CN102406547B - Method of preparing ultramicro medicinal powder for removing heat from the lung to relieve cough at normal temperature - Google Patents
Method of preparing ultramicro medicinal powder for removing heat from the lung to relieve cough at normal temperature Download PDFInfo
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- CN102406547B CN102406547B CN 201110382932 CN201110382932A CN102406547B CN 102406547 B CN102406547 B CN 102406547B CN 201110382932 CN201110382932 CN 201110382932 CN 201110382932 A CN201110382932 A CN 201110382932A CN 102406547 B CN102406547 B CN 102406547B
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Abstract
The invention discloses a method of preparing ultramicro medicinal powder for removing heat from the lung to relieve cough at normal temperature, which comprises the following steps of: firstly, selecting white mulberry root bark, rhizoma anemarrhenae, whiteflower hogfennel root, honeysuckle, fructus forsythiae, platycodon grandiflorum, liquorice, red orange and scutellaria baicalensis; next, cutting into long sections and grinding to obtain coarse powder; extracting apricot kernel oil from bitter apricot seed powder for use, and uniformly mixing medicinal residues with coarse powders of other raw herbs; then, placing the obtained coarse powder in a rod mill for grinding, blowing the ground powder to a special two-way air stream screening machine for screening with 500-mesh sieve, and conveying the screened powder to a cyclone material collector by air stream produced by a draught fan for collecting to obtain the ultramicro medicinal powder for removing heat from the lung to relieve cough; and then, collecting the powder unscreened with the 500-mesh sieve, and conveying the powder to the rod mill by a pipeline for circularly grinding; finally, uniformly mixing the collected ultramicro medicinal powder for removing heat from the lung to relieve cough with the apricot kernel oil to obtain the ultramicro medicinal powder for removing heat from the lung to relieve cough as a finished product. The method disclosed by the invention has the advantages that: the whole preparation process is carried out at normal temperature and the cell wall breaking rate is increased; and the preparation technology for the ultramicro medicinal powder for removing heat from the lung to relieve cough is simplified by the two-way air stream screening machine provided by the invention.
Description
Technical field
The present invention relates to the veterinary drug preparation field, especially relate to the diffusing normal temperature preparation method of superfine powder clearing away lung-heat to relieve cough; The invention still further relates to the special-purpose two-way airflow screening machine that is used for this method.
Background technology
The diffusing major function of clearing away lung-heat to relieve cough is clear eliminating the pathogens from the lung heat, preventing phlegm from forming and stopping coughing.The clearing away lung-heat to relieve cough that is applied to domestic animal at present looses and mostly to be the powder of coarse pulverization, has that dosage is big, dosage form thick, appearance poor, and effective ingredient can not fully discharge, and bioavailability is low to be waited not enoughly, has had a strong impact on Chinese medicine quality and therapeutic effect.
The broken technology of Chinese medicine ultra-fine powder is renewal and the development to traditional crushing technology; it had both kept the advantage of Chinese medicine technology of preparing; injected new vitality for the modern production of Chinese medicine again; have a extensive future, but remain in actual production in some problems and a difficult problem: (1) production efficiency is low, the power consumption height is the principal element of restriction Chinese medicine ultra-fine powder large-scale production for animals.Rod mill is in traditional closed circuit method crushing process, when most of material has reached fineness requirement, always there is the small part coarse powder to be mixed in wherein, make this part coarse powder further be crushed to the granularity that requires need prolong the pulverizing time significantly, make crush efficiency reduce, power consumption significantly increases; (2) it is poor that there are the material particular diameter uniformity after the classification in selecting crude drugs with winnower classification and grading wheel classification, influenced the quality of production of herbal medicine compound recipe superfine powder greatly, especially when being applied to the use of animal drinking-water, because a small amount of not existence of breaking cellular wall cell is difficult to reach instructions for use.(3) traditional one-way gas flow is sieved, because Chinese medicine is when carrying out micronizing, along with reducing of particle diameter, material particles surface area and surface energy increase, adsorptivity increases, and mobile variation easily is gathered into bulky grain etc. and causes the sieve classification of crossing that surpasses 200 order fineness medicated powder to be difficult to carry out.The existence of above-mentioned factor has had a strong impact on standardization, the large-scale production of herbal medicine superfine powder, and popularization on veterinary clinic and use.
