CN102397380B - Normal temperature preparation method of submicron powder Huanlian Jiedusan and special two-way airflow screen grader - Google Patents
Normal temperature preparation method of submicron powder Huanlian Jiedusan and special two-way airflow screen grader Download PDFInfo
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Abstract
The invention discloses a normal temperature preparation method of submicron powder Huanlian Jiedusan, which comprises the following steps that: prepared slices of coptis roots, Gardenia, radix scutellariae and phellodendron are selected according to weight part and are pulverized after being dried into coarse powder of 80 meshes; the coarse powder is placed into a rod mill to be pulverized after being uniformly blended according to a ratio: coptis root: Gardenia: radix scutellariae: phellodendron=2:3:4:4, then the pulverized powder is blown into a special two-way airflow screen grader to pass through a 500-mesh sieve, the screened powder with the granularity being less than or equal to 25 micrometers is conveyd into a cyclone collector through the airflow produced by a draught fan to obtain the submicron powder Huanlian Jiedusan finished product; and the powder which cannot pass through the 500-mesh sieve is collected by a funnel and is conveyed into the rod mill through a pipeline to be circularly pulverized. The normal temperature preparation method has advantages that: the entire preparation process is carried out under the normal temperature, the granularity of the prepared finished product medicine is less than or equal to 25 micrometers, so the cell wall breaking rate and the bioavailability can be greatly improved, and the pharmacological action can be enhanced; and the two-way airflow screen grader utilized in the method can simplify the preparation process of the submicron powder Huanlian Jiedusan.
Description
Technical field
The present invention relates to the veterinary drug preparation field, especially relate to the diffusing normal temperature preparation method of superfine powder coptis detoxifcation; The invention still further relates to the special-purpose two-way airflow screening machine for this method.
Background technology
Chinese herbal medicine is carrying out having the incomparable superiority of other chemical synthetic drugs aspect the prevention and treatment of diseases: safe, toxic and side effects is little, effective ingredient is many, hazard residue is few, action target spot is many, can bring into play combined effect, be difficult for producing drug resistance, scalable immunity of organisms, enhancing body resistance against diseases in anti-bacteria and anti-virus.More and more emphasize food safety in the our times various countries, call under green, the ecological overall background, apply prevention and the control that herbal medicine carries out Animal diseases and be of great practical significance.
The present invention adopts two diffusing prescriptions of the coptis detoxifcation that records of " People's Republic of China's veterinary drug allusion quotation " in 2010 version, and on animal medicine, we can be applicable to various acute inflammations such as septicemia, pyemia, dysentery, pneumonia.The coptis detoxifcation that is applied to fowl poultry kind at present looses and mostly is the powder of coarse pulverization, there are deficiencies such as dosage is big, dosage form thick, appearance poor, effective ingredient can not fully discharge, bioavailability is low, Chinese medicine quality and clinical therapeutic efficacy have been had a strong impact on, and can not evenly mix with pellet, can not directly add drinking-water and use.
The broken technology of Chinese medicine ultra-fine powder is renewal and the development to traditional crushing technology; it had both kept the advantage of Chinese medicine technology of preparing; injected new vitality for the modern production of Chinese medicine again; have a extensive future, but remain in actual production in some problems and a difficult problem: (1) production efficiency is low, the power consumption height is the principal element of restriction Chinese medicine ultra-fine powder large-scale production for animals.Rod mill is in traditional closed circuit method crushing process, when most of material has reached fineness requirement, always there is the small part coarse powder to be mixed in wherein, make this part coarse powder further be crushed to the granularity that requires need prolong the pulverizing time significantly, make crush efficiency reduce, power consumption significantly increases; (2) it is poor that there are the material particular diameter uniformity after the classification in selecting crude drugs with winnower classification and grading wheel classification, influenced the quality of production of herbal medicine compound recipe superfine powder greatly, especially when being applied to the use of animal drinking-water, because a small amount of not existence of breaking cellular wall cell is difficult to reach instructions for use.(3) traditional one-way gas flow is sieved, because Chinese medicine is when carrying out micronizing, along with reducing of particle diameter, material particles surface area and surface energy increase, adsorptivity increases, and mobile variation easily is gathered into bulky grain etc. and causes the sieve classification of crossing that surpasses 200 order fineness medicated powder to be difficult to carry out.The existence of above-mentioned factor has had a strong impact on standardization, the large-scale production of herbal medicine superfine powder, and the popularization on veterinary clinic and use.
