CN102488803B - Preparation method for superfine bupleurum powder under normal temperature - Google Patents
Preparation method for superfine bupleurum powder under normal temperature Download PDFInfo
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- CN102488803B CN102488803B CN2011103829130A CN201110382913A CN102488803B CN 102488803 B CN102488803 B CN 102488803B CN 2011103829130 A CN2011103829130 A CN 2011103829130A CN 201110382913 A CN201110382913 A CN 201110382913A CN 102488803 B CN102488803 B CN 102488803B
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Abstract
The invention discloses a preparation method for superfine bupleurum powder under a normal temperature; the preparation method comprises the following steps of: firstly selecting radix bupleuri, radix scutellariae, pinellia, dangshen and liquorice, cleaning and cutting the radix bupleuri, the radix scutellariae, the pinellia, the dangshen and the liquorice into sections; drying the sections, and then respectively grinding the sections to obtain crude traditional Chinese medicine powders; uniformly mixing the crude traditional Chinese medicine powders according to proportions of 3:3:2:3:1, then placing the mixed crude traditional Chinese medicine powder in a rod mill to be ground, leading the ground powder to enter a special bidirectional airflow sieving machine through air supply to pass through a sieve with 500 meshes, sieving the ground powder to obtain powder with the particle size of less than or equal to 25 micrometers, conveying the powder into a cyclone material collecting device through air currents generated by a draught fan to be collected, thereby obtaining the superfine bupleurum powder finished product; and collecting and conveying the powder which is not sieved by the sieve with 500 meshes into the rod mill for secondary cyclic grinding. The preparation method has the advantages that the whole preparation process is carried out under the normal temperature, and low temperature or special auxiliary conditions are not needed; the particle size of the prepared medicine finished product is less than or equal to 25 micrometers, and the wall-broken rate of cells and the bioavailability are greatly increased; and the bidirectional airflow sieving machine adopted in the preparation method simplifies the preparation process of the superfine bupleurum powder.
Description
Technical field
The present invention relates to the veterinary drug preparation field, especially relate to preparation method for superfine bupleurum powder under normal temperature; The invention still further relates to the special bilateral airflow sieving machine for the method.
Background technology
Chinese herbal medicine is carrying out aspect prevention and treatment of diseases having the incomparable superiority of other chemical synthetic drugs: safe, toxic and side effects is little, effective ingredient is many, hazard residue is few, action target spot is many, can bring into play combined effect, be difficult for producing drug resistance, scalable immunity of organisms, enhancing body resistance against diseases in anti-bacteria and anti-virus.More and more emphasize food safety in the our times various countries, under Calling for Green, ecological overall background, apply prevention and the control that herbal medicine carries out Animal diseases and be of great practical significance.
The veterinary drug bupleurum root powder of tradition use is comprised of Radix Bupleuri, Radix Scutellariae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Codonopsis and Radix Glycyrrhizae 5 flavor Chinese medicines, effect with antipyretic and anti-inflammatory, hepatic cholagogic, enhancing immunity, remarkable for card effects such as treatment horse sweating syndrome, mule conjunctivitis, faucitis of horses, the antenatal aphagia of donkey bosom mule, cattle epilepsy syndrome, Niu Fengwen folder damp syndrome, cattle puerperal fever and domestic animal low grade fever do not move back.Bupleurum root powder used mostly is the powder of coarse pulverization at present, there are dosage large (horse, cattle 100-250g, sheep, pig 30-60g), dosage form thick (particle diameter 250-850 micron), presentation quality and the deficiency such as palatability is poor, effective ingredient can not fully discharge, bioavailability is low, has had a strong impact on Chinese medicine quality and clinical therapeutic efficacy.
The Study on Supermicro-pulverization of Traditional Chinese Drugs technology is to the renewal of traditional crushing technology and development; it had both retained the advantage of Chinese medicine technology of preparing; injected new vitality for the modern production of Chinese medicine again; have a extensive future, but remain in actual production in some problems and a difficult problem: (1) production efficiency is low, the power consumption height is the principal element of restriction veterinary Chinese medicine superfine powder large-scale production.Rod mill is in traditional closed circuit method crushing process, when most of material has reached fineness requirement, always there is the small part coarse powder to be mixed in wherein, make this part coarse powder further be crushed to required granularity and need to significantly extend grinding time, make crush efficiency reduce, power consumption significantly increases; (2) it is poor that there are the material particular diameter uniformity after classification in selecting crude drugs with winnower classification and grading wheel classification, greatly affected the quality of production of herbal medicine compound recipe superfine powder, especially when being applied to the drinking water for animals use, due to a small amount of not existence of breaking cellular wall cell, be difficult to reach instructions for use.(3) traditional one-way gas flow screening, due to Chinese medicine when carrying out micronizing, along with reducing of particle diameter, material particles surface area and surface can increase, adsorptivity increases, and the mobility variation easily is gathered into bulky grain etc. and causes the sieve classification of crossing that surpasses 200 order fineness medicated powder to be difficult to carry out.The existence of above-mentioned factor has had a strong impact on standardization, the large-scale production of herbal medicine superfine powder, and the popularization on veterinary clinic and use.