Summary of the invention
The object of the invention is to provide a kind of superfine powder clearing away lung-heat to relieve cough normal temperature preparation method that looses, efficiently solve that the energy consumption that exists in the present production is big, the medicine maximum particle diameter is difficult to accurate control, can't continuous production, difficult problems such as dust is many in the production process, make the finished medicines of preparation have rapid-action, good effect, bioavailability height, effect that the clinical application amount is few.
Another purpose of the present invention is to provide a kind of special-purpose two-way airflow screening machine that is applied to the diffusing normal temperature preparation method of superfine powder clearing away lung-heat to relieve cough.
The superfine powder clearing away lung-heat to relieve cough of the present invention normal temperature preparation method that looses comprises the steps:
The first step, choose crude drug Cortex Mori, the Rhizoma Anemarrhenae, Radix Peucedani, Flos Lonicerae, Fructus Forsythiae, Radix Platycodonis, Radix Glycyrrhizae, dried tangerine peel, Radix Scutellariae respectively in following ratio; Clean, dry and cut into the long section of 3-5cm and dry to moisture≤10%, its crude drug ratio is: Cortex Mori: the Rhizoma Anemarrhenae: Semen Armeniacae Amarum: Radix Peucedani: Flos Lonicerae: Fructus Forsythiae: Radix Platycodonis: Radix Glycyrrhizae: dried tangerine peel: Radix Scutellariae=6:5:5:6:12:6:5:4:6:9;
In second step, respectively that above-mentioned raw materials medicated powder is broken under 20 ℃～25 ℃ temperature, obtaining granularity is 60～120 purpose coarse powder;
The 3rd step, to propose almond oil from the Semen Armeniacae Amarum powder standby, and nine kinds of former medicine coarse powder during medicinal residues go on foot with second are mixed together evenly;
The 4th step, with the 3rd step gained coarse powder place pulverize in the rod mill after, be fed into special-purpose two-way airflow screening machine by wind and cross 500 mesh sieves, the air-flow that the powder that obtains particle diameter≤25 micron of sieving is produced by air-introduced machine is transported to collect in the tornado feeder set and promptly gets the clearing away lung-heat to relieve cough powder ultramicro powder; The powder of not crossing 500 mesh sieves arrives circulation pulverizing once more in the described rod mill through the funnel collection and by line transportation;
The 5th clearing away lung-heat to relieve cough powder ultramicro powder and the 3rd almond oil mix homogeneously that goes on foot extraction that goes on foot, the 4th step was collected can obtain the diffusing finished product of superfine powder clearing away lung-heat to relieve cough.
Special-purpose two-way airflow screening machine of the present invention comprises casing and the downward screen drum of chamber intermediate openings that sets within it, the order number of described screen drum 〉=500 orders; The nozzle of screen drum is connected mutually with the funnel upper shed that is arranged on the casing bottom; Chassis cavity is connected with air-introduced machine by the negative pressure chamber on top; Be provided with the door font rotary jet pipe that constitutes by transverse tube and standpipe in the zone between screen drum and casing, the puff prot of described door font rotary jet pipe is for axially being opened in groove on its tube wall along described transverse tube and standpipe respectively, described groove is offered towards the screen drum direction respectively, the groove width 0.5-2 millimeter of groove, the middle part of transverse tube and drive motors driving coupling; Be provided with blast pipe in the screen drum centre position, the air outlet of described blast pipe passes that screen drum is connected with the transverse tube middle part of door font rotary jet pipe and rolls by rolling bearing and is connected; The air inlet of blast pipe extends outside the described hopper side walls and is connected with the blast orifice of aerator; Be provided with feed pipe in screen drum, be provided with the buffering umbrella above the discharging opening of described feed pipe, the charging aperture of feed pipe extends outside the hopper side walls and is communicated with powder conveying fan air outlet through wind stopping device.
The air inducing of described air-introduced machine is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The rotating speed of described drive motors is 155 rev/mins; The blast pressure of described aerator is 33kpa, and the blow rate required is 320m
3/ h; The wind pressure that goes out of described powder conveying fan is 24kpa, and air output is 150m
3/ h; The sidewall of described screen drum and roof respectively with corresponding standpipe and transverse tube between distance be 25 millimeters.