Summary of the invention
The object of the invention is to provide a kind of rapid-action, good effect, bioavailability height, superfine powder coptis detoxifcation that the clinical application amount the is few normal temperature preparation method that looses.
Another purpose of the present invention is to provide a kind of special-purpose two-way airflow screening machine that is applied to the diffusing normal temperature preparation method of superfine powder coptis detoxifcation.
The superfine powder coptis detoxifcation of the present invention normal temperature preparation method that looses comprises the steps:
The first step, choose Rhizoma Coptidis, Fructus Gardeniae, Radix Scutellariae, Cortex Phellodendri decoction pieces by weight, through natural drying or dry to moisture≤10%;
Second goes on foot, under 20 ℃～25 ℃ temperature the above-mentioned raw materials medicine is pulverized respectively, obtains granularity 60～80 purpose Chinese medicine coarse powder;
The 3rd step, with above-mentioned raw materials medicine coarse powder according to Rhizoma Coptidis: the weight portion ratio mix homogeneously of Fructus Gardeniae: Radix Scutellariae: Cortex Phellodendri=2:3:4:4;
The 4th step, with the 3rd step gained coarse powder place pulverize in the rod mill after, be fed into special-purpose two-way airflow screening machine by wind and cross 500 mesh sieves, the air-flow that the powder that obtains particle diameter≤25 micron of sieving is produced by air-introduced machine is transported to collect in the tornado feeder set and namely gets the superfine powder coptis detoxifcation finished product that looses; The powder of not crossing 500 mesh sieves arrives circulation pulverizing again in the described rod mill through the funnel collection and by line transportation.Finished product superfine powder coptis detoxifcation looses and is sub-packed in the aluminium foil bag, and every bag weighs 100g, 200g, 500g, 1000g, 2000g etc.
Special-purpose two-way airflow screening machine of the present invention comprises casing and the downward screen drum of chamber intermediate openings that sets within it, the order number of described screen drum 〉=500 orders; The nozzle of screen drum is connected mutually with the funnel upper shed that is arranged on the casing bottom; Chassis cavity is connected with air-introduced machine by the negative pressure chamber on top; Be provided with the door font rotary jet pipe that is constituted by transverse tube and standpipe in the zone between screen drum and casing, the puff prot of described door font rotary jet pipe is for axially being opened in groove on its tube wall along described transverse tube and standpipe respectively, described groove is offered towards the screen drum direction respectively, the groove width 0.5-2 millimeter of groove, the middle part of transverse tube and drive motors driving coupling; Be provided with blast pipe in the screen drum centre position, the air outlet of described blast pipe passes that screen drum is connected with the transverse tube middle part of door font rotary jet pipe and rolls by rolling bearing and is connected; The air inlet of blast pipe extends outside the described hopper side walls and is connected with the blast orifice of aerator; Be provided with feed pipe in screen drum, be provided with the buffering umbrella above the discharging opening of described feed pipe, the charging aperture of feed pipe extends outside the hopper side walls and is communicated with powder conveying fan air outlet through wind stopping device.
The air inducing of described air-introduced machine is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The rotating speed of described drive motors is 155 rev/mins; The blast pressure of described aerator is 33kpa, and the blow rate required is 320m
3/ h; The wind pressure that goes out of described powder conveying fan is 24kpa, and air output is 150m
3/ h; The sidewall of described screen drum and roof respectively with corresponding standpipe and transverse tube between distance be 25 millimeters.
The invention has the advantages that whole process of preparation all carries out at normal temperatures, do not need low temperature or special additional conditions; Final drug particle diameter≤25 micron of preparation, cell wall breaking rate (sporoderm-broken rate reaches more than 95%) and bioavailability have been improved greatly, strengthened pharmacological action, thereby reduced treatment disease dosage, saved medical material, abnormal smells from the patient and the mouthfeel of medicine have also been improved simultaneously, make and directly adopt the water way administration to be achieved, changed the deficiency that Chinese powder medicine can only spice can not be drunk water and takes, the coptis detoxifcation of ultra micro powder looses and can evenly stick on the animal pellet feed simultaneously, has solved particulate material and can not mix the problem of using with Chinese medicine; The two-way airflow screening machine that uses in the inventive method has been simplified the preparation technology that the superfine powder coptis detoxifcation looses greatly, has realized the purpose that the Chinese powder medicine quality standard is controlled, be suitable for large-scale industrial production.