Summary of the invention
The object of the invention is to provide a kind of rapid-action, good effect, bioavailability is high, the clinical application amount is few preparation method for superfine bupleurum powder under normal temperature.
Another purpose of the present invention is to provide a kind of special bilateral airflow sieving machine that is applied to preparation method for superfine bupleurum powder under normal temperature.
Preparation method for superfine bupleurum powder under normal temperature of the present invention, comprise the steps:
The first step, choose Radix Bupleuri, Radix Scutellariae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Codonopsis, Radix Glycyrrhizae, choosing is clean, cut into the long section of 3-5cm, through natural drying or dry to moisture≤10%;
Second step, at 20 ℃～25 ℃ temperature, the above-mentioned raw materials medicine is pulverized respectively, obtained granularity 60～80 purpose Chinese medicine coarse powder;
The 3rd step, by above-mentioned raw materials medicine coarse powder according to Radix Bupleuri: the weight ratio mix homogeneously of Radix Scutellariae: Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens): Radix Codonopsis: Radix Glycyrrhizae=3:3:2:3:1;
The 4th step, the 3rd step gained coarse powder is placed in rod mill and pulverizes after, be fed into special bilateral airflow sieving machine by wind and cross 500 mesh sieves, the air-flow that the powder that obtains particle diameter≤25 micron of sieving is produced by air-introduced machine is transported in tornado feeder set collects and obtains superfine powder bupleurum root powder finished product; Do not cross the powder of 500 mesh sieves and collect and be transported to by pipeline circulation pulverizing again in described rod mill through funnel.Finished product superfine powder bupleurum root powder is sub-packed in aluminium foil bag, and every bag weighs 100g, 200g, 500g, 1000g, 2000g etc.
Special bilateral airflow sieving machine of the present invention, comprise casing and the downward screen drum of chamber intermediate openings that sets within it, the order number of described screen drum >=500 orders; The nozzle of screen drum is connected mutually with the funnel upper shed that is arranged on the casing bottom; Chassis cavity is connected with air-introduced machine by the negative pressure chamber on top; The door font rotation spray trachea consisted of transverse tube and standpipe is arranged at the region division between screen drum and casing, the puff prot of described door font rotation spray trachea is for axially to be opened in the groove on its tube wall along described transverse tube and standpipe respectively, described groove is offered towards the screen drum direction respectively, the groove width 0.5-2 millimeter of groove, the middle part of transverse tube and drive motors driving coupling; Be provided with blast pipe in the screen drum centre position, the air outlet of described blast pipe is connected and rolls and be connected by rolling bearing with the transverse tube middle part of door font rotation spray trachea through screen drum; The air inlet of blast pipe extends outside described hopper side walls and is connected with the blast orifice of aerator; Be provided with feed pipe in screen drum, be provided with the buffering umbrella above the discharging opening of described feed pipe, the charging aperture of feed pipe extends outside hopper side walls and is communicated with powder conveying fan air outlet through wind stopping device.
The air inducing of described air-introduced machine is pressed as 1000pa, and the air inducing amount is 3000m
3/ h; The rotating speed of described drive motors is 155 rev/mins; The blast pressure of described aerator is 33kpa, and the blow rate required is 320m
3/ h; The wind pressure that goes out of described powder conveying fan is 24kpa, and air output is 150m
3/ h; The sidewall of described screen drum and roof respectively with corresponding standpipe and transverse tube between distance be 25 millimeters.
The invention has the advantages that whole preparation process all carries out at normal temperatures, do not need low temperature or special additional conditions; The final drug particle diameter of preparation≤25 microns, cell wall breaking rate (sporoderm-broken rate reaches more than 95%) and bioavailability have greatly been improved, strengthened pharmacological action, thereby reduced treatment disease dosage, saved medical material, abnormal smells from the patient and the mouthfeel of medicine have also been improved simultaneously, make the administration of direct employing water way be achieved, changed the deficiency that Chinese powder medicine can only spice can not be drunk water and takes, the bupleurum root powder of superfine powder can evenly stick on animal pellet feed simultaneously, has solved particulate material and can not mix with Chinese medicine the problem of using; The bidirectional airflow sieving machine used in the inventive method, simplified the preparation technology of superfine powder bupleurum root powder greatly, realized the purpose that the Chinese powder medicine quality standard is controlled, be suitable for large-scale industrial production.