The invention has the advantages that whole process of preparation all carries out at normal temperatures, do not need low temperature or special additional conditions; Final drug particle diameter≤25 micron of preparation, cell wall breaking rate and bioavailability have been improved greatly, strengthened pharmacological action, thereby reduced treatment disease dosage, saved medical material, also improve simultaneously the abnormal smells from the patient and the mouthfeel of medicine, make and directly adopt the water way administration to be achieved, changed the deficiency that Chinese powder medicine can only spice can not be drunk water and take; The two-way airflow screening machine that uses in the inventive method has been simplified the preparation technology that the superfine powder clearing away lung-heat to relieve cough looses greatly, has realized the purpose that the Chinese powder medicine quality standard is controlled, be suitable for large-scale industrial production.
The clinical therapeutic efficacy of preparation of the present invention is verified by following test:
1. experimental animal: 350 of the blue brown chickling in the healthy sea of 21 ages in days, be divided into 7 groups at random, experimental period is 7 days.
2. test and use Strain: infectious bronchitis virus type strain M41 and positive serum, check institute available from Chinese veterinary drug.
3. trial drug and grouping see Table 1.
Table 1 test grouping and medicining condition
| Group | Number of animals (only) | Medicining condition | Usage and dosage |
| 1 | 50 | Do not infect, do not treat group (blank group) | Need not any |
| 2 | 50 | Infect, do not treat group | Infect not medication |
| 3 | 50 | Infect moroxydine treatment group | 1.0g/kg water/sky |
| 4 | 50 | Infect the clearing away lung-heat to relieve cough fine powder high dose group of loosing | 2% spice/sky |
| 5 | 50 | Infect the superfine powder clearing away lung-heat to relieve cough high dose group of loosing | 1% spice/sky |
| 6 | 50 | Infect dosage group during the superfine powder clearing away lung-heat to relieve cough looses | 0.5% spice/sky |
| 7 | 50 | Infect the superfine powder clearing away lung-heat to relieve cough low dose group of loosing | 0.25% spice/sky |
Criterion:
Cure: recover normal with spirit, appetite, drug withdrawal 2 time-of-week inside not recidivist cure;
Produce effects: clinical symptoms obviously alleviates after the medication treatment, and spirit and appetite transfer the treatment produce effects well to;
Invalid: symptom does not disappear after medication, the state of an illness do not take a turn for the better and treat during because of primary disease death be invalid.
4. respectively organize the Drug therapy result and relatively see Table 2.
Table 2 is respectively organized Drug therapy infectious bronchitis of chicken effect test result relatively
| Group | Sickness rate (%) | Cure rate (%) | Obvious effective rate (%) | Case fatality rate (%) |
| 1 | 0 | 0 | 0 | 0 |
| 2 | 100 | 0 | 0 | 100 |
| 3 | 100 | 60 | 88 | 12 |
| 4 | 100 | 90 | 96 | 4 |
| 5 | 100 | 92 | 96 | 4 |
| 6 | 100 | 88 | 92 | 8 |
| 7 | 100 | 76 | 88 | 12 |
The result of the test that from table 2, shows as can be seen, the superfine powder clearing away lung-heat to relieve cough high dose group curative effect the best of loosing is 92%.Diffusing fine powder group of clearing away lung-heat to relieve cough and superfine powder group cure rate are all apparently higher than moroxydine group (p＜0.05), and the superfine powder clearing away lung-heat to relieve cough looses the group cure rate apparently higher than the diffusing fine powder group (p＜0.05) of clearing away lung-heat to relieve cough.On pharmaceutical quantities, the superfine powder clearing away lung-heat to relieve cough looses high dose group only for the diffusing fine powder group consumption of clearing away lung-heat to relieve cough half, has saved medical material greatly, has reduced the medical material consumption.
Description of drawings
Fig. 1 is the production equipment system figure of the method for the invention.
Fig. 2 is the structural representation of special-purpose two-way airflow screening machine of the present invention.
