Background technology
The loose powder that mostly is coarse pulverization of the Herba Artemisiae Scopariae that is applied at present domestic animal exists that dosage is large, dosage form thick, appearance poor, and effective ingredient can not fully discharge, and bioavailability is low to be waited not enoughly, has had a strong impact on Chinese medicine quality and therapeutic effect.Chinese medicine carry out aspect the prevention and treatment of diseases comparing with other chemical synthetic drugs have safe, toxic and side effects is little, effective ingredient is many, hazard residue is few, action target spot is many, can bring into play the advantages such as combined effect, and be difficult for producing drug resistance, scalable immunity of organisms, enhancing body resistance against diseases in anti-bacteria and anti-virus.More and more emphasize food safety in the our times various countries, under Calling for Green, the ecological overall background, apply prevention and the control that herbal medicine carries out Animal diseases and be of great practical significance.
The Study on Supermicro-pulverization of Traditional Chinese Drugs technology is to the renewal of traditional crushing technology and development; it had both kept the advantage of Chinese medicine technology of preparing; injected new vitality for the modern production of Chinese medicine again; have a extensive future, but remain in actual production in some problems and a difficult problem: (1) production efficiency is low, the power consumption height is the principal element of restriction veterinary Chinese medicine superfine powder large-scale production.Rod mill is in traditional closed circuit method crushing process, when most of material has reached fineness requirement, always there is the small part coarse powder to be mixed in wherein, make this part coarse powder further be crushed to institute's granularity that requires needs significantly to prolong grinding time, so that crush efficiency reduces, power consumption significantly increases; (2) it is poor that there are the material particular diameter uniformity after the classification in selecting crude drugs with winnower classification and grading wheel classification, greatly affected the quality of production of herbal medicine compound recipe superfine powder, especially when being applied to the drinking water for animals use, because a small amount of not existence of breaking cellular wall cell is difficult to reach instructions for use.(3) traditional one-way gas flow screening is because Chinese medicine is when carrying out micronizing, along with reducing of particle diameter, material particles surface area and surface energy increase, adsorptivity increases, and mobile variation easily is gathered into bulky grain etc. and causes the sieve classification of crossing that surpasses 200 order fineness medicated powder to be difficult to carry out.The existence of above-mentioned factor has had a strong impact on standardization, the large-scale production of herbal medicine superfine powder, and the popularization on veterinary clinic and use.
Summary of the invention
The object of the invention is to provide a kind of superfine powder Herba Artemisiae Scopariae normal temperature preparation method that falls apart, efficiently solve that present production Herba Artemisiae Scopariae loose exists that energy consumption is large, the medicine maximum particle diameter is difficult to accurate control, can't produce continuously, difficult problems such as dust is many in the production process so that the finished medicines of preparation has is rapid-action, good effect, bioavailability is high, the clinical application amount is few effect.
Another purpose of the present invention is to provide a kind of special bilateral airflow sieving machine that is applied to the loose normal temperature preparation method of superfine powder Herba Artemisiae Scopariae.
The superfine powder Herba Artemisiae Scopariae of the present invention normal temperature preparation method that falls apart comprises the steps:
The first step, choose crude drug decoction pieces Herba Artemisiae Scopariae, Fructus Gardeniae, Radix Et Rhizoma Rhei respectively; Naturally dry or dry to moisture≤10%;
Second step, respectively that above-mentioned raw materials medicated powder is broken under 20 ℃~25 ℃ temperature, obtaining granularity is 60~80 purpose coarse powder;
The 3rd step, with second step gained coarse powder by Herba Artemisiae Scopariae: the weight ratio mix homogeneously of Fructus Gardeniae: Radix Et Rhizoma Rhei=8:4:3;
The 4th step, with the 3rd step gained coarse powder place pulverize in the rod mill after, be fed into special bilateral airflow sieving machine by wind and cross 500 mesh sieves, the air-flow that the powder that obtains particle diameter≤25 micron of sieving is produced by air-introduced machine is transported to collect in the tornado feeder set and namely gets the loose finished product of superfine powder Herba Artemisiae Scopariae; The powder of not crossing 500 mesh sieves is transported to again circulation pulverizing in the described rod mill through the funnel collection and by pipeline.