The clinical therapeutic efficacy of preparation of the present invention is verified by following test:
1 materials and methods
1.1 test drug and material
Bupleurum root powder superfine powder: adopt the present invention's preparation.
The bupleurum root powder fine powder: according to two ones of " Chinese veterinary pharmacopoeia " versions in 2010, prepared by this laboratory, 80-100 order, particle diameter 150-190um traditionally.
Typhoid fever-paratyphoid fever the first and second mixed vaccines: institute of biological products, Ministry of Public Health Zhengzhou provides.
1.2 experimental animal
2-2.5kg/ 80 of the livid purple blue state of health only rabbits, Henan agricultural university Animal Experimental Study center provides.
1.3 test grouping
table 1test grouping and medication
| Group | Number of animals (only) | Medicining condition | Usage and dosage |
| 1 | 10 | Do not infect matched group | Do not infect not medication |
| 2 | 10 | Infect, not treatment group | Infect not medication |
| 3 | 10 | Infect 80-100 order fine powder high-dose therapy group | The 5g/kg spice |
| 4 | 10 | Infect dosage treatment group in 80-100 order fine powder | The 3g/ |
| 5 | 10 | Infect 80-100 order fine powder low dose therapy group | The 1g/kg spice |
| 6 | 10 | Infect 400-500 order superfine powder high dose group | The 5g/kg spice |
| 7 | 10 | Infect dosage group in 400-500 order superfine powder | The 3g/kg spice |
| 8 | 10 | Infect 400-500 order superfine powder low dose group | The 1g/kg spice |
Experimental animal is divided into 8 groups at random, and continuous use 4h, every a body temperature of 1h record.
1.4 test method
Experimental animal is bought back, and starts test after 3d.Experimental animal is divided into 8 groups at random, fasting 12h before experiment, freely drink water, and then according to the 1.5ml/kg ear vein, injects, record the body temperature of every group of rabbit before and after injection, after injection, 30min starts to the experimental animal spice, and high dose group is according to the 5g/kg spice, and middle dosage group is according to the 3g/kg spice, low dose group is according to the 1g/kg spice, 1, the equal spice not of 2 matched groups, be used in conjunction 4h, observes and record the effect (in Table 1, table 2) of bringing down a fever.
table 1variable concentrations, different process bupleurum root powder superfine powder are to the bring down a fever observation of effect of rabbit " fever "
| Group | Body temperature average before injection (℃) | Body temperature average after injection 30min (℃) | 1h body temperature average after administration (℃) | 2h body temperature average after administration (℃) | 3h body temperature average after administration (℃) | 4h body temperature average after administration (℃) |
| 1 | 38.8 | 38.9 | 38.9 | 38.8 | 38.8 | 38.8 |
| 2 | 38.9 | 39.5 | 40.1 | 40.3 | 40.5 | 41.0 |
| 3 | 38.8 | 39.4 | 39.7 | 40.1 | 40.3 | 40.6 |
| 4 | 38.8 | 39.5 | 39.9 | 40.2 | 40.4 | 40.8 |
| 5 | 39.0 | 39.6 | 40.0 | 40.3 | 40.5 | 41.0 |
| 6 | 39.0 | 39.5 | 39.7 | 39.9 | 40.1 | 40.3 |
| 7 | 38.9 | 39.5 | 39.7 | 40.0 | 40.3 | 40.5 |
| 8 | 39.0 | 39.6 | 39.9 | 40.2 | 40.4 | 40.7 |
Result of the test shows: the bupleurum root powder superfine powder of different amounts, different process is brought down a fever and is all had obvious therapeutic effect (to infect than matched group rabbit " fever ", except 80-100 order fine powder low dose therapy group), and the larger effect of consumption is better, and bupleurum root powder prepared than traditional handicraft by the bupleurum root powder superfine powder for preparing of the present invention is brought down a fever effect more.And drawn by statistical calculations: 3,4,8 three groups all with 2 groups of significant differences (P<0.05), 6,7 liang of groups all with 2 groups of differences extremely remarkable (P<0.01), 6 groups and 3 groups of significant differences (P<0.05), 7 groups and 4 groups of significant differences (P<0.05), 3 groups with 7 groups of difference not obvious (P > 0.05), 5 groups with 2 groups of difference not obvious (P > 0.05).In bupleurum root powder superfine powder prepared by the present invention, dosage group and the traditional handicraft high dose group effect of bringing down a fever is suitable, visible, and the preparation bioavailability that preparation technology of the present invention produces than traditional handicraft is higher, better effects if.