The specific embodiment
As shown in Figure 1, 2, the superfine powder clearing away lung-heat to relieve cough of the present invention normal temperature preparation method that looses comprises the steps:
The first step, choose crude drug Cortex Mori, the Rhizoma Anemarrhenae, Radix Peucedani, Flos Lonicerae, Fructus Forsythiae, Radix Platycodonis, Radix Glycyrrhizae, dried tangerine peel, Radix Scutellariae respectively in following ratio; Clean, dry and cut into the long section of 3-5cm and dry to moisture≤10%, its crude drug ratio is: Cortex Mori: the Rhizoma Anemarrhenae: Semen Armeniacae Amarum: Radix Peucedani: Flos Lonicerae: Fructus Forsythiae: Radix Platycodonis: Radix Glycyrrhizae: dried tangerine peel: Radix Scutellariae=6:5:5:6:12:6:5:4:6:9;
In second step, respectively that above-mentioned raw materials medicated powder is broken under 20 ℃～25 ℃ temperature, obtaining granularity is 60～120 purpose coarse powder;
The 3rd step, to propose almond oil from the Semen Armeniacae Amarum powder standby, and nine kinds of former medicine coarse powder during medicinal residues go on foot with second are mixed together evenly;
The 4th goes on foot, at first opens powder conveying fan 15, air-introduced machine 5, aerator 11, drive motors 8.The blow pressure of powder conveying fan 15 is 24kpa, and the blowing amount is 150m
3/ h; The air inducing of air-introduced machine 5 is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The blast pressure of aerator 11 is 33kpa, blow rate required 320m
3/ h; The rotating speed of drive motors 8 is 155 rev/mins;
1, the 3rd step gained coarse powder is placed pulverize in the rod mill 16 after, powder body to be fractionated are arranged in the downward screen drum 2 of casing 1 inner chamber intermediate openings being brought into by high velocity air through wind stopping device 14, feed pipe 12 under the power of the blowing effect of powder conveying fan 15 in the rod mill 16, and, powder body to be fractionated is disperseed in screen drum 2 by the impulsive force of buffering umbrella 13 reduction powder body to be fractionated in screen drum 2; The order number of screen drum 2 is 500 orders;
2, dispersive powder body to be fractionated carries out classification by screen drum 2 in the screen drum 2 under air-introduced machine 5 effects, and fine powder negative pressure chamber 4 through casing 1 top under the negative-pressure air-flow effect that air-introduced machine 5 produces of passing screen drum 2 is transported to collect in the tornado feeder set 17 and promptly gets the clearing away lung-heat to relieve cough powder ultramicro powder; The powder body by screen drum 2 does not sink through collecting with the funnel 3 that screen drum 2 under sheds are connected mutually and being transported to circulation pulverizing once more in the described rod mill 16 by pipeline 18;
3, door font rotary jet pipe rotates by rolling bearing 10 under drive motors 8 drives, the wind that aerator 11 is sent is in blast pipe 9 enters described transverse tube 6 and standpipe 7, and through be opened in the puff prot ejection that has the groove structure on transverse tube 6 and standpipe 7 tube walls respectively vertically towards screen drum 2 directions, form the evenly blowback air-flow in screen drum 2 at screen drum 2 end faces and side, powder body in the screen drum 2 is further atomized, stop powder body on screen drum 2, to lump simultaneously and stop up sieve screen apertures, make not powder body by screen drum 2 along with the air-flow whirlpool that forms sinks to entering in the funnel 3.The groove width that is opened in groove on transverse tube 6 and standpipe 7 tube walls is respectively vertically selected between 0.5 millimeter-2 millimeters as required, between the roof of transverse tube 6 and standpipe 7 and corresponding screen drum 2 and the sidewall apart from being respectively 25 millimeters;
The 5th clearing away lung-heat to relieve cough powder ultramicro powder and the 3rd almond oil mix homogeneously that goes on foot extraction that goes on foot, the 4th step was collected can obtain the diffusing finished product of superfine powder clearing away lung-heat to relieve cough.
The diffusing finished product of the superfine powder clearing away lung-heat to relieve cough of gained is sub-packed in the aluminium foil bag, every bag of 100g, 200g, 500g, 1000g or 2000g storage.