The clinical therapeutic efficacy of preparation of the present invention is verified by following test:
Test examples 1,Coptis detoxifcation powder ultramicro powder extracorporeal bacteria inhibitor test
1. the required experiment material of bacteriostatic experiment
1.1 strain (medical science antibacterial):
Staphylococcus albus, staphylococcus aureus, 2 type haemolysis type streptococcus, the reference culture that experiment provides for Microbiological Lab of Agricultural University Of He'nan with antibacterial.
1.2 culture medium:
LB culture medium Tryptone 1g, Yeast Extract 0.5g, NaCl 1g, 1% new Ox blood serum.Adding distil water is settled to 100mL, transfers pH 7.5, high pressure steam sterilization 20min.The agar powder that adds 1.5g when preparation is dull and stereotyped.
1.3 medicine:
Coptis detoxifcation powder ultramicro powder: adopt the present invention's preparation.
Coptis detoxifcation looses: according to second one of " Chinese veterinary drug allusion quotation " version in 2010, in prepared in laboratory.
Benzylpenicillin sun mark, the place of production is sky, Hangzhou and microorganism reagent company limited, lot number is 20060208, is numbered C023.
2. suppress the germ experiment method
2.1 test grouping:
Be divided into to coptis detoxifcation powder ultramicro powder, coptis detoxifcation loose, penicillin and 4 groups of blank, every kind of bacterium is divided into 3 samples.
2.2 bacterial vaccine inoculation method: fresh antibacterial liquid is used on the cotton rod difference coated plate LB solid plate culture medium.
2.3 cup-plate method:
Adopt the LB solid medium, each plate is placed two sterilizing stainless steel tubules that diameter is 5mm, the coptis detoxifcation powder ultramicro powder and the diffusing medicinal liquid of coptis detoxifcation and the blank liquid (normal saline) that add 250 μ l (0.675mg) in the pipe respectively, put into penicillin (10 μ g) standard drug sensitive test paper in the plate, place 37 ℃ of constant incubators, observed medicine to the effect of antibacterial in 14 hours.
2.4 suppress the germ experiment result: observed result after 24 hours, vernier caliper measurement inhibition zone diameter.
2.4 statistical analysis
The data SPSSl3.0 software kit carries out statistical analysis, relatively uses X between a plurality of rates of enumeration data
2The check, measurement data with
± S represents that a plurality of sample averages are relatively used variance analysis.
3. suppress the germ experiment result
3.1 coptis detoxifcation powder ultramicro powder, coptis detoxifcation loose and the antibacterial outcome record of chloromycetin sees Table 1.
Table 1 coptis detoxifcation powder ultramicro powder, coptis detoxifcation loose and the measurement result (mm) of penicillin inhibition zone diameter (
± S)
There is significant difference △ P＜0.05
Coptis detoxifcation powder ultramicro powder group is compared with the blank group and is treated examination bacterium inhibitory action significant difference (P＜0.05) is arranged, and illustrates that the coptis detoxifcation powder ultramicro powder has bacteriostasis; Coptis detoxifcation powder ultramicro powder group and the coptis detoxifcation group of loosing has significant difference (P＜O.05) to above-mentioned bacteriostasis, increasing progressively the relation explanation it is better than the coptis detoxifcation group of loosing according to antibacterial ring size and bacteriostasis.
Application example 2, coptis detoxifcation powder ultramicro powder interior therapeutic test
1. place: pig farm, Zhongmou County, Henan Province
2. medicine:
Coptis detoxifcation powder ultramicro powder, employing the present invention preparation.
Coptis detoxifcation looses: according to second one of " Chinese veterinary drug allusion quotation " version in 2010, in prepared in laboratory.
2. experimental technique
2.1 test grouping:
Long white growing and fattening pigs, about 83 ± 3 days, have 24 the feces drying appears, the why not depressed or alternately property limping of inappetence, spirit of degree of high fever when low, be 2 type streptococcal infections through blood sampling laboratory isolation identification.
