CN102423333B - Ultramicro powder epimedium constant-temperature preparation method - Google Patents
Ultramicro powder epimedium constant-temperature preparation method Download PDFInfo
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- CN102423333B CN102423333B CN2011103829643A CN201110382964A CN102423333B CN 102423333 B CN102423333 B CN 102423333B CN 2011103829643 A CN2011103829643 A CN 2011103829643A CN 201110382964 A CN201110382964 A CN 201110382964A CN 102423333 B CN102423333 B CN 102423333B
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Abstract
The invention discloses an ultramicro powder epimedium constant-temperature preparation method. The preparation method comprises the following steps of: taking the traditional Chinese medicine of epimedium, cleaning, and drying until the content of moisture is less than or equal to 10%; milling the epimedium under the room temperature to obtain coarse powder with the particle size of 60-80 meshes; placing the obtained coarse powder in a rod mill to be milled to enter a dedicated bidirectional air flow screening machine through the air to be subject to 500-mesh screening, obtaining powder with the particle size being less than or equal to 25 microns; and transmitting the powder into a cyclone collector through the air flow produced by a draught fan to obtain the finished product of the ultramicro powder epimedium, wherein the powder which is not subject to the 500-mesh screening is collected by a funnel, and is transmitted into the rod mill through a pipeline to be circulated and milled again. The invention has the advantages that the whole preparation process is carried out under the room temperature, no low temperature or special additional condition is needed, the prepared finished product of the ultramicro powder epimedium has the particle size being less than or equal to 25 microns, the cell wall-broken rate and the bioavailability are greatly improved, and the pharmacological effect of the medicine is strengthened. By the bidirectional air flow screening machine used in the invention, the preparation process of the ultramicro powder epimedium is simplified.
Description
Technical field
The present invention relates to veterinary additive, especially relate to superfine powder Herba Epimedii normal temperature preparation method; The invention still further relates to the special bilateral airflow sieving machine for the method.
Background technology
Carnis Gallus domesticus, egg are to improve and strengthen one of protein source of human diet structure, in modern breeding scale, generally add antibiotic in feedstuff, hormone improves the fertility performance of poultry, these medicines are in vivo after metabolism, easily produce cytotoxic substance, affect the Carnis Gallus domesticus egg quality, also easily cause that pathogenic microorganism develops immunity to drugs, cause the problems such as drug residue and environmental pollution, the health of harm humans.It is little that Chinese medicine additive has murder by poisoning, and without Drug resistance, drug residue free, process the characteristics such as simple and with low cost, can improve the fertility performance of poultry, can improve again immunity, reaches the effect of preventing and curing diseases, and is aquaculture research direction for a long time.
Herba Epimedii, begin to be stated from Shennong's Herbal, Wei Xiao Tiller section's herbaceos perennial Herba Epimedii and sword-like leave Herba Epimedii, the pubescence Herba Epimedii, Epimedium wushanense, and the dry aerial parts of Herba Epimedii, main product is in Shangxian county, Qinling Mountains in Shaanxi mountain area, Luanchuan, Lushi, Luoning and other places.The property of medicine is hot, sweet, warm, returns liver, kidney channel.Warming the kidney to invigorate YANG, bone and muscle strengthening, wind-damp dispelling.The chemical composition of Herba Epimedii is mainly flavone compound, suffer from lignanoid, alkaloid and volatilization wet goods. Herba Epimedii is promoting immunity of organisms, antibiotic, antiviral, parasiticide, antitumor, antiinflammatory, reduction blood fat and improve the aspect such as animal performance and have certain effect, so Herba Epimedii is the first-selected Chinese medicine that improves livestock and poultry production performance and improve the animal resistance.The Herba Epimedii that is applied at present additive for farm animal feed mostly is the powder of coarse pulverization, has the deficiencies such as dosage is large, dosage form thick, appearance poor, and effective ingredient can not fully discharge, and bioavailability is low, has had a strong impact on Chinese medicine quality and therapeutic effect.
