clinical efficacy of the white scour of piglet
Test drug and material:
White imperial powder ultramicro powder adopts the present invention's preparation.
The LIJUNJING powder; The 100g/ bag, content: 98.5%, the laboratory preparation.
Bai Long is loose: according to two ones of " Chinese veterinary pharmacopoeia " versions in 2010, manufacture experimently in the laboratory.
Swine escherichia coli K
88: China Veterinary Drugs Supervisory Inst. provides.
Experimental animal: 120 of the white commodity piglets of length in 3 ages in week, body weight 10kg ± 5kg, isolated rearing is also fed and is not contained the complete feed of medicine.
The test grouping: experimental animal is divided into 7 groups at random, 20 every group.
The I group adopts white imperial powder ultramicro powder high-dose therapy, and consumption is 20g/ day/head;
The II group adopts dosage treatment in the white imperial powder ultramicro powder, and consumption is 10g/ day/head;
The III group adopts white imperial powder ultramicro powder low dose therapy, and consumption is 5g/ day/head;
The IV group adopts the LIJUNJING powder as medicine for treatment, and consumption is 0.5g/kg;
The V group adopts white dragon loose, and the treatment consumption is 20g/ day/head;
The VI group is attacked poison, is not treated for infecting control group;
The VII group is the blank group, does not attack poison, does not treat.
Test method: with the Escherichia coli K that preserves
88Bacterial classification is cultivated, and the concentration of measuring bacterium liquid with colony counting method is 6 * 10
9CFU/mL.Except the blank group, other each group is attacked the poison amount and is every pig intramuscular injection 5mL bacterium liquid.According to incidence in conjunction with clinical symptoms, cut open inspection variation, laboratory diagnosis etc. and make a definite diagnosis, the test case of being allowed for access is evenly sneaked into trial drug by above-mentioned variable concentrations and to be fed in the feed, is used in conjunction 5 days, result for the treatment of sees Table 1.
Criterion:
Cure: clinical symptoms complete obiteration after the medication treatment, appetite, spirit and ight soil recover normal for curing;
Produce effects: clinical symptoms obviously alleviate after the medication treatment, and appetite, spirit and ight soil transfer well the treatment produce effects to;
Effectively: be cure rate and obvious effective rate sum;
Invalid: symptom does not disappear after medication, the state of an illness do not take a turn for the better and treat during die because originally dying of illness be invalid.
The white imperial powder ultramicro powder of table 1 variable concentrations is to the result for the treatment of of the white scour of piglet
Group |
Cure rate (%) |
Obvious effective rate (%) |
Efficient (%) |
Inefficiency (%) |
Ⅰ |
95.0 |
5.0 |
100 |
0 |
Ⅱ |
85.0 |
10.0 |
95.0 |
5.0 |
Ⅲ |
80.0 |
5.0 |
85.0 |
15.0 |
Ⅳ |
70.0 |
10.0 |
80.0 |
20.0 |
Ⅴ |
80.0 |
10.0 |
90.0 |
10.0 |
Ⅵ |
0 |
10 |
10 |
90.0 |
Ⅶ |
100 |
100 |
200 |
0 |
Result of the test shows: compare with infecting control group, the white imperial powder ultramicro powder of different therapeutic doses all has obvious result for the treatment of to the white scour of piglet, and the larger effect of consumption is better, has stable dose-effect relationship.Compare with meal, white imperial powder ultramicro powder is when Isodose or the dosage that reduces by half use, and result for the treatment of obviously is better than meal.Even the white imperial powder ultramicro powder result for the treatment of of minimum amount also is better than the result for the treatment of of LIJUNJING.This shows, white imperial powder ultramicro powder has Bai Long and falls apart and the unrivaled advantage of LIJUNJING when the treatment white scour of piglet.
The specific embodiment
As shown in Figure 1, 2, normal-temperature preparation method of ultramicro Bailong powder of the present invention comprises the steps:
The first step, choose respectively the Chinese bulbul, rough gentian, coptis medicine materical crude slice by weight, through natural drying or dry to moisture≤10%;
Second step, under 20 ℃~25 ℃ temperature with above-mentioned three the flavor bulk drugs pulverize respectively, obtain granularity 60~80 purpose Chinese medicine meal;
The 3rd step, with above-mentioned raw materials medicine meal by the Chinese bulbul: the weight ratio of rough gentian: the coptis=6:3:1 mixes;
The 4th goes on foot, at first opens powder conveying fan 15, air-introduced machine 5, air blast 11, drive motors 8.The blow pressure of powder conveying fan 15 is 24kpa, and the blowing amount is 150m
3/ h; The air inducing of air-introduced machine 5 is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The blast pressure of air blast 11 is 33kpa, blow rate required 320m
3/ h; The rotating speed of drive motors 8 is 155 rev/mins;
1, with after the 3rd step, the gained meal placed rod mill 16 interior pulverizing, rod mill 16 interior powders to be fractionated are arranged in the downward screen drum 2 of casing 1 inner chamber intermediate openings being brought into by high velocity air through wind stopping device 14, feed pipe 12 under the power of the blowing effect of powder conveying fan 15, and by the impulsive force of buffering umbrella 13 reduction powders to be fractionated in screen drum 2, make powder to be fractionated in screen drum 2 interior dispersions; The order number of screen drum 2 is 500 orders;
2, the powder to be fractionated of screen drum 2 interior dispersions carries out classification by screen drum 2 under air-introduced machine 5 effects, and fine powder negative pressure chamber 4 through casing 1 top under the negative-pressure air-flow effect that air-introduced machine 5 produces of passing screen drum 2 is transported to collect in the tornado feeder set 17 and namely gets the loose finished product of ultra micro whitewash dragon.The powder by screen drum 2 does not sink through collecting with the funnel 3 that screen drum 2 under sheds are connected mutually and being transported to again circulation pulverizing in the described rod mill 16 by pipeline 18;
3, door font rotation spray tracheae rotates by rolling bearing 10 under drive motors 8 drives, the wind that air blast 11 is sent is in blast pipe 9 enters described transverse tube 6 and standpipe 7, and through be opened in vertically respectively the puff prot ejection that has the groove structure on transverse tube 6 and standpipe 7 tube walls towards screen drum 2 directions, form even blowback air-flow in screen drum 2 at screen drum 2 end faces and side, powder in the screen drum 2 is further atomized, stop simultaneously powder at screen drum 2 caking blocking screen mesh, make not powder by screen drum 2 along with the air-flow whirlpool that forms sinks to entering in the funnel 3.The groove width that is opened in vertically respectively groove on transverse tube 6 and standpipe 7 tube walls is selected between 0.5 millimeter-2 millimeters as required, between the roof of transverse tube 6 and standpipe 7 and corresponding screen drum 2 and the sidewall apart from being respectively 25 millimeters.