Drug therapy is divided into the coptis detoxifcation powder ultramicro powder, coptis detoxifcation looses and 3 groups of blank, 8 every group.Dosage: coptis detoxifcation powder ultramicro powder group, 25g/ head/sky, spice; Coptis detoxifcation looses and organizes 50g/ head/sky, spice.
2.2 therapeutic outcome record
The medication group, through the searching for food of breeding observing pig, spirit, activity etc., record therapeutic outcome.
3. result
Result of the test sees Table 2, and as can be seen from Table 2: coptis detoxifcation powder ultramicro powder group and blank group compare as can be known, and the coptis detoxifcation powder ultramicro powder is obvious to therapeutic effect, illustrates that the coptis detoxifcation powder ultramicro powder has the 2 type streptococcicosis effects for the treatment of pig; The diffusing group of coptis detoxifcation powder ultramicro powder group and coptis detoxifcation is variant to above-mentioned growing and fattening pigs therapeutical effect, and coptis detoxifcation powder ultramicro powder group therapeutical effect obviously is better than the diffusing group of coptis detoxifcation.
Table 2 coptis detoxifcation powder ultramicro powder, coptis detoxifcation loose and treat 2 type streptococcicosis results
| Group | The coptis detoxifcation powder ultramicro powder | Coptis detoxifcation looses | Blank |
| Before curing (head) | 8 | 8 | 8 |
| Cure on (head) | 7 | 4 | 0 |
| Treatment rate (%) | 87.50 | 50.00 | 0 |
Description of drawings
Fig. 1 is the production equipment system figure of the method for the invention.
Fig. 2 is the structural representation of special-purpose two-way airflow screening machine of the present invention.
The specific embodiment
As shown in Figure 1, 2, the superfine powder coptis detoxifcation of the present invention normal temperature preparation method that looses comprises the steps:
The first step, choose Rhizoma Coptidis, Fructus Gardeniae, Radix Scutellariae, Cortex Phellodendri decoction pieces by weight, through natural drying or dry to moisture≤10%;
Second goes on foot, under 20 ℃～25 ℃ temperature the above-mentioned raw materials medicine is pulverized respectively, obtains granularity 60～80 purpose Chinese medicine coarse powder;
The 3rd step, with above-mentioned raw materials medicine coarse powder according to Rhizoma Coptidis: the weight portion ratio mix homogeneously of Fructus Gardeniae: Radix Scutellariae: Cortex Phellodendri=2:3:4:4;
The 4th goes on foot, at first opens powder conveying fan 15, air-introduced machine 5, aerator 11, drive motors 8.The blow pressure of powder conveying fan 15 is 24kpa, and the blowing amount is 150m
3/ h; The air inducing of air-introduced machine 5 is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The blast pressure of aerator 11 is 33kpa, blow rate required 320m
3/ h; The rotating speed of drive motors 8 is 155 rev/mins;
1, the 3rd step gained coarse powder is placed pulverize in the rod mill 16 after, powder body to be fractionated are arranged in the downward screen drum 2 of casing 1 inner chamber intermediate openings being brought into by high velocity air through wind stopping device 14, feed pipe 12 under the power of the blowing effect of powder conveying fan 15 in the rod mill 16, and by the impulsive force of buffering umbrella 13 reduction powder body to be fractionated in screen drum 2, powder body to be fractionated is disperseed in screen drum 2; The order number of screen drum 2 is 500 orders;
2, the screen drum 2 interior powder body to be fractionated that disperse carry out classification by screen drum 2 under air-introduced machine 5 effects, and fine powder negative pressure chamber 4 through casing 1 top under the negative-pressure air-flow effect that air-introduced machine 5 produces of passing screen drum 2 is transported to collect in the tornado feeder set 17 and namely gets the diffusing finished product of superfine powder coptis detoxifcation.The powder body by screen drum 2 does not sink through collecting with the funnel 3 that screen drum 2 under sheds are connected mutually and being transported to circulation pulverizing again in the described rod mill 16 by pipeline 18;
3, door font rotary jet pipe rotates by rolling bearing 10 under drive motors 8 drives, the wind that aerator 11 is sent is in blast pipe 9 enters described transverse tube 6 and standpipe 7, and through be opened in the puff prot ejection that has the groove structure on transverse tube 6 and standpipe 7 tube walls respectively vertically towards screen drum 2 directions, form even blowback air-flow in screen drum 2 at screen drum 2 end faces and side, powder body in the screen drum 2 is further atomized, stop powder body to stop up sieve screen apertures at screen drum 2 caking simultaneously, make not powder body by screen drum 2 along with the air-flow whirlpool that forms sinks to entering in the funnel 3.The groove width that is opened in groove on transverse tube 6 and standpipe 7 tube walls is respectively vertically selected between 0.5 millimeter-2 millimeters as required, between the roof of transverse tube 6 and standpipe 7 and corresponding screen drum 2 and the sidewall apart from being respectively 25 millimeters.