The Study on Supermicro-pulverization of Traditional Chinese Drugs technology is to the renewal of traditional crushing technology and development; it had both retained the advantage of Chinese medicine technology of preparing; injected new vitality for the modern production of Chinese medicine again; have a extensive future, but remain in actual production in some problems and a difficult problem: (1) production efficiency is low, the power consumption height is the principal element of restriction veterinary Chinese medicine superfine powder large-scale production.In traditional closed circuit method crushing process, when most of material has reached fineness requirement, always there is the small part coarse powder to be mixed in wherein, make this part coarse powder further be crushed to required granularity and need to significantly extend grinding time, make crush efficiency reduce, power consumption significantly increases; (2) it is poor that there are the material particular diameter uniformity after classification in selecting crude drugs with winnower classification and grading wheel classification, greatly affected the quality of production of herbal medicine compound recipe superfine powder, especially when being applied to drinking water for animals or the use of particulate material spice, due to a large amount of not existence of breaking cellular wall cell, be difficult to reach instructions for use.(3) traditional one-way gas flow screening, due to Chinese medicine when carrying out micronizing, along with reducing of particle diameter, material particles surface area and surface can increase, adsorptivity increases, and the mobility variation easily is gathered into bulky grain etc. and causes the sieve classification of crossing that surpasses 200 order fineness medicated powder to be difficult to carry out.The existence of above-mentioned factor has had a strong impact on standardization, large-scale production and the popularization on veterinary clinic and the use of herbal medicine superfine powder.
Summary of the invention
The object of the invention is to provide a kind of rapid-action, good effect, superfine powder Herba Epimedii normal temperature preparation method that high, the clinical additive capacity of bioavailability is few.
Another purpose of the present invention is to provide a kind of special bilateral airflow sieving machine that is applied to superfine powder Herba Epimedii normal temperature preparation method.
Superfine powder Herba Epimedii normal temperature preparation method of the present invention, comprise the steps:
The first step, get Herba Epimedii and clean, dry, natural drying or dry to moisture≤10%;
Second step, under 20 ℃～25 ℃, Herba Epimedii is pulverized, obtaining granularity is 60-80 purpose coarse powder;
The 3rd step, second step gained coarse powder is placed in rod mill and pulverizes after, be fed into special bilateral airflow sieving machine by wind and cross 500 mesh sieves, the air-flow that the powder that obtains particle diameter≤25 micron of sieving is produced by air-introduced machine is transported in tornado feeder set collects and obtains superfine powder Herba Epimedii finished product; Do not cross the powder of 500 mesh sieves and collect and be transported to by pipeline circulation pulverizing again in described rod mill through funnel.
Special bilateral airflow sieving machine of the present invention, comprise casing and the downward screen drum of chamber intermediate openings that sets within it, the order number of described screen drum >=500 orders; The nozzle of screen drum is connected mutually with the funnel upper shed that is arranged on the casing bottom; Chassis cavity is connected with air-introduced machine by the negative pressure chamber on top; The door font rotation spray trachea consisted of transverse tube and standpipe is arranged at the region division between screen drum and casing, the puff prot of described door font rotation spray trachea is for axially to be opened in the groove on its tube wall along described transverse tube and standpipe respectively, described groove is offered towards the screen drum direction respectively, the groove width 0.5-2 millimeter of groove, the middle part of transverse tube and drive motors driving coupling; Be provided with blast pipe in the screen drum centre position, the air outlet of described blast pipe is connected and rolls and be connected by rolling bearing with the transverse tube middle part of door font rotation spray trachea through screen drum; The air inlet of blast pipe extends outside described hopper side walls and is connected with the blast orifice of aerator; Be provided with feed pipe in screen drum, be provided with the buffering umbrella above the discharging opening of described feed pipe, the charging aperture of feed pipe extends outside hopper side walls and is communicated with powder conveying fan air outlet through wind stopping device.