Claims (2)
1. the diffusing normal temperature preparation method of superfine powder clearing away lung-heat to relieve cough is characterized in that: comprise the steps:
The first step, choose crude drug Cortex Mori, the Rhizoma Anemarrhenae, Radix Peucedani, Flos Lonicerae, Fructus Forsythiae, Radix Platycodonis, Radix Glycyrrhizae, dried tangerine peel, Radix Scutellariae respectively; Clean, dry and cut into the long section of 3-5cm and dry to moisture≤10%;
In second step, respectively that above-mentioned raw materials medicated powder is broken under 20 ℃～25 ℃ temperature, obtaining granularity is 60～120 purpose coarse powder;
The 3rd step, the crude drug Semen Armeniacae Amarum is proposed almond oil, the nine kind former medicine coarse powder of medicinal residues in second step are in Cortex Mori: the weight portion ratio mix homogeneously of the Rhizoma Anemarrhenae: Semen Armeniacae Amarum: Radix Peucedani: Flos Lonicerae: Fructus Forsythiae: Radix Platycodonis: Radix Glycyrrhizae: dried tangerine peel: Radix Scutellariae=6:5:5:6:12:6:5:4:6:9;
The 4th step, with the 3rd step gained coarse powder place pulverize in the rod mill (16) after, be fed into special-purpose two-way airflow screening machine by wind and cross 500 mesh sieves, the air-flow that the powder that obtains particle diameter≤25 micron of sieving is produced by air-introduced machine (5) is transported to collect in the tornado feeder set (17) and promptly get the diffusing finished product of superfine powder clearing away lung-heat to relieve cough; The powder of not crossing 500 mesh sieves is transported to circulation pulverizing once more in the described rod mill (16) through funnel (3) collection and by pipeline (18);
Described special-purpose two-way airflow screening machine is characterized in that: comprise casing (1) and the downward screen drum of chamber intermediate openings (2) that sets within it, the order number of described screen drum (2) 〉=500 orders; The nozzle of screen drum (2) is connected mutually with funnel (3) upper shed that is arranged on casing (1) bottom; Casing (1) inner chamber is connected with air-introduced machine (5) by the negative pressure chamber (4) on top; Be provided with the door font rotary jet pipe that constitutes by transverse tube (6) and standpipe (7) in the zone that is positioned between screen drum (2) and the casing (1), the puff prot of described door font rotary jet pipe is for axially being opened in groove on its tube wall along described transverse tube (6) and standpipe (7) respectively, described groove is offered towards screen drum (2) direction respectively, the groove width 0.5-2 millimeter of groove, the middle part of transverse tube (6) and drive motors (8) driving coupling; Be provided with blast pipe (9) in screen drum (2) centre position, the air outlet of described blast pipe (9) passes screen drum (2) and is connected with transverse tube (6) middle part of door font rotary jet pipe and is connected by rolling bearing (10) rolling; The air inlet of blast pipe (9) extends outside described funnel (3) sidewall and is connected with the blast orifice of aerator (11); In screen drum (2), be provided with feed pipe (12), be provided with buffering umbrella (13) in the discharging opening of described feed pipe (12) top, the charging aperture of feed pipe (12) extends outside funnel (3) sidewall and is communicated with powder conveying fan (15) air outlet through wind stopping device (14).
2. the superfine powder clearing away lung-heat to relieve cough according to claim 1 normal temperature preparation method that looses is characterized in that: the air inducing of described air-introduced machine (5) is pressed and is 1000pa, and the air inducing amount is 3000m
3/ h; The rotating speed of described drive motors (8) is 155 rev/mins; The blast pressure of described aerator (11) is 33kpa, and the blow rate required is 320m
3/ h; The wind pressure that goes out of described powder conveying fan (15) is 24kpa, and air output is 150m
3/ h; The sidewall of described screen drum (2) and roof respectively with corresponding standpipe (7) and transverse tube (6) between distance be 25 millimeters.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110382932 CN102406547B (en) | 2011-11-28 | 2011-11-28 | Method of preparing ultramicro medicinal powder for removing heat from the lung to relieve cough at normal temperature |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110382932 CN102406547B (en) | 2011-11-28 | 2011-11-28 | Method of preparing ultramicro medicinal powder for removing heat from the lung to relieve cough at normal temperature |
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| Publication Number | Publication Date |
|---|---|
| CN102406547A CN102406547A (en) | 2012-04-11 |
| CN102406547B true CN102406547B (en) | 2013-07-24 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN201415148Y (en) * | 2009-06-26 | 2010-03-03 | 丁相军 | Material superfine comminution system |
| CN101844133B (en) * | 2010-05-05 | 2012-09-05 | 贾平 | Air flow screening device for micron-sized powder materials |
| CN102247565A (en) * | 2010-12-16 | 2011-11-23 | 桑立功 | Prescription for cough relieving and lung-heat clearing |
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