The superfine powder coptis detoxifcation of the preparation finished product that looses is sub-packed in the aluminium foil bag and stores, every bag heavy 500g or 1000g.
Claims (2)
1. the diffusing normal temperature preparation method of superfine powder coptis detoxifcation is characterized in that: comprise the steps:
The first step, choose Rhizoma Coptidis, Fructus Gardeniae, Radix Scutellariae, Cortex Phellodendri decoction pieces by weight, through natural drying or dry to moisture≤10%;
Second goes on foot, under 20 ℃～25 ℃ temperature the above-mentioned raw materials medicine is pulverized respectively, obtains granularity 60～80 purpose Chinese medicine coarse powder;
The 3rd step, with above-mentioned raw materials medicine coarse powder according to Rhizoma Coptidis: the weight portion ratio mix homogeneously of Fructus Gardeniae: Radix Scutellariae: Cortex Phellodendri=2:3:4:4;
The 4th step, with the 3rd step gained coarse powder place pulverize in the rod mill (16) after, be fed into special-purpose two-way airflow screening machine by wind and cross 500 mesh sieves, the air-flow that the powder that obtains particle diameter≤25 micron of sieving is produced by air-introduced machine (5) is transported in the tornado feeder set (17) collection and namely gets the superfine powder coptis detoxifcation finished product that looses; The powder of not crossing 500 mesh sieves is transported to circulation pulverizing again in the described rod mill (16) through funnel (3) collection and by pipeline (18);
Described special-purpose two-way airflow screening machine is characterized in that: comprise casing (1) and the downward screen drum of chamber intermediate openings (2) that sets within it, the order number of described screen drum (2) 〉=500 orders; The nozzle of screen drum (2) is connected mutually with funnel (3) upper shed that is arranged on casing (1) bottom; Casing (1) inner chamber is connected with air-introduced machine (5) by the negative pressure chamber (4) on top; Be provided with the door font rotary jet pipe that is constituted by transverse tube (6) and standpipe (7) in the zone that is positioned between screen drum (2) and the casing (1), the puff prot of described door font rotary jet pipe is for axially being opened in groove on its tube wall along described transverse tube (6) and standpipe (7) respectively, described groove is offered towards screen drum (2) direction respectively, the groove width 0.5-2 millimeter of groove, the middle part of transverse tube (6) and drive motors (8) driving coupling; Be provided with blast pipe (9) in screen drum (2) centre position, the air outlet of described blast pipe (9) passes screen drum (2) and is connected with transverse tube (6) middle part of door font rotary jet pipe and is connected by rolling bearing (10) rolling; The air inlet of blast pipe (9) extends outside described funnel (3) sidewall and is connected with the blast orifice of aerator (11); In screen drum (2), be provided with feed pipe (12), be provided with buffering umbrella (13) in the discharging opening of described feed pipe (12) top, the charging aperture of feed pipe (12) extends outside funnel (3) sidewall and is communicated with powder conveying fan (15) air outlet through wind stopping device (14).
2. the superfine powder coptis detoxifcation according to claim 1 normal temperature preparation method that looses, it is characterized in that: the air inducing of described air-introduced machine (5) is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The rotating speed of described drive motors (8) is 155 rev/mins; The blast pressure of described aerator (11) is 33kpa, and the blow rate required is 320m
3/ h; The wind pressure that goes out of described powder conveying fan (15) is 24kpa, and air output is 150m
3/ h; The sidewall of described screen drum (2) and roof respectively with corresponding standpipe (7) and transverse tube (6) between distance be 25 millimeters.
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