The air inducing of described air-introduced machine is pressed as 1000pa, and the air inducing amount is 3000m
3/ h; The rotating speed of described drive motors is 155 rev/mins; The blast pressure of described aerator is 33kpa, and the blow rate required is 320m
3/ h; The wind pressure that goes out of described powder conveying fan is 24kpa, and air output is 150m
3/ h; The sidewall of described screen drum and roof respectively with corresponding standpipe and transverse tube between distance be 25 millimeters.
The invention has the advantages that whole preparation process all carries out at normal temperatures, do not need low temperature or special additional conditions; The finished product Herba Epimedii micropowder particle diameter of preparation≤25 microns, improved cell wall breaking rate (sporoderm-broken rate can reach more than 95%) and bioavailability greatly, strengthened the pharmacological action of medicine, thereby reduced dosage, saved medical material; The bidirectional airflow sieving machine used in the inventive method, simplified the preparation technology of superfine powder Herba Epimedii greatly, realized the purpose that the Chinese powder medicine quality standard is controlled, be suitable for large-scale industrial production.
The clinical health-care effect of the superfine powder Herba Epimedii prepared according to the inventive method is verified by following test:
Test example: the impact of Herba Epimedii superfine powder on broiler immune organ index
Test drug and material:
The Herba Epimedii superfine powder, adopt the present invention's preparation;
The Herba Epimedii coarse powder: 80 order coarse powder, at laboratory, make by oneself;
Experimental animal and grouping: 300 of the healthy Cyan-Shank Partridge Chicken of 14 ages in days, divide equally at random 3 groups, establish 2 repetitions for every group, add respectively 2% Herba Epimedii coarse powder and 1% Herba Epimedii superfine powder in test group 1 and test group 2.7 age in days 14 ages in days all routinely immunity carry out immunity, adopt solid to raise in cages, free choice feeding, freely drink water, the natural lighting on daytime, adopt lighting night, keep hygienically clean and good ventilation, chickling is in the execution that suffocates of 21 ages in days, and the rear dissection of weighing, take out spleen, fabricius bursa, thymus and female reproductive organ, weigh respectively, calculates the index (internal organs (mg)/body weight (g)) of each internal organs.
The impact on Immune Organs Index such as table 1 Herba Epimedii superfine powder
| Group | Number of animals | Index and spleen index | The fabricius bursa index | Thymus index |
| Matched |
10 | 1,59±0.116 | 3.641±0.300 | 1.282±0.035 |
| Test group 1 | 14 | 2.17±0.124 | 3.286±0.199 | 0.647±0.043 |
| |
15 | 2.38±0.240 | 3.913±0.221 | 1.335±0.050 |
The impact on female reproductive organ's index such as table 2 Herba Epimedii superfine powder
| Group | Number of animals/only | Female reproductive organ's index |
| Matched |
10 | 0.4523±0.0444 |
| Test group 1 | 14 | 0.6129±0.0289 |
| |
15 | 1.2939±0.0317 |
Result of the test shows, Herba Epimedii has a certain impact to the fabricius bursa index, raising to index and spleen index has obvious effect, Herba Epimedii has the chicken of causing body maincenter and peripheral lymphoid organ's weightening finish, lymphopoiesis, improve the function of cellular immunization and humoral immunization, aspect the impact of the index on the female reproductive organ, between processed group and matched group, there is notable difference.The superfine powder group is compared with the coarse powder group, and index and spleen index, fabricius bursa index, thymus index, female reproductive organ's index all are significantly improved, significant difference (P<0.05).As can be seen here, the Herba Epimedii superfine powder, for the growth of meat chicken process, is had to good clinical generalization value.
The accompanying drawing explanation
Fig. 1 is the production equipment system figure of the method for the invention.
Fig. 2 is the structural representation of special bilateral airflow sieving machine of the present invention.