Special bilateral airflow sieving machine of the present invention comprises casing and the downward screen drum of chamber intermediate openings that sets within it, the order number of described screen drum 〉=500 orders; The nozzle of screen drum is connected mutually with the funnel upper shed that is arranged on the casing bottom; Chassis cavity is connected with air-introduced machine by the negative pressure chamber on top; The door font rotation spray trachea that is made of transverse tube and standpipe is arranged at the region division between screen drum and casing, the puff prot of described door font rotation spray trachea is for axially being opened in groove on its tube wall along described transverse tube and standpipe respectively, described groove is offered towards the screen drum direction respectively, the groove width 0.5-2 millimeter of groove, the middle part of transverse tube and drive motors driving coupling; Be provided with blast pipe in the screen drum centre position, the air outlet of described blast pipe passes that screen drum is connected with the transverse tube middle part of door font rotation spray trachea and rolls by rolling bearing and is connected; The air inlet of blast pipe extends outside the described hopper side walls and is connected with the blast orifice of aerator; Be provided with feed pipe in screen drum, be provided with the buffering umbrella above the discharging opening of described feed pipe, the charging aperture of feed pipe extends outside the hopper side walls and is communicated with powder conveying fan air outlet through wind stopping device.
The air inducing of described air-introduced machine is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The rotating speed of described drive motors is 155 rev/mins; The blast pressure of described aerator is 33kpa, and the blow rate required is 320m
3/ h; The wind pressure that goes out of described powder conveying fan is 24kpa, and air output is 150m
3/ h; The sidewall of described screen drum and roof respectively with corresponding standpipe and transverse tube between distance be 25 millimeters.
The invention has the advantages that whole preparation process all carries out at normal temperatures, do not need low temperature or special additional conditions; The final drug particle diameter of preparation≤25 microns, cell wall breaking rate and bioavailability have greatly been improved, strengthened pharmacological action, thereby reduced treatment disease dosage, saved medical material, simultaneously also improve abnormal smells from the patient and the mouthfeel of medicine, be achieved so that directly adopt water way to take medicine to domestic animal, changed the deficiency that Chinese powder medicine can only spice can not be drunk water and take; The bidirectional airflow sieving machine that uses in the inventive method has been simplified the loose preparation technology of superfine powder Herba Artemisiae Scopariae greatly, has realized the purpose that the Chinese powder medicine quality standard is controlled, be suitable for large-scale industrial production.
Clinical therapeutic efficacy according to the superfine powder Herba Artemisiae Scopariae powder preparation of the inventive method preparation is verified by following test:
Trial drug:
1. adopt the superfine powder Herba Artemisiae Scopariae of the inventive method preparation loose.
2. oxytetracycline powder; The 100g/ bag, content: 98.5%, the laboratory preparation.
3. the loose fine powder of Herba Artemisiae Scopariae: according to two ones of " Chinese veterinary pharmacopoeia " versions in 2010, manufacture experimently at laboratory.
Experimental animal: the spontaneous eperythrozoonosis in pig farm fatten swinery, be diagnosed as swine eperythrozoonosis by clinical symptoms, pathological anatomy and bacteriology checking.
Test method: with sick pig is consistent according to parity, kind is identical, body weight is close, the principle of male and female half and half, be divided at random 4 groups, be respectively positive controls, oxytetracycline group, the loose fine powder group of Herba Artemisiae Scopariae, Herba Artemisiae Scopariae powder ultramicro powder group, usage and consumption see Table 1: the I group is matched group, need not any medicine; The II group by 1% spice feed (by 1% of feedstuff weight portion admix the material raise); The III group is fed by 45g/ pcs/day of spice, carries out therapeutic test; The IV group is fed by 22.5g/ pcs/day of spice, carries out therapeutic test.Experimental period is 6 days.
Table 1 test grouping and medicining condition
Group |
Number of animals (only) |
Medicining condition |
Usage and dosage |
1 |
10 |
Infect not medication group |
Not medication |
2 |
10 |
Infect the oxytetracycline group |
0.1%/sky/spice |
3 |
10 |
Infect the Herba Artemisiae Scopariae fine powder group of faling apart |
45g/ pcs/day/spice |
4 |
10 |
Infect Herba Artemisiae Scopariae powder ultramicro powder group |
22.5g/ pcs/day/spice |
Result of the test: see Table 2, table 3, table 4.