The accompanying drawing explanation
Fig. 1 is the production equipment system figure of the method for the invention.
Fig. 2 is the structural representation of special bilateral airflow sieving machine of the present invention.
The specific embodiment
As shown in Figure 1, 2, preparation method for superfine bupleurum powder under normal temperature of the present invention, comprise the steps:
The first step, choose Radix Bupleuri, Radix Scutellariae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Codonopsis, Radix Glycyrrhizae, choosing is clean, cut into the long section of 3-5cm, through natural drying or dry to moisture≤10%;
Second step, at 20 ℃～25 ℃ temperature, the above-mentioned raw materials medicine is pulverized respectively, obtained granularity 60～80 purpose Chinese medicine coarse powder;
The 3rd step, by above-mentioned raw materials medicine coarse powder according to Radix Bupleuri: the weight ratio mix homogeneously of Radix Scutellariae: Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens): Radix Codonopsis: Radix Glycyrrhizae=3:3:2:3:1;
The 4th step, at first open powder conveying fan 15, air-introduced machine 5, aerator 11, drive motors 8.The blow pressure of powder conveying fan 15 is 24kpa, and the blowing amount is 150m
3/ h; The air inducing of air-introduced machine 5 is pressed as 1000pa, and the air inducing amount is 3000m
3/ h; The blast pressure of aerator 11 is 33kpa, blow rate required 320m
3/ h; The rotating speed of drive motors 8 is 155 rev/mins;
1, after the 3rd step gained coarse powder is placed in to the interior pulverizing of rod mill 16, the interior powder body to be fractionated of rod mill 16 is brought into by high velocity air and is arranged in the downward screen drum 2 of casing 1 inner chamber intermediate openings through wind stopping device 14, feed pipe 12 under the power of the blowing effect of powder conveying fan 15, and reduce the impulsive force of powder body to be fractionated in screen drum 2 by buffering umbrella 13, make powder body to be fractionated in the interior dispersion of screen drum 2; The order number of screen drum 2 is 500 orders;
2, the powder body to be fractionated of screen drum 2 interior dispersions carries out classification by screen drum 2 under air-introduced machine 5 effects, through the fine powder of screen drum 2, under the negative-pressure air-flow effect of air-introduced machine 5 generations, collects and obtain superfine powder bupleurum root powder finished product in the negative pressure chamber 4 on casing 1 top is transported to tornado feeder set 17.By the funnel 3 of powder body sinking through being connected mutually with screen drum 2 under sheds of screen drum 2, do not collect and be transported to circulation pulverizing again in described rod mill 16 by pipeline 18;
3, door font rotation spray trachea rotates by rolling bearing 10 under drive motors 8 drives, the wind that aerator 11 is sent is in blast pipe 9 enters described transverse tube 6 and standpipe 7, and through be opened in vertically respectively the puff prot ejection that there is the groove structure on transverse tube 6 and standpipe 7 tube walls towards screen drum 2 directions, form even blowback air-flow in screen drum 2 at screen drum 2 end faces and side, make the further atomization of powder body in screen drum 2, stop the powder body blocking screen mesh that lumps simultaneously on screen drum 2, make not powder body by screen drum 2 along with the air-flow whirlpool formed sinks to entering in funnel 3.The groove width that is opened in vertically respectively groove on transverse tube 6 and standpipe 7 tube walls is selected as required between 0.5 millimeter-2 millimeters, between the roof of transverse tube 6 and standpipe 7 and corresponding screen drum 2 and sidewall apart from being respectively 25 millimeters.
The superfine powder bupleurum root powder finished product of preparation is sub-packed in aluminium foil bag and stores, and every bag weighs 500g or 1000g.