The specific embodiment
As shown in Figure 1, 2, superfine powder Herba Epimedii normal temperature preparation method of the present invention, comprise the steps:
The first step, choose stalk less, leaf is many, yellow skin is green, not broken high-quality Herba Epimedii, wherein take the lobule Herba Epimedii quality that produced from northwest as good, Herba Epimedii infantile malnutrition content is no less than 1.0%, it is dried naturally or dry to moisture≤10%;
Second step, under 20 ℃～25 ℃, Herba Epimedii is pulverized, obtaining granularity is 60-80 purpose coarse powder;
The 3rd step, at first open powder conveying fan 15, air-introduced machine 5, aerator 11, drive motors 8.The blow pressure of powder conveying fan 15 is 24kpa, and the blowing amount is 150m
3/ h; The air inducing of air-introduced machine 5 is pressed as 1000pa, and the air inducing amount is 3000m
3/ h; The blast pressure of aerator 11 is 33kpa, blow rate required 320m
3/ h; The rotating speed of drive motors 8 is 155 rev/mins.
1, after second step gained coarse powder is placed in to the interior pulverizing of rod mill 16, the interior powder body to be fractionated of rod mill 16 is brought into by high velocity air and is arranged in the downward screen drum 2 of casing 1 inner chamber intermediate openings through wind stopping device 14, feed pipe 12 under the power of the blowing effect of powder conveying fan 15, and reduce the impulsive force of powder body to be fractionated in screen drum 2 by buffering umbrella 13, make powder body to be fractionated in the interior dispersion of screen drum 2; The order number of screen drum 2 is 500 orders;
2, the powder body to be fractionated of screen drum 2 interior dispersions carries out classification by screen drum 2 under air-introduced machine 5 effect, collects and obtain the superfine powder Herba Epimedii finished product of particle diameter≤25 micron under the negative-pressure air-flow effect produced at air-introduced machine 5 through the fine powder of screen drum 2 in the negative pressure chamber 4 on casing 1 top is transported to tornado feeder set 17.By the funnel 3 of powder body sinking through being connected mutually with screen drum 2 under sheds of screen drum 2, do not collect and be transported to circulation pulverizing again in described rod mill 16 by pipeline 18;
3, door font rotation spray trachea rotates by rolling bearing 10 under drive motors 8 drives, the wind that aerator 11 is sent is in blast pipe 9 enters described transverse tube 6 and standpipe 7, and through be opened in vertically respectively the puff prot ejection that there is the groove structure on transverse tube 6 and standpipe 7 tube walls towards screen drum 2 directions, form even blowback air-flow in screen drum 2 at screen drum 2 end faces and side, make the further atomization of powder body in screen drum 2, stop the powder body blocking screen mesh that lumps simultaneously on screen drum 2, make not powder body by screen drum 2 along with the air-flow whirlpool formed sinks to entering in funnel 3.The groove width that is opened in vertically respectively groove on transverse tube 6 and standpipe 7 tube walls is selected as required between 0.5 millimeter-2 millimeters, between the roof of transverse tube 6 and standpipe 7 and corresponding screen drum 2 and sidewall apart from being respectively 25 millimeters.
The superfine powder Herba Epimedii finished product obtained is sub-packed in aluminium foil bag, and every bag weighs 500g or 1000g.