Table 2 is respectively organized the medication effect result of the test relatively
Table 3 is respectively organized the medication effect result of the test relatively
Table 4 is respectively organized the medication effect result of the test relatively
Group |
Cure rate (%) |
Effective percentage (%) |
Mortality rate (%) |
1 |
0 |
0 |
100 |
2 |
60 |
70 |
20 |
3 |
80 |
100 |
0 |
4 |
90 |
100 |
0 |
Conclusion: as can be seen from the test results, the oxytetracycline powder group, Herba Artemisiae Scopariae fall apart fine powder group, Herba Artemisiae Scopariae powder ultramicro powder group and infect not medication group there were significant differences (p<0.05), content of hemoglobin and erythrocyte sedimentation rate height can think that apparently higher than oxytetracycline group (p<0.05) the Herba Artemisiae Scopariae powder ultramicro powder has good effect at the treatment Eperythrozoon suis after the medication of Herba Artemisiae Scopariae powder ultramicro powder group; And the loose dosage of superfine powder Herba Artemisiae Scopariae is only for the loose fine powder of Herba Artemisiae Scopariae half, and curative effect is greatly improve but.
The specific embodiment
As shown in Figure 1, 2, the superfine powder Herba Artemisiae Scopariae of the present invention normal temperature preparation method that falls apart comprises the steps:
The first step, choose crude drug decoction pieces Herba Artemisiae Scopariae, Fructus Gardeniae, Radix Et Rhizoma Rhei respectively; Naturally dry or dry to moisture≤10%;
Second step, respectively that above-mentioned raw materials medicated powder is broken under 20 ℃~25 ℃ temperature, obtaining granularity is 60~80 purpose coarse powder;
The 3rd step, with second step gained coarse powder by Herba Artemisiae Scopariae: the weight ratio mix homogeneously of Fructus Gardeniae: Radix Et Rhizoma Rhei=8:4:3;
The 4th goes on foot, at first opens powder conveying fan 15, air-introduced machine 5, aerator 11, drive motors 8.The blow pressure of powder conveying fan 15 is 24kpa, and the blowing amount is 150m
3/ h; The air inducing of air-introduced machine 5 is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The blast pressure of aerator 11 is 33kpa, blow rate required 320m
3/ h; The rotating speed of drive motors 8 is 155 rev/mins.
1, with after the 3rd step, the gained coarse powder placed rod mill 16 interior pulverizing, rod mill 16 interior powder body to be fractionated are arranged in the downward screen drum 2 of casing 1 inner chamber intermediate openings being brought into by high velocity air through wind stopping device 14, feed pipe 12 under the power of the blowing effect of powder conveying fan 15, and by the impulsive force of buffering umbrella 13 reduction powder body to be fractionated in screen drum 2, make powder body to be fractionated in screen drum 2 interior dispersions; The order number of screen drum 2 is 500 orders;
2, the powder body to be fractionated of screen drum 2 interior dispersions carries out classification by screen drum 2 under air-introduced machine 5 effects, and fine powder negative pressure chamber 4 through casing 1 top under the negative-pressure air-flow effect that air-introduced machine 5 produces of passing screen drum 2 is transported to collect in the tornado feeder set 17 and namely gets the loose finished product of superfine powder Herba Artemisiae Scopariae.The powder body by screen drum 2 does not sink through collecting with the funnel 3 that screen drum 2 under sheds are connected mutually and being transported to again circulation pulverizing in the described rod mill 16 by pipeline 18;
3, door font rotation spray trachea rotates by rolling bearing 10 under drive motors 8 drives, the wind that aerator 11 is sent is in blast pipe 9 enters described transverse tube 6 and standpipe 7, and through be opened in vertically respectively the puff prot ejection that has the groove structure on transverse tube 6 and standpipe 7 tube walls towards screen drum 2 directions, form even blowback air-flow in screen drum 2 at screen drum 2 end faces and side, powder body in the screen drum 2 is further atomized, stop simultaneously powder body at screen drum 2 caking blocking screen mesh, make not powder body by screen drum 2 along with the air-flow whirlpool that forms sinks to entering in the funnel 3.The groove width that is opened in vertically respectively groove on transverse tube 6 and standpipe 7 tube walls is selected between 0.5 millimeter-2 millimeters as required, between the roof of transverse tube 6 and standpipe 7 and corresponding screen drum 2 and the sidewall apart from being respectively 25 millimeters.
The loose finished product of superfine powder Herba Artemisiae Scopariae of preparation is sub-packed in the aluminium foil bag, and every bag weighs 500g or 1000g storage.