Claims (2)
1. a preparation method for superfine bupleurum powder under normal temperature, is characterized in that: comprise the steps:
The first step, choose Radix Bupleuri, Radix Scutellariae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Codonopsis, Radix Glycyrrhizae, choosing is clean, cut into the long section of 3-5cm, through natural drying or dry to moisture≤10%;
Second step, at 20 ℃～25 ℃ temperature, the above-mentioned raw materials medicine is pulverized respectively, obtained granularity 60～80 purpose Chinese medicine coarse powder;
The 3rd step, by above-mentioned raw materials medicine coarse powder according to Radix Bupleuri: the weight ratio mix homogeneously of Radix Scutellariae: Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens): Radix Codonopsis: Radix Glycyrrhizae=3:3:2:3:1;
The 4th step, the 3rd step gained coarse powder is placed in rod mill (16) and pulverizes after, be fed into special bilateral airflow sieving machine by wind and cross 500 mesh sieves, the air-flow that the powder that obtains particle diameter≤25 micron of sieving is produced by air-introduced machine (5) is transported to collection in tornado feeder set (17) and obtains superfine powder bupleurum root powder finished product; The powder of not crossing 500 mesh sieves is collected and is passed through pipeline (18) through funnel (3) and is transported in described rod mill (16) circulation again and pulverizes;
Described special bilateral airflow sieving machine is characterized in that: comprise casing (1) and the downward screen drum of chamber intermediate openings (2) that sets within it, the order number of described screen drum (2) >=500 orders; The nozzle of screen drum (2) is connected mutually with funnel (3) upper shed that is arranged on casing (1) bottom; Casing (1) inner chamber is connected with air-introduced machine (5) by the negative pressure chamber (4) on top; At the region division be positioned between screen drum (2) and casing (1), the door font rotation spray trachea consisted of transverse tube (6) and standpipe (7) is arranged, the puff prot of described door font rotation spray trachea is for axially to be opened in the groove on its tube wall along described transverse tube (6) and standpipe (7) respectively, described groove is offered towards screen drum (2) direction respectively, the groove width 0.5-2 millimeter of groove, the middle part of transverse tube (6) and drive motors (8) driving coupling; Be provided with blast pipe (9) in screen drum (2) centre position, the air outlet of described blast pipe (9) is connected and passes through rolling bearing (10) rolling with transverse tube (6) middle part of door font rotation spray trachea through screen drum (2) and is connected; The air inlet of blast pipe (9) extends outside described funnel (3) sidewall and is connected with the blast orifice of aerator (11); Be provided with feed pipe (12) in screen drum (2), be provided with buffering umbrella (13) in the discharging opening of described feed pipe (12) top, the charging aperture of feed pipe (12) extends outside funnel (3) sidewall and is communicated with powder conveying fan (15) air outlet through wind stopping device (14).
2. preparation method for superfine bupleurum powder under normal temperature according to claim 1 is characterized in that: the air inducing of described air-introduced machine (5) is pressed as 1000pa, and the air inducing amount is 3000m
3/ h; The rotating speed of described drive motors (8) is 155 rev/mins; The blast pressure of described aerator (11) is 33kpa, and the blow rate required is 320m
3/ h; The wind pressure that goes out of described powder conveying fan (15) is 24kpa, and air output is 150m
3/ h; The sidewall of described screen drum (2) and roof respectively with corresponding standpipe (7) and transverse tube (6) between distance be 25 millimeters.
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| CN102406675B (en) * | 2011-11-28 | 2013-09-25 | 河南省康星药业股份有限公司 | Room-temperature preparation method of ultramicro powder angelica |
| CN102423333B (en) * | 2011-11-28 | 2013-12-04 | 河南省康星药业股份有限公司 | Ultramicro powder epimedium constant-temperature preparation method |
| CN102397163B (en) * | 2011-11-28 | 2014-02-12 | 河南省康星药业股份有限公司 | Method for preparing ultrafine medicine terminalia fruit, gardenia and szechwan chinaberry fruit powder at normal temperature |
| CN102406688B (en) * | 2011-11-28 | 2013-12-04 | 河南省康星药业股份有限公司 | Normal-temperature preparation method of codonopsis pilosula submicron powder |
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| 中国兽药典委员会.小柴胡散.<<中华人民共和国兽药典2000年版二部>>.2000,343. * |
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Address after: 451464, No. 2, Hing Road, Baisha Industrial Park, Zhongmu County, Henan, Zhengzhou Applicant after: Henan Health Star Pharmaceutical Co., Ltd. Address before: 451464, No. 2, Hing Road, Baisha Industrial Park, Zhongmu County, Henan, Zhengzhou Applicant before: Henan Kangxing Pharmaceutical Co., Ltd. |
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Inventor after: Xing Yujuan Inventor after: Liu Haixin Inventor after: Li Rongyu Inventor after: Yang Caixia Inventor after: Zhang Yongchang Inventor after: Huang Wenhua Inventor before: Liu Haixin Inventor before: Li Rongyu Inventor before: Yang Caixia Inventor before: Zhang Yongchang Inventor before: Huang Wenhua |