Claims (2)
1. a superfine powder Herba Epimedii normal temperature preparation method, is characterized in that: comprise the steps:
The first step, get Herba Epimedii and clean, dry, natural drying or dry to moisture≤10%;
Second step, under 20 ℃～25 ℃, Herba Epimedii is pulverized, obtaining granularity is 60-80 purpose coarse powder;
The 3rd step, second step gained coarse powder is placed in rod mill (16) and pulverizes after, be fed into special bilateral airflow sieving machine by wind and cross 500 mesh sieves, the air-flow that the powder that obtains particle diameter≤25 micron of sieving is produced by air-introduced machine (5) is transported to collection in tornado feeder set (17) and obtains superfine powder Herba Epimedii finished product; The powder of not crossing 500 mesh sieves is collected and is passed through pipeline (18) through funnel (3) and is transported in described rod mill (16) circulation again and pulverizes;
Described special bilateral airflow sieving machine is characterized in that: comprise casing (1) and the downward screen drum of chamber intermediate openings (2) that sets within it, the order number of described screen drum (2) >=500 orders; The nozzle of screen drum (2) is connected mutually with funnel (3) upper shed that is arranged on casing (1) bottom; Casing (1) inner chamber is connected with air-introduced machine (5) by the negative pressure chamber (4) on top; At the region division be positioned between screen drum (2) and casing (1), the door font rotation spray trachea consisted of transverse tube (6) and standpipe (7) is arranged, the puff prot of described door font rotation spray trachea is for axially to be opened in the groove on its tube wall along described transverse tube (6) and standpipe (7) respectively, described groove is offered towards screen drum (2) direction respectively, the groove width 0.5-2 millimeter of groove, the middle part of transverse tube (6) and drive motors (8) driving coupling; Be provided with blast pipe (9) in screen drum (2) centre position, the air outlet of described blast pipe (9) is connected and passes through rolling bearing (10) rolling with transverse tube (6) middle part of door font rotation spray trachea through screen drum (2) and is connected; The air inlet of blast pipe (9) extends outside described funnel (3) sidewall and is connected with the blast orifice of aerator (11); Be provided with feed pipe (12) in screen drum (2), be provided with buffering umbrella (13) in the discharging opening of described feed pipe (12) top, the charging aperture of feed pipe (12) extends outside funnel (3) sidewall and is communicated with powder conveying fan (15) air outlet through wind stopping device (14).
2. superfine powder Herba Epimedii normal temperature preparation method according to claim 1 is characterized in that: the air inducing of described air-introduced machine (5) is pressed as 1000pa, and the air inducing amount is 3000m
3/ h; The rotating speed of described drive motors (8) is 155 rev/mins; The blast pressure of described aerator (11) is 33kpa, and the blow rate required is 320m
3/ h; The wind pressure that goes out of described powder conveying fan (15) is 24kpa, and air output is 150m
3/ h; The sidewall of described screen drum (2) and roof respectively with corresponding standpipe (7) and transverse tube (6) between distance be 25 millimeters.
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Address after: 451464, No. 2, Hing Road, Baisha Industrial Park, Zhongmu County, Henan, Zhengzhou Applicant after: Henan Health Star Pharmaceutical Co., Ltd. Address before: 451464, No. 2, Hing Road, Baisha Industrial Park, Zhongmu County, Henan, Zhengzhou Applicant before: Henan Kangxing Pharmaceutical Co., Ltd. |
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Inventor after: Zhang Guozu Inventor after: Kong Weili Inventor after: Ma Xia Inventor after: Liu Ruili Inventor after: Li Qiuxia Inventor before: Zhang Guozu Inventor before: Liu Ruili Inventor before: Yang Caixia Inventor before: Li Qiuxia Inventor before: Liu Hongqiang |
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Free format text: CORRECT: INVENTOR; FROM: ZHANG GUOZU LIU RUILI YANG CAIXIA LI QIUXIA LIU HONGQIANG TO: ZHANG GUOZU KONG WEILI MA XIA LIU RUILI LI QIUXIA |
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Owner name: HENAN KANGXING BIOTECHNOLOGY CO., LTD. Effective date: 20131231 |
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Effective date of registration: 20131231 Address after: 451464, No. 2, Hing Road, Baisha Industrial Park, Zhongmu County, Henan, Zhengzhou Patentee after: Henan Health Star Pharmaceutical Co., Ltd. Patentee after: Henan Kang Xing Biotechnology Co., Ltd. Address before: 451464, No. 2, Hing Road, Baisha Industrial Park, Zhongmu County, Henan, Zhengzhou Patentee before: Henan Health Star Pharmaceutical Co., Ltd. |